Zymeworks Inc. (ZYME) Institutional Ownership

Institutions by Trading Activity

Ownership Statistics

75,775,214Shares Outstanding

72,010,207Shares held by institutions

$1,770,010,888Value of institutional holdings

95.03%Institutional ownership %

0.96%Shares Changed QoQ

203No. of institutional investors

Shares Owned by Institutions

Shares Purchased/Sold by Institutions

Ownership Summary

Zymeworks Inc. (NASDAQ:ZYME) appears in 203 institutional 13F filings for the quarter ending December 2025.

These investors collectively held 94.3% of Zymeworks's outstanding shares in December 2025, down from 97.6% in September 2025.
They increased total shares held in Zymeworks by 0.66% from the prior quarter, while the number of investors in ZYME increased 18.02% year over year.
During the quarter, 111 of these 203 funds increased positions in ZYME, 66 reduced exposure, and 26 held steady.
Institutional investors collectively held 71.44Mn shares in Zymeworks as of December 2025, up by 469.08K shares quarter on quarter, and down 1.57Mn shares year over year.
As of December 31, 2025, the biggest holder of Zymeworks is Capricorn Fund Managers Ltd at 1.01Mn shares, representing 1.33% of shares outstanding.
The most significant purchases of ZYME for the quarter ending December 2025 came from Assenagon Asset Management S.A. (80.61K), TEMA ETFS LLC (28.96K), STRS OHIO (3.5K), Global Wealth Strategies & Associates (1.64K), Abacus Wealth Partners, LLC (1.45K).
Top sellers of ZYME stock for the quarter ending December 2025 included Pictet Asset Management Holding SA (64.37K), Capricorn Fund Managers Ltd (15.63K), PSP Research LLC (10.31K), SG Americas Securities, LLC (7.13K), Farther Finance Advisors, LLC (222).
According to Business Quant data, leading holders of ZYME for December 2025 are Capricorn Fund Managers Ltd (1.01Mn), Assenagon Asset Management S.A. (727.99K), TEMA ETFS LLC (104.93K), North Growth Management Ltd. (46.0K), STRS OHIO (30.1K), JOURNEY STRATEGIC WEALTH LLC (29.05K), RITHOLTZ WEALTH MANAGEMENT (24.24K), Abacus Wealth Partners, LLC (11.67K), Janney Montgomery Scott LLC (11.49K), JAMES INVESTMENT RESEARCH, INC. (10.92K).

203 Institutional Holders

72,010,207 Total Shares Held

Rows:

Download Data

Owner Name	Date	Shares Held	Change (QoQ)	Change (%)	Value (USD)
EcoR1 Capital, LLC	31 Dec, 2025	22,970,388	0	0.00%	$604,810,316.00
Rubric Capital Management LP	31 Dec, 2025	5,750,000	1,039,449	22.07%	$151,397,500.00
BlackRock, Inc.	31 Dec, 2025	4,595,548	606,015	15.19%	$121,000,779.00
BVF INC/IL	31 Dec, 2025	3,938,641	0	0.00%	$103,704,418.00
PERCEPTIVE ADVISORS LLC	31 Dec, 2025	3,261,850	1,171,187	56.02%	$85,884,511.00
Morgan Stanley	31 Dec, 2025	2,593,080	-1,391,505	-34.92%	$68,275,801.00
VANGUARD GROUP INC	31 Dec, 2025	2,328,727	174,293	8.09%	$61,315,382.00
BNP Paribas Asset Management Holding S.A.	31 Dec, 2025	1,822,048	1,822,048	0.00%	$47,975.00
Siren, L.L.C.	31 Dec, 2025	1,680,121	1,680,121	0.00%	$44,237,586.00
DEUTSCHE BANK AG\	31 Dec, 2025	1,595,833	50,935	3.30%	$42,018,282.00
DIMENSIONAL FUND ADVISORS LP	31 Dec, 2025	1,159,215	-31,623	-2.66%	$30,523,404.00
Nextech Invest, Ltd.	31 Dec, 2025	1,113,946	0	0.00%	$29,330,198.00
State Street Corp	31 Dec, 2025	1,037,642	-43,547	-4.03%	$27,321,114.00
Capricorn Fund Managers Ltd	31 Dec, 2025	1,022,840	1,022,840	0.00%	$26,931,377.00
Vestal Point Capital, LP	31 Dec, 2025	865,000	-900,000	-50.99%	$22,775,450.00
Goldman Sachs Group Inc	31 Dec, 2025	840,414	396,889	89.49%	$22,128,102.00
ARROWSTREET CAPITAL, LIMITED PARTNERSHIP	31 Dec, 2025	700,002	386,249	123.11%	$18,431,053.00
ADAGE CAPITAL PARTNERS GP, L.L.C.	31 Dec, 2025	663,546	99,546	17.65%	$17,471,166.00
Nuveen, LLC	31 Dec, 2025	648,326	82,941	14.67%	$17,070,424.00
GEODE CAPITAL MANAGEMENT, LLC	31 Dec, 2025	647,970	-30,666	-4.52%	$17,060,446.00

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