VYNE Therapeutics Inc. (VYNE) Institutional Ownership

Institutions by Trading Activity

Ownership Statistics

42,801,000Shares Outstanding

8,485,529Shares held by institutions

$5,185,507Value of institutional holdings

19.83%Institutional ownership %

182.88%Shares Changed QoQ

44No. of institutional investors

Shares Owned by Institutions

Shares Purchased/Sold by Institutions

Ownership Summary

VYNE Therapeutics Inc. (NASDAQ:VYNE) is held by 44 institutional investors per 13F filings through December 2025.

Collectively, these holders controlled 19.8% of VYNE Therapeutics's outstanding shares in December 2025, up from 9.3% in September 2025.
They increased total shares held in VYNE Therapeutics by 182.88% from the prior quarter, while the number of investors in VYNE increased 22.22% year over year.
Activity in VYNE broke down as 22 buyers, 9 sellers, and 13 unchanged among 44 total holders.
Altogether, these fund groups held 8.49Mn shares in VYNE by December 2025, up by 5.49Mn shares quarter on quarter, and up 855.98K shares year over year.
As of December 31, 2025, the biggest holder of VYNE Therapeutics is Shay Capital LLC at 1.62Mn shares, representing 3.8% of shares outstanding.
The biggest buyers of VYNE Therapeutics for the quarter ending December 2025 included Anson Funds Management LP (1.27Mn), Shay Capital LLC (1.13Mn), Nantahala Capital Management, LLC (1.0Mn), T3 Companies, LLC (945.0K), ADAR1 Capital Management, LLC (507.58K).
The largest sellers of VYNE Therapeutics for the quarter ending December 2025 were ACORN CAPITAL ADVISORS, LLC (585.15K), JANE STREET GROUP, LLC (74.76K), BOOTHBAY FUND MANAGEMENT, LLC (25.09K), Ikarian Capital, LLC (25.09K), Bank Of America Corp /De/ (1.39K).
Per Business Quant, the top 10 investors in VYNE for the quarter ending December 2025 include Shay Capital LLC (1.62Mn), Anson Funds Management LP (1.27Mn), Nantahala Capital Management, LLC (1.0Mn), T3 Companies, LLC (945.0K), ACADIAN ASSET MANAGEMENT LLC (638.49K), ADAR1 Capital Management, LLC (507.58K), KVP Capital Advisors, LP (500.55K), VANGUARD GROUP INC (314.54K), Ikarian Capital, LLC (264.91K), GEODE CAPITAL MANAGEMENT, LLC (225.15K).

44 Institutional Holders

8,485,529 Total Shares Held

Rows:

Download Data

Owner Name	Date	Shares Held	Change (QoQ)	Change (%)	Value (USD)
Shay Capital LLC	31 Dec, 2025	1,624,349	1,131,772	229.77%	$942,285.00
Anson Funds Management LP	31 Dec, 2025	1,274,386	1,274,386	0.00%	$739,271.00
Nantahala Capital Management, LLC	31 Dec, 2025	1,000,000	1,000,000	0.00%	$580,100.00
T3 Companies, LLC	31 Dec, 2025	945,000	945,000	0.00%	$548,195.00
ACADIAN ASSET MANAGEMENT LLC	31 Dec, 2025	638,492	192,078	43.03%	$370.00
ADAR1 Capital Management, LLC	31 Dec, 2025	507,582	507,582	0.00%	$294,448.00
KVP Capital Advisors, LP	31 Dec, 2025	500,551	500,551	0.00%	$290,370.00
VANGUARD GROUP INC	31 Dec, 2025	314,545	124,162	65.22%	$182,436.00
Ikarian Capital, LLC	31 Dec, 2025	264,912	-25,088	-8.65%	$153,675.00
GEODE CAPITAL MANAGEMENT, LLC	31 Dec, 2025	225,152	88,030	64.20%	$130,614.00
TWO SIGMA INVESTMENTS, LP	31 Dec, 2025	220,000	-788	-0.36%	$127,622.00
TWO SIGMA ADVISERS, LP	31 Dec, 2025	163,100	106,500	188.16%	$94,614.00
SUSQUEHANNA INTERNATIONAL GROUP, LLP	31 Dec, 2025	100,341	42,578	73.71%	$58,207.00
Rangeley Capital, LLC	31 Dec, 2025	100,000	50,000	100.00%	$58,010.00
BOOTHBAY FUND MANAGEMENT, LLC	31 Dec, 2025	81,371	-25,088	-23.57%	$47,203.00
XTX Topco Ltd	31 Dec, 2025	79,040	79,040	0.00%	$45,851.00
JANE STREET GROUP, LLC	31 Dec, 2025	72,356	-74,764	-50.82%	$41,974.00
UBS Group AG	31 Dec, 2025	62,761	57,189	1,026.36%	$36,401.00
GSA CAPITAL PARTNERS LLP	31 Dec, 2025	53,961	18,040	50.22%	$31.00
STALEY CAPITAL ADVISERS INC	31 Dec, 2025	51,472	0	0.00%	$29,859.00

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