Zymeworks Inc. (ZYME) Institutional Ownership

Institutions by Trading Activity

Ownership Statistics

75,392,308Shares Outstanding

28,270,356Shares held by institutions

$652,197,113Value of institutional holdings

94.61%Institutional ownership %

0.77%Shares Changed QoQ

199No. of institutional investors

Shares Owned by Institutions

Shares Purchased/Sold by Institutions

Ownership Summary

According to SEC filings for the period ending December 2025, Zymeworks Inc. (NASDAQ:ZYME) is held by 199 institutional firms.

The collective stake of institutional investors in Zymeworks moved to 94.6% in December 2025, a shift down from the 98.1% reported for September 2025.
The company experienced a 0.77% quarterly change in institutional shares held, alongside an increase of 15.70% in total owners annually.
Among the 199 institutional holders of Zymeworks, 112 added to their stakes while 61 trimmed their positions and 26 held steady.
The aggregate institutional position in Zymeworks now stands at 71.33Mn shares as of December 2025, after investors increased their holdings (up by 543.13K shares quarter on quarter which is up 4.86Mn shares year over year).
With 22.97Mn shares, EcoR1 Capital, LLC commands the largest institutional position in Zymeworks as of December 31, 2025, equating to 30.47% of the company.
Among the most significant buyers of Zymeworks during December 2025 were BNP Paribas Asset Management Holding S.A. (1.82Mn), Siren, L.L.C. (1.68Mn), PERCEPTIVE ADVISORS LLC (1.17Mn), Rubric Capital Management LP (1.04Mn), Capricorn Fund Managers Ltd (1.02Mn).
Leading sellers of Zymeworks stock in December 2025 included Redmile Group, LLC (3.21Mn), MORGAN STANLEY (1.39Mn), UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC (1.39Mn), TANG CAPITAL MANAGEMENT LLC (1.07Mn), Vestal Point Capital, LP (900.00K).
The top 10 institutional holders of Zymeworks for the quarter ending December 2025 included EcoR1 Capital, LLC (22.97Mn), Rubric Capital Management LP (5.75Mn), BlackRock, Inc. (4.60Mn), BVF INC/IL (3.94Mn), PERCEPTIVE ADVISORS LLC (3.26Mn), MORGAN STANLEY (2.59Mn), VANGUARD GROUP INC (2.33Mn), BNP Paribas Asset Management Holding S.A. (1.82Mn), Siren, L.L.C. (1.68Mn), DEUTSCHE BANK AG\ (1.60Mn).

199 Institutional Holders

28,270,356 Total Shares Held

Rows:

Download Data

Owner Name	Date	Shares Held	Change (QoQ)	Change (%)	Value (USD)
EcoR1 Capital, LLC	31 Dec, 2025	22,970,388	0	0.00%	$604,810,316.00
Rubric Capital Management LP	31 Dec, 2025	5,750,000	1,039,449	22.07%	$151,397,500.00
BlackRock, Inc.	31 Dec, 2025	4,595,548	606,015	15.19%	$121,000,779.00
BVF INC/IL	31 Dec, 2025	3,938,641	0	0.00%	$103,704,418.00
PERCEPTIVE ADVISORS LLC	31 Dec, 2025	3,261,850	1,171,187	56.02%	$85,884,511.00
MORGAN STANLEY	31 Dec, 2025	2,593,080	-1,391,505	-34.92%	$68,275,801.00
VANGUARD GROUP INC	31 Dec, 2025	2,328,727	174,293	8.09%	$61,315,382.00
BNP Paribas Asset Management Holding S.A.	31 Dec, 2025	1,822,048	1,822,048	0.00%	$47,975.00
Siren, L.L.C.	31 Dec, 2025	1,680,121	1,680,121	0.00%	$44,237,586.00
DEUTSCHE BANK AG\	31 Dec, 2025	1,595,833	50,935	3.30%	$42,018,282.00
DIMENSIONAL FUND ADVISORS LP	31 Dec, 2025	1,159,215	-31,623	-2.66%	$30,523,404.00
Nextech Invest, Ltd.	31 Dec, 2025	1,113,946	0	0.00%	$29,330,198.00
STATE STREET CORP	31 Dec, 2025	1,037,642	-43,547	-4.03%	$27,321,114.00
Capricorn Fund Managers Ltd	31 Dec, 2025	1,022,840	1,022,840	0.00%	$26,931,377.00
Vestal Point Capital, LP	31 Dec, 2025	865,000	-900,000	-50.99%	$22,775,450.00
ARROWSTREET CAPITAL, LIMITED PARTNERSHIP	31 Dec, 2025	700,002	386,249	123.11%	$18,431,053.00
ADAGE CAPITAL PARTNERS GP, L.L.C.	31 Dec, 2025	663,546	99,546	17.65%	$17,471,166.00
Nuveen, LLC	31 Dec, 2025	648,326	82,941	14.67%	$17,070,424.00
GEODE CAPITAL MANAGEMENT, LLC	31 Dec, 2025	647,970	-30,666	-4.52%	$17,060,446.00
Assenagon Asset Management S.A.	31 Dec, 2025	647,374	-679,400	-51.21%	$17,045,357.00

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