Tyra Biosciences, Inc. (TYRA) Institutional Ownership

Institutions by Trading Activity

Ownership Statistics

0Shares Outstanding

17,303,249Shares held by institutions

$597,135,123Value of institutional holdings

94.33%Institutional ownership %

6.25%Shares Changed QoQ

119No. of institutional investors

Shares Owned by Institutions

Shares Purchased/Sold by Institutions

Ownership Summary

Tyra Biosciences, Inc. (NASDAQ:TYRA) has 130 institutional investors that have filed 13F reports for the period ending December 2025.

These investors collectively held 95.2% of Tyra Biosciences's outstanding shares in December 2025, down from 95.5% in September 2025.
Their total shares held in TYRA increased 1.43% from the prior quarter, while the number of investors in Tyra Biosciences increased 14.04% year over year.
During the quarter, 71 of these 130 funds increased positions in TYRA, 37 reduced exposure, and 22 held steady.
Institutional investors collectively held 56.8Mn shares in Tyra Biosciences as of December 2025, up by 801.23K shares quarter on quarter, and up 7.83Mn shares year over year.
RA CAPITAL MANAGEMENT, L.P. holds the largest position in TYRA at 12.2Mn shares as of December 31, 2025, or 20.44% of shares outstanding.
Leading buyers of Tyra Biosciences shares for the quarter ending December 2025 were Trails Edge Capital Partners, LP (700.0K), Point72 Asset Management, L.P. (592.16K), BOONE CAPITAL MANAGEMENT LLC (398.48K), Elmind Capital, LP (350.0K), State Street Corp (320.99K).
The largest sales of TYRA for the quarter ending December 2025 came from BVF INC/IL (1.52Mn), Kynam Capital Management, LP (765.51K), Alta Partners Management Company, L.P. (256.87K), Canaan Partners XI LLC (233.78K), Bank Of America Corp /De/ (230.33K).
According to Business Quant data, leading holders of TYRA for December 2025 are RA CAPITAL MANAGEMENT, L.P. (12.2Mn), Nextech Invest, Ltd. (4.06Mn), Alta Partners Management Company, L.P. (3.82Mn), Commodore Capital LP (3.38Mn), Canaan Partners XI LLC (3.37Mn), Janus Henderson Group Plc (2.94Mn), TCG Crossover Management, LLC (2.9Mn), Vestal Point Capital, LP (2.42Mn), BVF INC/IL (2.13Mn), BlackRock, Inc. (2.09Mn).

130 Institutional Holders

17,303,249 Total Shares Held

Rows:

Download Data

Owner Name	Date	Change (QoQ)	Change (%)	Value (USD)
BlackRock, Inc.	31 Dec, 2025	216,949	11.60%	$0.00
RA CAPITAL MANAGEMENT, L.P.	31 Dec, 2025	0	0.00%	$0.00
Alta Partners Management Company, L.P.	31 Dec, 2025	-256,871	-6.30%	$0.00
Barclays Plc	31 Dec, 2025	-18,442	-19.46%	$0.00
Nextech Invest, Ltd.	31 Dec, 2025	0	0.00%	$0.00
Commodore Capital LP	31 Dec, 2025	0	0.00%	$0.00
Rockefeller Capital Management L.P.	31 Dec, 2025	168	0.00%	$0.00
Janus Henderson Group Plc	31 Dec, 2025	60,638	2.11%	$0.00
Canaan Partners XI LLC	31 Dec, 2025	-233,780	-6.48%	$0.00
BVF INC/IL	31 Dec, 2025	-1,522,129	-41.70%	$0.00
TCG Crossover Management, LLC	31 Dec, 2025	0	0.00%	$0.00
FARALLON CAPITAL MANAGEMENT LLC	31 Dec, 2025	-220,818	-9.65%	$0.00
Vestal Point Capital, LP	31 Dec, 2025	0	0.00%	$0.00
VANGUARD GROUP INC	31 Dec, 2025	52,600	3.46%	$0.00
Kynam Capital Management, LP	31 Dec, 2025	-765,506	-32.85%	$0.00
BALYASNY ASSET MANAGEMENT L.P.	31 Dec, 2025	-28,259	-3.34%	$0.00
5AM Venture Management, LLC	31 Dec, 2025	90,000	9.58%	$0.00
State Street Corp	31 Dec, 2025	320,991	74.92%	$0.00
Caligan Partners LP	31 Dec, 2025	247,432	35.51%	$0.00
MARSHALL WACE, LLP	31 Dec, 2025	109,876	18.25%	$0.00

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