CRSP vs PGEN vs VCEL Stock Comparison

CRISPR Therapeutics AG, Precigen and Vericel Prices as of Oct 26, 2026 Peers: Industry group
CRSP CRISPR Therapeutics AG
$49.01 -9.6% 1M -27.5% 1Y
Market cap
$4.92B
P/E
–
Revenue (TTM)
$13.39M
Div. yield
–
Gene and Cell Therapy Healthcare
1 win
PGEN Precigen, Inc.
$6.04 -22.1% 1M +39.5% 1Y
Market cap
$2.19B
P/E
–
Revenue (TTM)
$85.72M
Div. yield
–
Gene and Cell Therapy Healthcare
5 wins
VCEL Vericel Corp
$43.04 +8.4% 1M +18.5% 1Y
Market cap
$2.22B
P/E
91.8x
Revenue (TTM)
$306.30M
Div. yield
–
Gene and Cell Therapy Healthcare
3 wins

Head to Head

9 decided of 12

Precigen leads on 5 of the 12 questions below (Precigen 5, Vericel 3, CRISPR Therapeutics AG 1). Which ones matter depends on what you are buying for; a cheap multiple and slow growth often come together.

QuestionCRSPPGENVCELLeader
Larger companyMarket capitalisation $4.92B $2.19B $2.22B CRSP
Cheaper on earningsLower P/E, profitable companies only -10.9x -6.5x 91.8x –
Cheaper on forward earningsLower price / next fiscal year consensus EPS — 35.5x 84.4x PGEN
Faster revenue growthRevenue growth, trailing twelve months -64.8% +1,875.0% +23.0% PGEN
More profitableNet margin, trailing twelve months -3,368.7% -392.8% 7.9% VCEL
Better return on capitalReturn on invested capital -22.6% — — –
Less leveragedLower net debt / EBITDA 3.4x -1.6x — PGEN
Higher dividend yieldTrailing dividend yield 0.00% 0.00% 0.00% –
Better 1-year returnPrice return, last 12 months -27.5% +39.5% +18.5% PGEN
Better 5-year returnAnnualised price return, 5 years -12.0%/yr +6.1%/yr -3.2%/yr PGEN
Less volatileAnnualised volatility, 1 year 57.1% 78.0% 40.9% VCEL
Higher overall scoreMean of the five percentile scores vs peers 44/100 55/100 81/100 VCEL

Percentile Scorecard

CRSPPGENVCEL

Each axis is the mean percentile of its metrics against the company's industry group. 100 is the best in the group, 50 the middle.

Scores by Axis

AxisCRSPPGENVCEL
Valuation 48 #327 of 626 58 #263 of 626 81 #119 of 626
Growth 32 #414 of 604 48 #312 of 604 94 #37 of 604
Profitability 32 #379 of 555 59 #229 of 555 88 #68 of 555
Financial Health 71 #191 of 658 26 #488 of 658 69 #207 of 658
Shareholder Returns 38 #230 of 368 83 #65 of 368 73 #100 of 368
Overall 44 55 81
  • CRSP ranked among 673 companies in Pharmaceuticals and Biotechnology
  • PGEN ranked among 673 companies in Pharmaceuticals and Biotechnology
  • VCEL ranked among 673 companies in Pharmaceuticals and Biotechnology

Price Performance

Price return, split-adjusted, before dividends. Click a name to hide or show it.

Returns

PeriodCRSPPGENVCELSPY
1 month -9.6%-22.1%+8.4% -0.8%
3 months +4.9%+11.4%-5.0% +3.5%
6 months -3.9%+52.5%+16.6% +7.0%
Year to date -6.5%+44.5%+19.5% +12.2%
1 year -27.5%+39.5%+18.5% +13.0%
3 years +26.5%+498.0%+31.1% +86.3%
3 years, per year +8.2%+81.6%+9.5% +23.1%
5 years -47.2%+34.2%-14.9% +68.6%
5 years, per year -12.0%+6.1%-3.2% +11.0%
10 years +231.1%-76.9%+1,693.3% +258.0%
10 years, per year +12.7%-13.6%+33.5% +13.6%

Risk

MeasureCRSPPGENVCELSPY
Volatility, 1Y 57.1%78.0%40.9% 12.7%
Downside volatility, 1Y 53.7%69.4%40.1% 12.7%
Beta vs S&P 500, 1Y 1.821.420.74 1.00
Return / volatility, 1Y -0.480.510.45 1.02
Max drawdown, 5Y -67.7%-87.8%-65.4% -25.4%
From 52-week high -25.4%-29.4%-10.9% -1.8%
52-week high $65.72$8.56$48.31 $779.14
52-week low $44.34$3.10$29.34 $631.97

Valuation History

Weekly multiples on trailing twelve-month fundamentals. Negative or extreme readings (a loss year, a collapsed denominator) are left out so the chart stays readable.

MultipleCRSPPGENVCEL
P/E now vs peer median -10.5xmedian 17.1x -6.4xmedian 17.1x 90.8xmedian 17.1x
P/S now vs peer median 353.7xmedian 8.8x 25.2xmedian 8.8x 7.2xmedian 8.8x
EV/EBITDA now vs peer median -5.7xmedian 17.1x -64.7xmedian 17.1x 65.0xmedian 17.1x
P/FCF now vs peer median -12.8xmedian 18.0x -18.8xmedian 18.0x 35.7xmedian 18.0x
P/B now vs peer median 2.7xmedian 2.1x 49.6xmedian 2.1x 6.0xmedian 2.1x
PEG now vs peer median -2.72median 0.31 0.05median 0.31 1.67median 0.31

Financial History

Reported figures by fiscal period, placed on the calendar year (or quarter) each period ended in, so companies with different fiscal years line up.

Trailing twelve monthsCRSPPGENVCEL
Revenue $13.39M $85.72M $306.30M
Gross profit – $77.72M $228.38M
Operating income -$534.34M -$39.50M $18.24M
Net income -$451.14M -$157.71M $24.22M
Free cash flow -$371.33M -$115.22M $61.66M
R&D $278.15M $32.29M $29.17M
EPS (diluted) $-4.67 $-0.81 $0.46
Cash & equivalents $291.34M $16.33M $125.40M
Total debt $586.20M $93.88M –
Shares (diluted) 96.51M 413.69M 52.31M
Enterprise value -$3.78B $1.88B $1.64B

All Metrics

58 metrics · best in bold

Bold marks the best reading: the lowest positive value for multiples, leverage and payout, the highest for everything else. The bar under each value is its percentile against that company's own peers. Hover a value for its rank and the peer median.

Valuation

12 metrics
MetricCRSPPGENVCEL
P/E -10.5x -6.4x 90.8x
P/FCF -12.8x -18.8x 35.7x
P/Operating cash flow -12.8x -18.9x 31.6x
P/S 353.7x 25.2x 7.2x
P/B 2.7x 49.6x 6.0x
P/Tangible book 2.7x 52.7x 6.0x
EV/EBITDA -5.7x -64.7x 65.0x
EV/EBIT -5.5x -56.2x 111.9x
EV/Revenue 221.0x 25.9x 6.7x
EV/FCF -8.0x -19.3x 33.1x
EV/Operating cash flow -8.0x -19.4x 29.3x
PEG (3Y EPS CAGR) -2.72 0.05 1.67

Growth

14 metrics
MetricCRSPPGENVCEL
Revenue growth (1Y) -64.8% 1,875% 23.0%
Revenue CAGR (3Y) -57.1% 57.1% 19.8%
Gross profit growth (1Y) – 259,173% 24.8%
Gross profit CAGR (3Y) – 69.2% 23.9%
Operating income growth (1Y) 3.3% 62.1% 1,428%
Operating income CAGR (3Y) -4.1% 18.9% 47.8%
Net income growth (1Y) 3.6% -26.7% 240.8%
Net income CAGR (3Y) -2.7% -108.9% 56.6%
EPS growth (1Y) 13.0% -93.8% 228.1%
EPS CAGR (3Y) 3.9% -123.2% 54.3%
Operating cash flow growth (1Y) -13.8% -72.3% 47.5%
Operating cash flow CAGR (3Y) -2.5% -15.9% 33.7%
Free cash flow growth (1Y) -14.1% -65.1% 842.9%
Free cash flow CAGR (3Y) -0.9% -15.3% 43.2%

Profitability

14 metrics
MetricCRSPPGENVCEL
Gross margin – 90.7% 74.6%
EBITDA margin -3,850% -40.0% 10.2%
Operating margin -3,990% -46.1% 6.0%
Pretax margin -3,346% -184.0% 8.2%
Net margin -3,369% -392.8% 7.9%
FCF margin -2,773% -134.4% 20.1%
Operating cash flow margin -2,760% -133.2% 22.7%
Return on equity -25.3% -494.3% 6.9%
Return on assets -16.8% -102.1% 5.1%
Return on invested capital -22.6% – –
Return on capital employed -20.9% -31.6% 4.1%
Asset turnover 0.0x 0.6x 0.6x
Cash conversion (OCF / net income) 0.8x 0.7x 2.9x
Stock comp / revenue 510.2% 15.3% 12.2%

Financial Health

11 metrics
MetricCRSPPGENVCEL
Debt / assets 22.1% 55.1% –
Debt / equity 0.3x 2.2x –
Net debt / EBITDA 3.4x -1.6x –
Debt / FCF -1.6x -0.8x –
Liabilities / assets 34.1% 74.4% 26.4%
Equity / assets 65.9% 25.6% 73.6%
Interest coverage – -4.1x 28.5x
Current ratio 17.8x 4.6x 5.0x
Quick ratio 17.8x 3.8x 4.5x
Cash ratio 17.8x 1.3x 3.1x
Altman Z-score 2.36 -8.43 10.12

Shareholder Returns

7 metrics
MetricCRSPPGENVCEL
Dividend yield – – –
Net buyback yield -9.0% -0.1% -0.3%
Shareholder yield -9.0% -0.1% -0.3%
Payout ratio (earnings) – – –
Payout ratio (FCF) – – –
Dividend growth (1Y) – – –
Dividend CAGR (3Y) – – –

Analyst Estimates

Solid lines are reported fiscal-year results; dashed lines are the consensus for the years ahead. Hover a year for the analysts' high and low, and how each result compared with its estimate.

ConsensusCRSPPGENVCEL
Forward P/E – 35.5xFY2026 84.4xFY2026
EPS, next fiscal year $-4.10FY2026 $0.17FY2026 $0.51FY2026
EPS growth, next FY – – +59.4%FY2026
EPS growth, the year after – +288.2% +74.5%
Revenue, next fiscal year $38.73MFY2026 $249.17MFY2026 $324.56MFY2026
Revenue growth, next FY +1,003.4%FY2026 +2,474.1%FY2026 +17.5%FY2026
Revenue growth, the year after +266.1% +82.3% +16.1%

Institutional Ownership

13F filings, quarter ended Jun 30, 2026
HoldersCRSPPGENVCEL
Held by institutions 78.9% 39.2% 100.0%
Institutions holding 518 210 317
Change in shares held, QoQ -1.0% +4.9% +0.4%
Institutions buying 237 123 187
Institutions selling 139 46 98
Buyers to sellers 1.71 2.67 1.91

Return Correlation

Daily returns, last 12 months

1.00 means two stocks move in lockstep, 0 that they move independently. Pairs below about 0.5 diversify each other.

CRSPPGENVCEL
CRSP 1.00 0.37 0.35
PGEN 0.37 1.00 0.16
VCEL 0.35 0.16 1.00

Add a Peer

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Frequently Asked Questions

Which is bigger, CRSP, PGEN and VCEL?

CRISPR Therapeutics AG (CRSP) is the largest by market capitalisation: CRISPR Therapeutics AG (CRSP) $4.92B, Precigen (PGEN) $2.19B, Vericel (VCEL) $2.22B.

Which company is growing faster?

Precigen (PGEN) grew revenue fastest over the trailing twelve months: CRISPR Therapeutics AG (CRSP) -64.8%, Precigen (PGEN) +1,875.0%, Vericel (VCEL) +23.0%.

Which company is more profitable?

Vericel (VCEL) has the highest net margin (CRISPR Therapeutics AG (CRSP) -3,368.7%, Precigen (PGEN) -392.8%, Vericel (VCEL) 7.9%).

Which stock has performed better?

Over the past year Precigen (PGEN) returned the most: CRISPR Therapeutics AG (CRSP) -27.5%, Precigen (PGEN) +39.5%, Vericel (VCEL) +18.5%. Over five years, Precigen (PGEN) compounded fastest (CRISPR Therapeutics AG (CRSP) -12.0%/yr, Precigen (PGEN) +6.1%/yr, Vericel (VCEL) -3.2%/yr). Returns are price only, before dividends.

Which stock is riskier?

By one-year price volatility, Vericel (VCEL) has been the steadiest (CRISPR Therapeutics AG (CRSP) 57.1%, Precigen (PGEN) 78.0%, Vericel (VCEL) 40.9%). Volatility measures how widely the price swings, not the risk of the business.

Which is the better stock, CRSP, PGEN and VCEL?

There is no single answer; it depends on what you are buying for. On the 12 head-to-head measures on this page, Precigen (PGEN) leads on 5. Business Quant does not give investment advice; use the comparison as a starting point for your own research.

Data from SEC filings, exchange prices and consensus estimates, via Business Quant. Percentile scores compare each company with its own peer group, so two companies' scores are each relative to different peers unless you rank against the whole market. Price returns exclude dividends. Nothing on this page is investment advice.