BNTX vs REGN vs AMGN Stock Comparison

BioNTech SE, Regeneron Pharmaceuticals and Amgen Prices as of Oct 27, 2026 Peers: Industry group
BNTX BioNTech SE
$87.06 -11.6% 1M -17.9% 1Y
Market cap
$22.02B
P/E
–
Revenue (TTM)
$3.09B
Div. yield
–
Biotechnology Healthcare
AMGN Amgen Inc
$447.95 +8.0% 1M +53.9% 1Y
Market cap
$242.16B
P/E
27.7x
Revenue (TTM)
$38.10B
Div. yield
2.22%
Biotechnology Healthcare
6 wins

Head to Head

12 decided of 12

Amgen leads on 6 of the 12 questions below (Amgen 6, Regeneron Pharmaceuticals 6). Which ones matter depends on what you are buying for; a cheap multiple and slow growth often come together.

QuestionBNTXREGNAMGNLeader
Larger companyMarket capitalisation $22.02B $83.90B $242.16B AMGN
Cheaper on earningsLower P/E, profitable companies only -10.7x 19.4x 27.7x REGN
Cheaper on forward earningsLower price / next fiscal year consensus EPS — 14.3x 20.5x REGN
Faster revenue growthRevenue growth, trailing twelve months -1.1% +9.3% +9.1% REGN
More profitableNet margin, trailing twelve months -63.5% 27.9% 23.0% REGN
Better return on capitalReturn on invested capital -10.7% 9.6% 14.3% AMGN
Less leveragedLower net debt / EBITDA 8.7x -1.4x 2.7x REGN
Higher dividend yieldTrailing dividend yield 0.00% 0.45% 2.22% AMGN
Better 1-year returnPrice return, last 12 months -17.9% +39.4% +53.9% AMGN
Better 5-year returnAnnualised price return, 5 years -21.1%/yr +5.5%/yr +16.7%/yr AMGN
Less volatileAnnualised volatility, 1 year 46.6% 32.8% 29.6% AMGN
Higher overall scoreMean of the five percentile scores vs peers 64/100 72/100 66/100 REGN

Percentile Scorecard

BNTXREGNAMGN

Each axis is the mean percentile of its metrics against the company's industry group. 100 is the best in the group, 50 the middle.

Scores by Axis

AxisBNTXREGNAMGN
Valuation 91 #58 of 625 89 #71 of 625 86 #90 of 625
Growth 14 #520 of 602 42 #351 of 602 62 #231 of 602
Profitability 77 #129 of 551 90 #54 of 551 95 #31 of 551
Financial Health 89 #71 of 656 74 #172 of 656 22 #510 of 656
Shareholder Returns 51 #179 of 365 65 #129 of 365 68 #117 of 365
Overall 64 72 66
  • BNTX ranked among 672 companies in Pharmaceuticals and Biotechnology
  • REGN ranked among 672 companies in Pharmaceuticals and Biotechnology
  • AMGN ranked among 672 companies in Pharmaceuticals and Biotechnology

Price Performance

Price return, split-adjusted, before dividends. Click a name to hide or show it.

Returns

PeriodBNTXREGNAMGNSPY
1 month -11.6%+3.6%+8.0% -0.2%
3 months -5.8%+17.4%+14.0% +3.9%
6 months -14.7%+11.5%+31.9% +8.2%
Year to date -8.6%+5.7%+36.9% +12.9%
1 year -17.9%+39.4%+53.9% +12.3%
3 years -4.5%+5.3%+71.3% +87.4%
3 years, per year -1.5%+1.7%+19.7% +23.3%
5 years -69.3%+30.5%+116.2% +67.9%
5 years, per year -21.1%+5.5%+16.7% +10.9%
10 years —+123.4%+179.0% +261.1%
10 years, per year —+8.4%+10.8% +13.7%

Risk

MeasureBNTXREGNAMGNSPY
Volatility, 1Y 46.6%32.8%29.6% 12.7%
Downside volatility, 1Y 46.5%30.0%27.9% 12.7%
Beta vs S&P 500, 1Y 0.950.470.46 1.00
Return / volatility, 1Y -0.381.201.82 0.97
Max drawdown, 5Y -78.4%-59.8%-26.7% -25.4%
From 52-week high -27.0%-4.2%0.0% -1.2%
52-week high $119.34$852.03$447.95 $779.14
52-week low $83.89$585.31$291.16 $631.97

Valuation History

Weekly multiples on trailing twelve-month fundamentals. Negative or extreme readings (a loss year, a collapsed denominator) are left out so the chart stays readable.

MultipleBNTXREGNAMGN
P/E now vs peer median -10.7xmedian 17.2x 19.4xmedian 17.2x 27.7xmedian 17.2x
P/S now vs peer median 7.1xmedian 9.0x 5.4xmedian 9.0x 6.4xmedian 9.0x
EV/EBITDA now vs peer median -5.7xmedian 16.3x 17.8xmedian 16.3x 17.7xmedian 16.3x
P/FCF now vs peer median 21.2xmedian 18.7x 22.3xmedian 18.7x 23.8xmedian 18.7x
P/B now vs peer median 1.1xmedian 2.2x 2.6xmedian 2.2x 20.7xmedian 2.2x
PEG now vs peer median 0.31median 0.33 7.29median 0.33 10.44median 0.33

Financial History

Reported figures by fiscal period, placed on the calendar year (or quarter) each period ended in, so companies with different fiscal years line up.

Trailing twelve monthsBNTXREGNAMGN
Revenue $3.09B $15.53B $38.10B
Gross profit $2.34B $13.18B $26.48B
Operating income -$2.33B $3.84B $11.43B
Net income -$1.97B $4.33B $8.74B
Free cash flow $1.04B $3.76B $10.18B
R&D $2.54B $6.28B $7.63B
EPS (diluted) $-8.13 $40.84 $16.07
Cash & equivalents $11.13B $2.46B $13.99B
Total debt $102.80M $1.99B $57.30B
Shares (diluted) 241.70M 106.00M 544.00M
Enterprise value -$24.46B $50.10B $197.56B

All Metrics

58 metrics · best in bold

Bold marks the best reading: the lowest positive value for multiples, leverage and payout, the highest for everything else. The bar under each value is its percentile against that company's own peers. Hover a value for its rank and the peer median.

Valuation

12 metrics
MetricBNTXREGNAMGN
P/E -10.7x 19.4x 27.7x
P/FCF 21.2x 22.3x 23.8x
P/Operating cash flow 27.8x 17.9x 19.4x
P/S 7.1x 5.4x 6.4x
P/B 1.1x 2.6x 20.7x
P/Tangible book 1.1x 2.8x -27.5x
EV/EBITDA -5.7x 17.8x 17.7x
EV/EBIT -3.7x 20.3x 25.0x
EV/Revenue 2.8x 5.0x 7.5x
EV/FCF 8.4x 20.7x 28.1x
EV/Operating cash flow 11.0x 16.6x 22.9x
PEG (3Y EPS CAGR) 0.31 7.29 10.44

Growth

14 metrics
MetricBNTXREGNAMGN
Revenue growth (1Y) -1.1% 9.3% 9.1%
Revenue CAGR (3Y) -31.0% 7.0% 12.7%
Gross profit growth (1Y) -6.4% 8.4% 17.6%
Gross profit CAGR (3Y) -34.2% 6.4% 10.3%
Operating income growth (1Y) -142.6% 0.1% 39.5%
Operating income CAGR (3Y) -33.8% -3.9% 6.4%
Net income growth (1Y) -417.0% -2.9% 32.1%
Net income CAGR (3Y) -34.6% 0.2% 3.1%
EPS growth (1Y) -393.7% -0.5% 31.4%
EPS CAGR (3Y) -34.9% 2.7% 2.7%
Operating cash flow growth (1Y) 142.8% -1.3% 3.9%
Operating cash flow CAGR (3Y) -56.6% -0.4% 4.9%
Free cash flow growth (1Y) 164.1% -2.4% -4.1%
Free cash flow CAGR (3Y) -53.1% -3.3% 1.7%

Profitability

14 metrics
MetricBNTXREGNAMGN
Gross margin 75.5% 84.9% 69.5%
EBITDA margin -49.7% 28.1% 42.2%
Operating margin -75.2% 24.7% 30.0%
Pretax margin -61.4% 33.3% 27.0%
Net margin -63.5% 27.9% 23.0%
FCF margin 33.6% 24.2% 26.7%
Operating cash flow margin 25.6% 30.1% 32.8%
Return on equity -10.3% 13.7% 83.8%
Return on assets -9.0% 10.5% 9.3%
Return on invested capital -10.7% 9.6% 14.3%
Return on capital employed -9.9% 10.7% 16.7%
Asset turnover 0.1x 0.4x 0.4x
Cash conversion (OCF / net income) -0.4x 1.1x 1.4x
Stock comp / revenue 3.6% 6.4% 1.3%

Financial Health

11 metrics
MetricBNTXREGNAMGN
Debt / assets 0.4% 4.8% 59.9%
Debt / equity 0.0x 0.1x 4.9x
Net debt / EBITDA 8.7x -1.4x 2.7x
Debt / FCF 0.1x 0.5x 5.6x
Liabilities / assets 12.7% 24.0% 87.8%
Equity / assets 87.3% 76.0% 12.2%
Interest coverage -41.1x 69.4x 4.3x
Current ratio 65.1x 3.3x 1.4x
Quick ratio 50.7x 2.6x 0.9x
Cash ratio 50.0x 1.4x 0.5x
Altman Z-score 6.31 7.33 2.32

Shareholder Returns

7 metrics
MetricBNTXREGNAMGN
Dividend yield – 0.5% 2.2%
Net buyback yield -2.9% 3.0% –
Shareholder yield -2.9% 3.5% 2.2%
Payout ratio (earnings) – – 60.4%
Payout ratio (FCF) – – 51.9%
Dividend growth (1Y) – – 6.3%
Dividend CAGR (3Y) – – 6.7%

Analyst Estimates

Solid lines are reported fiscal-year results; dashed lines are the consensus for the years ahead. Hover a year for the analysts' high and low, and how each result compared with its estimate.

ConsensusBNTXREGNAMGN
Forward P/E – 14.3xFY2026 20.5xFY2026
EPS, next fiscal year $-6.21FY2026 $57.08FY2026 $21.81FY2026
EPS growth, next FY – +28.8%FY2026 -0.1%FY2026
EPS growth, the year after – +15.5% +7.2%
Revenue, next fiscal year $1.90BFY2026 $17.05BFY2026 $41.51BFY2026
Revenue growth, next FY -43.7%FY2026 +18.9%FY2026 +12.9%FY2026
Revenue growth, the year after +11.9% +13.0% +2.3%

Institutional Ownership

13F filings, quarter ended Jun 30, 2026
HoldersBNTXREGNAMGN
Held by institutions 19.4% 66.2% 82.7%
Institutions holding 281 1,325 3,159
Change in shares held, QoQ -1.2% +3.8% +4.5%
Institutions buying 136 604 1,451
Institutions selling 73 534 1,217
Buyers to sellers 1.86 1.13 1.19

Return Correlation

Daily returns, last 12 months

1.00 means two stocks move in lockstep, 0 that they move independently. Pairs below about 0.5 diversify each other.

BNTXREGNAMGN
BNTX 1.00 0.26 0.33
REGN 0.26 1.00 0.51
AMGN 0.33 0.51 1.00

Add a Peer

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Frequently Asked Questions

Which is bigger, BNTX, REGN and AMGN?

Amgen (AMGN) is the largest by market capitalisation: BioNTech SE (BNTX) $22.02B, Regeneron Pharmaceuticals (REGN) $83.90B, Amgen (AMGN) $242.16B.

Which stock is cheaper, BNTX, REGN and AMGN?

Regeneron Pharmaceuticals (REGN) trades on the lowest price-to-earnings ratio (BioNTech SE (BNTX) -10.7x, Regeneron Pharmaceuticals (REGN) 19.4x, Amgen (AMGN) 27.7x). On next year's consensus earnings, Regeneron Pharmaceuticals (REGN) is cheapest (Regeneron Pharmaceuticals (REGN) 14.3x, Amgen (AMGN) 20.5x). A lower multiple can reflect slower expected growth, so read it next to the growth figures.

Which company is growing faster?

Regeneron Pharmaceuticals (REGN) grew revenue fastest over the trailing twelve months: BioNTech SE (BNTX) -1.1%, Regeneron Pharmaceuticals (REGN) +9.3%, Amgen (AMGN) +9.1%.

Which company is more profitable?

Regeneron Pharmaceuticals (REGN) has the highest net margin (BioNTech SE (BNTX) -63.5%, Regeneron Pharmaceuticals (REGN) 27.9%, Amgen (AMGN) 23.0%). On return on invested capital, Amgen (AMGN) leads (BioNTech SE (BNTX) -10.7%, Regeneron Pharmaceuticals (REGN) 9.6%, Amgen (AMGN) 14.3%).

Which stock has performed better?

Over the past year Amgen (AMGN) returned the most: BioNTech SE (BNTX) -17.9%, Regeneron Pharmaceuticals (REGN) +39.4%, Amgen (AMGN) +53.9%. Over five years, Amgen (AMGN) compounded fastest (BioNTech SE (BNTX) -21.1%/yr, Regeneron Pharmaceuticals (REGN) +5.5%/yr, Amgen (AMGN) +16.7%/yr). Returns are price only, before dividends.

Which pays a higher dividend?

Amgen (AMGN) has the highest dividend yield: BioNTech SE (BNTX) 0.00%, Regeneron Pharmaceuticals (REGN) 0.45%, Amgen (AMGN) 2.22%. BioNTech SE (BNTX) pays no regular dividend.

Which stock is riskier?

By one-year price volatility, Amgen (AMGN) has been the steadiest (BioNTech SE (BNTX) 46.6%, Regeneron Pharmaceuticals (REGN) 32.8%, Amgen (AMGN) 29.6%). Volatility measures how widely the price swings, not the risk of the business.

Which is the better stock, BNTX, REGN and AMGN?

There is no single answer; it depends on what you are buying for. On the 12 head-to-head measures on this page, Amgen (AMGN) leads on 6. Business Quant does not give investment advice; use the comparison as a starting point for your own research.

Data from SEC filings, exchange prices and consensus estimates, via Business Quant. Percentile scores compare each company with its own peer group, so two companies' scores are each relative to different peers unless you rank against the whole market. Price returns exclude dividends. Nothing on this page is investment advice.