CSTL vs GH vs LH Stock Comparison

Castle Biosciences, Guardant Health and Labcorp Holdings Prices as of Oct 27, 2026 Peers: Industry group
GH Guardant Health, Inc.
$178.06 +0.5% 1M +151.3% 1Y
Market cap
$24.38B
P/E
–
Revenue (TTM)
$1.18B
Div. yield
–
Diagnostic Labs Healthcare
3 wins
LH Labcorp Holdings Inc.
$331.39 +7.1% 1M +20.2% 1Y
Market cap
$29.55B
P/E
29.5x
Revenue (TTM)
$14.35B
Div. yield
–
Diagnostic Labs Healthcare
6 wins

Head to Head

9 decided of 12

Labcorp Holdings leads on 6 of the 12 questions below (Labcorp Holdings 6, Guardant Health 3). Which ones matter depends on what you are buying for; a cheap multiple and slow growth often come together.

QuestionCSTLGHLHLeader
Larger companyMarket capitalisation $1.13B $24.38B $29.55B LH
Cheaper on earningsLower P/E, profitable companies only -58.1x -53.8x 29.5x –
Cheaper on forward earningsLower price / next fiscal year consensus EPS — — 19.4x –
Faster revenue growthRevenue growth, trailing twelve months +3.2% +42.7% +6.4% GH
More profitableNet margin, trailing twelve months -5.4% -38.3% 7.0% LH
Better return on capitalReturn on invested capital -6.7% — 8.2% LH
Less leveragedLower net debt / EBITDA 15.5x — 2.6x LH
Higher dividend yieldTrailing dividend yield 0.00% 0.00% 0.00% –
Better 1-year returnPrice return, last 12 months +44.0% +151.3% +20.2% GH
Better 5-year returnAnnualised price return, 5 years -11.6%/yr +8.5%/yr +6.2%/yr GH
Less volatileAnnualised volatility, 1 year 58.3% 57.4% 24.0% LH
Higher overall scoreMean of the five percentile scores vs peers 50/100 28/100 56/100 LH

Percentile Scorecard

CSTLGHLH

Each axis is the mean percentile of its metrics against the company's industry group. 100 is the best in the group, 50 the middle.

Scores by Axis

AxisCSTLGHLH
Valuation 47 #49 of 92 18 #76 of 92 62 #36 of 92
Growth 52 #42 of 87 49 #45 of 87 30 #61 of 87
Profitability 39 #53 of 86 7 #80 of 86 68 #28 of 86
Financial Health 92 #9 of 97 52 #47 of 97 47 #52 of 97
Shareholder Returns 20 #45 of 56 15 #48 of 56 73 #16 of 56
Overall 50 28 56
  • CSTL ranked among 102 companies in Healthcare Providers
  • GH ranked among 102 companies in Healthcare Providers
  • LH ranked among 102 companies in Healthcare Providers

Price Performance

Price return, split-adjusted, before dividends. Click a name to hide or show it.

Returns

PeriodCSTLGHLHSPY
1 month -3.6%+0.5%+7.1% -0.2%
3 months +44.5%+24.0%+5.4% +3.9%
6 months +39.8%+114.3%+27.7% +8.2%
Year to date -11.3%+74.3%+32.1% +12.9%
1 year +44.0%+151.3%+20.2% +12.3%
3 years +164.2%+613.4%+66.6% +87.4%
3 years, per year +38.3%+92.6%+18.6% +23.3%
5 years -46.0%+50.7%+35.2% +67.9%
5 years, per year -11.6%+8.5%+6.2% +10.9%
10 years ——+211.2% +261.1%
10 years, per year ——+12.0% +13.7%

Risk

MeasureCSTLGHLHSPY
Volatility, 1Y 58.3%57.4%24.0% 12.7%
Downside volatility, 1Y 61.4%48.7%24.1% 12.7%
Beta vs S&P 500, 1Y 0.961.030.34 1.00
Return / volatility, 1Y 0.762.640.84 0.97
Max drawdown, 5Y -82.1%-86.7%-35.0% -25.4%
From 52-week high -19.8%-4.9%-2.4% -1.2%
52-week high $43.04$187.22$339.40 $779.14
52-week low $18.15$69.58$246.64 $631.97

Valuation History

Weekly multiples on trailing twelve-month fundamentals. Negative or extreme readings (a loss year, a collapsed denominator) are left out so the chart stays readable.

MultipleCSTLGHLH
P/E now vs peer median -54.0xmedian 24.6x -52.2xmedian 24.6x 27.0xmedian 24.6x
P/S now vs peer median 2.9xmedian 1.6x 20.1xmedian 1.6x 1.9xmedian 1.6x
EV/EBITDA now vs peer median -48.2xmedian 14.6x -52.7xmedian 14.6x 14.8xmedian 14.6x
P/FCF now vs peer median -2,153xmedian 21.6x -98.8xmedian 21.6x 23.2xmedian 21.6x
P/B now vs peer median 2.2xmedian 3.2x -106.8xmedian 3.2x 3.1xmedian 3.2x
PEG now vs peer median -1.28median 0.66 -5.25median 0.66 2.87median 0.66

Financial History

Reported figures by fiscal period, placed on the calendar year (or quarter) each period ended in, so companies with different fiscal years line up.

Trailing twelve monthsCSTLGHLH
Revenue $357.28M $1.18B $14.35B
Gross profit $276.03M $769.16M $4.14B
Operating income -$32.11M -$470.26M $1.50B
Net income -$19.42M -$453.44M $1.00B
Free cash flow -$489.00K -$240.72M $1.16B
R&D $55.45M $375.79M –
EPS (diluted) $-0.64 $-3.41 $12.22
Cash & equivalents $62.12M $1.05B $141.80M
Total debt $10.08M – $5.86B
Shares (diluted) 30.40M 132.87M 82.00M
Enterprise value $12.01M $20.44B $27.30B

All Metrics

58 metrics · best in bold

Bold marks the best reading: the lowest positive value for multiples, leverage and payout, the highest for everything else. The bar under each value is its percentile against that company's own peers. Hover a value for its rank and the peer median.

Valuation

12 metrics
MetricCSTLGHLH
P/E -54.0x -52.2x 27.0x
P/FCF -2,153x -98.8x 23.2x
P/Operating cash flow 24.7x -128.5x 16.4x
P/S 2.9x 20.1x 1.9x
P/B 2.2x -106.8x 3.1x
P/Tangible book 2.2x -95.9x 5.4x
EV/EBITDA -48.2x -52.7x 14.8x
EV/EBIT -24.8x -48.4x 21.7x
EV/Revenue 2.2x 19.2x 2.3x
EV/FCF -1,628x -94.5x 28.2x
EV/Operating cash flow 18.7x -122.8x 19.9x
PEG (3Y EPS CAGR) -1.28 -5.25 2.87

Growth

14 metrics
MetricCSTLGHLH
Revenue growth (1Y) 3.2% 42.7% 6.4%
Revenue CAGR (3Y) 28.7% 32.4% 6.5%
Gross profit growth (1Y) -1.6% 47.7% 9.2%
Gross profit CAGR (3Y) 29.2% – 7.1%
Operating income growth (1Y) -39.3% -2.1% 25.6%
Operating income CAGR (3Y) 30.8% 4.8% 14.4%
Net income growth (1Y) -105.1% -9.6% 31.3%
Net income CAGR (3Y) 39.8% 3.7% 6.5%
EPS growth (1Y) -99.3% -2.4% 34.3%
EPS CAGR (3Y) 42.3% 9.9% 9.4%
Operating cash flow growth (1Y) -31.8% 22.4% -3.3%
Operating cash flow CAGR (3Y) 45.1% 18.1% 3.0%
Free cash flow growth (1Y) -101.4% 11.4% -8.4%
Free cash flow CAGR (3Y) 78.8% 14.4% 0.5%

Profitability

14 metrics
MetricCSTLGHLH
Gross margin 77.3% 65.0% 28.9%
EBITDA margin -4.6% -36.5% 15.3%
Operating margin -9.0% -39.7% 10.4%
Pretax margin -5.4% -38.4% 8.6%
Net margin -5.4% -38.3% 7.0%
FCF margin -0.1% -20.3% 8.1%
Operating cash flow margin 11.9% -15.7% 11.4%
Return on equity -4.2% – 11.6%
Return on assets -3.5% -23.7% 5.3%
Return on invested capital -6.7% – 8.2%
Return on capital employed -6.4% -29.9% 9.0%
Asset turnover 0.6x 0.6x 0.8x
Cash conversion (OCF / net income) -2.2x 0.4x 1.6x
Stock comp / revenue 12.6% 16.2% 0.9%

Financial Health

11 metrics
MetricCSTLGHLH
Debt / assets 1.8% – 31.6%
Debt / equity 0.0x – 0.7x
Net debt / EBITDA 15.5x – 2.6x
Debt / FCF -20.6x – 5.1x
Liabilities / assets 16.2% 111.7% 53.6%
Equity / assets 83.8% -11.7% 46.4%
Interest coverage -85.6x -97.6x 6.6x
Current ratio 6.0x 4.0x 1.8x
Quick ratio 5.6x 3.5x 1.2x
Cash ratio 4.7x 3.1x 0.1x
Altman Z-score 7.39 4.77 3.43

Shareholder Returns

7 metrics
MetricCSTLGHLH
Dividend yield – – 0.9%
Net buyback yield -0.5% -1.7% 2.4%
Shareholder yield -0.5% -1.7% 3.3%
Payout ratio (earnings) – – –
Payout ratio (FCF) – – –
Dividend growth (1Y) – – –
Dividend CAGR (3Y) – – –

Analyst Estimates

Solid lines are reported fiscal-year results; dashed lines are the consensus for the years ahead. Hover a year for the analysts' high and low, and how each result compared with its estimate.

ConsensusCSTLGHLH
Forward P/E – – 19.4xFY2026
EPS, next fiscal year $-1.31FY2026 $-3.33FY2026 $17.07FY2026
EPS growth, next FY – – +3.8%FY2026
EPS growth, the year after – – +9.3%
Revenue, next fiscal year $385.85MFY2026 $1.42BFY2026 $14.31BFY2026
Revenue growth, next FY +12.1%FY2026 +44.5%FY2026 +2.6%FY2026
Revenue growth, the year after +2.3% +27.0% +11.9%

Institutional Ownership

13F filings, quarter ended Jun 30, 2026
HoldersCSTLGHLH
Held by institutions 89.6% 100.0% 97.0%
Institutions holding 177 594 1,051
Change in shares held, QoQ -1.0% -2.6% +1.6%
Institutions buying 104 353 465
Institutions selling 55 180 393
Buyers to sellers 1.89 1.96 1.18

Return Correlation

Daily returns, last 12 months

1.00 means two stocks move in lockstep, 0 that they move independently. Pairs below about 0.5 diversify each other.

CSTLGHLH
CSTL 1.00 0.45 0.14
GH 0.45 1.00 0.26
LH 0.14 0.26 1.00

Add a Peer

Largest companies in the same industry

Related Comparisons

Frequently Asked Questions

Which is bigger, CSTL, GH and LH?

Labcorp Holdings (LH) is the largest by market capitalisation: Castle Biosciences (CSTL) $1.13B, Guardant Health (GH) $24.38B, Labcorp Holdings (LH) $29.55B.

Which company is growing faster?

Guardant Health (GH) grew revenue fastest over the trailing twelve months: Castle Biosciences (CSTL) +3.2%, Guardant Health (GH) +42.7%, Labcorp Holdings (LH) +6.4%.

Which company is more profitable?

Labcorp Holdings (LH) has the highest net margin (Castle Biosciences (CSTL) -5.4%, Guardant Health (GH) -38.3%, Labcorp Holdings (LH) 7.0%). On return on invested capital, Labcorp Holdings (LH) leads (Castle Biosciences (CSTL) -6.7%, Labcorp Holdings (LH) 8.2%).

Which stock has performed better?

Over the past year Guardant Health (GH) returned the most: Castle Biosciences (CSTL) +44.0%, Guardant Health (GH) +151.3%, Labcorp Holdings (LH) +20.2%. Over five years, Guardant Health (GH) compounded fastest (Castle Biosciences (CSTL) -11.6%/yr, Guardant Health (GH) +8.5%/yr, Labcorp Holdings (LH) +6.2%/yr). Returns are price only, before dividends.

Which stock is riskier?

By one-year price volatility, Labcorp Holdings (LH) has been the steadiest (Castle Biosciences (CSTL) 58.3%, Guardant Health (GH) 57.4%, Labcorp Holdings (LH) 24.0%). Volatility measures how widely the price swings, not the risk of the business.

Which is the better stock, CSTL, GH and LH?

There is no single answer; it depends on what you are buying for. On the 12 head-to-head measures on this page, Labcorp Holdings (LH) leads on 6. Business Quant does not give investment advice; use the comparison as a starting point for your own research.

Data from SEC filings, exchange prices and consensus estimates, via Business Quant. Percentile scores compare each company with its own peer group, so two companies' scores are each relative to different peers unless you rank against the whole market. Price returns exclude dividends. Nothing on this page is investment advice.