CSTL vs SHC vs NTRA Stock Comparison

Castle Biosciences, Sotera Health and Natera Prices as of Oct 27, 2026 Peers: Industry group
SHC Sotera Health Co
$18.49 +0.8% 1M +10.7% 1Y
Market cap
$5.30B
P/E
32.4x
Revenue (TTM)
$1.22B
Div. yield
–
Diagnostic Labs Healthcare
5 wins
NTRA Natera, Inc.
$410.82 -0.4% 1M +113.7% 1Y
Market cap
$61.46B
P/E
–
Revenue (TTM)
$2.71B
Div. yield
–
Diagnostic Labs Healthcare
4 wins

Head to Head

9 decided of 12

Sotera Health leads on 5 of the 12 questions below (Sotera Health 5, Natera 4). Which ones matter depends on what you are buying for; a cheap multiple and slow growth often come together.

QuestionCSTLSHCNTRALeader
Larger companyMarket capitalisation $1.11B $5.30B $61.46B NTRA
Cheaper on earningsLower P/E, profitable companies only -57.1x 32.4x -319.5x –
Cheaper on forward earningsLower price / next fiscal year consensus EPS — 20.1x — –
Faster revenue growthRevenue growth, trailing twelve months +3.2% +8.1% +37.8% NTRA
More profitableNet margin, trailing twelve months -5.4% 13.4% -7.1% SHC
Better return on capitalReturn on invested capital -6.7% 9.1% -11.7% SHC
Less leveragedLower net debt / EBITDA 15.5x 3.3x 4.5x SHC
Higher dividend yieldTrailing dividend yield 0.00% 0.00% 0.00% –
Better 1-year returnPrice return, last 12 months +44.0% +10.7% +113.7% NTRA
Better 5-year returnAnnualised price return, 5 years -11.6%/yr -5.8%/yr +28.5%/yr NTRA
Less volatileAnnualised volatility, 1 year 58.3% 28.4% 47.8% SHC
Higher overall scoreMean of the five percentile scores vs peers 50/100 59/100 50/100 SHC

Percentile Scorecard

CSTLSHCNTRA

Each axis is the mean percentile of its metrics against the company's industry group. 100 is the best in the group, 50 the middle.

Scores by Axis

AxisCSTLSHCNTRA
Valuation 47 #49 of 92 52 #45 of 92 17 #77 of 92
Growth 52 #42 of 87 66 #30 of 87 71 #26 of 87
Profitability 39 #53 of 86 82 #16 of 86 33 #58 of 86
Financial Health 92 #9 of 97 37 #62 of 97 85 #15 of 97
Shareholder Returns 20 #45 of 56 – 46 #31 of 56
Overall 50 59 50
  • CSTL ranked among 102 companies in Healthcare Providers
  • SHC ranked among 102 companies in Healthcare Providers
  • NTRA ranked among 102 companies in Healthcare Providers

Price Performance

Price return, split-adjusted, before dividends. Click a name to hide or show it.

Returns

PeriodCSTLSHCNTRASPY
1 month -3.6%+0.8%-0.4% -0.2%
3 months +44.5%+4.1%+62.9% +3.9%
6 months +39.8%+19.0%+105.2% +8.2%
Year to date -11.3%+4.8%+79.3% +12.9%
1 year +44.0%+10.7%+113.7% +12.3%
3 years +164.2%+47.8%+973.8% +87.4%
3 years, per year +38.3%+13.9%+120.7% +23.3%
5 years -46.0%-25.6%+250.5% +67.9%
5 years, per year -11.6%-5.8%+28.5% +10.9%
10 years ——+4,464.7% +261.1%
10 years, per year ——+46.5% +13.7%

Risk

MeasureCSTLSHCNTRASPY
Volatility, 1Y 58.3%28.4%47.8% 12.7%
Downside volatility, 1Y 61.4%27.0%44.5% 12.7%
Beta vs S&P 500, 1Y 0.961.011.23 1.00
Return / volatility, 1Y 0.760.382.38 0.97
Max drawdown, 5Y -82.1%-78.2%-76.4% -25.4%
From 52-week high -19.8%-5.5%-3.5% -1.2%
52-week high $43.04$19.57$425.64 $779.14
52-week low $18.15$13.13$182.65 $631.97

Valuation History

Weekly multiples on trailing twelve-month fundamentals. Negative or extreme readings (a loss year, a collapsed denominator) are left out so the chart stays readable.

MultipleCSTLSHCNTRA
P/E now vs peer median -54.0xmedian 24.6x 32.3xmedian 24.6x -305.9xmedian 24.6x
P/S now vs peer median 2.9xmedian 1.6x 4.3xmedian 1.6x 21.8xmedian 1.6x
EV/EBITDA now vs peer median -48.2xmedian 14.6x 13.0xmedian 14.6x -258.6xmedian 14.6x
P/FCF now vs peer median -2,153xmedian 21.6x 46.8xmedian 21.6x 700.7xmedian 21.6x
P/B now vs peer median 2.2xmedian 3.2x 7.9xmedian 3.2x 32.4xmedian 3.2x
PEG now vs peer median -1.28median 0.66 0.86median 0.66 -9.22median 0.66

Financial History

Reported figures by fiscal period, placed on the calendar year (or quarter) each period ended in, so companies with different fiscal years line up.

Trailing twelve monthsCSTLSHCNTRA
Revenue $357.28M $1.22B $2.71B
Gross profit $276.03M $668.51M $1.71B
Operating income -$32.11M $411.34M -$289.67M
Net income -$19.42M $163.48M -$192.36M
Free cash flow -$489.00K $112.70M $84.20M
R&D $55.45M – $787.38M
EPS (diluted) $-0.64 $0.57 $-1.34
Cash & equivalents $62.12M $356.72M $1.10B
Total debt $10.08M $2.14B $80.29M
Shares (diluted) 30.40M 288.15M 143.28M
Enterprise value -$6.46M $3.98B $57.14B

All Metrics

58 metrics · best in bold

Bold marks the best reading: the lowest positive value for multiples, leverage and payout, the highest for everything else. The bar under each value is its percentile against that company's own peers. Hover a value for its rank and the peer median.

Valuation

12 metrics
MetricCSTLSHCNTRA
P/E -54.0x 32.3x -305.9x
P/FCF -2,153x 46.8x 700.7x
P/Operating cash flow 24.7x 18.1x 258.5x
P/S 2.9x 4.3x 21.8x
P/B 2.2x 7.9x 32.4x
P/Tangible book 2.2x 13.3x 40.4x
EV/EBITDA -48.2x 13.0x -258.6x
EV/EBIT -24.8x 17.2x -200.2x
EV/Revenue 2.2x 5.8x 21.4x
EV/FCF -1,628x 62.6x 688.6x
EV/Operating cash flow 18.7x 24.2x 254.0x
PEG (3Y EPS CAGR) -1.28 0.86 -9.22

Growth

14 metrics
MetricCSTLSHCNTRA
Revenue growth (1Y) 3.2% 8.1% 37.8%
Revenue CAGR (3Y) 28.7% 7.6% 42.7%
Gross profit growth (1Y) -1.6% 7.1% 43.6%
Gross profit CAGR (3Y) 29.2% 8.1% 68.1%
Operating income growth (1Y) -39.3% 21.8% 1.3%
Operating income CAGR (3Y) 30.8% 23.2% 17.3%
Net income growth (1Y) -105.1% 580.5% 24.0%
Net income CAGR (3Y) 39.8% 37.7% 27.8%
EPS growth (1Y) -99.3% 574.9% 27.7%
EPS CAGR (3Y) 42.3% 37.5% 33.2%
Operating cash flow growth (1Y) -31.8% 9.8% 22.2%
Operating cash flow CAGR (3Y) 45.1% 61.3% 38.6%
Free cash flow growth (1Y) -101.4% 0.0% -26.8%
Free cash flow CAGR (3Y) 78.8% 32.6% 30.4%

Profitability

14 metrics
MetricCSTLSHCNTRA
Gross margin 77.3% 55.0% 63.2%
EBITDA margin -4.6% 44.6% -8.3%
Operating margin -9.0% 33.8% -10.7%
Pretax margin -5.4% 21.7% -9.3%
Net margin -5.4% 13.4% -7.1%
FCF margin -0.1% 9.3% 3.1%
Operating cash flow margin 11.9% 24.0% 8.4%
Return on equity -4.2% 25.4% -10.7%
Return on assets -3.5% 5.0% -7.3%
Return on invested capital -6.7% 9.1% -11.7%
Return on capital employed -6.4% 13.5% -13.9%
Asset turnover 0.6x 0.4x 1.0x
Cash conversion (OCF / net income) -2.2x 1.8x -1.2x
Stock comp / revenue 12.6% 3.1% 14.1%

Financial Health

11 metrics
MetricCSTLSHCNTRA
Debt / assets 1.8% 64.7% 3.0%
Debt / equity 0.0x 3.2x 0.0x
Net debt / EBITDA 15.5x 3.3x 4.5x
Debt / FCF -20.6x 19.0x 1.0x
Liabilities / assets 16.2% 79.9% 31.5%
Equity / assets 83.8% 20.1% 68.5%
Interest coverage -85.6x – -75.9x
Current ratio 6.0x 2.8x 3.0x
Quick ratio 5.6x 2.4x 2.8x
Cash ratio 4.7x 1.5x 2.0x
Altman Z-score 7.39 1.94 41.96

Shareholder Returns

7 metrics
MetricCSTLSHCNTRA
Dividend yield – – –
Net buyback yield -0.5% – -0.1%
Shareholder yield -0.5% – -0.1%
Payout ratio (earnings) – – –
Payout ratio (FCF) – – –
Dividend growth (1Y) – – –
Dividend CAGR (3Y) – – –

Analyst Estimates

Solid lines are reported fiscal-year results; dashed lines are the consensus for the years ahead. Hover a year for the analysts' high and low, and how each result compared with its estimate.

ConsensusCSTLSHCNTRA
Forward P/E – 20.1xFY2026 –
EPS, next fiscal year $-1.31FY2026 $0.92FY2026 $-1.48FY2026
EPS growth, next FY – +7.0%FY2026 –
EPS growth, the year after – +21.7% –
Revenue, next fiscal year $385.85MFY2026 $1.33BFY2026 $3.07BFY2026
Revenue growth, next FY +12.1%FY2026 +14.8%FY2026 +32.8%FY2026
Revenue growth, the year after +2.3% -4.2% +7.2%

Institutional Ownership

13F filings, quarter ended Jun 30, 2026
HoldersCSTLSHCNTRA
Held by institutions 89.6% 100.0% 95.5%
Institutions holding 177 316 847
Change in shares held, QoQ -1.0% +5.9% +2.7%
Institutions buying 104 220 513
Institutions selling 55 64 240
Buyers to sellers 1.89 3.44 2.14

Return Correlation

Daily returns, last 12 months

1.00 means two stocks move in lockstep, 0 that they move independently. Pairs below about 0.5 diversify each other.

CSTLSHCNTRA
CSTL 1.00 0.33 0.41
SHC 0.33 1.00 0.36
NTRA 0.41 0.36 1.00

Add a Peer

Largest companies in the same industry

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Frequently Asked Questions

Which is bigger, CSTL, SHC and NTRA?

Natera (NTRA) is the largest by market capitalisation: Castle Biosciences (CSTL) $1.11B, Sotera Health (SHC) $5.30B, Natera (NTRA) $61.46B.

Which company is growing faster?

Natera (NTRA) grew revenue fastest over the trailing twelve months: Castle Biosciences (CSTL) +3.2%, Sotera Health (SHC) +8.1%, Natera (NTRA) +37.8%.

Which company is more profitable?

Sotera Health (SHC) has the highest net margin (Castle Biosciences (CSTL) -5.4%, Sotera Health (SHC) 13.4%, Natera (NTRA) -7.1%). On return on invested capital, Sotera Health (SHC) leads (Castle Biosciences (CSTL) -6.7%, Sotera Health (SHC) 9.1%, Natera (NTRA) -11.7%).

Which stock has performed better?

Over the past year Natera (NTRA) returned the most: Castle Biosciences (CSTL) +44.0%, Sotera Health (SHC) +10.7%, Natera (NTRA) +113.7%. Over five years, Natera (NTRA) compounded fastest (Castle Biosciences (CSTL) -11.6%/yr, Sotera Health (SHC) -5.8%/yr, Natera (NTRA) +28.5%/yr). Returns are price only, before dividends.

Which stock is riskier?

By one-year price volatility, Sotera Health (SHC) has been the steadiest (Castle Biosciences (CSTL) 58.3%, Sotera Health (SHC) 28.4%, Natera (NTRA) 47.8%). Volatility measures how widely the price swings, not the risk of the business.

Which is the better stock, CSTL, SHC and NTRA?

There is no single answer; it depends on what you are buying for. On the 12 head-to-head measures on this page, Sotera Health (SHC) leads on 5. Business Quant does not give investment advice; use the comparison as a starting point for your own research.

Data from SEC filings, exchange prices and consensus estimates, via Business Quant. Percentile scores compare each company with its own peer group, so two companies' scores are each relative to different peers unless you rank against the whole market. Price returns exclude dividends. Nothing on this page is investment advice.