Tyra Biosciences, Inc. (TYRA) Institutional Ownership

Ownership Summary

Tyra Biosciences, Inc. (NASDAQ:TYRA) currently has 115 active institutional owners and shareholders as of today (September 2025), that have filed 13F forms with the Securities Exchange Commission (SEC).

• The percentage of Tyra Biosciences owned by institutions changed from 106.0% in June 2025 to 104.3% in September 2025, marking a slight down trend.
• In percentage terms, this reflects as a holdings change of 0.75% quarter on quarter, and an increase of 21.05% year over year.
• A review of institutional activity for Tyra Biosciences shows 49 of 115 filers increasing their positions, while 38 reduced their stake, and 28 remained unchanged.
• Collectively, institutional investors increased their stake in Tyra Biosciences to 55.60Mn shares as of September 2025, a change that is up by 415.04K shares quarter on quarter and up 8.51Mn shares year over year.
• The top institutional stake in Tyra Biosciences as of September 30, 2025 belongs to RA CAPITAL MANAGEMENT, L.P., which owns 12.20Mn shares, or 22.89% of the company.
• Among the most significant buyers of Tyra Biosciences during September 2025 were Caligan Partners LP (506.88K), Commodore Capital LP (275.00K), Eversept Partners, LP (272.71K), BALYASNY ASSET MANAGEMENT L.P. (263.20K), MARSHALL WACE, LLP (173.91K).
• Leading sellers of Tyra Biosciences stock in September 2025 included Sio Capital Management, LLC (295.33K), BVF INC/IL (294.40K), MILLENNIUM MANAGEMENT LLC (263.45K), BANK OF AMERICA CORP /DE/ (238.65K), Vestal Point Capital, LP (230.00K).
• The top 10 institutional holders of Tyra Biosciences for the quarter ending September 2025 included RA CAPITAL MANAGEMENT, L.P. (12.20Mn), Alta Partners Management Company, L.P. (4.08Mn), Nextech Invest, Ltd. (4.06Mn), BVF INC/IL (3.65Mn), Canaan Partners XI LLC (3.61Mn), Commodore Capital LP (3.38Mn), TCG Crossover Management, LLC (2.90Mn), JANUS HENDERSON GROUP PLC (2.87Mn), Vestal Point Capital, LP (2.42Mn), Kynam Capital Management, LP (2.33Mn).