BNTX vs ARGX vs ALNY Stock Comparison

BioNTech SE, Argenx Se and Alnylam Pharmaceuticals Prices as of Oct 28, 2026 Peers: Industry group
BNTX BioNTech SE
$87.99 -11.2% 1M -16.2% 1Y
Market cap
$22.25B
P/E
–
Revenue (TTM)
$3.09B
Div. yield
–
Biotechnology Healthcare
ARGX Argenx Se
$891.76 -8.3% 1M +6.6% 1Y
Market cap
$55.19B
P/E
29.1x
Revenue (TTM)
$5.82B
Div. yield
–
Biotechnology Healthcare
8 wins

Head to Head

9 decided of 12

Argenx Se leads on 8 of the 12 questions below (Argenx Se 8, Alnylam Pharmaceuticals 1). Which ones matter depends on what you are buying for; a cheap multiple and slow growth often come together.

QuestionBNTXARGXALNYLeader
Larger companyMarket capitalisation $22.25B $55.19B $31.08B ARGX
Cheaper on earningsLower P/E, profitable companies only -10.8x 29.1x 42.4x ARGX
Cheaper on forward earningsLower price / next fiscal year consensus EPS — 29.1x 34.4x ARGX
Faster revenue growthRevenue growth, trailing twelve months -1.1% +61.5% +90.1% ALNY
More profitableNet margin, trailing twelve months -63.5% 32.3% 15.3% ARGX
Better return on capitalReturn on invested capital -10.7% — — –
Less leveragedLower net debt / EBITDA 8.7x — — –
Higher dividend yieldTrailing dividend yield 0.00% — — –
Better 1-year returnPrice return, last 12 months -16.2% +6.6% -51.2% ARGX
Better 5-year returnAnnualised price return, 5 years -20.6%/yr +24.2%/yr +7.8%/yr ARGX
Less volatileAnnualised volatility, 1 year 46.7% 36.9% 51.3% ARGX
Higher overall scoreMean of the five percentile scores vs peers 65/100 92/100 77/100 ARGX

Percentile Scorecard

BNTXARGXALNY

Each axis is the mean percentile of its metrics against the company's industry group. 100 is the best in the group, 50 the middle.

Scores by Axis

AxisBNTXARGXALNY
Valuation 91 #59 of 625 84 #101 of 625 81 #119 of 625
Growth 14 #516 of 602 94 #35 of 602 98 #13 of 602
Profitability 77 #126 of 549 98 #11 of 549 93 #41 of 549
Financial Health 89 #71 of 654 – 46 #357 of 654
Shareholder Returns 52 #178 of 367 – 68 #120 of 367
Overall 65 92 77
  • BNTX ranked among 672 companies in Pharmaceuticals and Biotechnology
  • ARGX ranked among 672 companies in Pharmaceuticals and Biotechnology
  • ALNY ranked among 672 companies in Pharmaceuticals and Biotechnology

Price Performance

Price return, split-adjusted, before dividends. Click a name to hide or show it.

Returns

PeriodBNTXARGXALNYSPY
1 month -11.2%-8.3%-9.0% +0.9%
3 months -5.3%+1.0%-18.9% +5.9%
6 months -13.4%+14.9%-22.8% +8.5%
Year to date -7.6%+6.0%-41.6% +13.3%
1 year -16.2%+6.6%-51.2% +12.4%
3 years -3.5%+93.9%+53.1% +88.1%
3 years, per year -1.2%+24.7%+15.3% +23.5%
5 years -68.4%+195.3%+45.7% +68.2%
5 years, per year -20.6%+24.2%+7.8% +11.0%
10 years ——+539.5% +263.4%
10 years, per year ——+20.4% +13.8%

Risk

MeasureBNTXARGXALNYSPY
Volatility, 1Y 46.7%36.9%51.3% 12.7%
Downside volatility, 1Y 46.6%34.6%62.9% 12.7%
Beta vs S&P 500, 1Y 0.950.390.35 1.00
Return / volatility, 1Y -0.350.18-1.00 0.98
Max drawdown, 5Y -78.4%-38.2%-58.2% -25.4%
From 52-week high -26.3%-15.8%-51.7% -0.9%
52-week high $119.34$1,058.90$481.59 $779.14
52-week low $83.89$663.93$205.48 $631.97

Valuation History

Weekly multiples on trailing twelve-month fundamentals. Negative or extreme readings (a loss year, a collapsed denominator) are left out so the chart stays readable.

MultipleBNTXARGXALNY
P/E now vs peer median -10.8xmedian 17.4x 29.1xmedian 17.4x 42.4xmedian 17.4x
P/S now vs peer median 7.2xmedian 9.1x 9.5xmedian 9.1x 6.5xmedian 9.1x
EV/EBITDA now vs peer median -5.8xmedian 17.1x —median 17.1x 26.3xmedian 17.1x
P/FCF now vs peer median 21.4xmedian 19.0x —median 19.0x 37.9xmedian 19.0x
P/B now vs peer median 1.1xmedian 2.2x —median 2.2x 23.0xmedian 2.2x
PEG now vs peer median 0.31median 0.34 0.28median 0.34 1.12median 0.34

Financial History

Reported figures by fiscal period, placed on the calendar year (or quarter) each period ended in, so companies with different fiscal years line up.

Trailing twelve monthsBNTXARGXALNY
Revenue $3.09B $5.82B $4.80B
Gross profit $2.34B $5.24B $3.83B
Operating income -$2.33B $1.74B $999.78M
Net income -$1.97B $1.88B $733.11M
Free cash flow $1.04B – $819.87M
R&D $2.54B $1.80B $1.51B
EPS (diluted) $-8.13 $28.43 $5.30
Cash & equivalents $11.13B – $1.71B
Total debt $102.80M – –
Shares (diluted) 241.70M 66.03M 138.28M
Enterprise value -$24.22B $55.19B $19.13B

All Metrics

58 metrics · best in bold

Bold marks the best reading: the lowest positive value for multiples, leverage and payout, the highest for everything else. The bar under each value is its percentile against that company's own peers. Hover a value for its rank and the peer median.

Valuation

12 metrics
MetricBNTXARGXALNY
P/E -10.8x 29.1x 42.4x
P/FCF 21.4x – 37.9x
P/Operating cash flow 28.1x – 34.1x
P/S 7.2x 9.5x 6.5x
P/B 1.1x – 23.0x
P/Tangible book 1.1x – 23.0x
EV/EBITDA -5.8x – 26.3x
EV/EBIT -3.8x 31.7x 27.8x
EV/Revenue 2.9x 9.5x 5.8x
EV/FCF 8.6x – 33.9x
EV/Operating cash flow 11.3x – 30.5x
PEG (3Y EPS CAGR) 0.31 0.28 1.12

Growth

14 metrics
MetricBNTXARGXALNY
Revenue growth (1Y) -1.1% 61.5% 90.1%
Revenue CAGR (3Y) -31.0% 80.5% 57.2%
Gross profit growth (1Y) -6.4% 62.2% 79.7%
Gross profit CAGR (3Y) -34.2% 80.0% 54.6%
Operating income growth (1Y) -142.6% 120.6% 654.9%
Operating income CAGR (3Y) -33.8% 85.1% 47.5%
Net income growth (1Y) -417.0% 22.5% 356.5%
Net income CAGR (3Y) -34.6% 115.5% 39.1%
EPS growth (1Y) -393.7% 20.9% 342.3%
EPS CAGR (3Y) -34.9% 104.8% 37.9%
Operating cash flow growth (1Y) 142.8% – 2,299%
Operating cash flow CAGR (3Y) -56.6% – 57.8%
Free cash flow growth (1Y) 164.1% – 1,151%
Free cash flow CAGR (3Y) -53.1% – 52.1%

Profitability

14 metrics
MetricBNTXARGXALNY
Gross margin 75.5% 90.0% 79.8%
EBITDA margin -49.7% – 22.0%
Operating margin -75.2% 29.9% 20.8%
Pretax margin -61.4% 32.6% 16.0%
Net margin -63.5% 32.3% 15.3%
FCF margin 33.6% – 17.1%
Operating cash flow margin 25.6% – 19.0%
Return on equity -10.3% – 63.8%
Return on assets -9.0% – 14.5%
Return on invested capital -10.7% – –
Return on capital employed -9.9% – 26.1%
Asset turnover 0.1x – 0.9x
Cash conversion (OCF / net income) -0.4x – 1.2x
Stock comp / revenue 3.6% – 7.0%

Financial Health

11 metrics
MetricBNTXARGXALNY
Debt / assets 0.4% – –
Debt / equity 0.0x – –
Net debt / EBITDA 8.7x – –
Debt / FCF 0.1x – –
Liabilities / assets 12.7% – 75.6%
Equity / assets 87.3% – 24.4%
Interest coverage -41.1x 10,120x 3.8x
Current ratio 65.1x – 3.1x
Quick ratio 50.7x – 2.8x
Cash ratio 50.0x – 2.2x
Altman Z-score 6.36 – 4.97

Shareholder Returns

7 metrics
MetricBNTXARGXALNY
Dividend yield – – –
Net buyback yield -2.9% – -0.5%
Shareholder yield -2.9% – -0.5%
Payout ratio (earnings) – – –
Payout ratio (FCF) – – –
Dividend growth (1Y) – – –
Dividend CAGR (3Y) – – –

Analyst Estimates

Solid lines are reported fiscal-year results; dashed lines are the consensus for the years ahead. Hover a year for the analysts' high and low, and how each result compared with its estimate.

ConsensusBNTXARGXALNY
Forward P/E – 29.1xFY2026 34.4xFY2026
EPS, next fiscal year $-6.21FY2026 $30.63FY2026 $6.76FY2026
EPS growth, next FY – +56.5%FY2026 +190.1%FY2026
EPS growth, the year after – +26.9% +34.3%
Revenue, next fiscal year $1.90BFY2026 $6.08BFY2026 $5.68BFY2026
Revenue growth, next FY -43.7%FY2026 +43.1%FY2026 +53.1%FY2026
Revenue growth, the year after +11.9% +22.9% +27.8%

Institutional Ownership

13F filings, quarter ended Jun 30, 2026
HoldersBNTXARGXALNY
Held by institutions 19.4% 46.1% 99.7%
Institutions holding 281 504 786
Change in shares held, QoQ -1.2% -2.0% +3.8%
Institutions buying 136 264 412
Institutions selling 73 160 277
Buyers to sellers 1.86 1.65 1.49

Return Correlation

Daily returns, last 12 months

1.00 means two stocks move in lockstep, 0 that they move independently. Pairs below about 0.5 diversify each other.

BNTXARGXALNY
BNTX 1.00 0.23 0.24
ARGX 0.23 1.00 0.19
ALNY 0.24 0.19 1.00

Add a Peer

Largest companies in the same industry

Related Comparisons

Frequently Asked Questions

Which is bigger, BNTX, ARGX and ALNY?

Argenx Se (ARGX) is the largest by market capitalisation: BioNTech SE (BNTX) $22.25B, Argenx Se (ARGX) $55.19B, Alnylam Pharmaceuticals (ALNY) $31.08B.

Which stock is cheaper, BNTX, ARGX and ALNY?

Argenx Se (ARGX) trades on the lowest price-to-earnings ratio (BioNTech SE (BNTX) -10.8x, Argenx Se (ARGX) 29.1x, Alnylam Pharmaceuticals (ALNY) 42.4x). On next year's consensus earnings, Argenx Se (ARGX) is cheapest (Argenx Se (ARGX) 29.1x, Alnylam Pharmaceuticals (ALNY) 34.4x). A lower multiple can reflect slower expected growth, so read it next to the growth figures.

Which company is growing faster?

Alnylam Pharmaceuticals (ALNY) grew revenue fastest over the trailing twelve months: BioNTech SE (BNTX) -1.1%, Argenx Se (ARGX) +61.5%, Alnylam Pharmaceuticals (ALNY) +90.1%.

Which company is more profitable?

Argenx Se (ARGX) has the highest net margin (BioNTech SE (BNTX) -63.5%, Argenx Se (ARGX) 32.3%, Alnylam Pharmaceuticals (ALNY) 15.3%).

Which stock has performed better?

Over the past year Argenx Se (ARGX) returned the most: BioNTech SE (BNTX) -16.2%, Argenx Se (ARGX) +6.6%, Alnylam Pharmaceuticals (ALNY) -51.2%. Over five years, Argenx Se (ARGX) compounded fastest (BioNTech SE (BNTX) -20.6%/yr, Argenx Se (ARGX) +24.2%/yr, Alnylam Pharmaceuticals (ALNY) +7.8%/yr). Returns are price only, before dividends.

Which stock is riskier?

By one-year price volatility, Argenx Se (ARGX) has been the steadiest (BioNTech SE (BNTX) 46.7%, Argenx Se (ARGX) 36.9%, Alnylam Pharmaceuticals (ALNY) 51.3%). Volatility measures how widely the price swings, not the risk of the business.

Which is the better stock, BNTX, ARGX and ALNY?

There is no single answer; it depends on what you are buying for. On the 12 head-to-head measures on this page, Argenx Se (ARGX) leads on 8. Business Quant does not give investment advice; use the comparison as a starting point for your own research.

Data from SEC filings, exchange prices and consensus estimates, via Business Quant. Percentile scores compare each company with its own peer group, so two companies' scores are each relative to different peers unless you rank against the whole market. Price returns exclude dividends. Nothing on this page is investment advice.