ARGX vs MDGL vs ROIV Stock Comparison

Argenx Se, Madrigal Pharmaceuticals and Roivant Sciences Prices as of Oct 27, 2026 Peers: Industry group
ARGX Argenx Se
$882.48 -8.0% 1M +6.3% 1Y
Market cap
$54.62B
P/E
29.1x
Revenue (TTM)
$5.82B
Div. yield
–
Biotechnology Healthcare
4 wins
ROIV Roivant Sciences Ltd.
$36.54 +2.1% 1M +94.3% 1Y
Market cap
$26.55B
P/E
–
Revenue (TTM)
$7.53M
Div. yield
–
Biotechnology Healthcare
1 win

Head to Head

7 decided of 12

Argenx Se leads on 4 of the 12 questions below (Argenx Se 4, Madrigal Pharmaceuticals 2, Roivant Sciences 1). Which ones matter depends on what you are buying for; a cheap multiple and slow growth often come together.

QuestionARGXMDGLROIVLeader
Larger companyMarket capitalisation $54.62B $12.52B $26.55B ARGX
Cheaper on earningsLower P/E, profitable companies only 29.1x -38.5x -99.7x –
Cheaper on forward earningsLower price / next fiscal year consensus EPS 28.8x — — –
Faster revenue growthRevenue growth, trailing twelve months +61.5% +149.0% -67.6% MDGL
More profitableNet margin, trailing twelve months 32.3% -25.3% -3,535.0% ARGX
Better return on capitalReturn on invested capital — — — –
Less leveragedLower net debt / EBITDA — 1.6x — –
Higher dividend yieldTrailing dividend yield 0.00% 0.00% 0.00% –
Better 1-year returnPrice return, last 12 months +6.3% +1.0% +94.3% ROIV
Better 5-year returnAnnualised price return, 5 years +25.8%/yr +41.0%/yr +35.7%/yr MDGL
Less volatileAnnualised volatility, 1 year 36.9% 43.5% 45.2% ARGX
Higher overall scoreMean of the five percentile scores vs peers 92/100 66/100 65/100 ARGX

Percentile Scorecard

ARGXMDGLROIV

Each axis is the mean percentile of its metrics against the company's industry group. 100 is the best in the group, 50 the middle.

Scores by Axis

AxisARGXMDGLROIV
Valuation 84 #99 of 625 74 #163 of 625 64 #229 of 625
Growth 94 #35 of 602 68 #194 of 602 49 #306 of 602
Profitability 98 #11 of 551 74 #144 of 551 30 #384 of 551
Financial Health – 41 #389 of 656 93 #47 of 656
Shareholder Returns – 75 #91 of 365 90 #37 of 365
Overall 92 66 65
  • ARGX ranked among 672 companies in Pharmaceuticals and Biotechnology
  • MDGL ranked among 672 companies in Pharmaceuticals and Biotechnology
  • ROIV ranked among 672 companies in Pharmaceuticals and Biotechnology

Price Performance

Price return, split-adjusted, before dividends. Click a name to hide or show it.

Returns

PeriodARGXMDGLROIVSPY
1 month -8.0%-14.8%+2.1% -0.2%
3 months +1.2%-18.3%+8.0% +3.9%
6 months +13.9%-14.8%+31.6% +8.2%
Year to date +4.9%-24.4%+68.4% +12.9%
1 year +6.3%+1.0%+94.3% +12.3%
3 years +91.9%+265.7%+336.0% +87.4%
3 years, per year +24.3%+54.1%+63.4% +23.3%
5 years +214.2%+457.5%+359.0% +67.9%
5 years, per year +25.8%+41.0%+35.7% +10.9%
10 years —+2,491.7%— +261.1%
10 years, per year —+38.5%— +13.7%

Risk

MeasureARGXMDGLROIVSPY
Volatility, 1Y 36.9%43.5%45.2% 12.7%
Downside volatility, 1Y 34.6%41.4%32.6% 12.7%
Beta vs S&P 500, 1Y 0.390.300.97 1.00
Return / volatility, 1Y 0.170.022.08 0.97
Max drawdown, 5Y -38.2%-61.4%-79.2% -25.4%
From 52-week high -16.7%-27.0%-12.6% -1.2%
52-week high $1,058.90$602.83$41.81 $779.14
52-week low $663.93$412.35$18.41 $631.97

Valuation History

Weekly multiples on trailing twelve-month fundamentals. Negative or extreme readings (a loss year, a collapsed denominator) are left out so the chart stays readable.

MultipleARGXMDGLROIV
P/E now vs peer median 28.8xmedian 17.2x -39.5xmedian 17.2x -98.9xmedian 17.2x
P/S now vs peer median 9.4xmedian 9.0x 10.0xmedian 9.0x 3,506xmedian 9.0x
EV/EBITDA now vs peer median —median 16.3x -38.6xmedian 16.3x -38.0xmedian 16.3x
P/FCF now vs peer median —median 18.7x -62.2xmedian 18.7x -32.2xmedian 18.7x
P/B now vs peer median —median 2.2x 24.5xmedian 2.2x 5.4xmedian 2.2x
PEG now vs peer median 0.27median 0.33 -2.67median 0.33 -2.92median 0.33

Financial History

Reported figures by fiscal period, placed on the calendar year (or quarter) each period ended in, so companies with different fiscal years line up.

Trailing twelve monthsARGXMDGLROIV
Revenue $5.82B $1.28B $7.53M
Gross profit $5.24B – $6.12M
Operating income $1.74B -$322.62M -$596.14M
Net income $1.88B -$325.11M -$414.60M
Free cash flow – -$206.29M -$821.06M
R&D $1.80B $490.14M $730.91M
EPS (diluted) $28.43 $-11.15 $-0.37
Cash & equivalents – $292.73M $1.25B
Total debt – $340.79M –
Shares (diluted) 66.03M 29.15M 720.78M
Enterprise value $54.62B $8.77B $9.50B

All Metrics

58 metrics · best in bold

Bold marks the best reading: the lowest positive value for multiples, leverage and payout, the highest for everything else. The bar under each value is its percentile against that company's own peers. Hover a value for its rank and the peer median.

Valuation

12 metrics
MetricARGXMDGLROIV
P/E 28.8x -39.5x -98.9x
P/FCF – -62.2x -32.2x
P/Operating cash flow – -64.9x -32.3x
P/S 9.4x 10.0x 3,506x
P/B – 24.5x 5.4x
P/Tangible book – 24.8x 5.4x
EV/EBITDA – -38.6x -38.0x
EV/EBIT 31.4x -38.2x -37.9x
EV/Revenue 9.4x 9.6x 2,996x
EV/FCF – -59.8x -27.5x
EV/Operating cash flow – -62.4x -27.6x
PEG (3Y EPS CAGR) 0.27 -2.67 -2.92

Growth

14 metrics
MetricARGXMDGLROIV
Revenue growth (1Y) 61.5% 149.0% -67.6%
Revenue CAGR (3Y) 80.5% – -46.4%
Gross profit growth (1Y) 62.2% – -72.7%
Gross profit CAGR (3Y) 80.0% – -47.9%
Operating income growth (1Y) 120.6% -4.1% 49.7%
Operating income CAGR (3Y) 85.1% 0.8% 12.9%
Net income growth (1Y) 22.5% -15.3% 34.9%
Net income CAGR (3Y) 115.5% 0.5% 26.5%
EPS growth (1Y) 20.9% 12.1% 48.8%
EPS CAGR (3Y) 104.8% 14.8% 33.9%
Operating cash flow growth (1Y) – 35.7% 4.1%
Operating cash flow CAGR (3Y) – 10.6% 1.0%
Free cash flow growth (1Y) – 33.1% 4.4%
Free cash flow CAGR (3Y) – 9.4% 1.0%

Profitability

14 metrics
MetricARGXMDGLROIV
Gross margin 90.0% – 81.2%
EBITDA margin – -24.9% -7,877%
Operating margin 29.9% -25.1% -7,915%
Pretax margin 32.6% -24.8% -3,849%
Net margin 32.3% -25.3% -3,535%
FCF margin – -16.1% -10,901%
Operating cash flow margin – -15.4% -10,840%
Return on equity – -59.8% -8.1%
Return on assets – -25.8% -7.5%
Return on invested capital – – –
Return on capital employed – -37.4% -11.4%
Asset turnover – 1.0x 0.0x
Cash conversion (OCF / net income) – 0.6x 2.0x
Stock comp / revenue – 9.5% 4,611%

Financial Health

11 metrics
MetricARGXMDGLROIV
Debt / assets – 27.4% –
Debt / equity – 0.7x –
Net debt / EBITDA – 1.6x –
Debt / FCF – -1.7x –
Liabilities / assets – 57.9% 7.2%
Equity / assets – 42.1% 92.8%
Interest coverage 10,120x -10.2x –
Current ratio – 3.2x 16.7x
Quick ratio – 2.8x 13.5x
Cash ratio – 2.2x 13.5x
Altman Z-score – 9.13 41.59

Shareholder Returns

7 metrics
MetricARGXMDGLROIV
Dividend yield – – –
Net buyback yield – -0.3% 0.0%
Shareholder yield – -0.3% 0.0%
Payout ratio (earnings) – – –
Payout ratio (FCF) – – –
Dividend growth (1Y) – – –
Dividend CAGR (3Y) – – –

Analyst Estimates

Solid lines are reported fiscal-year results; dashed lines are the consensus for the years ahead. Hover a year for the analysts' high and low, and how each result compared with its estimate.

ConsensusARGXMDGLROIV
Forward P/E 28.8xFY2026 – –
EPS, next fiscal year $30.63FY2026 $-6.25FY2026 $-1.43FY2026
EPS growth, next FY +56.5%FY2026 – –
EPS growth, the year after +26.9% – –
Revenue, next fiscal year $6.08BFY2026 $1.46BFY2026 $55.64MFY2026
Revenue growth, next FY +43.1%FY2026 +52.7%FY2026 +573.6%FY2026
Revenue growth, the year after +22.9% +36.3% +681.6%

Institutional Ownership

13F filings, quarter ended Jun 30, 2026
HoldersARGXMDGLROIV
Held by institutions 46.1% 80.9% 77.0%
Institutions holding 504 412 498
Change in shares held, QoQ -2.0% -0.6% +5.1%
Institutions buying 264 225 303
Institutions selling 160 128 138
Buyers to sellers 1.65 1.76 2.20

Return Correlation

Daily returns, last 12 months

1.00 means two stocks move in lockstep, 0 that they move independently. Pairs below about 0.5 diversify each other.

ARGXMDGLROIV
ARGX 1.00 0.29 0.19
MDGL 0.29 1.00 0.21
ROIV 0.19 0.21 1.00

Add a Peer

Largest companies in the same industry

Related Comparisons

Frequently Asked Questions

Which is bigger, ARGX, MDGL and ROIV?

Argenx Se (ARGX) is the largest by market capitalisation: Argenx Se (ARGX) $54.62B, Madrigal Pharmaceuticals (MDGL) $12.52B, Roivant Sciences (ROIV) $26.55B.

Which company is growing faster?

Madrigal Pharmaceuticals (MDGL) grew revenue fastest over the trailing twelve months: Argenx Se (ARGX) +61.5%, Madrigal Pharmaceuticals (MDGL) +149.0%, Roivant Sciences (ROIV) -67.6%.

Which company is more profitable?

Argenx Se (ARGX) has the highest net margin (Argenx Se (ARGX) 32.3%, Madrigal Pharmaceuticals (MDGL) -25.3%, Roivant Sciences (ROIV) -3,535.0%).

Which stock has performed better?

Over the past year Roivant Sciences (ROIV) returned the most: Argenx Se (ARGX) +6.3%, Madrigal Pharmaceuticals (MDGL) +1.0%, Roivant Sciences (ROIV) +94.3%. Over five years, Madrigal Pharmaceuticals (MDGL) compounded fastest (Argenx Se (ARGX) +25.8%/yr, Madrigal Pharmaceuticals (MDGL) +41.0%/yr, Roivant Sciences (ROIV) +35.7%/yr). Returns are price only, before dividends.

Which stock is riskier?

By one-year price volatility, Argenx Se (ARGX) has been the steadiest (Argenx Se (ARGX) 36.9%, Madrigal Pharmaceuticals (MDGL) 43.5%, Roivant Sciences (ROIV) 45.2%). Volatility measures how widely the price swings, not the risk of the business.

Which is the better stock, ARGX, MDGL and ROIV?

There is no single answer; it depends on what you are buying for. On the 12 head-to-head measures on this page, Argenx Se (ARGX) leads on 4. Business Quant does not give investment advice; use the comparison as a starting point for your own research.

Data from SEC filings, exchange prices and consensus estimates, via Business Quant. Percentile scores compare each company with its own peer group, so two companies' scores are each relative to different peers unless you rank against the whole market. Price returns exclude dividends. Nothing on this page is investment advice.