Tyra Biosciences TYRA Institutional Ownership

NASDAQ TYRA

$21.47 -0.40 (-1.83%)

As of: Oct 1, 2026 · 10:12 AM EDT

Institutions by Trading Activity

172 Institutions

Increased 108 62.8%

Unchanged 20 11.6%

Reduced 44 25.6%

Ownership Statistics

13F · as of 30 Jun, 2026

Institutional Ownership

105.49%

▼-1.29 pp QoQ

Shares Held by Institutions

69.61Mn

of 65.99Mn outstanding

▲+22.98% QoQ

Shares Outstanding

65.99Mn

-3.62Mn held outside 13F filers

Institutional Investors

172

filed 13F for Jun 2026

▲+9 vs prior quarter

Net Shares Added (QoQ)

+13.01Mn

accumulated since last quarter

Value of Holdings

$1.52Bn

reported market value

Shares Owned by Institutions

Shares held % of outstanding

Latest —

Average ownership —

Peak ownership —

Shares Purchased/Sold by Institutions

Accumulated Distributed

Latest quarter —

Net over range —

Accumulating quarters —

Ownership Summary

Quarter ending 30 Jun, 2026

Tyra Biosciences, Inc. (NASDAQ:TYRA) has 172 institutional investors with active 13F positions as of June 2026.

Their combined ownership stood at 105.5% of outstanding shares in June 2026, down from 106.8% in March 2026.
They increased total shares held in Tyra Biosciences by 22.98% from last quarter, and the number of investors in TYRA increased 44.54% annually.
Activity in TYRA broke down as 108 buyers, 44 sellers, and 20 unchanged among 172 total holders.
In total, institutional investors held 69.61Mn shares in Tyra Biosciences as of June 2026, up by 13.01Mn shares quarter on quarter, and up 13.62Mn shares year over year.
As of June 30, 2026, the biggest holder of Tyra Biosciences is RA CAPITAL MANAGEMENT, L.P. at 12.2Mn shares, representing 18.49% of shares outstanding.
The biggest buyers of Tyra Biosciences for the quarter ending June 2026 included Jupiter Topco LLC (4.35Mn), PRICE T ROWE ASSOCIATES INC /MD/ (1.8Mn), FMR LLC (1.17Mn), Hood River Capital Management LLC (1.02Mn), State Street Corp (924.29K).
The largest sales of TYRA for the quarter ending June 2026 came from Barclays Plc (813.12K), Commodore Capital LP (600.0K), Nextech Invest Ltd. (502.28K), BVF INC/IL (500.0K), Caligan Partners LP (469.98K).
Per Business Quant, the top 10 investors in TYRA for the quarter ending June 2026 include RA CAPITAL MANAGEMENT, L.P. (12.2Mn), FMR LLC (8.92Mn), Jupiter Topco LLC (4.35Mn), Alta Partners Management Company, L.P. (3.82Mn), Nextech Invest Ltd. (3.55Mn), TCG Crossover Management, LLC (3.25Mn), BlackRock, Inc. (3.03Mn), PRICE T ROWE ASSOCIATES INC /MD/ (2.78Mn), State Street Corp (2.14Mn), Commodore Capital LP (1.88Mn).

Form 13F Holdings

172 Institutional Holders

Report period 30 Jun, 2026

Total shares held 69.61Mn

Of outstanding 105.49%

#	Institution	CIK	Shares Held	% of Outstanding	Change (QoQ)	Change (%)	Value (USD)
1	RA CAPITAL MANAGEMENT, L.P.	0001346824	12,198,625	18.49%	0	0.00%	$389.62Mn
2	FMR LLC	0000315066	8,920,513	13.52%	▲1,172,865	+15.14%	$284.92Mn
3	Jupiter Topco LLC	0002146052	4,352,448	6.60%	▲4,352,448	0.00%	$139.16Mn
4	Alta Partners Management Company, L.P.	0002054419	3,823,425	5.79%	0	0.00%	$122.12Mn
5	Nextech Invest Ltd.	0001595430	3,553,585	5.38%	▼502,276	-12.38%	$113.50Mn
6	TCG Crossover Management, LLC	0001839948	3,248,980	4.92%	0	0.00%	$103.77Mn
7	BlackRock, Inc.	0002012383	3,031,972	4.59%	▲814,043	+36.70%	$96.84Mn
8	PRICE T ROWE ASSOCIATES INC /MD/	0000080255	2,782,567	4.22%	▲1,796,506	+182.19%	$88.88K
9	State Street Corp	0000093751	2,140,368	3.24%	▲924,290	+76.01%	$68.36Mn
10	Commodore Capital LP	0001831942	1,875,000	2.84%	▼600,000	-24.24%	$59.89Mn
11	Paradigm Biocapital Advisors LP	0001855655	1,828,607	2.77%	▼226,384	-11.02%	$58.41Mn
12	VANGUARD CAPITAL MANAGEMENT LLC	0002100119	1,508,447	2.29%	▲382,477	+33.97%	$48.18Mn
13	BVF INC/IL	0001056807	1,476,196	2.24%	▼500,000	-25.30%	$47.15Mn
14	5AM Venture Management, LLC	0001799883	1,029,298	1.56%	0	0.00%	$32.88Mn
15	DEERFIELD MANAGEMENT COMPANY, L.P.	0001009258	1,017,000	1.54%	▲468,000	+85.25%	$32.48Mn
16	Hood River Capital Management LLC	0001578177	1,016,775	1.54%	▲1,016,775	0.00%	$32.48Mn
17	GEODE CAPITAL MANAGEMENT, LLC	0001214717	970,734	1.47%	▲312,252	+47.42%	$31.01Mn
18	Caligan Partners LP	0001727492	806,986	1.22%	▼469,982	-36.80%	$25.78Mn
19	Canaan Partners XI LLC	0001850694	750,000	1.14%	0	0.00%	$23.96Mn
20	Siren, L.L.C.	0002005245	725,000	1.10%	▲725,000	0.00%	$23.16Mn

Showing 1 to 20 of 172 holders