BIIB vs MRNA vs AMGN Stock Comparison

Biogen, Moderna and Amgen Prices as of Oct 29, 2026 Peers: Industry group
BIIB Biogen Inc.
$249.65 +9.9% 1M +68.8% 1Y
Market cap
$36.90B
P/E
106.2x
Revenue (TTM)
$10.30B
Div. yield
–
Biotechnology Healthcare
1 win
MRNA Moderna, Inc.
$222.76 +9.5% 1M +801.9% 1Y
Market cap
$88.88B
P/E
–
Revenue (TTM)
$2.23B
Div. yield
–
Biotechnology Healthcare
2 wins
AMGN Amgen Inc
$460.73 +8.8% 1M +57.9% 1Y
Market cap
$249.07B
P/E
28.5x
Revenue (TTM)
$38.10B
Div. yield
2.16%
Biotechnology Healthcare
8 wins

Head to Head

11 decided of 12

Amgen leads on 8 of the 12 questions below (Amgen 8, Moderna 2, Biogen 1). Which ones matter depends on what you are buying for; a cheap multiple and slow growth often come together.

QuestionBIIBMRNAAMGNLeader
Larger companyMarket capitalisation $36.90B $88.88B $249.07B AMGN
Cheaper on earningsLower P/E, profitable companies only 106.2x -28.1x 28.5x AMGN
Cheaper on forward earningsLower price / next fiscal year consensus EPS 19.5x — 21.1x BIIB
Faster revenue growthRevenue growth, trailing twelve months +2.3% -27.6% +9.1% AMGN
More profitableNet margin, trailing twelve months 3.4% -141.4% 23.0% AMGN
Better return on capitalReturn on invested capital 1.3% -43.3% 14.3% AMGN
Less leveragedLower net debt / EBITDA 4.5x 1.5x 2.7x MRNA
Higher dividend yieldTrailing dividend yield — — 2.16% –
Better 1-year returnPrice return, last 12 months +68.8% +801.9% +57.9% MRNA
Better 5-year returnAnnualised price return, 5 years -1.3%/yr -8.4%/yr +17.4%/yr AMGN
Less volatileAnnualised volatility, 1 year 34.3% 130.6% 29.7% AMGN
Higher overall scoreMean of the five percentile scores vs peers 60/100 57/100 66/100 AMGN

Percentile Scorecard

BIIBMRNAAMGN

Each axis is the mean percentile of its metrics against the company's industry group. 100 is the best in the group, 50 the middle.

Scores by Axis

AxisBIIBMRNAAMGN
Valuation 92 #53 of 624 70 #191 of 624 85 #95 of 624
Growth 26 #444 of 601 19 #485 of 601 61 #234 of 601
Profitability 87 #72 of 541 58 #230 of 541 94 #31 of 541
Financial Health 33 #432 of 647 54 #296 of 647 21 #509 of 647
Shareholder Returns – 86 #52 of 359 68 #114 of 359
Overall 60 57 66
  • BIIB ranked among 671 companies in Pharmaceuticals and Biotechnology
  • MRNA ranked among 671 companies in Pharmaceuticals and Biotechnology
  • AMGN ranked among 671 companies in Pharmaceuticals and Biotechnology

Price Performance

Price return, split-adjusted, before dividends. Click a name to hide or show it.

Returns

PeriodBIIBMRNAAMGNSPY
1 month +9.9%+9.5%+8.8% +0.7%
3 months +20.1%+284.6%+18.9% +3.7%
6 months +31.9%+384.9%+33.1% +7.1%
Year to date +41.9%+655.4%+40.8% +12.8%
1 year +68.8%+801.9%+57.9% +11.9%
3 years +5.2%+200.7%+75.1% +85.2%
3 years, per year +1.7%+44.4%+20.5% +22.8%
5 years -6.4%-35.5%+122.6% +67.6%
5 years, per year -1.3%-8.4%+17.4% +10.9%
10 years -12.0%—+217.4% +262.0%
10 years, per year -1.3%—+12.2% +13.7%

Risk

MeasureBIIBMRNAAMGNSPY
Volatility, 1Y 34.3%130.6%29.7% 12.7%
Downside volatility, 1Y 32.8%79.8%28.0% 12.6%
Beta vs S&P 500, 1Y 0.252.150.45 1.00
Return / volatility, 1Y 2.016.141.95 0.94
Max drawdown, 5Y -64.4%-93.9%-26.7% -25.4%
From 52-week high -1.7%-9.4%0.0% -1.2%
52-week high $253.84$245.81$460.73 $779.14
52-week low $147.86$22.36$291.77 $631.97

Valuation History

Weekly multiples on trailing twelve-month fundamentals. Negative or extreme readings (a loss year, a collapsed denominator) are left out so the chart stays readable.

MultipleBIIBMRNAAMGN
P/E now vs peer median 106.2xmedian 17.8x -28.1xmedian 17.8x 28.5xmedian 17.8x
P/S now vs peer median 3.6xmedian 9.1x 39.9xmedian 9.1x 6.5xmedian 9.1x
EV/EBITDA now vs peer median 32.3xmedian 15.0x -27.4xmedian 15.0x 18.2xmedian 15.0x
P/FCF now vs peer median 17.8xmedian 21.7x -71.4xmedian 21.7x 24.5xmedian 21.7x
P/B now vs peer median 2.0xmedian 2.2x 13.1xmedian 2.2x 21.3xmedian 2.2x
PEG now vs peer median -2.76median 0.35 0.43median 0.35 10.73median 0.35

Financial History

Reported figures by fiscal period, placed on the calendar year (or quarter) each period ended in, so companies with different fiscal years line up.

Trailing twelve monthsBIIBMRNAAMGN
Revenue $10.30B $2.23B $38.10B
Gross profit $7.62B $521.00M $26.48B
Operating income $445.10M -$3.32B $11.43B
Net income $347.50M -$3.15B $8.74B
Free cash flow $2.07B -$1.24B $10.18B
R&D $2.15B $2.88B $7.63B
EPS (diluted) $2.35 $-7.92 $16.07
Cash & equivalents $1.30B $1.72B $13.99B
Total debt $7.29B $591.00M $57.30B
Shares (diluted) 147.80M 398.00M 544.00M
Enterprise value $26.22B $68.24B $204.47B

All Metrics

58 metrics · best in bold

Bold marks the best reading: the lowest positive value for multiples, leverage and payout, the highest for everything else. The bar under each value is its percentile against that company's own peers. Hover a value for its rank and the peer median.

Valuation

12 metrics
MetricBIIBMRNAAMGN
P/E 106.2x -28.1x 28.5x
P/FCF 17.8x -71.4x 24.5x
P/Operating cash flow 16.4x -82.8x 20.0x
P/S 3.6x 39.9x 6.5x
P/B 2.0x 13.1x 21.3x
P/Tangible book 6.7x 13.1x -28.3x
EV/EBITDA 32.3x -27.4x 18.2x
EV/EBIT 96.4x -25.4x 25.6x
EV/Revenue 4.2x 37.9x 7.7x
EV/FCF 20.7x -67.8x 28.7x
EV/Operating cash flow 19.1x -78.6x 23.4x
PEG (3Y EPS CAGR) -2.76 0.43 10.73

Growth

14 metrics
MetricBIIBMRNAAMGN
Revenue growth (1Y) 2.3% -27.6% 9.1%
Revenue CAGR (3Y) 1.0% -40.6% 12.7%
Gross profit growth (1Y) 0.6% -67.8% 17.6%
Gross profit CAGR (3Y) 0.5% -56.0% 10.3%
Operating income growth (1Y) -76.6% -1.4% 39.5%
Operating income CAGR (3Y) -34.8% -103.9% 6.4%
Net income growth (1Y) -78.4% -8.5% 32.1%
Net income CAGR (3Y) -38.1% -66.4% 3.1%
EPS growth (1Y) -78.5% -5.8% 31.4%
EPS CAGR (3Y) -38.5% -65.1% 2.7%
Operating cash flow growth (1Y) -8.4% 60.2% 3.9%
Operating cash flow CAGR (3Y) 18.2% -68.1% 4.9%
Free cash flow growth (1Y) -10.1% 64.4% -4.1%
Free cash flow CAGR (3Y) 24.9% -18.2% 1.7%

Profitability

14 metrics
MetricBIIBMRNAAMGN
Gross margin 74.0% 23.4% 69.5%
EBITDA margin 12.9% -138.2% 42.2%
Operating margin 4.3% -149.0% 30.0%
Pretax margin 4.3% -138.6% 27.0%
Net margin 3.4% -141.4% 23.0%
FCF margin 20.1% -55.8% 26.7%
Operating cash flow margin 21.8% -48.2% 32.8%
Return on equity 1.8% -44.5% 83.8%
Return on assets 1.1% -28.1% 9.3%
Return on invested capital 1.3% -43.3% 14.3%
Return on capital employed 1.6% -38.2% 16.7%
Asset turnover 0.3x 0.2x 0.4x
Cash conversion (OCF / net income) 6.5x 0.3x 1.4x
Stock comp / revenue 2.9% 20.7% 1.3%

Financial Health

11 metrics
MetricBIIBMRNAAMGN
Debt / assets 22.7% 5.4% 59.9%
Debt / equity 0.4x 0.1x 4.9x
Net debt / EBITDA 4.5x 1.5x 2.7x
Debt / FCF 3.5x -0.5x 5.6x
Liabilities / assets 41.0% 38.3% 87.8%
Equity / assets 59.0% 61.7% 12.2%
Interest coverage – – 4.3x
Current ratio 1.9x 2.3x 1.4x
Quick ratio 0.9x 2.0x 0.9x
Cash ratio 0.3x 2.0x 0.5x
Altman Z-score 3.11 12.91 2.37

Shareholder Returns

7 metrics
MetricBIIBMRNAAMGN
Dividend yield – – 2.2%
Net buyback yield – -0.1% –
Shareholder yield – -0.1% 2.2%
Payout ratio (earnings) – – 60.4%
Payout ratio (FCF) – – 51.9%
Dividend growth (1Y) – – 6.3%
Dividend CAGR (3Y) – – 6.7%

Analyst Estimates

Solid lines are reported fiscal-year results; dashed lines are the consensus for the years ahead. Hover a year for the analysts' high and low, and how each result compared with its estimate.

ConsensusBIIBMRNAAMGN
Forward P/E 19.5xFY2026 – 21.1xFY2026
EPS, next fiscal year $12.81FY2026 $-8.02FY2026 $21.81FY2026
EPS growth, next FY -16.2%FY2026 – -0.1%FY2026
EPS growth, the year after +36.5% – +7.2%
Revenue, next fiscal year $9.96BFY2026 $2.04BFY2026 $41.51BFY2026
Revenue growth, next FY +0.7%FY2026 +5.1%FY2026 +12.9%FY2026
Revenue growth, the year after +11.9% +26.8% +2.3%

Institutional Ownership

13F filings, quarter ended Jun 30, 2026
HoldersBIIBMRNAAMGN
Held by institutions 96.4% 80.2% 82.7%
Institutions holding 1,037 785 3,161
Change in shares held, QoQ +6.0% +3.4% +4.5%
Institutions buying 549 402 1,452
Institutions selling 294 239 1,218
Buyers to sellers 1.87 1.68 1.19

Return Correlation

Daily returns, last 12 months

1.00 means two stocks move in lockstep, 0 that they move independently. Pairs below about 0.5 diversify each other.

BIIBMRNAAMGN
BIIB 1.00 0.22 0.49
MRNA 0.22 1.00 0.25
AMGN 0.49 0.25 1.00

Add a Peer

Largest companies in the same industry

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Frequently Asked Questions

Which is bigger, BIIB, MRNA and AMGN?

Amgen (AMGN) is the largest by market capitalisation: Biogen (BIIB) $36.90B, Moderna (MRNA) $88.88B, Amgen (AMGN) $249.07B.

Which stock is cheaper, BIIB, MRNA and AMGN?

Amgen (AMGN) trades on the lowest price-to-earnings ratio (Biogen (BIIB) 106.2x, Moderna (MRNA) -28.1x, Amgen (AMGN) 28.5x). On next year's consensus earnings, Biogen (BIIB) is cheapest (Biogen (BIIB) 19.5x, Amgen (AMGN) 21.1x). A lower multiple can reflect slower expected growth, so read it next to the growth figures.

Which company is growing faster?

Amgen (AMGN) grew revenue fastest over the trailing twelve months: Biogen (BIIB) +2.3%, Moderna (MRNA) -27.6%, Amgen (AMGN) +9.1%.

Which company is more profitable?

Amgen (AMGN) has the highest net margin (Biogen (BIIB) 3.4%, Moderna (MRNA) -141.4%, Amgen (AMGN) 23.0%). On return on invested capital, Amgen (AMGN) leads (Biogen (BIIB) 1.3%, Moderna (MRNA) -43.3%, Amgen (AMGN) 14.3%).

Which stock has performed better?

Over the past year Moderna (MRNA) returned the most: Biogen (BIIB) +68.8%, Moderna (MRNA) +801.9%, Amgen (AMGN) +57.9%. Over five years, Amgen (AMGN) compounded fastest (Biogen (BIIB) -1.3%/yr, Moderna (MRNA) -8.4%/yr, Amgen (AMGN) +17.4%/yr). Returns are price only, before dividends.

Which pays a higher dividend?

Only one of these companies pays a dividend: Amgen (AMGN) 2.16%. Biogen (BIIB) and Moderna (MRNA) pays no regular dividend.

Which stock is riskier?

By one-year price volatility, Amgen (AMGN) has been the steadiest (Biogen (BIIB) 34.3%, Moderna (MRNA) 130.6%, Amgen (AMGN) 29.7%). Volatility measures how widely the price swings, not the risk of the business.

Which is the better stock, BIIB, MRNA and AMGN?

There is no single answer; it depends on what you are buying for. On the 12 head-to-head measures on this page, Amgen (AMGN) leads on 8. Business Quant does not give investment advice; use the comparison as a starting point for your own research.

Data from SEC filings, exchange prices and consensus estimates, via Business Quant. Percentile scores compare each company with its own peer group, so two companies' scores are each relative to different peers unless you rank against the whole market. Price returns exclude dividends. Nothing on this page is investment advice.