AMGN vs PTCT vs MRNA Stock Comparison

Amgen, Ptc Therapeutics and Moderna Prices as of Oct 27, 2026 Peers: Industry group
AMGN Amgen Inc
$447.95 +8.0% 1M +53.9% 1Y
Market cap
$242.16B
P/E
27.7x
Revenue (TTM)
$38.10B
Div. yield
2.22%
Biotechnology Healthcare
8 wins
MRNA Moderna, Inc.
$207.97 +4.6% 1M +680.1% 1Y
Market cap
$82.98B
P/E
–
Revenue (TTM)
$2.23B
Div. yield
–
Biotechnology Healthcare
1 win

Head to Head

10 decided of 12

Amgen leads on 8 of the 12 questions below (Amgen 8, Ptc Therapeutics 1, Moderna 1). Which ones matter depends on what you are buying for; a cheap multiple and slow growth often come together.

QuestionAMGNPTCTMRNALeader
Larger companyMarket capitalisation $242.16B $5.17B $82.98B AMGN
Cheaper on earningsLower P/E, profitable companies only 27.7x -134.3x -26.3x –
Cheaper on forward earningsLower price / next fiscal year consensus EPS 20.5x 56.4x — AMGN
Faster revenue growthRevenue growth, trailing twelve months +9.1% -42.8% -27.6% AMGN
More profitableNet margin, trailing twelve months 23.0% -3.8% -141.4% AMGN
Better return on capitalReturn on invested capital 14.3% 12.5% -43.3% AMGN
Less leveragedLower net debt / EBITDA 2.7x -7.3x 1.5x PTCT
Higher dividend yieldTrailing dividend yield 2.22% — — –
Better 1-year returnPrice return, last 12 months +53.9% -7.4% +680.1% MRNA
Better 5-year returnAnnualised price return, 5 years +16.7%/yr +11.3%/yr -9.8%/yr AMGN
Less volatileAnnualised volatility, 1 year 29.6% 40.8% 130.8% AMGN
Higher overall scoreMean of the five percentile scores vs peers 66/100 64/100 57/100 AMGN

Percentile Scorecard

AMGNPTCTMRNA

Each axis is the mean percentile of its metrics against the company's industry group. 100 is the best in the group, 50 the middle.

Scores by Axis

AxisAMGNPTCTMRNA
Valuation 86 #90 of 625 95 #34 of 625 69 #193 of 625
Growth 62 #231 of 602 42 #347 of 602 18 #493 of 602
Profitability 95 #31 of 551 86 #76 of 551 57 #239 of 551
Financial Health 22 #510 of 656 42 #381 of 656 55 #298 of 656
Shareholder Returns 68 #117 of 365 55 #165 of 365 85 #57 of 365
Overall 66 64 57
  • AMGN ranked among 672 companies in Pharmaceuticals and Biotechnology
  • PTCT ranked among 672 companies in Pharmaceuticals and Biotechnology
  • MRNA ranked among 672 companies in Pharmaceuticals and Biotechnology

Price Performance

Price return, split-adjusted, before dividends. Click a name to hide or show it.

Returns

PeriodAMGNPTCTMRNASPY
1 month +8.0%-0.9%+4.6% -0.2%
3 months +14.0%-17.6%+272.6% +3.9%
6 months +31.9%-11.6%+341.2% +8.2%
Year to date +36.9%-18.3%+605.2% +12.9%
1 year +53.9%-7.4%+680.1% +12.3%
3 years +71.3%+235.4%+189.2% +87.4%
3 years, per year +19.7%+49.7%+42.5% +23.3%
5 years +116.2%+70.4%-40.2% +67.9%
5 years, per year +16.7%+11.3%-9.8% +10.9%
10 years +179.0%+868.6%— +261.1%
10 years, per year +10.8%+25.5%— +13.7%

Risk

MeasureAMGNPTCTMRNASPY
Volatility, 1Y 29.6%40.8%130.8% 12.7%
Downside volatility, 1Y 27.9%40.9%79.5% 12.7%
Beta vs S&P 500, 1Y 0.460.722.15 1.00
Return / volatility, 1Y 1.82-0.185.20 0.97
Max drawdown, 5Y -26.7%-69.4%-93.9% -25.4%
From 52-week high 0.0%-30.7%-15.4% -1.2%
52-week high $447.95$89.55$245.81 $779.14
52-week low $291.16$59.24$22.36 $631.97

Valuation History

Weekly multiples on trailing twelve-month fundamentals. Negative or extreme readings (a loss year, a collapsed denominator) are left out so the chart stays readable.

MultipleAMGNPTCTMRNA
P/E now vs peer median 27.7xmedian 17.2x -134.3xmedian 17.2x -26.3xmedian 17.2x
P/S now vs peer median 6.4xmedian 9.0x 5.1xmedian 9.0x 37.2xmedian 9.0x
EV/EBITDA now vs peer median 17.7xmedian 16.3x 21.1xmedian 16.3x -25.5xmedian 16.3x
P/FCF now vs peer median 23.8xmedian 18.7x -130.1xmedian 18.7x -66.7xmedian 18.7x
P/B now vs peer median 20.7xmedian 2.2x -31.3xmedian 2.2x 12.3xmedian 2.2x
PEG now vs peer median 10.44median 0.33 -2.13median 0.33 0.40median 0.33

Financial History

Reported figures by fiscal period, placed on the calendar year (or quarter) each period ended in, so companies with different fiscal years line up.

Trailing twelve monthsAMGNPTCTMRNA
Revenue $38.10B $1.01B $2.23B
Gross profit $26.48B $938.07M $521.00M
Operating income $11.43B $125.60M -$3.32B
Net income $8.74B -$38.38M -$3.15B
Free cash flow $10.18B -$39.78M -$1.24B
R&D $7.63B $433.31M $2.88B
EPS (diluted) $16.07 $-0.42 $-7.92
Cash & equivalents $13.99B $1.05B $1.72B
Total debt $57.30B $905.19M $591.00M
Shares (diluted) 544.00M 92.02M 398.00M
Enterprise value $197.56B -$2.58B $62.33B

All Metrics

58 metrics · best in bold

Bold marks the best reading: the lowest positive value for multiples, leverage and payout, the highest for everything else. The bar under each value is its percentile against that company's own peers. Hover a value for its rank and the peer median.

Valuation

12 metrics
MetricAMGNPTCTMRNA
P/E 27.7x -134.3x -26.3x
P/FCF 23.8x -130.1x -66.7x
P/Operating cash flow 19.4x -169.6x -77.3x
P/S 6.4x 5.1x 37.2x
P/B 20.7x -31.3x 12.3x
P/Tangible book -27.5x -9.1x 12.3x
EV/EBITDA 17.7x 21.1x -25.5x
EV/EBIT 25.0x 30.7x -23.6x
EV/Revenue 7.5x 3.8x 35.2x
EV/FCF 28.1x -96.8x -63.0x
EV/Operating cash flow 22.9x -126.2x -73.1x
PEG (3Y EPS CAGR) 10.44 -2.13 0.40

Growth

14 metrics
MetricAMGNPTCTMRNA
Revenue growth (1Y) 9.1% -42.8% -27.6%
Revenue CAGR (3Y) 12.7% 7.2% -40.6%
Gross profit growth (1Y) 17.6% -45.3% -67.8%
Gross profit CAGR (3Y) 10.3% 6.9% -56.0%
Operating income growth (1Y) 39.5% -82.5% -1.4%
Operating income CAGR (3Y) 6.4% 30.3% -103.9%
Net income growth (1Y) 32.1% -106.1% -8.5%
Net income CAGR (3Y) 3.1% 60.4% -66.4%
EPS growth (1Y) 31.4% -105.2% -5.8%
EPS CAGR (3Y) 2.7% 63.1% -65.1%
Operating cash flow growth (1Y) 3.9% -104.3% 60.2%
Operating cash flow CAGR (3Y) 4.9% 50.2% -68.1%
Free cash flow growth (1Y) -4.1% -105.7% 64.4%
Free cash flow CAGR (3Y) 1.7% 47.7% -18.2%

Profitability

14 metrics
MetricAMGNPTCTMRNA
Gross margin 69.5% 93.0% 23.4%
EBITDA margin 42.2% 18.1% -138.2%
Operating margin 30.0% 12.5% -149.0%
Pretax margin 27.0% -6.6% -138.6%
Net margin 23.0% -3.8% -141.4%
FCF margin 26.7% -3.9% -55.8%
Operating cash flow margin 32.8% -3.0% -48.2%
Return on equity 83.8% – -44.5%
Return on assets 9.3% -1.3% -28.1%
Return on invested capital 14.3% 12.5% -43.3%
Return on capital employed 16.7% 5.5% -38.2%
Asset turnover 0.4x 0.3x 0.2x
Cash conversion (OCF / net income) 1.4x 0.8x 0.3x
Stock comp / revenue 1.3% 8.4% 20.7%

Financial Health

11 metrics
MetricAMGNPTCTMRNA
Debt / assets 59.9% 27.8% 5.4%
Debt / equity 4.9x -5.5x 0.1x
Net debt / EBITDA 2.7x -7.3x 1.5x
Debt / FCF 5.6x -22.8x -0.5x
Liabilities / assets 87.8% 105.1% 38.3%
Equity / assets 12.2% -5.1% 61.7%
Interest coverage 4.3x – –
Current ratio 1.4x 3.4x 2.3x
Quick ratio 0.9x 3.2x 2.0x
Cash ratio 0.5x 2.9x 2.0x
Altman Z-score 2.32 0.79 12.07

Shareholder Returns

7 metrics
MetricAMGNPTCTMRNA
Dividend yield 2.2% – –
Net buyback yield – -2.0% -0.1%
Shareholder yield 2.2% -2.0% -0.1%
Payout ratio (earnings) 60.4% – –
Payout ratio (FCF) 51.9% – –
Dividend growth (1Y) 6.3% – –
Dividend CAGR (3Y) 6.7% – –

Analyst Estimates

Solid lines are reported fiscal-year results; dashed lines are the consensus for the years ahead. Hover a year for the analysts' high and low, and how each result compared with its estimate.

ConsensusAMGNPTCTMRNA
Forward P/E 20.5xFY2026 56.4xFY2026 –
EPS, next fiscal year $21.81FY2026 $1.10FY2026 $-8.02FY2026
EPS growth, next FY -0.1%FY2026 -85.9%FY2026 –
EPS growth, the year after +7.2% +125.5% –
Revenue, next fiscal year $41.51BFY2026 $1.33BFY2026 $2.04BFY2026
Revenue growth, next FY +12.9%FY2026 -23.2%FY2026 +5.1%FY2026
Revenue growth, the year after +2.3% -1.0% +26.8%

Institutional Ownership

13F filings, quarter ended Jun 30, 2026
HoldersAMGNPTCTMRNA
Held by institutions 82.7% 100.0% 80.2%
Institutions holding 3,159 381 784
Change in shares held, QoQ +4.5% +5.0% +3.4%
Institutions buying 1,451 218 402
Institutions selling 1,217 111 238
Buyers to sellers 1.19 1.96 1.69

Return Correlation

Daily returns, last 12 months

1.00 means two stocks move in lockstep, 0 that they move independently. Pairs below about 0.5 diversify each other.

AMGNPTCTMRNA
AMGN 1.00 0.26 0.25
PTCT 0.26 1.00 0.25
MRNA 0.25 0.25 1.00

Add a Peer

Largest companies in the same industry

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Frequently Asked Questions

Which is bigger, AMGN, PTCT and MRNA?

Amgen (AMGN) is the largest by market capitalisation: Amgen (AMGN) $242.16B, Ptc Therapeutics (PTCT) $5.17B, Moderna (MRNA) $82.98B.

Which company is growing faster?

Amgen (AMGN) grew revenue fastest over the trailing twelve months: Amgen (AMGN) +9.1%, Ptc Therapeutics (PTCT) -42.8%, Moderna (MRNA) -27.6%.

Which company is more profitable?

Amgen (AMGN) has the highest net margin (Amgen (AMGN) 23.0%, Ptc Therapeutics (PTCT) -3.8%, Moderna (MRNA) -141.4%). On return on invested capital, Amgen (AMGN) leads (Amgen (AMGN) 14.3%, Ptc Therapeutics (PTCT) 12.5%, Moderna (MRNA) -43.3%).

Which stock has performed better?

Over the past year Moderna (MRNA) returned the most: Amgen (AMGN) +53.9%, Ptc Therapeutics (PTCT) -7.4%, Moderna (MRNA) +680.1%. Over five years, Amgen (AMGN) compounded fastest (Amgen (AMGN) +16.7%/yr, Ptc Therapeutics (PTCT) +11.3%/yr, Moderna (MRNA) -9.8%/yr). Returns are price only, before dividends.

Which pays a higher dividend?

Only one of these companies pays a dividend: Amgen (AMGN) 2.22%. Ptc Therapeutics (PTCT) and Moderna (MRNA) pays no regular dividend.

Which stock is riskier?

By one-year price volatility, Amgen (AMGN) has been the steadiest (Amgen (AMGN) 29.6%, Ptc Therapeutics (PTCT) 40.8%, Moderna (MRNA) 130.8%). Volatility measures how widely the price swings, not the risk of the business.

Which is the better stock, AMGN, PTCT and MRNA?

There is no single answer; it depends on what you are buying for. On the 12 head-to-head measures on this page, Amgen (AMGN) leads on 8. Business Quant does not give investment advice; use the comparison as a starting point for your own research.

Data from SEC filings, exchange prices and consensus estimates, via Business Quant. Percentile scores compare each company with its own peer group, so two companies' scores are each relative to different peers unless you rank against the whole market. Price returns exclude dividends. Nothing on this page is investment advice.