CRSP vs IMMX vs LEGN Stock Comparison

CRISPR Therapeutics AG, Immix Biopharma and Legend Biotech Prices as of Oct 28, 2026 Peers: Industry group
CRSP CRISPR Therapeutics AG
$54.11 +0.0% 1M -15.7% 1Y
Market cap
$5.23B
P/E
–
Revenue (TTM)
$13.39M
Div. yield
–
Gene and Cell Therapy Healthcare
4 wins
IMMX Immix Biopharma, Inc.
$8.12 -29.2% 1M +108.2% 1Y
Market cap
$580.87M
P/E
–
Revenue (TTM)
—
Div. yield
–
Gene and Cell Therapy Healthcare
1 win
LEGN Legend Biotech Corp
$22.53 +21.0% 1M -30.8% 1Y
Market cap
$4.15B
P/E
–
Revenue (TTM)
$1.27B
Div. yield
–
Gene and Cell Therapy Healthcare
4 wins

Head to Head

9 decided of 12

CRISPR Therapeutics AG leads on 4 of the 12 questions below (CRISPR Therapeutics AG 4, Legend Biotech 4, Immix Biopharma 1). Which ones matter depends on what you are buying for; a cheap multiple and slow growth often come together.

QuestionCRSPIMMXLEGNLeader
Larger companyMarket capitalisation $5.23B $580.87M $4.15B CRSP
Cheaper on earningsLower P/E, profitable companies only -11.6x -13.0x -45.3x –
Cheaper on forward earningsLower price / next fiscal year consensus EPS — — — –
Faster revenue growthRevenue growth, trailing twelve months -64.8% — +59.5% LEGN
More profitableNet margin, trailing twelve months -3,368.7% — -7.2% LEGN
Better return on capitalReturn on invested capital -22.6% — -4.2% LEGN
Less leveragedLower net debt / EBITDA 3.4x — 28.0x CRSP
Higher dividend yieldTrailing dividend yield — — — –
Better 1-year returnPrice return, last 12 months -15.7% +108.2% -30.8% IMMX
Better 5-year returnAnnualised price return, 5 years -9.9%/yr — -15.6%/yr CRSP
Less volatileAnnualised volatility, 1 year 57.4% 82.8% 72.3% CRSP
Higher overall scoreMean of the five percentile scores vs peers 45/100 53/100 73/100 LEGN

Percentile Scorecard

CRSPIMMXLEGN

Each axis is the mean percentile of its metrics against the company's industry group. 100 is the best in the group, 50 the middle.

Scores by Axis

AxisCRSPIMMXLEGN
Valuation 50 #311 of 625 73 #170 of 625 89 #72 of 625
Growth 31 #413 of 602 6 #569 of 602 96 #23 of 602
Profitability 32 #374 of 549 79 #119 of 549 80 #109 of 549
Financial Health 71 #189 of 654 97 #18 of 654 54 #299 of 654
Shareholder Returns 38 #227 of 367 9 #334 of 367 44 #206 of 367
Overall 45 53 73
  • CRSP ranked among 672 companies in Pharmaceuticals and Biotechnology
  • IMMX ranked among 672 companies in Pharmaceuticals and Biotechnology
  • LEGN ranked among 672 companies in Pharmaceuticals and Biotechnology

Price Performance

Price return, split-adjusted, before dividends. Click a name to hide or show it.

Returns

PeriodCRSPIMMXLEGNSPY
1 month +0.0%-29.2%+21.0% +0.9%
3 months +13.6%-0.6%+19.5% +5.9%
6 months +6.7%-5.9%-1.1% +8.5%
Year to date +3.2%+55.3%+3.6% +13.3%
1 year -15.7%+108.2%-30.8% +12.4%
3 years +39.7%+139.5%-64.6% +88.1%
3 years, per year +11.8%+33.8%-29.3% +23.5%
5 years -40.8%—-57.1% +68.2%
5 years, per year -9.9%—-15.6% +11.0%
10 years +223.2%—— +263.4%
10 years, per year +12.4%—— +13.8%

Risk

MeasureCRSPIMMXLEGNSPY
Volatility, 1Y 57.4%82.8%72.3% 12.7%
Downside volatility, 1Y 53.8%76.3%62.7% 12.7%
Beta vs S&P 500, 1Y 1.841.570.44 1.00
Return / volatility, 1Y -0.271.31-0.43 0.98
Max drawdown, 5Y -67.7%-88.9%-78.2% -25.4%
From 52-week high -15.7%-43.9%-37.9% -0.9%
52-week high $64.17$14.47$36.28 $779.14
52-week low $44.34$3.03$16.65 $631.97

Valuation History

Weekly multiples on trailing twelve-month fundamentals. Negative or extreme readings (a loss year, a collapsed denominator) are left out so the chart stays readable.

MultipleCRSPIMMXLEGN
P/E now vs peer median -11.6xmedian 17.4x -13.0xmedian 17.4x -45.3xmedian 17.4x
P/S now vs peer median 390.6xmedian 9.1x —median 9.1x 3.3xmedian 9.1x
EV/EBITDA now vs peer median -6.7xmedian 17.1x -8.4xmedian 17.1x -197.3xmedian 17.1x
P/FCF now vs peer median -14.1xmedian 19.0x -14.9xmedian 19.0x -64.3xmedian 19.0x
P/B now vs peer median 3.0xmedian 2.2x 2.5xmedian 2.2x 3.4xmedian 2.2x
PEG now vs peer median -3.01median 0.34 -2.10median 0.34 -0.96median 0.34

Financial History

Reported figures by fiscal period, placed on the calendar year (or quarter) each period ended in, so companies with different fiscal years line up.

Trailing twelve monthsCRSPIMMXLEGN
Revenue $13.39M – $1.27B
Gross profit – – $727.10M
Operating income -$534.34M -$41.82M -$55.25M
Net income -$451.14M -$39.88M -$80.39M
Free cash flow -$371.33M -$39.09M -$64.60M
R&D $278.15M $21.62M $396.15M
EPS (diluted) $-4.67 $-0.63 $-0.50
Cash & equivalents $291.34M $225.49M $672.90M
Total debt $586.20M – $1.06B
Shares (diluted) 96.51M 63.77M 184.32M
Enterprise value -$3.47B $348.77M $1.65B

All Metrics

58 metrics · best in bold

Bold marks the best reading: the lowest positive value for multiples, leverage and payout, the highest for everything else. The bar under each value is its percentile against that company's own peers. Hover a value for its rank and the peer median.

Valuation

12 metrics
MetricCRSPIMMXLEGN
P/E -11.6x -13.0x -45.3x
P/FCF -14.1x -14.9x -64.3x
P/Operating cash flow -14.2x -15.1x -46.5x
P/S 390.6x – 3.3x
P/B 3.0x 2.5x 3.4x
P/Tangible book 3.0x 2.5x 3.4x
EV/EBITDA -6.7x -8.4x -197.3x
EV/EBIT -6.5x -8.3x -65.8x
EV/Revenue 257.8x – 2.9x
EV/FCF -9.3x -8.9x -56.3x
EV/Operating cash flow -9.3x -9.1x -40.7x
PEG (3Y EPS CAGR) -3.01 -2.10 -0.96

Growth

14 metrics
MetricCRSPIMMXLEGN
Revenue growth (1Y) -64.8% – 59.5%
Revenue CAGR (3Y) -57.1% – 97.6%
Gross profit growth (1Y) – – 42.4%
Gross profit CAGR (3Y) – – 147.5%
Operating income growth (1Y) 3.3% -75.8% 75.3%
Operating income CAGR (3Y) -4.1% -53.5% 49.1%
Net income growth (1Y) 3.6% -72.4% 75.3%
Net income CAGR (3Y) -2.7% -51.7% 46.7%
EPS growth (1Y) 13.0% 18.9% 72.0%
EPS CAGR (3Y) 3.9% 6.2% 47.0%
Operating cash flow growth (1Y) -13.8% -207.8% 67.5%
Operating cash flow CAGR (3Y) -2.5% -51.9% 37.1%
Free cash flow growth (1Y) -14.1% -190.0% 77.8%
Free cash flow CAGR (3Y) -0.9% -52.7% 44.5%

Profitability

14 metrics
MetricCRSPIMMXLEGN
Gross margin – – 57.2%
EBITDA margin -3,850% – -1.5%
Operating margin -3,990% – -4.3%
Pretax margin -3,346% – -4.4%
Net margin -3,369% – -7.2%
FCF margin -2,773% – -5.1%
Operating cash flow margin -2,760% – -7.0%
Return on equity -25.3% -25.5% -8.3%
Return on assets -16.8% -23.8% -5.5%
Return on invested capital -22.6% – -4.2%
Return on capital employed -20.9% -26.4% -4.3%
Asset turnover 0.0x – 0.8x
Cash conversion (OCF / net income) 0.8x 1.0x 1.1x
Stock comp / revenue 510.2% – 5.2%

Financial Health

11 metrics
MetricCRSPIMMXLEGN
Debt / assets 22.1% – 8.9%
Debt / equity 0.3x – 0.1x
Net debt / EBITDA 3.4x – 28.0x
Debt / FCF -1.6x – -2.4x
Liabilities / assets 34.1% 4.3% 29.8%
Equity / assets 65.9% 95.7% 70.2%
Interest coverage – – -4.8x
Current ratio 17.8x 25.1x 3.0x
Quick ratio 17.8x 25.0x 1.7x
Cash ratio 17.8x 25.0x 1.7x
Altman Z-score 2.68 – 6.95

Shareholder Returns

7 metrics
MetricCRSPIMMXLEGN
Dividend yield – – –
Net buyback yield -8.2% -42.8% -5.2%
Shareholder yield -8.2% -42.8% -5.2%
Payout ratio (earnings) – – –
Payout ratio (FCF) – – –
Dividend growth (1Y) – – –
Dividend CAGR (3Y) – – –

Analyst Estimates

Solid lines are reported fiscal-year results; dashed lines are the consensus for the years ahead. Hover a year for the analysts' high and low, and how each result compared with its estimate.

ConsensusCRSPIMMXLEGN
EPS, next fiscal year $-4.10FY2026 $-0.70FY2026 $-0.04FY2026
Revenue, next fiscal year $38.73MFY2026 $0.00FY2026 $1.37BFY2026
Revenue growth, next FY +1,003.4%FY2026 – +32.9%FY2026
Revenue growth, the year after +266.1% – +35.9%

Institutional Ownership

13F filings, quarter ended Jun 30, 2026
HoldersCRSPIMMXLEGN
Held by institutions 78.9% 78.6% 55.9%
Institutions holding 518 110 218
Change in shares held, QoQ -1.0% +107.6% +7.3%
Institutions buying 237 81 117
Institutions selling 139 13 78
Buyers to sellers 1.71 6.23 1.50

Return Correlation

Daily returns, last 12 months

1.00 means two stocks move in lockstep, 0 that they move independently. Pairs below about 0.5 diversify each other.

CRSPIMMXLEGN
CRSP 1.00 0.32 0.05
IMMX 0.32 1.00 0.04
LEGN 0.05 0.04 1.00

Add a Peer

Largest companies in the same industry

Related Comparisons

Frequently Asked Questions

Which is bigger, CRSP, IMMX and LEGN?

CRISPR Therapeutics AG (CRSP) is the largest by market capitalisation: CRISPR Therapeutics AG (CRSP) $5.23B, Immix Biopharma (IMMX) $580.87M, Legend Biotech (LEGN) $4.15B.

Which company is growing faster?

Legend Biotech (LEGN) grew revenue fastest over the trailing twelve months: CRISPR Therapeutics AG (CRSP) -64.8%, Legend Biotech (LEGN) +59.5%.

Which company is more profitable?

Legend Biotech (LEGN) has the highest net margin (CRISPR Therapeutics AG (CRSP) -3,368.7%, Legend Biotech (LEGN) -7.2%). On return on invested capital, Legend Biotech (LEGN) leads (CRISPR Therapeutics AG (CRSP) -22.6%, Legend Biotech (LEGN) -4.2%).

Which stock has performed better?

Over the past year Immix Biopharma (IMMX) returned the most: CRISPR Therapeutics AG (CRSP) -15.7%, Immix Biopharma (IMMX) +108.2%, Legend Biotech (LEGN) -30.8%. Over five years, CRISPR Therapeutics AG (CRSP) compounded fastest (CRISPR Therapeutics AG (CRSP) -9.9%/yr, Legend Biotech (LEGN) -15.6%/yr). Returns are price only, before dividends.

Which stock is riskier?

By one-year price volatility, CRISPR Therapeutics AG (CRSP) has been the steadiest (CRISPR Therapeutics AG (CRSP) 57.4%, Immix Biopharma (IMMX) 82.8%, Legend Biotech (LEGN) 72.3%). Volatility measures how widely the price swings, not the risk of the business.

Which is the better stock, CRSP, IMMX and LEGN?

There is no single answer; it depends on what you are buying for. On the 12 head-to-head measures on this page, CRISPR Therapeutics AG (CRSP) leads on 4. Business Quant does not give investment advice; use the comparison as a starting point for your own research.

Data from SEC filings, exchange prices and consensus estimates, via Business Quant. Percentile scores compare each company with its own peer group, so two companies' scores are each relative to different peers unless you rank against the whole market. Price returns exclude dividends. Nothing on this page is investment advice.