BEAM vs SRPT vs PGEN Stock Comparison

Beam Therapeutics, Sarepta Therapeutics and Precigen Prices as of Oct 29, 2026 Peers: Industry group
BEAM Beam Therapeutics Inc.
$28.84 +17.6% 1M +16.4% 1Y
Market cap
$2.98B
P/E
–
Revenue (TTM)
$156.04M
Div. yield
–
Gene and Cell Therapy Healthcare
3 wins
PGEN Precigen, Inc.
$6.64 -17.5% 1M +65.6% 1Y
Market cap
$2.38B
P/E
–
Revenue (TTM)
$85.72M
Div. yield
–
Gene and Cell Therapy Healthcare
4 wins

Head to Head

9 decided of 12

Precigen leads on 4 of the 12 questions below (Precigen 4, Beam Therapeutics 3, Sarepta Therapeutics 2). Which ones matter depends on what you are buying for; a cheap multiple and slow growth often come together.

QuestionBEAMSRPTPGENLeader
Larger companyMarket capitalisation $2.98B $2.03B $2.38B BEAM
Cheaper on earningsLower P/E, profitable companies only -35.2x -17.4x -7.0x –
Cheaper on forward earningsLower price / next fiscal year consensus EPS — 6.7x 39.1x SRPT
Faster revenue growthRevenue growth, trailing twelve months +158.9% -20.4% +1,875.0% PGEN
More profitableNet margin, trailing twelve months -54.7% -5.9% -392.8% SRPT
Better return on capitalReturn on invested capital — -6.1% — –
Less leveragedLower net debt / EBITDA 3.0x -0.6x -1.6x PGEN
Higher dividend yieldTrailing dividend yield 0.00% — — –
Better 1-year returnPrice return, last 12 months +16.4% -18.0% +65.6% PGEN
Better 5-year returnAnnualised price return, 5 years -20.1%/yr -24.7%/yr +6.6%/yr PGEN
Less volatileAnnualised volatility, 1 year 70.4% 81.1% 78.1% BEAM
Higher overall scoreMean of the five percentile scores vs peers 70/100 67/100 55/100 BEAM

Percentile Scorecard

BEAMSRPTPGEN

Each axis is the mean percentile of its metrics against the company's industry group. 100 is the best in the group, 50 the middle.

Scores by Axis

AxisBEAMSRPTPGEN
Valuation 57 #269 of 624 97 #23 of 624 60 #252 of 624
Growth 77 #138 of 601 64 #220 of 601 48 #314 of 601
Profitability 64 #193 of 541 80 #111 of 541 59 #224 of 541
Financial Health 81 #122 of 647 34 #430 of 647 27 #475 of 647
Shareholder Returns 68 #116 of 359 61 #141 of 359 82 #67 of 359
Overall 70 67 55
  • BEAM ranked among 671 companies in Pharmaceuticals and Biotechnology
  • SRPT ranked among 671 companies in Pharmaceuticals and Biotechnology
  • PGEN ranked among 671 companies in Pharmaceuticals and Biotechnology

Price Performance

Price return, split-adjusted, before dividends. Click a name to hide or show it.

Returns

PeriodBEAMSRPTPGENSPY
1 month +17.6%+3.2%-17.5% +0.7%
3 months +8.9%+23.6%+11.8% +3.7%
6 months -4.9%-7.9%+59.6% +7.1%
Year to date +4.0%-10.6%+58.9% +12.8%
1 year +16.4%-18.0%+65.6% +11.9%
3 years +50.9%-82.1%+520.6% +85.2%
3 years, per year +14.7%-43.7%+83.8% +22.8%
5 years -67.5%-75.7%+37.5% +67.6%
5 years, per year -20.1%-24.7%+6.6% +10.9%
10 years —-53.0%-74.2% +262.0%
10 years, per year —-7.3%-12.7% +13.7%

Risk

MeasureBEAMSRPTPGENSPY
Volatility, 1Y 70.4%81.1%78.1% 12.7%
Downside volatility, 1Y 63.6%85.8%69.2% 12.6%
Beta vs S&P 500, 1Y 2.092.081.41 1.00
Return / volatility, 1Y 0.23-0.220.84 0.94
Max drawdown, 5Y -85.3%-92.7%-87.8% -25.4%
From 52-week high -23.9%-21.3%-22.4% -1.2%
52-week high $37.92$24.45$8.56 $779.14
52-week low $20.60$14.86$3.10 $631.97

Valuation History

Weekly multiples on trailing twelve-month fundamentals. Negative or extreme readings (a loss year, a collapsed denominator) are left out so the chart stays readable.

MultipleBEAMSRPTPGEN
P/E now vs peer median -35.2xmedian 17.8x -17.4xmedian 17.8x -7.0xmedian 17.8x
P/S now vs peer median 19.1xmedian 9.1x 1.0xmedian 9.1x 27.7xmedian 9.1x
EV/EBITDA now vs peer median -5.4xmedian 15.0x -21.2xmedian 15.0x -70.9xmedian 15.0x
P/FCF now vs peer median -8.0xmedian 21.7x 24.8xmedian 21.7x -20.6xmedian 21.7x
P/B now vs peer median 2.8xmedian 2.2x 1.3xmedian 2.2x 54.6xmedian 2.2x
PEG now vs peer median -0.83median 0.35 -0.33median 0.35 0.06median 0.35

Financial History

Reported figures by fiscal period, placed on the calendar year (or quarter) each period ended in, so companies with different fiscal years line up.

Trailing twelve monthsBEAMSRPTPGEN
Revenue $156.04M $1.97B $85.72M
Gross profit – $1.17B $77.72M
Operating income -$378.02M -$143.25M -$39.50M
Net income -$86.52M -$136.73M -$157.71M
Free cash flow -$372.77M $81.85M -$115.22M
R&D $408.66M $789.44M $32.29M
EPS (diluted) $-0.82 $-1.11 $-0.81
Cash & equivalents $219.83M $571.15M $16.33M
Total debt $100.26M $847.62M $93.88M
Shares (diluted) 104.33M 105.43M 413.69M
Enterprise value -$1.71B -$1.20B $2.06B

All Metrics

58 metrics · best in bold

Bold marks the best reading: the lowest positive value for multiples, leverage and payout, the highest for everything else. The bar under each value is its percentile against that company's own peers. Hover a value for its rank and the peer median.

Valuation

12 metrics
MetricBEAMSRPTPGEN
P/E -35.2x -17.4x -7.0x
P/FCF -8.0x 24.8x -20.6x
P/Operating cash flow -8.3x 18.3x -20.8x
P/S 19.1x 1.0x 27.7x
P/B 2.8x 1.3x 54.6x
P/Tangible book 2.8x 1.4x 57.9x
EV/EBITDA -5.4x -21.2x -70.9x
EV/EBIT -5.1x -14.6x -61.6x
EV/Revenue 12.3x 1.1x 28.4x
EV/FCF -5.2x 25.5x -21.1x
EV/Operating cash flow -5.4x 18.8x -21.3x
PEG (3Y EPS CAGR) -0.83 -0.33 0.06

Growth

14 metrics
MetricBEAMSRPTPGEN
Revenue growth (1Y) 158.9% -20.4% 1,875%
Revenue CAGR (3Y) 24.9% 25.3% 57.1%
Gross profit growth (1Y) – -40.7% 259,173%
Gross profit CAGR (3Y) – 10.6% 69.2%
Operating income growth (1Y) 15.2% -15,270% 62.1%
Operating income CAGR (3Y) 0.3% 34.5% 18.9%
Net income growth (1Y) 78.2% -135.9% -26.7%
Net income CAGR (3Y) 35.8% 46.8% -108.9%
EPS growth (1Y) 79.0% -215.7% -93.8%
EPS CAGR (3Y) 42.4% 52.3% -123.2%
Operating cash flow growth (1Y) -4.2% 136.9% -72.3%
Operating cash flow CAGR (3Y) -2.0% 30.6% -15.9%
Free cash flow growth (1Y) -4.8% 118.1% -65.1%
Free cash flow CAGR (3Y) 0.7% 29.1% -15.3%

Profitability

14 metrics
MetricBEAMSRPTPGEN
Gross margin – 59.1% 90.7%
EBITDA margin -228.0% -5.0% -40.0%
Operating margin -242.3% -7.3% -46.1%
Pretax margin -54.4% -6.6% -184.0%
Net margin -54.7% -5.9% -392.8%
FCF margin -238.9% 4.1% -134.4%
Operating cash flow margin -230.3% 5.6% -133.2%
Return on equity -7.6% -9.0% -494.3%
Return on assets -5.9% -4.3% -102.1%
Return on invested capital – -6.1% –
Return on capital employed -27.9% -5.3% -31.6%
Asset turnover 0.1x 0.6x 0.6x
Cash conversion (OCF / net income) 4.2x -0.8x 0.7x
Stock comp / revenue 52.2% 6.3% 15.3%

Financial Health

11 metrics
MetricBEAMSRPTPGEN
Debt / assets 7.2% 26.6% 55.1%
Debt / equity 0.1x 0.6x 2.2x
Net debt / EBITDA 3.0x -0.6x -1.6x
Debt / FCF -0.3x 10.4x -0.8x
Liabilities / assets 23.0% 52.1% 74.4%
Equity / assets 77.0% 47.9% 25.6%
Interest coverage – – -4.1x
Current ratio 14.6x 4.4x 4.6x
Quick ratio 14.3x 2.4x 3.8x
Cash ratio 14.3x 1.6x 1.3x
Altman Z-score 3.85 -0.15 -7.41

Shareholder Returns

7 metrics
MetricBEAMSRPTPGEN
Dividend yield – – –
Net buyback yield -0.5% -1.1% -0.1%
Shareholder yield -0.5% -1.1% -0.1%
Payout ratio (earnings) – – –
Payout ratio (FCF) – – –
Dividend growth (1Y) – – –
Dividend CAGR (3Y) – – –

Analyst Estimates

Solid lines are reported fiscal-year results; dashed lines are the consensus for the years ahead. Hover a year for the analysts' high and low, and how each result compared with its estimate.

ConsensusBEAMSRPTPGEN
Forward P/E – 6.7xFY2026 39.1xFY2026
EPS, next fiscal year $-4.22FY2026 $2.88FY2026 $0.17FY2026
EPS growth, the year after – -88.5% +288.2%
Revenue, next fiscal year $49.46MFY2026 $1.76BFY2026 $249.17MFY2026
Revenue growth, next FY -64.6%FY2026 -20.1%FY2026 +2,474.1%FY2026
Revenue growth, the year after +23.6% -21.5% +82.3%

Institutional Ownership

13F filings, quarter ended Jun 30, 2026
HoldersBEAMSRPTPGEN
Held by institutions 100.0% 100.0% 39.2%
Institutions holding 277 325 211
Change in shares held, QoQ +1.0% +4.5% +4.9%
Institutions buying 154 148 123
Institutions selling 75 116 46
Buyers to sellers 2.05 1.28 2.67

Return Correlation

Daily returns, last 12 months

1.00 means two stocks move in lockstep, 0 that they move independently. Pairs below about 0.5 diversify each other.

BEAMSRPTPGEN
BEAM 1.00 0.36 0.25
SRPT 0.36 1.00 0.23
PGEN 0.25 0.23 1.00

Add a Peer

Largest companies in the same industry

Related Comparisons

Frequently Asked Questions

Which is bigger, BEAM, SRPT and PGEN?

Beam Therapeutics (BEAM) is the largest by market capitalisation: Beam Therapeutics (BEAM) $2.98B, Sarepta Therapeutics (SRPT) $2.03B, Precigen (PGEN) $2.38B.

Which company is growing faster?

Precigen (PGEN) grew revenue fastest over the trailing twelve months: Beam Therapeutics (BEAM) +158.9%, Sarepta Therapeutics (SRPT) -20.4%, Precigen (PGEN) +1,875.0%.

Which company is more profitable?

Sarepta Therapeutics (SRPT) has the highest net margin (Beam Therapeutics (BEAM) -54.7%, Sarepta Therapeutics (SRPT) -5.9%, Precigen (PGEN) -392.8%).

Which stock has performed better?

Over the past year Precigen (PGEN) returned the most: Beam Therapeutics (BEAM) +16.4%, Sarepta Therapeutics (SRPT) -18.0%, Precigen (PGEN) +65.6%. Over five years, Precigen (PGEN) compounded fastest (Beam Therapeutics (BEAM) -20.1%/yr, Sarepta Therapeutics (SRPT) -24.7%/yr, Precigen (PGEN) +6.6%/yr). Returns are price only, before dividends.

Which stock is riskier?

By one-year price volatility, Beam Therapeutics (BEAM) has been the steadiest (Beam Therapeutics (BEAM) 70.4%, Sarepta Therapeutics (SRPT) 81.1%, Precigen (PGEN) 78.1%). Volatility measures how widely the price swings, not the risk of the business.

Which is the better stock, BEAM, SRPT and PGEN?

There is no single answer; it depends on what you are buying for. On the 12 head-to-head measures on this page, Precigen (PGEN) leads on 4. Business Quant does not give investment advice; use the comparison as a starting point for your own research.

Data from SEC filings, exchange prices and consensus estimates, via Business Quant. Percentile scores compare each company with its own peer group, so two companies' scores are each relative to different peers unless you rank against the whole market. Price returns exclude dividends. Nothing on this page is investment advice.