Zymeworks Inc. (ZYME) Institutional Ownership

Ownership Summary

Zymeworks Inc. (NASDAQ:ZYME) showed up in the 13F filings of 203 institutional investors as of December 2025.

• Their combined ownership stood at 94.3% of outstanding shares in December 2025, down from 97.6% in September 2025.
• They increased total shares held in Zymeworks by 0.66% from last quarter, and the number of investors in ZYME increased 18.02% annually.
• Of these 203 funds, 111 grew their exposure to Zymeworks, 66 cut back, and 26 maintained positions.
• The aggregate institutional position in Zymeworks amounted to 71.44Mn shares as of December 2025, up by 469.08K shares quarter on quarter, and down 1.57Mn shares year over year.
• EcoR1 Capital, LLC is the top holder of Zymeworks as of December 31, 2025, with 22.97Mn shares representing 30.31% of outstanding stock.
• The largest buyers of Zymeworks for the quarter ending December 2025 were BNP Paribas Asset Management Holding S.A. (1.82Mn), Siren, L.L.C. (1.68Mn), PERCEPTIVE ADVISORS LLC (1.17Mn), Rubric Capital Management LP (1.04Mn), Capricorn Fund Managers Ltd (1.02Mn).
• The largest sellers of Zymeworks for the quarter ending December 2025 were Redmile Group, LLC (3.21Mn), Morgan Stanley (1.39Mn), UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC (1.39Mn), TANG CAPITAL MANAGEMENT LLC (1.07Mn), Vestal Point Capital, LP (900.0K).
• Business Quant data shows the 10 biggest positions in Zymeworks as of December 2025 are held by EcoR1 Capital, LLC (22.97Mn), Rubric Capital Management LP (5.75Mn), BlackRock, Inc. (4.6Mn), BVF INC/IL (3.94Mn), PERCEPTIVE ADVISORS LLC (3.26Mn), Morgan Stanley (2.59Mn), VANGUARD GROUP INC (2.33Mn), BNP Paribas Asset Management Holding S.A. (1.82Mn), Siren, L.L.C. (1.68Mn), DEUTSCHE BANK AG\ (1.6Mn).