BEAM vs PGEN vs TSHA Stock Comparison

Beam Therapeutics, Precigen and Taysha Gene Therapies Prices as of Oct 28, 2026 Peers: Industry group
BEAM Beam Therapeutics Inc.
$28.78 +18.8% 1M +8.9% 1Y
Market cap
$2.97B
P/E
–
Revenue (TTM)
$156.04M
Div. yield
–
Gene and Cell Therapy Healthcare
4 wins
PGEN Precigen, Inc.
$6.08 -22.2% 1M +49.8% 1Y
Market cap
$2.18B
P/E
–
Revenue (TTM)
$85.72M
Div. yield
–
Gene and Cell Therapy Healthcare
4 wins

Head to Head

8 decided of 12

Beam Therapeutics leads on 4 of the 12 questions below (Beam Therapeutics 4, Precigen 4). Which ones matter depends on what you are buying for; a cheap multiple and slow growth often come together.

QuestionBEAMPGENTSHALeader
Larger companyMarket capitalisation $2.97B $2.18B $1.38B BEAM
Cheaper on earningsLower P/E, profitable companies only -35.1x -6.4x -10.4x –
Cheaper on forward earningsLower price / next fiscal year consensus EPS — 35.8x — –
Faster revenue growthRevenue growth, trailing twelve months +158.9% +1,875.0% -32.3% PGEN
More profitableNet margin, trailing twelve months -54.7% -392.8% -2,728.0% BEAM
Better return on capitalReturn on invested capital — — — –
Less leveragedLower net debt / EBITDA 3.0x -1.6x 2.7x PGEN
Higher dividend yieldTrailing dividend yield 0.00% — — –
Better 1-year returnPrice return, last 12 months +8.9% +49.8% -15.2% PGEN
Better 5-year returnAnnualised price return, 5 years -20.2%/yr +4.7%/yr -23.0%/yr PGEN
Less volatileAnnualised volatility, 1 year 70.7% 77.7% 71.5% BEAM
Higher overall scoreMean of the five percentile scores vs peers 69/100 55/100 49/100 BEAM

Percentile Scorecard

BEAMPGENTSHA

Each axis is the mean percentile of its metrics against the company's industry group. 100 is the best in the group, 50 the middle.

Scores by Axis

AxisBEAMPGENTSHA
Valuation 57 #272 of 625 58 #265 of 625 45 #344 of 625
Growth 77 #139 of 602 48 #311 of 602 17 #503 of 602
Profitability 64 #197 of 549 59 #225 of 549 28 #396 of 549
Financial Health 81 #123 of 654 27 #480 of 654 76 #158 of 654
Shareholder Returns 68 #119 of 367 82 #66 of 367 78 #80 of 367
Overall 69 55 49
  • BEAM ranked among 672 companies in Pharmaceuticals and Biotechnology
  • PGEN ranked among 672 companies in Pharmaceuticals and Biotechnology
  • TSHA ranked among 672 companies in Pharmaceuticals and Biotechnology

Price Performance

Price return, split-adjusted, before dividends. Click a name to hide or show it.

Returns

PeriodBEAMPGENTSHASPY
1 month +18.8%-22.2%-15.2% +0.9%
3 months +10.6%+11.6%-24.6% +5.9%
6 months -2.0%+47.6%-32.5% +8.5%
Year to date +3.8%+45.5%-23.1% +13.3%
1 year +8.9%+49.8%-15.2% +12.4%
3 years +54.6%+502.0%+91.4% +88.1%
3 years, per year +15.6%+82.0%+24.2% +23.5%
5 years -67.6%+25.9%-73.0% +68.2%
5 years, per year -20.2%+4.7%-23.0% +11.0%
10 years —-76.4%— +263.4%
10 years, per year —-13.4%— +13.8%

Risk

MeasureBEAMPGENTSHASPY
Volatility, 1Y 70.7%77.7%71.5% 12.7%
Downside volatility, 1Y 64.0%69.0%69.8% 12.7%
Beta vs S&P 500, 1Y 2.091.431.83 1.00
Return / volatility, 1Y 0.130.64-0.21 0.98
Max drawdown, 5Y -85.3%-87.8%-96.5% -25.4%
From 52-week high -24.1%-29.0%-39.4% -0.9%
52-week high $37.92$8.56$6.98 $779.14
52-week low $20.60$3.10$3.51 $631.97

Valuation History

Weekly multiples on trailing twelve-month fundamentals. Negative or extreme readings (a loss year, a collapsed denominator) are left out so the chart stays readable.

MultipleBEAMPGENTSHA
P/E now vs peer median -35.1xmedian 17.4x -6.4xmedian 17.4x -10.4xmedian 17.4x
P/S now vs peer median 19.0xmedian 9.1x 25.4xmedian 9.1x 250.9xmedian 9.1x
EV/EBITDA now vs peer median -5.4xmedian 17.1x -65.1xmedian 17.1x -6.4xmedian 17.1x
P/FCF now vs peer median -8.0xmedian 19.0x -18.9xmedian 19.0x -10.4xmedian 19.0x
P/B now vs peer median 2.8xmedian 2.2x 50.0xmedian 2.2x 3.6xmedian 2.2x
PEG now vs peer median -0.83median 0.34 0.05median 0.34 -0.26median 0.34

Financial History

Reported figures by fiscal period, placed on the calendar year (or quarter) each period ended in, so companies with different fiscal years line up.

Trailing twelve monthsBEAMPGENTSHA
Revenue $156.04M $85.72M $5.49M
Gross profit – $77.72M –
Operating income -$378.02M -$39.50M -$153.16M
Net income -$86.52M -$157.71M -$149.63M
Free cash flow -$372.77M -$115.22M -$132.57M
R&D $408.66M $32.29M $123.14M
EPS (diluted) $-0.82 $-0.81 $-0.41
Cash & equivalents $219.83M $16.33M $455.41M
Total debt $100.26M $93.88M $49.26M
Shares (diluted) 104.33M 413.69M 369.04M
Enterprise value -$1.71B $1.86B $26.91M

All Metrics

58 metrics · best in bold

Bold marks the best reading: the lowest positive value for multiples, leverage and payout, the highest for everything else. The bar under each value is its percentile against that company's own peers. Hover a value for its rank and the peer median.

Valuation

12 metrics
MetricBEAMPGENTSHA
P/E -35.1x -6.4x -10.4x
P/FCF -8.0x -18.9x -10.4x
P/Operating cash flow -8.3x -19.1x -10.4x
P/S 19.0x 25.4x 250.9x
P/B 2.8x 50.0x 3.6x
P/Tangible book 2.8x 53.0x 3.6x
EV/EBITDA -5.4x -65.1x -6.4x
EV/EBIT -5.1x -56.5x -6.3x
EV/Revenue 12.3x 26.0x 176.8x
EV/FCF -5.1x -19.4x -7.3x
EV/Operating cash flow -5.3x -19.6x -7.3x
PEG (3Y EPS CAGR) -0.83 0.05 -0.26

Growth

14 metrics
MetricBEAMPGENTSHA
Revenue growth (1Y) 158.9% 1,875% -32.3%
Revenue CAGR (3Y) 24.9% 57.1% -9.1%
Gross profit growth (1Y) – 259,173% –
Gross profit CAGR (3Y) – 69.2% –
Operating income growth (1Y) 15.2% 62.1% -62.9%
Operating income CAGR (3Y) 0.3% 18.9% -8.7%
Net income growth (1Y) 78.2% -26.7% -61.4%
Net income CAGR (3Y) 35.8% -108.9% -6.5%
EPS growth (1Y) 79.0% -93.8% -30.3%
EPS CAGR (3Y) 42.4% -123.2% 40.5%
Operating cash flow growth (1Y) -4.2% -72.3% -61.0%
Operating cash flow CAGR (3Y) -2.0% -15.9% -35.6%
Free cash flow growth (1Y) -4.8% -65.1% -60.6%
Free cash flow CAGR (3Y) 0.7% -15.3% -29.4%

Profitability

14 metrics
MetricBEAMPGENTSHA
Gross margin – 90.7% –
EBITDA margin -228.0% -40.0% -2,770%
Operating margin -242.3% -46.1% -2,792%
Pretax margin -54.4% -184.0% -2,593%
Net margin -54.7% -392.8% -2,728%
FCF margin -238.9% -134.4% -2,417%
Operating cash flow margin -230.3% -133.2% -2,410%
Return on equity -7.6% -494.3% -47.5%
Return on assets -5.9% -102.1% -36.9%
Return on invested capital – – –
Return on capital employed -27.9% -31.6% -42.6%
Asset turnover 0.1x 0.6x 0.0x
Cash conversion (OCF / net income) 4.2x 0.7x 0.9x
Stock comp / revenue 52.2% 15.3% 331.3%

Financial Health

11 metrics
MetricBEAMPGENTSHA
Debt / assets 7.2% 55.1% 10.5%
Debt / equity 0.1x 2.2x 0.1x
Net debt / EBITDA 3.0x -1.6x 2.7x
Debt / FCF -0.3x -0.8x -0.4x
Liabilities / assets 23.0% 74.4% 17.7%
Equity / assets 77.0% 25.6% 82.3%
Interest coverage – -4.1x -3,647x
Current ratio 14.6x 4.6x 17.8x
Quick ratio 14.3x 3.8x 17.5x
Cash ratio 14.3x 1.3x 17.5x
Altman Z-score 3.84 -8.36 7.59

Shareholder Returns

7 metrics
MetricBEAMPGENTSHA
Dividend yield – – –
Net buyback yield -0.5% -0.1% -0.2%
Shareholder yield -0.5% -0.1% -0.2%
Payout ratio (earnings) – – –
Payout ratio (FCF) – – –
Dividend growth (1Y) – – –
Dividend CAGR (3Y) – – –

Analyst Estimates

Solid lines are reported fiscal-year results; dashed lines are the consensus for the years ahead. Hover a year for the analysts' high and low, and how each result compared with its estimate.

ConsensusBEAMPGENTSHA
Forward P/E – 35.8xFY2026 –
EPS, next fiscal year $-4.22FY2026 $0.17FY2026 $-0.47FY2026
EPS growth, the year after – +288.2% –
Revenue, next fiscal year $49.46MFY2026 $249.17MFY2026 $1.96MFY2026
Revenue growth, next FY -64.6%FY2026 +2,474.1%FY2026 -80.0%FY2026
Revenue growth, the year after +23.6% +82.3% +1,298.6%

Institutional Ownership

13F filings, quarter ended Jun 30, 2026
HoldersBEAMPGENTSHA
Held by institutions 100.0% 39.2% 81.2%
Institutions holding 277 210 209
Change in shares held, QoQ +1.0% +4.9% +12.7%
Institutions buying 154 123 140
Institutions selling 75 46 42
Buyers to sellers 2.05 2.67 3.33

Return Correlation

Daily returns, last 12 months

1.00 means two stocks move in lockstep, 0 that they move independently. Pairs below about 0.5 diversify each other.

BEAMPGENTSHA
BEAM 1.00 0.25 0.45
PGEN 0.25 1.00 0.27
TSHA 0.45 0.27 1.00

Add a Peer

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Frequently Asked Questions

Which is bigger, BEAM, PGEN and TSHA?

Beam Therapeutics (BEAM) is the largest by market capitalisation: Beam Therapeutics (BEAM) $2.97B, Precigen (PGEN) $2.18B, Taysha Gene Therapies (TSHA) $1.38B.

Which company is growing faster?

Precigen (PGEN) grew revenue fastest over the trailing twelve months: Beam Therapeutics (BEAM) +158.9%, Precigen (PGEN) +1,875.0%, Taysha Gene Therapies (TSHA) -32.3%.

Which company is more profitable?

Beam Therapeutics (BEAM) has the highest net margin (Beam Therapeutics (BEAM) -54.7%, Precigen (PGEN) -392.8%, Taysha Gene Therapies (TSHA) -2,728.0%).

Which stock has performed better?

Over the past year Precigen (PGEN) returned the most: Beam Therapeutics (BEAM) +8.9%, Precigen (PGEN) +49.8%, Taysha Gene Therapies (TSHA) -15.2%. Over five years, Precigen (PGEN) compounded fastest (Beam Therapeutics (BEAM) -20.2%/yr, Precigen (PGEN) +4.7%/yr, Taysha Gene Therapies (TSHA) -23.0%/yr). Returns are price only, before dividends.

Which stock is riskier?

By one-year price volatility, Beam Therapeutics (BEAM) has been the steadiest (Beam Therapeutics (BEAM) 70.7%, Precigen (PGEN) 77.7%, Taysha Gene Therapies (TSHA) 71.5%). Volatility measures how widely the price swings, not the risk of the business.

Which is the better stock, BEAM, PGEN and TSHA?

There is no single answer; it depends on what you are buying for. On the 12 head-to-head measures on this page, Beam Therapeutics (BEAM) leads on 4. Business Quant does not give investment advice; use the comparison as a starting point for your own research.

Data from SEC filings, exchange prices and consensus estimates, via Business Quant. Percentile scores compare each company with its own peer group, so two companies' scores are each relative to different peers unless you rank against the whole market. Price returns exclude dividends. Nothing on this page is investment advice.