ALNY vs MRNA Stock Comparison

Alnylam Pharmaceuticals and Moderna Prices as of Oct 23, 2026 Peers: Industry group
MRNA Moderna, Inc.
$200.10 +9.9% 1M +662.3% 1Y
Market cap
$79.24B
P/E
–
Revenue (TTM)
$2.23B
Div. yield
–
Biotechnology Healthcare
2 wins

Head to Head

7 decided of 12

Alnylam Pharmaceuticals leads on 5 of the 12 questions below (Alnylam Pharmaceuticals 5, Moderna 2). Which ones matter depends on what you are buying for; a cheap multiple and slow growth often come together.

QuestionALNYMRNALeader
Larger companyMarket capitalisation $30.46B $79.24B MRNA
Cheaper on earningsLower P/E, profitable companies only 41.6x -25.1x –
Cheaper on forward earningsLower price / next fiscal year consensus EPS 32.4x — –
Faster revenue growthRevenue growth, trailing twelve months +90.1% -27.6% ALNY
More profitableNet margin, trailing twelve months 15.3% -141.4% ALNY
Better return on capitalReturn on invested capital — -43.3% –
Less leveragedLower net debt / EBITDA — 1.5x –
Higher dividend yieldTrailing dividend yield 0.00% 0.00% –
Better 1-year returnPrice return, last 12 months -51.7% +662.3% MRNA
Better 5-year returnAnnualised price return, 5 years +2.4%/yr -9.3%/yr ALNY
Less volatileAnnualised volatility, 1 year 51.3% 130.7% ALNY
Higher overall scoreMean of the five percentile scores vs peers 77/100 57/100 ALNY

Percentile Scorecard

ALNYMRNA

Each axis is the mean percentile of its metrics against the company's industry group. 100 is the best in the group, 50 the middle.

Scores by Axis

AxisALNYMRNA
Valuation 81 #122 of 624 69 #196 of 624
Growth 98 #12 of 603 18 #494 of 603
Profitability 93 #40 of 555 57 #242 of 555
Financial Health 45 #359 of 657 55 #299 of 657
Shareholder Returns 67 #123 of 370 85 #58 of 370
Overall 77 57
  • ALNY ranked among 671 companies in Pharmaceuticals and Biotechnology
  • MRNA ranked among 671 companies in Pharmaceuticals and Biotechnology

Price Performance

Price return, split-adjusted, before dividends. Click a name to hide or show it.

Returns

PeriodALNYMRNASPY
1 month -9.1%+9.9% -1.0%
3 months -17.6%+270.1% +2.9%
6 months -26.7%+294.4% +6.4%
Year to date -43.7%+578.5% +11.4%
1 year -51.7%+662.3% +13.1%
3 years +36.6%+150.9% +79.4%
3 years, per year +11.0%+35.9% +21.5%
5 years +12.8%-38.7% +67.7%
5 years, per year +2.4%-9.3% +10.9%
10 years +510.9%— +255.2%
10 years, per year +19.8%— +13.5%

Risk

MeasureALNYMRNASPY
Volatility, 1Y 51.3%130.7% 12.7%
Downside volatility, 1Y 62.6%79.5% 12.7%
Beta vs S&P 500, 1Y 0.362.12 1.00
Return / volatility, 1Y -1.015.07 1.03
Max drawdown, 5Y -58.2%-93.9% -25.4%
From 52-week high -53.5%-18.6% -2.5%
52-week high $481.59$245.81 $779.14
52-week low $205.48$22.36 $631.97

Valuation History

Weekly multiples on trailing twelve-month fundamentals. Negative or extreme readings (a loss year, a collapsed denominator) are left out so the chart stays readable.

MultipleALNYMRNA
P/E now vs peer median 40.8xmedian 17.2x -25.3xmedian 17.2x
P/S now vs peer median 6.2xmedian 8.8x 35.8xmedian 8.8x
EV/EBITDA now vs peer median 25.3xmedian 16.0x -24.5xmedian 16.0x
P/FCF now vs peer median 36.5xmedian 17.8x -64.2xmedian 17.8x
P/B now vs peer median 22.1xmedian 2.1x 11.8xmedian 2.1x
PEG now vs peer median 1.08median 0.32 0.39median 0.32

Financial History

Reported figures by fiscal period, placed on the calendar year (or quarter) each period ended in, so companies with different fiscal years line up.

Trailing twelve monthsALNYMRNA
Revenue $4.80B $2.23B
Gross profit $3.83B $521.00M
Operating income $999.78M -$3.32B
Net income $733.11M -$3.15B
Free cash flow $819.87M -$1.24B
R&D $1.51B $2.88B
EPS (diluted) $5.30 $-7.92
Cash & equivalents $1.71B $1.72B
Total debt – $591.00M
Shares (diluted) 138.28M 398.00M
Enterprise value $18.51B $58.60B

All Metrics

58 metrics · best in bold

Bold marks the best reading: the lowest positive value for multiples, leverage and payout, the highest for everything else. The bar under each value is its percentile against that company's own peers. Hover a value for its rank and the peer median.

Valuation

12 metrics
MetricALNYMRNA
P/E 40.8x -25.3x
P/FCF 36.5x -64.2x
P/Operating cash flow 32.9x -74.4x
P/S 6.2x 35.8x
P/B 22.1x 11.8x
P/Tangible book 22.1x 11.8x
EV/EBITDA 25.3x -24.5x
EV/EBIT 26.7x -22.7x
EV/Revenue 5.5x 33.8x
EV/FCF 32.5x -60.5x
EV/Operating cash flow 29.2x -70.2x
PEG (3Y EPS CAGR) 1.08 0.39

Growth

14 metrics
MetricALNYMRNA
Revenue growth (1Y) 90.1% -27.6%
Revenue CAGR (3Y) 57.2% -40.6%
Gross profit growth (1Y) 79.7% -67.8%
Gross profit CAGR (3Y) 54.6% -56.0%
Operating income growth (1Y) 654.9% -1.4%
Operating income CAGR (3Y) 47.5% -103.9%
Net income growth (1Y) 356.5% -8.5%
Net income CAGR (3Y) 39.1% -66.4%
EPS growth (1Y) 342.3% -5.8%
EPS CAGR (3Y) 37.9% -65.1%
Operating cash flow growth (1Y) 2,299% 60.2%
Operating cash flow CAGR (3Y) 57.8% -68.1%
Free cash flow growth (1Y) 1,151% 64.4%
Free cash flow CAGR (3Y) 52.1% -18.2%

Profitability

14 metrics
MetricALNYMRNA
Gross margin 79.8% 23.4%
EBITDA margin 22.0% -138.2%
Operating margin 20.8% -149.0%
Pretax margin 16.0% -138.6%
Net margin 15.3% -141.4%
FCF margin 17.1% -55.8%
Operating cash flow margin 19.0% -48.2%
Return on equity 63.8% -44.5%
Return on assets 14.5% -28.1%
Return on invested capital – -43.3%
Return on capital employed 26.1% -38.2%
Asset turnover 0.9x 0.2x
Cash conversion (OCF / net income) 1.2x 0.3x
Stock comp / revenue 7.0% 20.7%

Financial Health

11 metrics
MetricALNYMRNA
Debt / assets – 5.4%
Debt / equity – 0.1x
Net debt / EBITDA – 1.5x
Debt / FCF – -0.5x
Liabilities / assets 75.6% 38.3%
Equity / assets 24.4% 61.7%
Interest coverage 3.8x –
Current ratio 3.1x 2.3x
Quick ratio 2.8x 2.0x
Cash ratio 2.2x 2.0x
Altman Z-score 4.81 11.62

Shareholder Returns

7 metrics
MetricALNYMRNA
Dividend yield – –
Net buyback yield -0.6% -0.1%
Shareholder yield -0.6% -0.1%
Payout ratio (earnings) – –
Payout ratio (FCF) – –
Dividend growth (1Y) – –
Dividend CAGR (3Y) – –

Analyst Estimates

Solid lines are reported fiscal-year results; dashed lines are the consensus for the years ahead. Hover a year for the analysts' high and low, and how each result compared with its estimate.

ConsensusALNYMRNA
Forward P/E 32.4xFY2026 –
EPS, next fiscal year $6.92FY2026 $-7.92FY2026
EPS growth, next FY +197.0%FY2026 –
EPS growth, the year after +34.0% –
Revenue, next fiscal year $5.68BFY2026 $2.04BFY2026
Revenue growth, next FY +53.1%FY2026 +5.1%FY2026
Revenue growth, the year after +27.4% +26.8%

Institutional Ownership

13F filings, quarter ended Jun 30, 2026
HoldersALNYMRNA
Held by institutions 99.7% 80.2%
Institutions holding 786 784
Change in shares held, QoQ +3.8% +3.4%
Institutions buying 412 402
Institutions selling 277 238
Buyers to sellers 1.49 1.69

Return Correlation

Daily returns, last 12 months

1.00 means two stocks move in lockstep, 0 that they move independently. Pairs below about 0.5 diversify each other.

ALNYMRNA
ALNY 1.00 0.21
MRNA 0.21 1.00

Add a Peer

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Frequently Asked Questions

Which is bigger, ALNY and MRNA?

Moderna (MRNA) is the largest by market capitalisation: Alnylam Pharmaceuticals (ALNY) $30.46B, Moderna (MRNA) $79.24B.

Which company is growing faster?

Alnylam Pharmaceuticals (ALNY) grew revenue fastest over the trailing twelve months: Alnylam Pharmaceuticals (ALNY) +90.1%, Moderna (MRNA) -27.6%.

Which company is more profitable?

Alnylam Pharmaceuticals (ALNY) has the highest net margin (Alnylam Pharmaceuticals (ALNY) 15.3%, Moderna (MRNA) -141.4%).

Which stock has performed better?

Over the past year Moderna (MRNA) returned the most: Alnylam Pharmaceuticals (ALNY) -51.7%, Moderna (MRNA) +662.3%. Over five years, Alnylam Pharmaceuticals (ALNY) compounded fastest (Alnylam Pharmaceuticals (ALNY) +2.4%/yr, Moderna (MRNA) -9.3%/yr). Returns are price only, before dividends.

Which stock is riskier?

By one-year price volatility, Alnylam Pharmaceuticals (ALNY) has been the steadiest (Alnylam Pharmaceuticals (ALNY) 51.3%, Moderna (MRNA) 130.7%). Volatility measures how widely the price swings, not the risk of the business.

Do ALNY and MRNA move together?

Their daily returns over the past year have a correlation of 0.21, a weak relationship. Holding both diversifies more than two closely linked stocks would.

Which is the better stock, ALNY and MRNA?

There is no single answer; it depends on what you are buying for. On the 12 head-to-head measures on this page, Alnylam Pharmaceuticals (ALNY) leads on 5. Business Quant does not give investment advice; use the comparison as a starting point for your own research.

Data from SEC filings, exchange prices and consensus estimates, via Business Quant. Percentile scores compare each company with its own peer group, so two companies' scores are each relative to different peers unless you rank against the whole market. Price returns exclude dividends. Nothing on this page is investment advice.