Zenas BioPharma, Inc. (ZBIO) Institutional Ownership

Institutions by Trading Activity

Ownership Statistics

42,212,295Shares Outstanding

3,763,788Shares held by institutions

$100,756,605Value of institutional holdings

195.13%Institutional ownership %

26.83%Shares Changed QoQ

230No. of institutional investors

Shares Owned by Institutions

Shares Purchased/Sold by Institutions

Ownership Summary

Zenas BioPharma, Inc. (NASDAQ:ZBIO) currently has 230 active institutional owners and shareholders as of today (December 2025), that have filed 13F forms with the Securities Exchange Commission (SEC).

The collective stake of institutional investors in Zenas BioPharma moved to 195.1% in December 2025, a shift up from the 165.0% reported for September 2025.
Quarterly data indicates a 26.83% shift in institutional share volume, and the annual owner count reflects an increase of 76.92%.
Among the 230 institutional holders of Zenas BioPharma, 166 added to their stakes while 46 trimmed their positions and 18 held steady.
This class of investors increased its holdings in Zenas BioPharma to 82.37Mn shares for the 13F-cycle ending December 2025, up by 17.42Mn shares quarter on quarter, and up 22.64Mn shares year over year.
With 7.70Mn shares, FMR LLC commands the largest institutional position in Zenas BioPharma as of December 31, 2025, equating to 18.25% of the company.
Among the most significant buyers of Zenas BioPharma during December 2025 were FMR LLC (2.88Mn), FMR LLC (2.88Mn), Polar Capital Holdings Plc (1.06Mn), Polar Capital Holdings Plc (1.06Mn), FEDERATED HERMES, INC. (853.74K).
Leading sellers of Zenas BioPharma stock in December 2025 included Novo Holdings A/S (550.00K), Novo Holdings A/S (550.00K), Vivo Capital, LLC (329.76K), Vivo Capital, LLC (329.76K), Pivotal bioVenture Partners Investment Advisor LLC (187.05K).
The top 10 institutional holders of Zenas BioPharma for the quarter ending December 2025 included FMR LLC (7.70Mn), FMR LLC (7.70Mn), SR ONE CAPITAL MANAGEMENT, LP (5.04Mn), SR ONE CAPITAL MANAGEMENT, LP (5.04Mn), Enavate Sciences GP, LLC (3.92Mn), Enavate Sciences GP, LLC (3.92Mn), NEA Management Company, LLC (3.52Mn), NEA Management Company, LLC (3.52Mn), FEDERATED HERMES, INC. (2.72Mn), FEDERATED HERMES, INC. (2.72Mn).

230 Institutional Holders

3,763,788 Total Shares Held

Rows:

Download Data

Owner Name	Date	Shares Held	Change (QoQ)	Change (%)	Value (USD)
FMR LLC	31 Dec, 2025	7,704,255	2,883,885	59.83%	$279,741,500.00
FMR LLC	31 Dec, 2025	7,704,255	2,883,885	59.83%	$279,741,500.00
SR ONE CAPITAL MANAGEMENT, LP	31 Dec, 2025	5,037,854	126,315	2.57%	$182,924,479.00
SR ONE CAPITAL MANAGEMENT, LP	31 Dec, 2025	5,037,854	126,315	2.57%	$182,924,479.00
Enavate Sciences GP, LLC	31 Dec, 2025	3,919,159	157,800	4.20%	$142,304,663.00
Enavate Sciences GP, LLC	31 Dec, 2025	3,919,159	157,800	4.20%	$142,304,663.00
NEA Management Company, LLC	31 Dec, 2025	3,523,219	789,500	28.88%	$127,928,082.00
NEA Management Company, LLC	31 Dec, 2025	3,523,219	789,500	28.88%	$127,928,082.00
FEDERATED HERMES, INC.	31 Dec, 2025	2,715,578	853,740	45.85%	$98,602,637.00
FEDERATED HERMES, INC.	31 Dec, 2025	2,715,578	853,740	45.85%	$98,602,637.00
Fairmount Funds Management LLC	31 Dec, 2025	2,209,025	316,219	16.71%	$80,209,698.00
Fairmount Funds Management LLC	31 Dec, 2025	2,209,025	316,219	16.71%	$80,209,698.00
NVP Associates, LLC	31 Dec, 2025	1,838,482	0	0.00%	$66,755,281.00
NVP Associates, LLC	31 Dec, 2025	1,838,482	0	0.00%	$66,755,281.00
BlackRock, Inc.	31 Dec, 2025	1,767,518	538,877	43.86%	$64,178,579.00
BlackRock, Inc.	31 Dec, 2025	1,767,518	538,877	43.86%	$64,178,579.00
VANGUARD GROUP INC	31 Dec, 2025	1,453,065	290,307	24.97%	$52,760,791.00
VANGUARD GROUP INC	31 Dec, 2025	1,453,065	290,307	24.97%	$52,760,791.00
Novo Holdings A/S	31 Dec, 2025	1,450,000	-550,000	-27.50%	$52,649,500.00
Novo Holdings A/S	31 Dec, 2025	1,450,000	-550,000	-27.50%	$52,649,500.00

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