ARGX vs BIIB vs GRFS Stock Comparison

Argenx Se, Biogen and Grifols Prices as of Oct 27, 2026 Peers: Industry group
ARGX Argenx Se
$882.48 -8.0% 1M +6.3% 1Y
Market cap
$54.62B
P/E
29.1x
Revenue (TTM)
$5.82B
Div. yield
–
Biotechnology Healthcare
5 wins
BIIB Biogen Inc.
$252.73 +11.0% 1M +68.0% 1Y
Market cap
$36.25B
P/E
43.4x
Revenue (TTM)
$10.03B
Div. yield
–
Biotechnology Healthcare
1 win
GRFS Grifols SA
$8.10 +10.2% 1M -13.6% 1Y
Market cap
$5.54B
P/E
12.1x
Revenue (TTM)
—
Div. yield
–
Biotechnology Healthcare
3 wins

Head to Head

9 decided of 12

Argenx Se leads on 5 of the 12 questions below (Argenx Se 5, Grifols 3, Biogen 1). Which ones matter depends on what you are buying for; a cheap multiple and slow growth often come together.

QuestionARGXBIIBGRFSLeader
Larger companyMarket capitalisation $54.62B $36.25B $5.54B ARGX
Cheaper on earningsLower P/E, profitable companies only 29.1x 43.4x 12.1x GRFS
Cheaper on forward earningsLower price / next fiscal year consensus EPS 28.8x 19.7x 8.6x GRFS
Faster revenue growthRevenue growth, trailing twelve months +61.5% +0.3% — ARGX
More profitableNet margin, trailing twelve months 32.3% 8.3% — ARGX
Better return on capitalReturn on invested capital — 3.3% — –
Less leveragedLower net debt / EBITDA — 3.2x — –
Higher dividend yieldTrailing dividend yield 0.00% 0.00% 0.00% –
Better 1-year returnPrice return, last 12 months +6.3% +68.0% -13.6% BIIB
Better 5-year returnAnnualised price return, 5 years +25.8%/yr -0.9%/yr -9.4%/yr ARGX
Less volatileAnnualised volatility, 1 year 36.9% 34.0% 32.4% GRFS
Higher overall scoreMean of the five percentile scores vs peers 92/100 63/100 56/100 ARGX

Percentile Scorecard

ARGXBIIBGRFS

Each axis is the mean percentile of its metrics against the company's industry group. 100 is the best in the group, 50 the middle.

Scores by Axis

AxisARGXBIIBGRFS
Valuation 84 #99 of 625 92 #52 of 625 99 #7 of 625
Growth 94 #35 of 602 35 #392 of 602 –
Profitability 98 #11 of 551 89 #64 of 551 –
Financial Health – 35 #425 of 656 14 #564 of 656
Shareholder Returns – – 56 #161 of 365
Overall 92 63 56
  • ARGX ranked among 672 companies in Pharmaceuticals and Biotechnology
  • BIIB ranked among 672 companies in Pharmaceuticals and Biotechnology
  • GRFS ranked among 672 companies in Pharmaceuticals and Biotechnology

Price Performance

Price return, split-adjusted, before dividends. Click a name to hide or show it.

Returns

PeriodARGXBIIBGRFSSPY
1 month -8.0%+11.0%+10.2% -0.2%
3 months +1.2%+22.9%+1.2% +3.9%
6 months +13.9%+37.8%+0.4% +8.2%
Year to date +4.9%+43.6%-13.4% +12.9%
1 year +6.3%+68.0%-13.6% +12.3%
3 years +91.9%+7.8%+3.3% +87.4%
3 years, per year +24.3%+2.5%+1.1% +23.3%
5 years +214.2%-4.6%-39.0% +67.9%
5 years, per year +25.8%-0.9%-9.4% +10.9%
10 years —-13.1%-44.7% +261.1%
10 years, per year —-1.4%-5.8% +13.7%

Risk

MeasureARGXBIIBGRFSSPY
Volatility, 1Y 36.9%34.0%32.4% 12.7%
Downside volatility, 1Y 34.6%32.3%34.1% 12.7%
Beta vs S&P 500, 1Y 0.390.260.95 1.00
Return / volatility, 1Y 0.172.00-0.42 0.97
Max drawdown, 5Y -38.2%-64.4%-58.8% -25.4%
From 52-week high -16.7%-0.4%-16.7% -1.2%
52-week high $1,058.90$253.84$9.72 $779.14
52-week low $663.93$147.86$7.02 $631.97

Valuation History

Weekly multiples on trailing twelve-month fundamentals. Negative or extreme readings (a loss year, a collapsed denominator) are left out so the chart stays readable.

MultipleARGXBIIBGRFS
P/E now vs peer median 28.8xmedian 17.2x 44.7xmedian 17.2x 12.1xmedian 17.2x
P/S now vs peer median 9.4xmedian 9.0x 3.7xmedian 9.0x 0.6xmedian 9.0x
EV/EBITDA now vs peer median —median 16.3x 23.4xmedian 16.3x —median 16.3x
P/FCF now vs peer median —median 18.7x 13.8xmedian 18.7x 7.8xmedian 18.7x
P/B now vs peer median —median 2.2x 2.0xmedian 2.2x 0.6xmedian 2.2x
PEG now vs peer median 0.27median 0.33 -1.37median 0.33 —median 0.33

Financial History

Reported figures by fiscal period, placed on the calendar year (or quarter) each period ended in, so companies with different fiscal years line up.

Trailing twelve monthsARGXBIIBGRFS
Revenue $5.82B $10.03B –
Gross profit $5.24B $7.42B –
Operating income $1.74B $1.01B –
Net income $1.88B $834.60M –
Free cash flow – $2.70B –
R&D $1.80B $2.01B –
EPS (diluted) $28.43 $5.61 –
Cash & equivalents – $1.29B $969.15M
Total debt – $7.29B $44.00B
Shares (diluted) 66.03M 148.70M 681.57M
Enterprise value $54.62B $22.91B $1.89B

All Metrics

58 metrics · best in bold

Bold marks the best reading: the lowest positive value for multiples, leverage and payout, the highest for everything else. The bar under each value is its percentile against that company's own peers. Hover a value for its rank and the peer median.

Valuation

12 metrics
MetricARGXBIIBGRFS
P/E 28.8x 44.7x 12.1x
P/FCF – 13.8x 7.8x
P/Operating cash flow – 13.0x –
P/S 9.4x 3.7x 0.6x
P/B – 2.0x 0.6x
P/Tangible book – 7.0x 1.0x
EV/EBITDA – 23.4x –
EV/EBIT 31.4x 42.9x –
EV/Revenue 9.4x 4.3x –
EV/FCF – 16.1x –
EV/Operating cash flow – 15.1x –
PEG (3Y EPS CAGR) 0.27 -1.37 –

Growth

14 metrics
MetricARGXBIIBGRFS
Revenue growth (1Y) 61.5% 0.3% –
Revenue CAGR (3Y) 80.5% 0.2% –
Gross profit growth (1Y) 62.2% -1.6% –
Gross profit CAGR (3Y) 80.0% -1.1% –
Operating income growth (1Y) 120.6% -43.7% –
Operating income CAGR (3Y) 85.1% -31.3% –
Net income growth (1Y) 22.5% -45.5% –
Net income CAGR (3Y) 115.5% -32.1% –
EPS growth (1Y) 20.9% -46.2% –
EPS CAGR (3Y) 104.8% -32.6% –
Operating cash flow growth (1Y) – 36.0% –
Operating cash flow CAGR (3Y) – 26.3% –
Free cash flow growth (1Y) – 36.3% –
Free cash flow CAGR (3Y) – 33.0% –

Profitability

14 metrics
MetricARGXBIIBGRFS
Gross margin 90.0% 74.0% –
EBITDA margin – 18.5% –
Operating margin 29.9% 10.1% –
Pretax margin 32.6% 10.1% –
Net margin 32.3% 8.3% –
FCF margin – 26.9% –
Operating cash flow margin – 28.7% –
Return on equity – 4.5% –
Return on assets – 2.7% –
Return on invested capital – 3.3% –
Return on capital employed – 3.8% –
Asset turnover – 0.3x –
Cash conversion (OCF / net income) – 3.4x –
Stock comp / revenue – 3.0% –

Financial Health

11 metrics
MetricARGXBIIBGRFS
Debt / assets – 22.7% 48.9%
Debt / equity – 0.4x 1.3x
Net debt / EBITDA – 3.2x –
Debt / FCF – 2.7x –
Liabilities / assets – 41.3% 61.4%
Equity / assets – 58.7% 38.6%
Interest coverage 10,120x – –
Current ratio – 1.9x 2.5x
Quick ratio – 1.1x 0.8x
Cash ratio – 0.3x 0.4x
Altman Z-score – 3.15 –

Shareholder Returns

7 metrics
MetricARGXBIIBGRFS
Dividend yield – – 1.4%
Net buyback yield – – –
Shareholder yield – – 1.4%
Payout ratio (earnings) – – –
Payout ratio (FCF) – – –
Dividend growth (1Y) – – –
Dividend CAGR (3Y) – – –

Analyst Estimates

Solid lines are reported fiscal-year results; dashed lines are the consensus for the years ahead. Hover a year for the analysts' high and low, and how each result compared with its estimate.

ConsensusARGXBIIBGRFS
Forward P/E 28.8xFY2026 19.7xFY2026 8.6xFY2026
EPS, next fiscal year $30.63FY2026 $12.81FY2026 $0.94FY2026
EPS growth, next FY +56.5%FY2026 -16.2%FY2026 +10.6%FY2026
EPS growth, the year after +26.9% +36.5% +26.6%
Revenue, next fiscal year $6.08BFY2026 $9.96BFY2026 $8.88BFY2026
Revenue growth, next FY +43.1%FY2026 +0.7%FY2026 +0.0%FY2026
Revenue growth, the year after +22.9% +11.9% +10.3%

Institutional Ownership

13F filings, quarter ended Jun 30, 2026
HoldersARGXBIIBGRFS
Held by institutions 46.1% 96.4% 21.0%
Institutions holding 504 1,036 166
Change in shares held, QoQ -2.0% +6.0% -0.5%
Institutions buying 264 548 73
Institutions selling 160 294 65
Buyers to sellers 1.65 1.86 1.12

Return Correlation

Daily returns, last 12 months

1.00 means two stocks move in lockstep, 0 that they move independently. Pairs below about 0.5 diversify each other.

ARGXBIIBGRFS
ARGX 1.00 0.21 0.15
BIIB 0.21 1.00 0.11
GRFS 0.15 0.11 1.00

Add a Peer

Largest companies in the same industry

Related Comparisons

Frequently Asked Questions

Which is bigger, ARGX, BIIB and GRFS?

Argenx Se (ARGX) is the largest by market capitalisation: Argenx Se (ARGX) $54.62B, Biogen (BIIB) $36.25B, Grifols (GRFS) $5.54B.

Which stock is cheaper, ARGX, BIIB and GRFS?

Grifols (GRFS) trades on the lowest price-to-earnings ratio (Argenx Se (ARGX) 29.1x, Biogen (BIIB) 43.4x, Grifols (GRFS) 12.1x). On next year's consensus earnings, Grifols (GRFS) is cheapest (Argenx Se (ARGX) 28.8x, Biogen (BIIB) 19.7x, Grifols (GRFS) 8.6x). A lower multiple can reflect slower expected growth, so read it next to the growth figures.

Which company is growing faster?

Argenx Se (ARGX) grew revenue fastest over the trailing twelve months: Argenx Se (ARGX) +61.5%, Biogen (BIIB) +0.3%.

Which company is more profitable?

Argenx Se (ARGX) has the highest net margin (Argenx Se (ARGX) 32.3%, Biogen (BIIB) 8.3%).

Which stock has performed better?

Over the past year Biogen (BIIB) returned the most: Argenx Se (ARGX) +6.3%, Biogen (BIIB) +68.0%, Grifols (GRFS) -13.6%. Over five years, Argenx Se (ARGX) compounded fastest (Argenx Se (ARGX) +25.8%/yr, Biogen (BIIB) -0.9%/yr, Grifols (GRFS) -9.4%/yr). Returns are price only, before dividends.

Which stock is riskier?

By one-year price volatility, Grifols (GRFS) has been the steadiest (Argenx Se (ARGX) 36.9%, Biogen (BIIB) 34.0%, Grifols (GRFS) 32.4%). Volatility measures how widely the price swings, not the risk of the business.

Which is the better stock, ARGX, BIIB and GRFS?

There is no single answer; it depends on what you are buying for. On the 12 head-to-head measures on this page, Argenx Se (ARGX) leads on 5. Business Quant does not give investment advice; use the comparison as a starting point for your own research.

Data from SEC filings, exchange prices and consensus estimates, via Business Quant. Percentile scores compare each company with its own peer group, so two companies' scores are each relative to different peers unless you rank against the whole market. Price returns exclude dividends. Nothing on this page is investment advice.