BIIB vs GRFS vs MRNA Stock Comparison

Biogen, Grifols and Moderna Prices as of Oct 28, 2026 Peers: Industry group
BIIB Biogen Inc.
$244.05 +6.7% 1M +63.6% 1Y
Market cap
$37.30B
P/E
107.3x
Revenue (TTM)
$10.30B
Div. yield
–
Biotechnology Healthcare
5 wins
GRFS Grifols SA
$8.12 +9.6% 1M -13.2% 1Y
Market cap
$5.49B
P/E
12.2x
Revenue (TTM)
—
Div. yield
–
Biotechnology Healthcare
3 wins
MRNA Moderna, Inc.
$214.16 +8.6% 1M +744.8% 1Y
Market cap
$88.10B
P/E
–
Revenue (TTM)
$2.23B
Div. yield
–
Biotechnology Healthcare
3 wins

Head to Head

11 decided of 12

Biogen leads on 5 of the 12 questions below (Biogen 5, Moderna 3, Grifols 3). Which ones matter depends on what you are buying for; a cheap multiple and slow growth often come together.

QuestionBIIBGRFSMRNALeader
Larger companyMarket capitalisation $37.30B $5.49B $88.10B MRNA
Cheaper on earningsLower P/E, profitable companies only 107.3x 12.2x -28.0x GRFS
Cheaper on forward earningsLower price / next fiscal year consensus EPS 19.1x 8.6x — GRFS
Faster revenue growthRevenue growth, trailing twelve months +2.3% — -27.6% BIIB
More profitableNet margin, trailing twelve months 3.4% — -141.4% BIIB
Better return on capitalReturn on invested capital 1.3% — -43.3% BIIB
Less leveragedLower net debt / EBITDA 4.5x — 1.5x MRNA
Higher dividend yieldTrailing dividend yield 0.00% 0.00% 0.00% –
Better 1-year returnPrice return, last 12 months +63.6% -13.2% +744.8% MRNA
Better 5-year returnAnnualised price return, 5 years -1.8%/yr -9.1%/yr -9.1%/yr BIIB
Less volatileAnnualised volatility, 1 year 34.2% 32.4% 130.6% GRFS
Higher overall scoreMean of the five percentile scores vs peers 59/100 56/100 57/100 BIIB

Percentile Scorecard

BIIBGRFSMRNA

Each axis is the mean percentile of its metrics against the company's industry group. 100 is the best in the group, 50 the middle.

Scores by Axis

AxisBIIBGRFSMRNA
Valuation 92 #54 of 625 99 #6 of 625 69 #192 of 625
Growth 26 #446 of 602 – 19 #488 of 602
Profitability 87 #73 of 549 – 57 #235 of 549
Financial Health 33 #437 of 654 14 #564 of 654 55 #298 of 654
Shareholder Returns – 56 #162 of 367 85 #57 of 367
Overall 59 56 57
  • BIIB ranked among 672 companies in Pharmaceuticals and Biotechnology
  • GRFS ranked among 672 companies in Pharmaceuticals and Biotechnology
  • MRNA ranked among 672 companies in Pharmaceuticals and Biotechnology

Price Performance

Price return, split-adjusted, before dividends. Click a name to hide or show it.

Returns

PeriodBIIBGRFSMRNASPY
1 month +6.7%+9.6%+8.6% +0.9%
3 months +16.6%-0.4%+293.0% +5.9%
6 months +25.6%+2.7%+368.4% +8.5%
Year to date +38.7%-13.2%+626.2% +13.3%
1 year +63.6%-13.2%+744.8% +12.4%
3 years +4.1%+3.6%+197.8% +88.1%
3 years, per year +1.3%+1.2%+43.9% +23.5%
5 years -8.5%-38.1%-38.0% +68.2%
5 years, per year -1.8%-9.1%-9.1% +11.0%
10 years -14.0%-44.0%— +263.4%
10 years, per year -1.5%-5.6%— +13.8%

Risk

MeasureBIIBGRFSMRNASPY
Volatility, 1Y 34.2%32.4%130.6% 12.7%
Downside volatility, 1Y 32.7%34.2%79.5% 12.7%
Beta vs S&P 500, 1Y 0.250.952.16 1.00
Return / volatility, 1Y 1.86-0.415.70 0.98
Max drawdown, 5Y -64.4%-58.8%-93.9% -25.4%
From 52-week high -3.9%-16.5%-12.9% -0.9%
52-week high $253.84$9.72$245.81 $779.14
52-week low $147.86$7.02$22.36 $631.97

Valuation History

Weekly multiples on trailing twelve-month fundamentals. Negative or extreme readings (a loss year, a collapsed denominator) are left out so the chart stays readable.

MultipleBIIBGRFSMRNA
P/E now vs peer median 103.8xmedian 17.4x 12.2xmedian 17.4x -27.1xmedian 17.4x
P/S now vs peer median 3.5xmedian 9.1x 0.7xmedian 9.1x 38.4xmedian 9.1x
EV/EBITDA now vs peer median 31.7xmedian 17.1x —median 17.1x -26.3xmedian 17.1x
P/FCF now vs peer median 17.4xmedian 19.0x 7.8xmedian 19.0x -68.7xmedian 19.0x
P/B now vs peer median 1.9xmedian 2.2x 0.6xmedian 2.2x 12.6xmedian 2.2x
PEG now vs peer median -2.70median 0.34 —median 0.34 0.42median 0.34

Financial History

Reported figures by fiscal period, placed on the calendar year (or quarter) each period ended in, so companies with different fiscal years line up.

Trailing twelve monthsBIIBGRFSMRNA
Revenue $10.30B – $2.23B
Gross profit $7.62B – $521.00M
Operating income $445.10M – -$3.32B
Net income $347.50M – -$3.15B
Free cash flow $2.07B – -$1.24B
R&D $2.15B – $2.88B
EPS (diluted) $2.35 – $-7.92
Cash & equivalents $1.30B $969.15M $1.72B
Total debt $7.29B $44.00B $591.00M
Shares (diluted) 147.80M 681.57M 398.00M
Enterprise value $26.61B $1.83B $67.45B

All Metrics

58 metrics · best in bold

Bold marks the best reading: the lowest positive value for multiples, leverage and payout, the highest for everything else. The bar under each value is its percentile against that company's own peers. Hover a value for its rank and the peer median.

Valuation

12 metrics
MetricBIIBGRFSMRNA
P/E 103.8x 12.2x -27.1x
P/FCF 17.4x 7.8x -68.7x
P/Operating cash flow 16.1x – -79.6x
P/S 3.5x 0.7x 38.4x
P/B 1.9x 0.6x 12.6x
P/Tangible book 6.5x 1.0x 12.6x
EV/EBITDA 31.7x – -26.3x
EV/EBIT 94.5x – -24.4x
EV/Revenue 4.1x – 36.3x
EV/FCF 20.3x – -65.0x
EV/Operating cash flow 18.7x – -75.4x
PEG (3Y EPS CAGR) -2.70 – 0.42

Growth

14 metrics
MetricBIIBGRFSMRNA
Revenue growth (1Y) 2.3% – -27.6%
Revenue CAGR (3Y) 1.0% – -40.6%
Gross profit growth (1Y) 0.6% – -67.8%
Gross profit CAGR (3Y) 0.5% – -56.0%
Operating income growth (1Y) -76.6% – -1.4%
Operating income CAGR (3Y) -34.8% – -103.9%
Net income growth (1Y) -78.4% – -8.5%
Net income CAGR (3Y) -38.1% – -66.4%
EPS growth (1Y) -78.5% – -5.8%
EPS CAGR (3Y) -38.5% – -65.1%
Operating cash flow growth (1Y) -8.4% – 60.2%
Operating cash flow CAGR (3Y) 18.2% – -68.1%
Free cash flow growth (1Y) -10.1% – 64.4%
Free cash flow CAGR (3Y) 24.9% – -18.2%

Profitability

14 metrics
MetricBIIBGRFSMRNA
Gross margin 74.0% – 23.4%
EBITDA margin 12.9% – -138.2%
Operating margin 4.3% – -149.0%
Pretax margin 4.3% – -138.6%
Net margin 3.4% – -141.4%
FCF margin 20.1% – -55.8%
Operating cash flow margin 21.8% – -48.2%
Return on equity 1.8% – -44.5%
Return on assets 1.1% – -28.1%
Return on invested capital 1.3% – -43.3%
Return on capital employed 1.6% – -38.2%
Asset turnover 0.3x – 0.2x
Cash conversion (OCF / net income) 6.5x – 0.3x
Stock comp / revenue 2.9% – 20.7%

Financial Health

11 metrics
MetricBIIBGRFSMRNA
Debt / assets 22.7% 48.9% 5.4%
Debt / equity 0.4x 1.3x 0.1x
Net debt / EBITDA 4.5x – 1.5x
Debt / FCF 3.5x – -0.5x
Liabilities / assets 41.0% 61.4% 38.3%
Equity / assets 59.0% 38.6% 61.7%
Interest coverage – – –
Current ratio 1.9x 2.5x 2.3x
Quick ratio 0.9x 0.8x 2.0x
Cash ratio 0.3x 0.4x 2.0x
Altman Z-score 3.07 – 12.42

Shareholder Returns

7 metrics
MetricBIIBGRFSMRNA
Dividend yield – 1.4% –
Net buyback yield – – -0.1%
Shareholder yield – 1.4% -0.1%
Payout ratio (earnings) – – –
Payout ratio (FCF) – – –
Dividend growth (1Y) – – –
Dividend CAGR (3Y) – – –

Analyst Estimates

Solid lines are reported fiscal-year results; dashed lines are the consensus for the years ahead. Hover a year for the analysts' high and low, and how each result compared with its estimate.

ConsensusBIIBGRFSMRNA
Forward P/E 19.1xFY2026 8.6xFY2026 –
EPS, next fiscal year $12.81FY2026 $0.94FY2026 $-8.02FY2026
EPS growth, next FY -16.2%FY2026 +10.6%FY2026 –
EPS growth, the year after +36.5% +26.6% –
Revenue, next fiscal year $9.96BFY2026 $8.88BFY2026 $2.04BFY2026
Revenue growth, next FY +0.7%FY2026 +0.0%FY2026 +5.1%FY2026
Revenue growth, the year after +11.9% +10.3% +26.8%

Institutional Ownership

13F filings, quarter ended Jun 30, 2026
HoldersBIIBGRFSMRNA
Held by institutions 96.4% 21.0% 80.2%
Institutions holding 1,036 166 784
Change in shares held, QoQ +6.0% -0.5% +3.4%
Institutions buying 548 73 402
Institutions selling 294 65 238
Buyers to sellers 1.86 1.12 1.69

Return Correlation

Daily returns, last 12 months

1.00 means two stocks move in lockstep, 0 that they move independently. Pairs below about 0.5 diversify each other.

BIIBGRFSMRNA
BIIB 1.00 0.11 0.22
GRFS 0.11 1.00 0.26
MRNA 0.22 0.26 1.00

Add a Peer

Largest companies in the same industry

Related Comparisons

Frequently Asked Questions

Which is bigger, BIIB, GRFS and MRNA?

Moderna (MRNA) is the largest by market capitalisation: Biogen (BIIB) $37.30B, Grifols (GRFS) $5.49B, Moderna (MRNA) $88.10B.

Which stock is cheaper, BIIB, GRFS and MRNA?

Grifols (GRFS) trades on the lowest price-to-earnings ratio (Biogen (BIIB) 107.3x, Grifols (GRFS) 12.2x, Moderna (MRNA) -28.0x). On next year's consensus earnings, Grifols (GRFS) is cheapest (Biogen (BIIB) 19.1x, Grifols (GRFS) 8.6x). A lower multiple can reflect slower expected growth, so read it next to the growth figures.

Which company is growing faster?

Biogen (BIIB) grew revenue fastest over the trailing twelve months: Biogen (BIIB) +2.3%, Moderna (MRNA) -27.6%.

Which company is more profitable?

Biogen (BIIB) has the highest net margin (Biogen (BIIB) 3.4%, Moderna (MRNA) -141.4%). On return on invested capital, Biogen (BIIB) leads (Biogen (BIIB) 1.3%, Moderna (MRNA) -43.3%).

Which stock has performed better?

Over the past year Moderna (MRNA) returned the most: Biogen (BIIB) +63.6%, Grifols (GRFS) -13.2%, Moderna (MRNA) +744.8%. Over five years, Biogen (BIIB) compounded fastest (Biogen (BIIB) -1.8%/yr, Grifols (GRFS) -9.1%/yr, Moderna (MRNA) -9.1%/yr). Returns are price only, before dividends.

Which stock is riskier?

By one-year price volatility, Grifols (GRFS) has been the steadiest (Biogen (BIIB) 34.2%, Grifols (GRFS) 32.4%, Moderna (MRNA) 130.6%). Volatility measures how widely the price swings, not the risk of the business.

Which is the better stock, BIIB, GRFS and MRNA?

There is no single answer; it depends on what you are buying for. On the 12 head-to-head measures on this page, Biogen (BIIB) leads on 5. Business Quant does not give investment advice; use the comparison as a starting point for your own research.

Data from SEC filings, exchange prices and consensus estimates, via Business Quant. Percentile scores compare each company with its own peer group, so two companies' scores are each relative to different peers unless you rank against the whole market. Price returns exclude dividends. Nothing on this page is investment advice.