CSTL vs SHC vs BLLN Stock Comparison

Castle Biosciences, Sotera Health and BillionToOne Prices as of Oct 28, 2026 Peers: Industry group
CSTL Castle Biosciences Inc
$36.68 +2.1% 1M +51.9% 1Y
Market cap
$1.12B
P/E
–
Revenue (TTM)
$357.28M
Div. yield
–
Diagnostic Labs Healthcare
1 win
SHC Sotera Health Co
$18.65 +1.1% 1M +12.6% 1Y
Market cap
$5.32B
P/E
32.6x
Revenue (TTM)
$1.22B
Div. yield
–
Diagnostic Labs Healthcare
7 wins
BLLN BillionToOne, Inc.
$114.00 -6.3% 1M
Market cap
$5.34B
P/E
176.0x
Revenue (TTM)
$397.41M
Div. yield
–
Diagnostic Labs Healthcare
3 wins

Head to Head

11 decided of 12

Sotera Health leads on 7 of the 12 questions below (Sotera Health 7, BillionToOne 3, Castle Biosciences 1). Which ones matter depends on what you are buying for; a cheap multiple and slow growth often come together.

QuestionCSTLSHCBLLNLeader
Larger companyMarket capitalisation $1.12B $5.32B $5.34B BLLN
Cheaper on earningsLower P/E, profitable companies only -57.4x 32.6x 176.0x SHC
Cheaper on forward earningsLower price / next fiscal year consensus EPS — 20.3x 150.0x SHC
Faster revenue growthRevenue growth, trailing twelve months +3.2% +8.1% +90.1% BLLN
More profitableNet margin, trailing twelve months -5.4% 13.4% 7.6% SHC
Better return on capitalReturn on invested capital -6.7% 9.1% 7.0% SHC
Less leveragedLower net debt / EBITDA 15.5x 3.3x -9.1x BLLN
Higher dividend yieldTrailing dividend yield — — — –
Better 1-year returnPrice return, last 12 months +51.9% +12.6% — CSTL
Better 5-year returnAnnualised price return, 5 years -10.1%/yr -5.5%/yr — SHC
Less volatileAnnualised volatility, 1 year 58.6% 28.4% 94.3% SHC
Higher overall scoreMean of the five percentile scores vs peers 50/100 59/100 57/100 SHC

Percentile Scorecard

CSTLSHCBLLN

Each axis is the mean percentile of its metrics against the company's industry group. 100 is the best in the group, 50 the middle.

Scores by Axis

AxisCSTLSHCBLLN
Valuation 46 #50 of 92 52 #45 of 92 21 #73 of 92
Growth 51 #43 of 87 67 #29 of 87 100 #1 of 87
Profitability 39 #53 of 86 82 #16 of 86 61 #34 of 86
Financial Health 91 #10 of 97 35 #63 of 97 96 #5 of 97
Shareholder Returns 24 #42 of 55 – 7 #51 of 55
Overall 50 59 57
  • CSTL ranked among 102 companies in Healthcare Providers
  • SHC ranked among 102 companies in Healthcare Providers
  • BLLN ranked among 102 companies in Healthcare Providers

Price Performance

Price return, split-adjusted, before dividends. Click a name to hide or show it.

Returns

PeriodCSTLSHCBLLNSPY
1 month +2.1%+1.1%-6.3% +0.9%
3 months +50.0%+6.4%-14.0% +5.9%
6 months +51.3%+20.7%+54.7% +8.5%
Year to date -5.7%+5.7%+39.3% +13.3%
1 year +51.9%+12.6%— +12.4%
3 years +180.9%+49.1%— +88.1%
3 years, per year +41.1%+14.2%— +23.5%
5 years -41.2%-24.5%— +68.2%
5 years, per year -10.1%-5.5%— +11.0%

Risk

MeasureCSTLSHCBLLNSPY
Volatility, 1Y 58.6%28.4%94.3% 12.7%
Downside volatility, 1Y 61.4%27.1%107.3% 12.7%
Beta vs S&P 500, 1Y 0.971.011.66 1.00
Return / volatility, 1Y 0.890.44— 0.98
Max drawdown, 5Y -82.1%-78.2%-50.8% -25.4%
From 52-week high -14.8%-4.7%-24.0% -0.9%
52-week high $43.04$19.57$149.97 $779.14
52-week low $18.15$13.13$64.03 $631.97

Valuation History

Weekly multiples on trailing twelve-month fundamentals. Negative or extreme readings (a loss year, a collapsed denominator) are left out so the chart stays readable.

MultipleCSTLSHCBLLN
P/E now vs peer median -57.4xmedian 25.6x 32.6xmedian 25.6x 176.0xmedian 25.6x
P/S now vs peer median 3.1xmedian 1.6x 4.4xmedian 1.6x 13.4xmedian 1.6x
EV/EBITDA now vs peer median -52.2xmedian 16.3x 13.1xmedian 16.3x 97.1xmedian 16.3x
P/FCF now vs peer median -2,288xmedian 21.3x 47.2xmedian 21.3x 160.9xmedian 21.3x
P/B now vs peer median 2.4xmedian 3.3x 8.0xmedian 3.3x 9.9xmedian 3.3x
PEG now vs peer median -1.36median 0.68 0.87median 0.68 —median 0.68

Financial History

Reported figures by fiscal period, placed on the calendar year (or quarter) each period ended in, so companies with different fiscal years line up.

Trailing twelve monthsCSTLSHCBLLN
Revenue $357.28M $1.22B $397.41M
Gross profit $276.03M $668.51M $283.22M
Operating income -$32.11M $411.34M $43.30M
Net income -$19.42M $163.48M $37.71M
Free cash flow -$489.00K $112.70M $33.18M
R&D $55.45M – $59.21M
EPS (diluted) $-0.64 $0.57 $0.55
Cash & equivalents $62.12M $356.72M $548.63M
Total debt $10.08M $2.14B $91.03M
Shares (diluted) 30.40M 288.15M 54.46M
Enterprise value $3.41M $4.01B $3.56B

All Metrics

58 metrics · best in bold

Bold marks the best reading: the lowest positive value for multiples, leverage and payout, the highest for everything else. The bar under each value is its percentile against that company's own peers. Hover a value for its rank and the peer median.

Valuation

12 metrics
MetricCSTLSHCBLLN
P/E -57.4x 32.6x 176.0x
P/FCF -2,288x 47.2x 160.9x
P/Operating cash flow 26.2x 18.2x 117.7x
P/S 3.1x 4.4x 13.4x
P/B 2.4x 8.0x 9.9x
P/Tangible book 2.4x 13.5x 9.9x
EV/EBITDA -52.2x 13.1x 97.1x
EV/EBIT -26.9x 17.3x 112.7x
EV/Revenue 2.4x 5.8x 12.3x
EV/FCF -1,763x 63.0x 147.1x
EV/Operating cash flow 20.2x 24.3x 107.6x
PEG (3Y EPS CAGR) -1.36 0.87 –

Growth

14 metrics
MetricCSTLSHCBLLN
Revenue growth (1Y) 3.2% 8.1% 90.1%
Revenue CAGR (3Y) 28.7% 7.6% –
Gross profit growth (1Y) -1.6% 7.1% 122.4%
Gross profit CAGR (3Y) 29.2% 8.1% –
Operating income growth (1Y) -39.3% 21.8% 253.2%
Operating income CAGR (3Y) 30.8% 23.2% –
Net income growth (1Y) -105.1% 580.5% 223.2%
Net income CAGR (3Y) 39.8% 37.7% –
EPS growth (1Y) -99.3% 574.9% 118.7%
EPS CAGR (3Y) 42.3% 37.5% –
Operating cash flow growth (1Y) -31.8% 9.8% –
Operating cash flow CAGR (3Y) 45.1% 61.3% –
Free cash flow growth (1Y) -101.4% 0.0% –
Free cash flow CAGR (3Y) 78.8% 32.6% –

Profitability

14 metrics
MetricCSTLSHCBLLN
Gross margin 77.3% 55.0% 71.3%
EBITDA margin -4.6% 44.6% 12.6%
Operating margin -9.0% 33.8% 10.9%
Pretax margin -5.4% 21.7% 9.5%
Net margin -5.4% 13.4% 7.6%
FCF margin -0.1% 9.3% 8.3%
Operating cash flow margin 11.9% 24.0% 11.4%
Return on equity -4.2% 25.4% 7.2%
Return on assets -3.5% 5.0% 5.3%
Return on invested capital -6.7% 9.1% 7.0%
Return on capital employed -6.4% 13.5% 6.6%
Asset turnover 0.6x 0.4x 0.6x
Cash conversion (OCF / net income) -2.2x 1.8x 1.2x
Stock comp / revenue 12.6% 3.1% 6.4%

Financial Health

11 metrics
MetricCSTLSHCBLLN
Debt / assets 1.8% 64.7% 12.5%
Debt / equity 0.0x 3.2x 0.2x
Net debt / EBITDA 15.5x 3.3x -9.1x
Debt / FCF -20.6x 19.0x 2.7x
Liabilities / assets 16.2% 79.9% 26.4%
Equity / assets 83.8% 20.1% 73.6%
Interest coverage -85.6x – 1,056x
Current ratio 6.0x 2.8x 11.7x
Quick ratio 5.6x 2.4x 11.2x
Cash ratio 4.7x 1.5x 9.8x
Altman Z-score 7.82 1.95 17.85

Shareholder Returns

7 metrics
MetricCSTLSHCBLLN
Dividend yield – – –
Net buyback yield -0.5% – -5.7%
Shareholder yield -0.5% – -5.7%
Payout ratio (earnings) – – –
Payout ratio (FCF) – – –
Dividend growth (1Y) – – –
Dividend CAGR (3Y) – – –

Analyst Estimates

Solid lines are reported fiscal-year results; dashed lines are the consensus for the years ahead. Hover a year for the analysts' high and low, and how each result compared with its estimate.

ConsensusCSTLSHCBLLN
Forward P/E – 20.3xFY2026 150.0xFY2026
EPS, next fiscal year $-1.31FY2026 $0.92FY2026 $0.76FY2026
EPS growth, next FY – +7.0%FY2026 +442.9%FY2026
EPS growth, the year after – +21.7% +22.4%
Revenue, next fiscal year $385.85MFY2026 $1.33BFY2026 $481.76MFY2026
Revenue growth, next FY +12.1%FY2026 +14.8%FY2026 +57.9%FY2026
Revenue growth, the year after +2.3% -4.2% +27.1%

Institutional Ownership

13F filings, quarter ended Jun 30, 2026
HoldersCSTLSHCBLLN
Held by institutions 89.6% 100.0% 36.1%
Institutions holding 177 316 155
Change in shares held, QoQ -1.0% +5.9% +34.7%
Institutions buying 104 220 127
Institutions selling 55 64 13
Buyers to sellers 1.89 3.44 9.77

Return Correlation

Daily returns, last 12 months

1.00 means two stocks move in lockstep, 0 that they move independently. Pairs below about 0.5 diversify each other.

CSTLSHCBLLN
CSTL 1.00 0.33 0.16
SHC 0.33 1.00 0.14
BLLN 0.16 0.14 1.00

Add a Peer

Largest companies in the same industry

Related Comparisons

Frequently Asked Questions

Which is bigger, CSTL, SHC and BLLN?

BillionToOne (BLLN) is the largest by market capitalisation: Castle Biosciences (CSTL) $1.12B, Sotera Health (SHC) $5.32B, BillionToOne (BLLN) $5.34B.

Which stock is cheaper, CSTL, SHC and BLLN?

Sotera Health (SHC) trades on the lowest price-to-earnings ratio (Castle Biosciences (CSTL) -57.4x, Sotera Health (SHC) 32.6x, BillionToOne (BLLN) 176.0x). On next year's consensus earnings, Sotera Health (SHC) is cheapest (Sotera Health (SHC) 20.3x, BillionToOne (BLLN) 150.0x). A lower multiple can reflect slower expected growth, so read it next to the growth figures.

Which company is growing faster?

BillionToOne (BLLN) grew revenue fastest over the trailing twelve months: Castle Biosciences (CSTL) +3.2%, Sotera Health (SHC) +8.1%, BillionToOne (BLLN) +90.1%.

Which company is more profitable?

Sotera Health (SHC) has the highest net margin (Castle Biosciences (CSTL) -5.4%, Sotera Health (SHC) 13.4%, BillionToOne (BLLN) 7.6%). On return on invested capital, Sotera Health (SHC) leads (Castle Biosciences (CSTL) -6.7%, Sotera Health (SHC) 9.1%, BillionToOne (BLLN) 7.0%).

Which stock has performed better?

Over the past year Castle Biosciences (CSTL) returned the most: Castle Biosciences (CSTL) +51.9%, Sotera Health (SHC) +12.6%. Over five years, Sotera Health (SHC) compounded fastest (Castle Biosciences (CSTL) -10.1%/yr, Sotera Health (SHC) -5.5%/yr). Returns are price only, before dividends.

Which stock is riskier?

By one-year price volatility, Sotera Health (SHC) has been the steadiest (Castle Biosciences (CSTL) 58.6%, Sotera Health (SHC) 28.4%, BillionToOne (BLLN) 94.3%). Volatility measures how widely the price swings, not the risk of the business.

Which is the better stock, CSTL, SHC and BLLN?

There is no single answer; it depends on what you are buying for. On the 12 head-to-head measures on this page, Sotera Health (SHC) leads on 7. Business Quant does not give investment advice; use the comparison as a starting point for your own research.

Data from SEC filings, exchange prices and consensus estimates, via Business Quant. Percentile scores compare each company with its own peer group, so two companies' scores are each relative to different peers unless you rank against the whole market. Price returns exclude dividends. Nothing on this page is investment advice.