CRL vs TMO vs GH Stock Comparison

Charles River Laboratories International, Thermo Fisher Scientific and Guardant Health Prices as of Oct 26, 2026 Peers: Industry group
GH Guardant Health, Inc.
$173.25 -2.3% 1M +140.1% 1Y
Market cap
$23.68B
P/E
–
Revenue (TTM)
$1.18B
Div. yield
–
Diagnostic Labs Healthcare
3 wins

Head to Head

8 decided of 12

Thermo Fisher Scientific leads on 4 of the 12 questions below (Thermo Fisher Scientific 4, Guardant Health 3, Charles River Laboratories International 1). Which ones matter depends on what you are buying for; a cheap multiple and slow growth often come together.

QuestionCRLTMOGHLeader
Larger companyMarket capitalisation $17.24B $257.69B $23.68B TMO
Cheaper on earningsLower P/E, profitable companies only -72.3x 36.4x -52.2x –
Cheaper on forward earningsLower price / next fiscal year consensus EPS 32.8x 26.4x — TMO
Faster revenue growthRevenue growth, trailing twelve months -0.7% +8.3% +42.7% GH
More profitableNet margin, trailing twelve months -6.0% — -38.3% CRL
Better return on capitalReturn on invested capital 1.6% — — –
Less leveragedLower net debt / EBITDA 6.3x — — –
Higher dividend yieldTrailing dividend yield 0.00% 0.00% 0.00% –
Better 1-year returnPrice return, last 12 months +81.4% +19.6% +140.1% GH
Better 5-year returnAnnualised price return, 5 years -3.6%/yr +2.3%/yr +9.1%/yr GH
Less volatileAnnualised volatility, 1 year 46.0% 29.9% 57.4% TMO
Higher overall scoreMean of the five percentile scores vs peers 45/100 51/100 28/100 TMO

Percentile Scorecard

CRLTMOGH

Each axis is the mean percentile of its metrics against the company's industry group. 100 is the best in the group, 50 the middle.

Scores by Axis

AxisCRLTMOGH
Valuation 60 #5 of 11 49 #116 of 228 17 #77 of 93
Growth 10 #10 of 11 40 #133 of 221 48 #46 of 88
Profitability 70 #4 of 11 70 #63 of 208 7 #81 of 87
Financial Health 42 #8 of 13 – 51 #50 of 100
Shareholder Returns – 44 #77 of 137 15 #48 of 56
Overall 45 51 28
  • CRL ranked among 13 companies in Pharma Services
  • TMO ranked among 248 companies in Medical Devices and Diagnostics
  • GH ranked among 103 companies in Healthcare Providers

Price Performance

Price return, split-adjusted, before dividends. Click a name to hide or show it.

Returns

PeriodCRLTMOGHSPY
1 month +21.9%+1.7%-2.3% -0.8%
3 months +59.4%+22.4%+19.1% +3.5%
6 months +108.7%+46.3%+95.8% +7.0%
Year to date +79.1%+18.2%+69.6% +12.2%
1 year +81.4%+19.6%+140.1% +13.0%
3 years +107.1%+58.7%+594.1% +86.3%
3 years, per year +27.5%+16.7%+90.8% +23.1%
5 years -16.9%+11.8%+54.3% +68.6%
5 years, per year -3.6%+2.3%+9.1% +11.0%
10 years +358.2%+362.6%— +258.0%
10 years, per year +16.4%+16.6%— +13.6%

Risk

MeasureCRLTMOGHSPY
Volatility, 1Y 46.0%29.9%57.4% 12.7%
Downside volatility, 1Y 43.0%28.3%48.7% 12.7%
Beta vs S&P 500, 1Y 1.270.621.02 1.00
Return / volatility, 1Y 1.770.662.44 1.02
Max drawdown, 5Y -77.8%-41.5%-86.7% -25.4%
From 52-week high 0.0%-1.7%-7.5% -1.8%
52-week high $357.35$696.55$187.22 $779.14
52-week low $149.93$438.34$69.58 $631.97

Valuation History

Weekly multiples on trailing twelve-month fundamentals. Negative or extreme readings (a loss year, a collapsed denominator) are left out so the chart stays readable.

MultipleCRLTMOGH
P/E now vs peer median -72.0xmedian 36.5x 35.9xmedian 30.6x -50.8xmedian 25.1x
P/S now vs peer median 4.3xmedian 2.7x 5.3xmedian 3.0x 19.6xmedian 1.6x
EV/EBITDA now vs peer median 50.2xmedian 37.7x —median 17.5x -51.2xmedian 14.5x
P/FCF now vs peer median 46.0xmedian 20.7x 34.0xmedian 23.3x -96.2xmedian 22.4x
P/B now vs peer median 6.0xmedian 2.9x 4.6xmedian 2.4x -103.9xmedian 3.1x
PEG now vs peer median 1.99median 2.04 4.74median 0.87 -5.11median 0.66

Financial History

Reported figures by fiscal period, placed on the calendar year (or quarter) each period ended in, so companies with different fiscal years line up.

Trailing twelve monthsCRLTMOGH
Revenue $4.00B $47.35B $1.18B
Gross profit $1.31B – $769.16M
Operating income $90.14M $8.47B -$470.26M
Net income -$239.23M $7.09B -$453.44M
Free cash flow $370.61M – -$240.72M
R&D – $1.40B $375.79M
EPS (diluted) $-4.97 $19.06 $-3.41
Cash & equivalents $192.03M $5.46B $1.05B
Total debt $2.62B – –
Shares (diluted) 48.02M 371.00M 132.87M
Enterprise value $16.43B $257.69B $19.74B

All Metrics

58 metrics · best in bold

Bold marks the best reading: the lowest positive value for multiples, leverage and payout, the highest for everything else. The bar under each value is its percentile against that company's own peers. Hover a value for its rank and the peer median.

Valuation

12 metrics
MetricCRLTMOGH
P/E -72.0x 35.9x -50.8x
P/FCF 46.0x 34.0x -96.2x
P/Operating cash flow 29.3x 27.2x -125.0x
P/S 4.3x 5.3x 19.6x
P/B 6.0x 4.6x -103.9x
P/Tangible book 6.6x 6.9x -93.3x
EV/EBITDA 50.2x – -51.2x
EV/EBIT 216.1x – -47.0x
EV/Revenue 4.9x 5.3x 18.7x
EV/FCF 52.6x – -91.8x
EV/Operating cash flow 33.5x 27.2x -119.3x
PEG (3Y EPS CAGR) 1.99 4.74 -5.11

Growth

14 metrics
MetricCRLTMOGH
Revenue growth (1Y) -0.7% 8.3% 42.7%
Revenue CAGR (3Y) -1.5% 2.9% 32.4%
Gross profit growth (1Y) -0.1% – 47.7%
Gross profit CAGR (3Y) -5.5% – –
Operating income growth (1Y) -27.6% 12.8% -2.1%
Operating income CAGR (3Y) -48.2% 7.2% 4.8%
Net income growth (1Y) -268.7% 7.9% -9.6%
Net income CAGR (3Y) -35.5% 6.2% 3.7%
EPS growth (1Y) -253.8% 9.7% -2.4%
EPS CAGR (3Y) -36.2% 7.6% 9.9%
Operating cash flow growth (1Y) -26.1% 21.9% 22.4%
Operating cash flow CAGR (3Y) -2.3% 4.5% 18.1%
Free cash flow growth (1Y) -35.9% – 11.4%
Free cash flow CAGR (3Y) 8.6% – 14.4%

Profitability

14 metrics
MetricCRLTMOGH
Gross margin 32.7% – 65.0%
EBITDA margin 9.7% – -36.5%
Operating margin 2.3% – -39.7%
Pretax margin -4.6% – -38.4%
Net margin -6.0% – -38.3%
FCF margin 9.3% – -20.3%
Operating cash flow margin 14.6% 19.7% -15.7%
Return on equity -8.2% 13.2% –
Return on assets -3.1% 6.2% -23.7%
Return on invested capital 1.6% – –
Return on capital employed 1.4% – -29.9%
Asset turnover 0.5x 0.4x 0.6x
Cash conversion (OCF / net income) -2.4x 1.3x 0.4x
Stock comp / revenue 2.1% – 16.2%

Financial Health

11 metrics
MetricCRLTMOGH
Debt / assets 34.8% – –
Debt / equity 0.9x – –
Net debt / EBITDA 6.3x – –
Debt / FCF 7.1x – –
Liabilities / assets 62.2% – 111.7%
Equity / assets 37.8% 47.9% -11.7%
Interest coverage 0.8x – -97.6x
Current ratio 1.3x 1.8x 4.0x
Quick ratio 0.8x – 3.5x
Cash ratio 0.2x – 3.1x
Altman Z-score 3.07 – 4.59

Shareholder Returns

7 metrics
MetricCRLTMOGH
Dividend yield – 0.3% –
Net buyback yield 1.9% – -1.7%
Shareholder yield 1.9% 0.3% -1.7%
Payout ratio (earnings) – – –
Payout ratio (FCF) – – –
Dividend growth (1Y) – – –
Dividend CAGR (3Y) – – –

Analyst Estimates

Solid lines are reported fiscal-year results; dashed lines are the consensus for the years ahead. Hover a year for the analysts' high and low, and how each result compared with its estimate.

ConsensusCRLTMOGH
Forward P/E 32.8xFY2026 26.4xFY2026 –
EPS, next fiscal year $10.90FY2026 $25.91FY2026 $-3.33FY2026
EPS growth, next FY +6.0%FY2026 +13.3%FY2026 –
EPS growth, the year after +20.5% +2.0% –
Revenue, next fiscal year $3.82BFY2026 $50.12BFY2026 $1.42BFY2026
Revenue growth, next FY -4.9%FY2026 +12.5%FY2026 +44.5%FY2026
Revenue growth, the year after +0.7% -2.8% +27.0%

Institutional Ownership

13F filings, quarter ended Jun 30, 2026
HoldersCRLTMOGH
Held by institutions 100.0% 90.2% 100.0%
Institutions holding 570 2,621 594
Change in shares held, QoQ -0.7% +0.8% -2.6%
Institutions buying 270 1,141 353
Institutions selling 204 1,144 180
Buyers to sellers 1.32 1.00 1.96

Return Correlation

Daily returns, last 12 months

1.00 means two stocks move in lockstep, 0 that they move independently. Pairs below about 0.5 diversify each other.

CRLTMOGH
CRL 1.00 0.64 0.32
TMO 0.64 1.00 0.34
GH 0.32 0.34 1.00

Add a Peer

Largest companies in the same industry

Related Comparisons

Frequently Asked Questions

Which is bigger, CRL, TMO and GH?

Thermo Fisher Scientific (TMO) is the largest by market capitalisation: Charles River Laboratories International (CRL) $17.24B, Thermo Fisher Scientific (TMO) $257.69B, Guardant Health (GH) $23.68B.

Which company is growing faster?

Guardant Health (GH) grew revenue fastest over the trailing twelve months: Charles River Laboratories International (CRL) -0.7%, Thermo Fisher Scientific (TMO) +8.3%, Guardant Health (GH) +42.7%.

Which company is more profitable?

Charles River Laboratories International (CRL) has the highest net margin (Charles River Laboratories International (CRL) -6.0%, Guardant Health (GH) -38.3%).

Which stock has performed better?

Over the past year Guardant Health (GH) returned the most: Charles River Laboratories International (CRL) +81.4%, Thermo Fisher Scientific (TMO) +19.6%, Guardant Health (GH) +140.1%. Over five years, Guardant Health (GH) compounded fastest (Charles River Laboratories International (CRL) -3.6%/yr, Thermo Fisher Scientific (TMO) +2.3%/yr, Guardant Health (GH) +9.1%/yr). Returns are price only, before dividends.

Which stock is riskier?

By one-year price volatility, Thermo Fisher Scientific (TMO) has been the steadiest (Charles River Laboratories International (CRL) 46.0%, Thermo Fisher Scientific (TMO) 29.9%, Guardant Health (GH) 57.4%). Volatility measures how widely the price swings, not the risk of the business.

Which is the better stock, CRL, TMO and GH?

There is no single answer; it depends on what you are buying for. On the 12 head-to-head measures on this page, Thermo Fisher Scientific (TMO) leads on 4. Business Quant does not give investment advice; use the comparison as a starting point for your own research.

Data from SEC filings, exchange prices and consensus estimates, via Business Quant. Percentile scores compare each company with its own peer group, so two companies' scores are each relative to different peers unless you rank against the whole market. Price returns exclude dividends. Nothing on this page is investment advice.