Zenas BioPharma, Inc. (ZBIO) Institutional Ownership

Institutions by Trading Activity

Ownership Statistics

42,159,340Shares Outstanding

41,322,624Shares held by institutions

$901,659,656Value of institutional holdings

98.02%Institutional ownership %

26.46%Shares Changed QoQ

114No. of institutional investors

Shares Owned by Institutions

Shares Purchased/Sold by Institutions

Ownership Summary

Zenas BioPharma, Inc. (NASDAQ:ZBIO) is held by 114 institutional investors per 13F filings through December 2025.

Their combined ownership stood at 97.7% of outstanding shares in December 2025, up from 82.7% in September 2025.
Their total shares held in ZBIO increased 26.2% from the prior quarter, while the number of investors in Zenas BioPharma increased 75.38% year over year.
During the quarter, 81 of these 114 funds increased positions in ZBIO, 23 reduced exposure, and 10 held steady.
Institutional investors collectively held 41.19Mn shares in Zenas BioPharma as of December 2025, up by 8.55Mn shares quarter on quarter, and up 10.89Mn shares year over year.
FMR LLC leads ownership in ZBIO with 7.7Mn shares as of December 31, 2025, equal to 18.27% of outstanding shares.
The most significant purchases of ZBIO for the quarter ending December 2025 came from FMR LLC (2.88Mn), Polar Capital Holdings Plc (1.06Mn), Federated Hermes, Inc. (853.74K), EcoR1 Capital, LLC (789.5K), NEA Management Company, LLC (789.5K).
The largest sellers of Zenas BioPharma for the quarter ending December 2025 were Novo Holdings A/S (550.0K), Vivo Capital, LLC (329.76K), Pivotal bioVenture Partners Investment Advisor LLC (187.05K), Rock Springs Capital Management LP (78.6K), ArrowMark Colorado Holdings LLC (73.51K).
Per Business Quant, the top 10 investors in ZBIO for the quarter ending December 2025 include FMR LLC (7.7Mn), SR ONE CAPITAL MANAGEMENT, LP (5.04Mn), Enavate Sciences GP, LLC (3.92Mn), NEA Management Company, LLC (3.52Mn), Federated Hermes, Inc. (2.72Mn), Fairmount Funds Management LLC (2.21Mn), NVP Associates, LLC (1.84Mn), BlackRock, Inc. (1.77Mn), VANGUARD GROUP INC (1.45Mn), Novo Holdings A/S (1.45Mn).

114 Institutional Holders

41,322,624 Total Shares Held

Rows:

Download Data

Owner Name	Date	Shares Held	Change (QoQ)	Change (%)	Value (USD)
FMR LLC	31 Dec, 2025	7,704,255	2,883,885	59.83%	$279,741,500.00
SR ONE CAPITAL MANAGEMENT, LP	31 Dec, 2025	5,037,854	126,315	2.57%	$182,924,479.00
Enavate Sciences GP, LLC	31 Dec, 2025	3,919,159	157,800	4.20%	$142,304,663.00
NEA Management Company, LLC	31 Dec, 2025	3,523,219	789,500	28.88%	$127,928,082.00
Federated Hermes, Inc.	31 Dec, 2025	2,715,578	853,740	45.85%	$98,602,637.00
Fairmount Funds Management LLC	31 Dec, 2025	2,209,025	316,219	16.71%	$80,209,698.00
NVP Associates, LLC	31 Dec, 2025	1,838,482	0	0.00%	$66,755,281.00
BlackRock, Inc.	31 Dec, 2025	1,767,518	538,877	43.86%	$64,178,579.00
VANGUARD GROUP INC	31 Dec, 2025	1,453,065	290,307	24.97%	$52,760,791.00
Novo Holdings A/S	31 Dec, 2025	1,450,000	-550,000	-27.50%	$52,649,500.00
Polar Capital Holdings Plc	31 Dec, 2025	1,057,609	1,057,609	0.00%	$38,401,783.00
WELLINGTON MANAGEMENT GROUP LLP	31 Dec, 2025	855,334	-2,190	-0.26%	$31,057,177.00
Vivo Capital, LLC	31 Dec, 2025	853,495	-329,765	-27.87%	$30,990,403.00
EcoR1 Capital, LLC	31 Dec, 2025	789,500	789,500	0.00%	$28,666,745.00
ArrowMark Colorado Holdings LLC	31 Dec, 2025	751,161	-73,507	-8.91%	$27,274,656.00
Pivotal bioVenture Partners Investment Advisor LLC	31 Dec, 2025	591,991	-187,054	-24.01%	$21,495,193.00
GEODE CAPITAL MANAGEMENT, LLC	31 Dec, 2025	588,393	118,358	25.18%	$21,370,527.00
Rock Springs Capital Management LP	31 Dec, 2025	502,077	-78,600	-13.54%	$18,230,416.00
State Street Corp	31 Dec, 2025	438,294	60,809	16.11%	$15,914,455.00
Point72 Asset Management, L.P.	31 Dec, 2025	368,400	368,400	0.00%	$9,213,684.00

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