AMGN vs ARQT vs GRFS Stock Comparison

Amgen, Arcutis Biotherapeutics and Grifols Prices as of Oct 27, 2026 Peers: Industry group
AMGN Amgen Inc
$447.95 +8.0% 1M +53.9% 1Y
Market cap
$242.16B
P/E
27.7x
Revenue (TTM)
$38.10B
Div. yield
2.22%
Biotechnology Healthcare
6 wins
GRFS Grifols SA
$8.10 +10.2% 1M -13.6% 1Y
Market cap
$5.51B
P/E
12.1x
Revenue (TTM)
—
Div. yield
1.36%
Biotechnology Healthcare
2 wins

Head to Head

11 decided of 12

Amgen leads on 6 of the 12 questions below (Amgen 6, Arcutis Biotherapeutics 3, Grifols 2). Which ones matter depends on what you are buying for; a cheap multiple and slow growth often come together.

QuestionAMGNARQTGRFSLeader
Larger companyMarket capitalisation $242.16B $3.98B $5.51B AMGN
Cheaper on earningsLower P/E, profitable companies only 27.7x 145.0x 12.1x GRFS
Cheaper on forward earningsLower price / next fiscal year consensus EPS 20.5x 63.4x 8.6x GRFS
Faster revenue growthRevenue growth, trailing twelve months +9.1% +76.1% — ARQT
More profitableNet margin, trailing twelve months 23.0% 6.1% — AMGN
Better return on capitalReturn on invested capital 14.3% 10.6% — AMGN
Less leveragedLower net debt / EBITDA 2.7x — — –
Higher dividend yieldTrailing dividend yield 2.22% — 1.36% AMGN
Better 1-year returnPrice return, last 12 months +53.9% +61.3% -13.6% ARQT
Better 5-year returnAnnualised price return, 5 years +16.7%/yr +7.9%/yr -9.4%/yr AMGN
Less volatileAnnualised volatility, 1 year 29.6% 56.7% 32.4% AMGN
Higher overall scoreMean of the five percentile scores vs peers 66/100 76/100 56/100 ARQT

Percentile Scorecard

AMGNARQTGRFS

Each axis is the mean percentile of its metrics against the company's industry group. 100 is the best in the group, 50 the middle.

Scores by Axis

AxisAMGNARQTGRFS
Valuation 86 #90 of 625 70 #187 of 625 99 #7 of 625
Growth 62 #231 of 602 96 #28 of 602 –
Profitability 95 #31 of 551 89 #61 of 551 –
Financial Health 22 #510 of 656 47 #348 of 656 14 #564 of 656
Shareholder Returns 68 #117 of 365 77 #85 of 365 56 #161 of 365
Overall 66 76 56
  • AMGN ranked among 672 companies in Pharmaceuticals and Biotechnology
  • ARQT ranked among 672 companies in Pharmaceuticals and Biotechnology
  • GRFS ranked among 672 companies in Pharmaceuticals and Biotechnology

Price Performance

Price return, split-adjusted, before dividends. Click a name to hide or show it.

Returns

PeriodAMGNARQTGRFSSPY
1 month +8.0%+17.7%+10.2% -0.2%
3 months +14.0%+11.5%+1.2% +3.9%
6 months +31.9%+36.0%+0.4% +8.2%
Year to date +36.9%+9.1%-13.4% +12.9%
1 year +53.9%+61.3%-13.6% +12.3%
3 years +71.3%+1,256.7%+3.3% +87.4%
3 years, per year +19.7%+138.6%+1.1% +23.3%
5 years +116.2%+46.4%-39.0% +67.9%
5 years, per year +16.7%+7.9%-9.4% +10.9%
10 years +179.0%—-44.7% +261.1%
10 years, per year +10.8%—-5.8% +13.7%

Risk

MeasureAMGNARQTGRFSSPY
Volatility, 1Y 29.6%56.7%32.4% 12.7%
Downside volatility, 1Y 27.9%49.3%34.1% 12.7%
Beta vs S&P 500, 1Y 0.461.080.95 1.00
Return / volatility, 1Y 1.821.08-0.42 0.97
Max drawdown, 5Y -26.7%-93.2%-58.8% -25.4%
From 52-week high 0.0%-3.5%-16.7% -1.2%
52-week high $447.95$32.82$9.72 $779.14
52-week low $291.16$19.50$7.02 $631.97

Valuation History

Weekly multiples on trailing twelve-month fundamentals. Negative or extreme readings (a loss year, a collapsed denominator) are left out so the chart stays readable.

MultipleAMGNARQTGRFS
P/E now vs peer median 27.7xmedian 17.2x 145.0xmedian 17.2x 12.1xmedian 17.2x
P/S now vs peer median 6.4xmedian 9.0x 8.6xmedian 9.0x 0.6xmedian 9.0x
EV/EBITDA now vs peer median 17.7xmedian 16.3x —median 16.3x —median 16.3x
P/FCF now vs peer median 23.8xmedian 18.7x 101.6xmedian 18.7x 7.8xmedian 18.7x
P/B now vs peer median 20.7xmedian 2.2x 18.0xmedian 2.2x 0.6xmedian 2.2x
PEG now vs peer median 10.44median 0.33 5.41median 0.33 —median 0.33

Financial History

Reported figures by fiscal period, placed on the calendar year (or quarter) each period ended in, so companies with different fiscal years line up.

Trailing twelve monthsAMGNARQTGRFS
Revenue $38.10B $463.98M –
Gross profit $26.48B $422.89M –
Operating income $11.43B $34.25M –
Net income $8.74B $28.52M –
Free cash flow $10.18B $39.15M –
R&D $7.63B $91.04M –
EPS (diluted) $16.07 $0.21 –
Cash & equivalents $13.99B – $969.15M
Total debt $57.30B $108.90M $44.00B
Shares (diluted) 544.00M 135.90M 681.57M
Enterprise value $197.56B $3.26B $4.59B

All Metrics

58 metrics · best in bold

Bold marks the best reading: the lowest positive value for multiples, leverage and payout, the highest for everything else. The bar under each value is its percentile against that company's own peers. Hover a value for its rank and the peer median.

Valuation

12 metrics
MetricAMGNARQTGRFS
P/E 27.7x 145.0x 12.1x
P/FCF 23.8x 101.6x 7.8x
P/Operating cash flow 19.4x 101.2x –
P/S 6.4x 8.6x 0.6x
P/B 20.7x 18.0x 0.6x
P/Tangible book -27.5x 19.2x 1.0x
EV/EBITDA 17.7x – –
EV/EBIT 25.0x 113.4x –
EV/Revenue 7.5x 8.4x –
EV/FCF 28.1x 99.2x –
EV/Operating cash flow 22.9x 98.8x –
PEG (3Y EPS CAGR) 10.44 5.41 –

Growth

14 metrics
MetricAMGNARQTGRFS
Revenue growth (1Y) 9.1% 76.1% –
Revenue CAGR (3Y) 12.7% 241.4% –
Gross profit growth (1Y) 17.6% 80.2% –
Gross profit CAGR (3Y) 10.3% 256.4% –
Operating income growth (1Y) 39.5% 139.9% –
Operating income CAGR (3Y) 6.4% 28.2% –
Net income growth (1Y) 32.1% 130.6% –
Net income CAGR (3Y) 3.1% 27.8% –
EPS growth (1Y) 31.4% 128.6% –
EPS CAGR (3Y) 2.7% 26.8% –
Operating cash flow growth (1Y) 3.9% 160.0% –
Operating cash flow CAGR (3Y) 4.9% 28.8% –
Free cash flow growth (1Y) -4.1% 159.0% –
Free cash flow CAGR (3Y) 1.7% 28.8% –

Profitability

14 metrics
MetricAMGNARQTGRFS
Gross margin 69.5% 91.1% –
EBITDA margin 42.2% – –
Operating margin 30.0% 7.4% –
Pretax margin 27.0% 6.3% –
Net margin 23.0% 6.1% –
FCF margin 26.7% 8.4% –
Operating cash flow margin 32.8% 8.5% –
Return on equity 83.8% 13.9% –
Return on assets 9.3% 6.0% –
Return on invested capital 14.3% 10.6% –
Return on capital employed 16.7% 10.9% –
Asset turnover 0.4x 1.0x –
Cash conversion (OCF / net income) 1.4x 1.4x –
Stock comp / revenue 1.3% 9.4% –

Financial Health

11 metrics
MetricAMGNARQTGRFS
Debt / assets 59.9% 22.3% 48.9%
Debt / equity 4.9x 0.5x 1.3x
Net debt / EBITDA 2.7x – –
Debt / FCF 5.6x 2.8x –
Liabilities / assets 87.8% 54.8% 61.4%
Equity / assets 12.2% 45.2% 38.6%
Interest coverage 4.3x 2.5x –
Current ratio 1.4x 2.9x 2.5x
Quick ratio 0.9x 2.2x 0.8x
Cash ratio 0.5x 1.3x 0.4x
Altman Z-score 2.32 7.59 –

Shareholder Returns

7 metrics
MetricAMGNARQTGRFS
Dividend yield 2.2% – 1.4%
Net buyback yield – -0.2% –
Shareholder yield 2.2% -0.2% 1.4%
Payout ratio (earnings) 60.4% – –
Payout ratio (FCF) 51.9% – –
Dividend growth (1Y) 6.3% – –
Dividend CAGR (3Y) 6.7% – –

Analyst Estimates

Solid lines are reported fiscal-year results; dashed lines are the consensus for the years ahead. Hover a year for the analysts' high and low, and how each result compared with its estimate.

ConsensusAMGNARQTGRFS
Forward P/E 20.5xFY2026 63.4xFY2026 8.6xFY2026
EPS, next fiscal year $21.81FY2026 $0.50FY2026 $0.94FY2026
EPS growth, next FY -0.1%FY2026 – +10.6%FY2026
EPS growth, the year after +7.2% +152.0% +26.6%
Revenue, next fiscal year $41.51BFY2026 $565.04MFY2026 $8.88BFY2026
Revenue growth, next FY +12.9%FY2026 +50.2%FY2026 +0.0%FY2026
Revenue growth, the year after +2.3% +17.0% +10.3%

Institutional Ownership

13F filings, quarter ended Jun 30, 2026
HoldersAMGNARQTGRFS
Held by institutions 82.7% 100.0% 21.0%
Institutions holding 3,159 271 166
Change in shares held, QoQ +4.5% -0.4% -0.5%
Institutions buying 1,451 138 73
Institutions selling 1,217 98 65
Buyers to sellers 1.19 1.41 1.12

Return Correlation

Daily returns, last 12 months

1.00 means two stocks move in lockstep, 0 that they move independently. Pairs below about 0.5 diversify each other.

AMGNARQTGRFS
AMGN 1.00 0.21 0.24
ARQT 0.21 1.00 0.29
GRFS 0.24 0.29 1.00

Add a Peer

Largest companies in the same industry

Related Comparisons

Frequently Asked Questions

Which is bigger, AMGN, ARQT and GRFS?

Amgen (AMGN) is the largest by market capitalisation: Amgen (AMGN) $242.16B, Arcutis Biotherapeutics (ARQT) $3.98B, Grifols (GRFS) $5.51B.

Which stock is cheaper, AMGN, ARQT and GRFS?

Grifols (GRFS) trades on the lowest price-to-earnings ratio (Amgen (AMGN) 27.7x, Arcutis Biotherapeutics (ARQT) 145.0x, Grifols (GRFS) 12.1x). On next year's consensus earnings, Grifols (GRFS) is cheapest (Amgen (AMGN) 20.5x, Arcutis Biotherapeutics (ARQT) 63.4x, Grifols (GRFS) 8.6x). A lower multiple can reflect slower expected growth, so read it next to the growth figures.

Which company is growing faster?

Arcutis Biotherapeutics (ARQT) grew revenue fastest over the trailing twelve months: Amgen (AMGN) +9.1%, Arcutis Biotherapeutics (ARQT) +76.1%.

Which company is more profitable?

Amgen (AMGN) has the highest net margin (Amgen (AMGN) 23.0%, Arcutis Biotherapeutics (ARQT) 6.1%). On return on invested capital, Amgen (AMGN) leads (Amgen (AMGN) 14.3%, Arcutis Biotherapeutics (ARQT) 10.6%).

Which stock has performed better?

Over the past year Arcutis Biotherapeutics (ARQT) returned the most: Amgen (AMGN) +53.9%, Arcutis Biotherapeutics (ARQT) +61.3%, Grifols (GRFS) -13.6%. Over five years, Amgen (AMGN) compounded fastest (Amgen (AMGN) +16.7%/yr, Arcutis Biotherapeutics (ARQT) +7.9%/yr, Grifols (GRFS) -9.4%/yr). Returns are price only, before dividends.

Which pays a higher dividend?

Amgen (AMGN) has the highest dividend yield: Amgen (AMGN) 2.22%, Grifols (GRFS) 1.36%. Arcutis Biotherapeutics (ARQT) pays no regular dividend.

Which stock is riskier?

By one-year price volatility, Amgen (AMGN) has been the steadiest (Amgen (AMGN) 29.6%, Arcutis Biotherapeutics (ARQT) 56.7%, Grifols (GRFS) 32.4%). Volatility measures how widely the price swings, not the risk of the business.

Which is the better stock, AMGN, ARQT and GRFS?

There is no single answer; it depends on what you are buying for. On the 12 head-to-head measures on this page, Amgen (AMGN) leads on 6. Business Quant does not give investment advice; use the comparison as a starting point for your own research.

Data from SEC filings, exchange prices and consensus estimates, via Business Quant. Percentile scores compare each company with its own peer group, so two companies' scores are each relative to different peers unless you rank against the whole market. Price returns exclude dividends. Nothing on this page is investment advice.