BEAM vs IOVA vs CRSP Stock Comparison

Beam Therapeutics, Iovance Biotherapeutics and CRISPR Therapeutics AG Prices as of Oct 27, 2026 Peers: Industry group
BEAM Beam Therapeutics Inc.
$24.90 +2.6% 1M -6.8% 1Y
Market cap
$2.94B
P/E
–
Revenue (TTM)
$156.04M
Div. yield
–
Gene and Cell Therapy Healthcare
4 wins
CRSP CRISPR Therapeutics AG
$51.47 -5.1% 1M -21.7% 1Y
Market cap
$5.13B
P/E
–
Revenue (TTM)
$13.39M
Div. yield
–
Gene and Cell Therapy Healthcare
1 win

Head to Head

8 decided of 12

Beam Therapeutics leads on 4 of the 12 questions below (Beam Therapeutics 4, Iovance Biotherapeutics 3, CRISPR Therapeutics AG 1). Which ones matter depends on what you are buying for; a cheap multiple and slow growth often come together.

QuestionBEAMIOVACRSPLeader
Larger companyMarket capitalisation $2.94B $6.62B $5.13B IOVA
Cheaper on earningsLower P/E, profitable companies only -34.4x -22.9x -11.4x –
Cheaper on forward earningsLower price / next fiscal year consensus EPS — — — –
Faster revenue growthRevenue growth, trailing twelve months +158.9% +34.5% -64.8% BEAM
More profitableNet margin, trailing twelve months -54.7% -89.1% -3,368.7% BEAM
Better return on capitalReturn on invested capital — — -22.6% –
Less leveragedLower net debt / EBITDA 3.0x — 3.4x BEAM
Higher dividend yieldTrailing dividend yield 0.00% 0.00% 0.00% –
Better 1-year returnPrice return, last 12 months -6.8% +531.2% -21.7% IOVA
Better 5-year returnAnnualised price return, 5 years -23.4%/yr -10.4%/yr -11.4%/yr IOVA
Less volatileAnnualised volatility, 1 year 69.2% 99.2% 57.2% CRSP
Higher overall scoreMean of the five percentile scores vs peers 69/100 64/100 44/100 BEAM

Percentile Scorecard

BEAMIOVACRSP

Each axis is the mean percentile of its metrics against the company's industry group. 100 is the best in the group, 50 the middle.

Scores by Axis

AxisBEAMIOVACRSP
Valuation 54 #286 of 625 67 #209 of 625 49 #322 of 625
Growth 77 #137 of 602 81 #114 of 602 32 #411 of 602
Profitability 64 #198 of 551 62 #210 of 551 32 #375 of 551
Financial Health 81 #128 of 656 64 #238 of 656 71 #190 of 656
Shareholder Returns 67 #123 of 365 44 #205 of 365 38 #228 of 365
Overall 69 64 44
  • BEAM ranked among 672 companies in Pharmaceuticals and Biotechnology
  • IOVA ranked among 672 companies in Pharmaceuticals and Biotechnology
  • CRSP ranked among 672 companies in Pharmaceuticals and Biotechnology

Price Performance

Price return, split-adjusted, before dividends. Click a name to hide or show it.

Returns

PeriodBEAMIOVACRSPSPY
1 month +2.6%+32.5%-5.1% -0.2%
3 months -5.3%+210.2%+8.2% +3.9%
6 months -18.5%+331.4%-1.1% +8.2%
Year to date -10.2%+434.1%-1.8% +12.9%
1 year -6.8%+531.2%-21.7% +12.3%
3 years +33.7%+316.6%+32.9% +87.4%
3 years, per year +10.2%+61.0%+9.9% +23.3%
5 years -73.6%-42.3%-45.2% +67.9%
5 years, per year -23.4%-10.4%-11.4% +10.9%
10 years —+143.0%+225.3% +261.1%
10 years, per year —+9.3%+12.5% +13.7%

Risk

MeasureBEAMIOVACRSPSPY
Volatility, 1Y 69.2%99.2%57.2% 12.7%
Downside volatility, 1Y 63.8%71.2%53.7% 12.7%
Beta vs S&P 500, 1Y 2.061.281.83 1.00
Return / volatility, 1Y -0.105.36-0.38 0.97
Max drawdown, 5Y -85.3%-93.4%-67.7% -25.4%
From 52-week high -34.3%-1.9%-21.7% -1.2%
52-week high $37.92$14.86$65.72 $779.14
52-week low $20.60$1.81$44.34 $631.97

Valuation History

Weekly multiples on trailing twelve-month fundamentals. Negative or extreme readings (a loss year, a collapsed denominator) are left out so the chart stays readable.

MultipleBEAMIOVACRSP
P/E now vs peer median -30.4xmedian 17.2x -22.7xmedian 17.2x -11.0xmedian 17.2x
P/S now vs peer median 16.5xmedian 9.0x 20.3xmedian 9.0x 371.5xmedian 9.0x
EV/EBITDA now vs peer median -4.3xmedian 16.3x -23.9xmedian 16.3x -6.2xmedian 16.3x
P/FCF now vs peer median -6.9xmedian 18.7x -22.3xmedian 18.7x -13.4xmedian 18.7x
P/B now vs peer median 2.4xmedian 2.2x 9.0xmedian 2.2x 2.8xmedian 2.2x
PEG now vs peer median -0.72median 0.33 -0.76median 0.33 -2.86median 0.33

Financial History

Reported figures by fiscal period, placed on the calendar year (or quarter) each period ended in, so companies with different fiscal years line up.

Trailing twelve monthsBEAMIOVACRSP
Revenue $156.04M $324.97M $13.39M
Gross profit – $157.29M –
Operating income -$378.02M -$301.31M -$534.34M
Net income -$86.52M -$289.51M -$451.14M
Free cash flow -$372.77M -$296.40M -$371.33M
R&D $408.66M $267.72M $278.15M
EPS (diluted) $-0.82 $-0.64 $-4.67
Cash & equivalents $219.83M $110.80M $291.34M
Total debt $100.26M – $586.20M
Shares (diluted) 104.33M 450.19M 96.51M
Enterprise value -$1.75B $5.42B -$3.57B

All Metrics

58 metrics · best in bold

Bold marks the best reading: the lowest positive value for multiples, leverage and payout, the highest for everything else. The bar under each value is its percentile against that company's own peers. Hover a value for its rank and the peer median.

Valuation

12 metrics
MetricBEAMIOVACRSP
P/E -30.4x -22.7x -11.0x
P/FCF -6.9x -22.3x -13.4x
P/Operating cash flow -7.2x -25.0x -13.5x
P/S 16.5x 20.3x 371.5x
P/B 2.4x 9.0x 2.8x
P/Tangible book 2.4x 14.0x 2.8x
EV/EBITDA -4.3x -23.9x -6.2x
EV/EBIT -4.0x -20.9x -6.0x
EV/Revenue 9.7x 19.4x 238.7x
EV/FCF -4.1x -21.3x -8.6x
EV/Operating cash flow -4.2x -23.9x -8.7x
PEG (3Y EPS CAGR) -0.72 -0.76 -2.86

Growth

14 metrics
MetricBEAMIOVACRSP
Revenue growth (1Y) 158.9% 34.5% -64.8%
Revenue CAGR (3Y) 24.9% 1,009% -57.1%
Gross profit growth (1Y) – 95.1% –
Gross profit CAGR (3Y) – – –
Operating income growth (1Y) 15.2% 26.6% 3.3%
Operating income CAGR (3Y) 0.3% 11.1% -4.1%
Net income growth (1Y) 78.2% 25.8% 3.6%
Net income CAGR (3Y) 35.8% 11.6% -2.7%
EPS growth (1Y) 79.0% 44.8% 13.0%
EPS CAGR (3Y) 42.4% 29.9% 3.9%
Operating cash flow growth (1Y) -4.2% 12.9% -13.8%
Operating cash flow CAGR (3Y) -2.0% 7.6% -2.5%
Free cash flow growth (1Y) -4.8% 8.4% -14.1%
Free cash flow CAGR (3Y) 0.7% 5.8% -0.9%

Profitability

14 metrics
MetricBEAMIOVACRSP
Gross margin – 48.4% –
EBITDA margin -228.0% -81.4% -3,850%
Operating margin -242.3% -92.7% -3,990%
Pretax margin -54.4% -90.4% -3,346%
Net margin -54.7% -89.1% -3,369%
FCF margin -238.9% -91.2% -2,773%
Operating cash flow margin -230.3% -81.3% -2,760%
Return on equity -7.6% -39.7% -25.3%
Return on assets -5.9% -31.4% -16.8%
Return on invested capital – – -22.6%
Return on capital employed -27.9% -37.0% -20.9%
Asset turnover 0.1x 0.4x 0.0x
Cash conversion (OCF / net income) 4.2x 0.9x 0.8x
Stock comp / revenue 52.2% 14.4% 510.2%

Financial Health

11 metrics
MetricBEAMIOVACRSP
Debt / assets 7.2% – 22.1%
Debt / equity 0.1x – 0.3x
Net debt / EBITDA 3.0x – 3.4x
Debt / FCF -0.3x – -1.6x
Liabilities / assets 23.0% 19.6% 34.1%
Equity / assets 77.0% 80.4% 65.9%
Interest coverage – – –
Current ratio 14.6x 4.3x 17.8x
Quick ratio 14.3x 3.7x 17.8x
Cash ratio 14.3x 2.8x 17.8x
Altman Z-score 3.08 17.38 2.51

Shareholder Returns

7 metrics
MetricBEAMIOVACRSP
Dividend yield – – –
Net buyback yield -0.6% -4.5% -8.6%
Shareholder yield -0.6% -4.5% -8.6%
Payout ratio (earnings) – – –
Payout ratio (FCF) – – –
Dividend growth (1Y) – – –
Dividend CAGR (3Y) – – –

Analyst Estimates

Solid lines are reported fiscal-year results; dashed lines are the consensus for the years ahead. Hover a year for the analysts' high and low, and how each result compared with its estimate.

ConsensusBEAMIOVACRSP
EPS, next fiscal year $-4.22FY2026 $-0.47FY2026 $-4.10FY2026
Revenue, next fiscal year $49.46MFY2026 $434.71MFY2026 $38.73MFY2026
Revenue growth, next FY -64.6%FY2026 +65.0%FY2026 +1,003.4%FY2026
Revenue growth, the year after +23.6% +33.0% +266.1%

Institutional Ownership

13F filings, quarter ended Jun 30, 2026
HoldersBEAMIOVACRSP
Held by institutions 100.0% 63.3% 78.9%
Institutions holding 277 292 518
Change in shares held, QoQ +1.0% +6.5% -1.0%
Institutions buying 154 174 237
Institutions selling 75 66 139
Buyers to sellers 2.05 2.64 1.71

Return Correlation

Daily returns, last 12 months

1.00 means two stocks move in lockstep, 0 that they move independently. Pairs below about 0.5 diversify each other.

BEAMIOVACRSP
BEAM 1.00 0.33 0.76
IOVA 0.33 1.00 0.36
CRSP 0.76 0.36 1.00

Add a Peer

Largest companies in the same industry

Related Comparisons

Frequently Asked Questions

Which is bigger, BEAM, IOVA and CRSP?

Iovance Biotherapeutics (IOVA) is the largest by market capitalisation: Beam Therapeutics (BEAM) $2.94B, Iovance Biotherapeutics (IOVA) $6.62B, CRISPR Therapeutics AG (CRSP) $5.13B.

Which company is growing faster?

Beam Therapeutics (BEAM) grew revenue fastest over the trailing twelve months: Beam Therapeutics (BEAM) +158.9%, Iovance Biotherapeutics (IOVA) +34.5%, CRISPR Therapeutics AG (CRSP) -64.8%.

Which company is more profitable?

Beam Therapeutics (BEAM) has the highest net margin (Beam Therapeutics (BEAM) -54.7%, Iovance Biotherapeutics (IOVA) -89.1%, CRISPR Therapeutics AG (CRSP) -3,368.7%).

Which stock has performed better?

Over the past year Iovance Biotherapeutics (IOVA) returned the most: Beam Therapeutics (BEAM) -6.8%, Iovance Biotherapeutics (IOVA) +531.2%, CRISPR Therapeutics AG (CRSP) -21.7%. Over five years, Iovance Biotherapeutics (IOVA) compounded fastest (Beam Therapeutics (BEAM) -23.4%/yr, Iovance Biotherapeutics (IOVA) -10.4%/yr, CRISPR Therapeutics AG (CRSP) -11.4%/yr). Returns are price only, before dividends.

Which stock is riskier?

By one-year price volatility, CRISPR Therapeutics AG (CRSP) has been the steadiest (Beam Therapeutics (BEAM) 69.2%, Iovance Biotherapeutics (IOVA) 99.2%, CRISPR Therapeutics AG (CRSP) 57.2%). Volatility measures how widely the price swings, not the risk of the business.

Which is the better stock, BEAM, IOVA and CRSP?

There is no single answer; it depends on what you are buying for. On the 12 head-to-head measures on this page, Beam Therapeutics (BEAM) leads on 4. Business Quant does not give investment advice; use the comparison as a starting point for your own research.

Data from SEC filings, exchange prices and consensus estimates, via Business Quant. Percentile scores compare each company with its own peer group, so two companies' scores are each relative to different peers unless you rank against the whole market. Price returns exclude dividends. Nothing on this page is investment advice.