CSTL vs IDXG vs SHC Stock Comparison

Castle Biosciences, Interpace Biosciences and Sotera Health Prices as of Oct 29, 2026 Peers: Industry group
SHC Sotera Health Co
$18.70 +0.5% 1M +12.8% 1Y
Market cap
$5.14B
P/E
31.5x
Revenue (TTM)
$1.22B
Div. yield
–
Diagnostic Labs Healthcare
6 wins

Head to Head

10 decided of 12

Sotera Health leads on 6 of the 12 questions below (Sotera Health 6, Interpace Biosciences 4). Which ones matter depends on what you are buying for; a cheap multiple and slow growth often come together.

QuestionCSTLIDXGSHCLeader
Larger companyMarket capitalisation $1.13B $148.20M $5.14B SHC
Cheaper on earningsLower P/E, profitable companies only -58.4x 6.1x 31.5x IDXG
Cheaper on forward earningsLower price / next fiscal year consensus EPS — — 20.3x –
Faster revenue growthRevenue growth, trailing twelve months +3.2% -20.5% +8.1% SHC
More profitableNet margin, trailing twelve months -5.4% 67.6% 13.4% IDXG
Better return on capitalReturn on invested capital -6.7% — 9.1% SHC
Less leveragedLower net debt / EBITDA 15.5x — 3.3x SHC
Higher dividend yieldTrailing dividend yield 0.00% 0.00% 0.00% –
Better 1-year returnPrice return, last 12 months +62.2% +420.0% +12.8% IDXG
Better 5-year returnAnnualised price return, 5 years -9.2%/yr — -5.4%/yr SHC
Less volatileAnnualised volatility, 1 year 58.8% 182.5% 28.4% SHC
Higher overall scoreMean of the five percentile scores vs peers 51/100 66/100 60/100 IDXG

Percentile Scorecard

CSTLIDXGSHC

Each axis is the mean percentile of its metrics against the company's industry group. 100 is the best in the group, 50 the middle.

Scores by Axis

AxisCSTLIDXGSHC
Valuation 46 #50 of 92 57 #40 of 92 52 #45 of 92
Growth 52 #42 of 87 49 #45 of 87 67 #29 of 87
Profitability 39 #53 of 86 92 #8 of 86 85 #14 of 86
Financial Health 92 #9 of 97 67 #33 of 97 37 #62 of 97
Shareholder Returns 24 #42 of 55 – –
Overall 51 66 60
  • CSTL ranked among 102 companies in Healthcare Providers
  • IDXG ranked among 102 companies in Healthcare Providers
  • SHC ranked among 102 companies in Healthcare Providers

Price Performance

Price return, split-adjusted, before dividends. Click a name to hide or show it.

Returns

PeriodCSTLIDXGSHCSPY
1 month +10.4%-10.9%+0.5% +0.7%
3 months +43.7%+297.2%+4.8% +3.7%
6 months +57.2%+188.9%+20.2% +7.1%
Year to date -1.0%+365.0%+6.0% +12.8%
1 year +62.2%+420.0%+12.8% +11.9%
3 years +170.6%—+48.3% +85.2%
3 years, per year +39.4%—+14.0% +22.8%
5 years -38.2%—-24.3% +67.6%
5 years, per year -9.2%—-5.4% +10.9%

Risk

MeasureCSTLIDXGSHCSPY
Volatility, 1Y 58.8%182.5%28.4% 12.7%
Downside volatility, 1Y 61.6%84.4%27.1% 12.6%
Beta vs S&P 500, 1Y 0.96-0.091.01 1.00
Return / volatility, 1Y 1.062.300.45 0.94
Max drawdown, 5Y -82.1%-81.1%-78.2% -25.4%
From 52-week high -10.5%-24.9%-4.4% -1.2%
52-week high $43.04$7.62$19.57 $779.14
52-week low $18.15$0.83$13.13 $631.97

Valuation History

Weekly multiples on trailing twelve-month fundamentals. Negative or extreme readings (a loss year, a collapsed denominator) are left out so the chart stays readable.

MultipleCSTLIDXGSHC
P/E now vs peer median -60.3xmedian 26.0x 6.5xmedian 26.0x 32.7xmedian 26.0x
P/S now vs peer median 3.3xmedian 1.6x 4.4xmedian 1.6x 4.4xmedian 1.6x
EV/EBITDA now vs peer median -55.6xmedian 15.4x 33.3xmedian 15.4x 13.1xmedian 15.4x
P/FCF now vs peer median -2,403xmedian 21.5x 38.6xmedian 21.5x 47.4xmedian 21.5x
P/B now vs peer median 2.5xmedian 3.2x 6.8xmedian 3.2x 8.0xmedian 3.2x
PEG now vs peer median -1.43median 0.87 0.21median 0.87 0.87median 0.87

Financial History

Reported figures by fiscal period, placed on the calendar year (or quarter) each period ended in, so companies with different fiscal years line up.

Trailing twelve monthsCSTLIDXGSHC
Revenue $357.28M $36.14M $1.22B
Gross profit $276.03M $23.04M $668.51M
Operating income -$32.11M $4.17M $411.34M
Net income -$19.42M $24.45M $163.48M
Free cash flow -$489.00K $4.10M $112.70M
R&D $55.45M $594.00K –
EPS (diluted) $-0.64 $0.88 $0.57
Cash & equivalents $62.12M $2.70M $356.72M
Total debt $10.08M – $2.14B
Shares (diluted) 30.40M 27.71M 288.15M
Enterprise value $18.09M $138.93M $3.83B

All Metrics

58 metrics · best in bold

Bold marks the best reading: the lowest positive value for multiples, leverage and payout, the highest for everything else. The bar under each value is its percentile against that company's own peers. Hover a value for its rank and the peer median.

Valuation

12 metrics
MetricCSTLIDXGSHC
P/E -60.3x 6.5x 32.7x
P/FCF -2,403x 38.6x 47.4x
P/Operating cash flow 27.6x 35.6x 18.3x
P/S 3.3x 4.4x 4.4x
P/B 2.5x 6.8x 8.0x
P/Tangible book 2.5x 6.8x 13.5x
EV/EBITDA -55.6x 33.3x 13.1x
EV/EBIT -28.6x 37.4x 17.3x
EV/Revenue 2.6x 4.3x 5.9x
EV/FCF -1,878x 38.0x 63.2x
EV/Operating cash flow 21.5x 34.9x 24.4x
PEG (3Y EPS CAGR) -1.43 0.21 0.87

Growth

14 metrics
MetricCSTLIDXGSHC
Revenue growth (1Y) 3.2% -20.5% 8.1%
Revenue CAGR (3Y) 28.7% -1.0% 7.6%
Gross profit growth (1Y) -1.6% -19.0% 7.1%
Gross profit CAGR (3Y) 29.2% -0.1% 8.1%
Operating income growth (1Y) -39.3% -27.2% 21.8%
Operating income CAGR (3Y) 30.8% 46.4% 23.2%
Net income growth (1Y) -105.1% 435.6% 580.5%
Net income CAGR (3Y) 39.8% 54.2% 37.7%
EPS growth (1Y) -99.3% -14.5% 574.9%
EPS CAGR (3Y) 42.3% 31.2% 37.5%
Operating cash flow growth (1Y) -31.8% -11.8% 9.8%
Operating cash flow CAGR (3Y) 45.1% 62.1% 61.3%
Free cash flow growth (1Y) -101.4% -6.8% 0.0%
Free cash flow CAGR (3Y) 78.8% 54.9% 32.6%

Profitability

14 metrics
MetricCSTLIDXGSHC
Gross margin 77.3% 63.7% 55.0%
EBITDA margin -4.6% 12.9% 44.6%
Operating margin -9.0% 11.5% 33.8%
Pretax margin -5.4% 11.1% 21.7%
Net margin -5.4% 67.6% 13.4%
FCF margin -0.1% 11.4% 9.3%
Operating cash flow margin 11.9% 12.3% 24.0%
Return on equity -4.2% 105.5% 25.4%
Return on assets -3.5% 72.0% 5.0%
Return on invested capital -6.7% – 9.1%
Return on capital employed -6.4% 14.4% 13.5%
Asset turnover 0.6x 1.1x 0.4x
Cash conversion (OCF / net income) -2.2x 0.2x 1.8x
Stock comp / revenue 12.6% 0.1% 3.1%

Financial Health

11 metrics
MetricCSTLIDXGSHC
Debt / assets 1.8% – 64.7%
Debt / equity 0.0x – 3.2x
Net debt / EBITDA 15.5x – 3.3x
Debt / FCF -20.6x – 19.0x
Liabilities / assets 16.2% 32.7% 79.9%
Equity / assets 83.8% 67.3% 20.1%
Interest coverage -85.6x – –
Current ratio 6.0x 2.2x 2.8x
Quick ratio 5.6x 1.8x 2.4x
Cash ratio 4.7x 0.5x 1.5x
Altman Z-score 8.19 1.56 1.95

Shareholder Returns

7 metrics
MetricCSTLIDXGSHC
Dividend yield – – –
Net buyback yield -0.5% – –
Shareholder yield -0.5% – –
Payout ratio (earnings) – – –
Payout ratio (FCF) – – –
Dividend growth (1Y) – – –
Dividend CAGR (3Y) – – –

Analyst Estimates

Solid lines are reported fiscal-year results; dashed lines are the consensus for the years ahead. Hover a year for the analysts' high and low, and how each result compared with its estimate.

ConsensusCSTLIDXGSHC
Forward P/E – – 20.3xFY2026
EPS, next fiscal year $-1.31FY2026 $-0.72FY2023 $0.92FY2026
EPS growth, next FY – – +7.0%FY2026
EPS growth, the year after – – +21.7%
Revenue, next fiscal year $385.85MFY2026 – $1.33BFY2026
Revenue growth, next FY +12.1%FY2026 – +14.8%FY2026
Revenue growth, the year after +2.3% – -4.2%

Institutional Ownership

13F filings, quarter ended Jun 30, 2026
HoldersCSTLIDXGSHC
Held by institutions 89.6% – 100.0%
Institutions holding 177 – 316
Change in shares held, QoQ -1.0% – +5.9%
Institutions buying 104 – 220
Institutions selling 55 – 64
Buyers to sellers 1.89 – 3.44

Return Correlation

Daily returns, last 12 months

1.00 means two stocks move in lockstep, 0 that they move independently. Pairs below about 0.5 diversify each other.

CSTLIDXGSHC
CSTL 1.00 0.01 0.33
IDXG 0.01 1.00 -0.01
SHC 0.33 -0.01 1.00

Add a Peer

Largest companies in the same industry

Related Comparisons

Frequently Asked Questions

Which is bigger, CSTL, IDXG and SHC?

Sotera Health (SHC) is the largest by market capitalisation: Castle Biosciences (CSTL) $1.13B, Interpace Biosciences (IDXG) $148.20M, Sotera Health (SHC) $5.14B.

Which stock is cheaper, CSTL, IDXG and SHC?

Interpace Biosciences (IDXG) trades on the lowest price-to-earnings ratio (Castle Biosciences (CSTL) -58.4x, Interpace Biosciences (IDXG) 6.1x, Sotera Health (SHC) 31.5x). A lower multiple can reflect slower expected growth, so read it next to the growth figures.

Which company is growing faster?

Sotera Health (SHC) grew revenue fastest over the trailing twelve months: Castle Biosciences (CSTL) +3.2%, Interpace Biosciences (IDXG) -20.5%, Sotera Health (SHC) +8.1%.

Which company is more profitable?

Interpace Biosciences (IDXG) has the highest net margin (Castle Biosciences (CSTL) -5.4%, Interpace Biosciences (IDXG) 67.6%, Sotera Health (SHC) 13.4%). On return on invested capital, Sotera Health (SHC) leads (Castle Biosciences (CSTL) -6.7%, Sotera Health (SHC) 9.1%).

Which stock has performed better?

Over the past year Interpace Biosciences (IDXG) returned the most: Castle Biosciences (CSTL) +62.2%, Interpace Biosciences (IDXG) +420.0%, Sotera Health (SHC) +12.8%. Over five years, Sotera Health (SHC) compounded fastest (Castle Biosciences (CSTL) -9.2%/yr, Sotera Health (SHC) -5.4%/yr). Returns are price only, before dividends.

Which stock is riskier?

By one-year price volatility, Sotera Health (SHC) has been the steadiest (Castle Biosciences (CSTL) 58.8%, Interpace Biosciences (IDXG) 182.5%, Sotera Health (SHC) 28.4%). Volatility measures how widely the price swings, not the risk of the business.

Which is the better stock, CSTL, IDXG and SHC?

There is no single answer; it depends on what you are buying for. On the 12 head-to-head measures on this page, Sotera Health (SHC) leads on 6. Business Quant does not give investment advice; use the comparison as a starting point for your own research.

Data from SEC filings, exchange prices and consensus estimates, via Business Quant. Percentile scores compare each company with its own peer group, so two companies' scores are each relative to different peers unless you rank against the whole market. Price returns exclude dividends. Nothing on this page is investment advice.