Tyra Biosciences, Inc. (TYRA) Institutional Ownership

Institutions by Trading Activity

Ownership Statistics

59,724,064Shares Outstanding

25,154,726Shares held by institutions

$732,505,621Value of institutional holdings

94.46%Institutional ownership %

3.51%Shares Changed QoQ

127No. of institutional investors

Shares Owned by Institutions

Shares Purchased/Sold by Institutions

Ownership Summary

Recent 13F filings as of December 2025 show that 127 institutional investors hold a position in Tyra Biosciences, Inc. (NASDAQ:TYRA).

Tyra Biosciences saw its institutional ownership percentage rose to 94.5% in December 2025 from 93.1% in September 2025.
Institutional share ownership changed by 3.51% QoQ, while the number of institutional owners saw an increase of 11.40% YoY.
The latest 13F cycle for Tyra Biosciences reveals that of 127 total investors, 69 funds grew their exposure, whereas 36 reduced theirs and 22 made no changes.
Collectively, institutional investors increased their stake in Tyra Biosciences to 56.41Mn shares as of December 2025, a change that is up by 1.91Mn shares quarter on quarter and up 7.80Mn shares year over year.
The top institutional stake in Tyra Biosciences as of December 31, 2025 belongs to RA CAPITAL MANAGEMENT, L.P., which owns 12.20Mn shares, or 20.42% of the company.
Among the most significant buyers of Tyra Biosciences during December 2025 were FARALLON CAPITAL MANAGEMENT LLC (923.00K), Trails Edge Capital Partners, LP (700.00K), Point72 Asset Management, L.P. (592.16K), BOONE CAPITAL MANAGEMENT LLC (398.48K), Elmind Capital, LP (350.00K).
Leading sellers of Tyra Biosciences stock in December 2025 included BVF INC/IL (1.52Mn), Kynam Capital Management, LP (765.51K), Alta Partners Management Company, L.P. (256.87K), Canaan Partners XI LLC (233.78K), MORGAN STANLEY (203.25K).
The top 10 institutional holders of Tyra Biosciences for the quarter ending December 2025 included RA CAPITAL MANAGEMENT, L.P. (12.20Mn), Nextech Invest, Ltd. (4.06Mn), Alta Partners Management Company, L.P. (3.82Mn), Commodore Capital LP (3.38Mn), Canaan Partners XI LLC (3.37Mn), JANUS HENDERSON GROUP PLC (2.94Mn), TCG Crossover Management, LLC (2.90Mn), Vestal Point Capital, LP (2.42Mn), BVF INC/IL (2.13Mn), BlackRock, Inc. (2.09Mn).

127 Institutional Holders

25,154,726 Total Shares Held

Rows:

Download Data

Owner Name	Date	Shares Held	Change (QoQ)	Change (%)	Value (USD)
RA CAPITAL MANAGEMENT, L.P.	31 Dec, 2025	12,198,625	0	0.00%	$320,701,851.00
Nextech Invest, Ltd.	31 Dec, 2025	4,055,861	0	0.00%	$106,628,586.00
Alta Partners Management Company, L.P.	31 Dec, 2025	3,823,425	-256,871	-6.30%	$100,517,843.00
Commodore Capital LP	31 Dec, 2025	3,375,000	0	0.00%	$88,728,750.00
Canaan Partners XI LLC	31 Dec, 2025	3,374,329	-233,780	-6.48%	$88,711,109.00
JANUS HENDERSON GROUP PLC	31 Dec, 2025	2,935,442	60,638	2.11%	$77,084,707.00
TCG Crossover Management, LLC	31 Dec, 2025	2,898,103	0	0.00%	$76,191,128.00
Vestal Point Capital, LP	31 Dec, 2025	2,425,000	0	0.00%	$63,753,250.00
BVF INC/IL	31 Dec, 2025	2,127,665	-1,522,129	-41.70%	$55,936,313.00
BlackRock, Inc.	31 Dec, 2025	2,086,423	216,949	11.60%	$54,852,060.00
FARALLON CAPITAL MANAGEMENT LLC	31 Dec, 2025	2,066,818	923,000	80.69%	$54,336,645.00
VANGUARD GROUP INC	31 Dec, 2025	1,572,785	52,600	3.46%	$41,348,518.00
Kynam Capital Management, LP	31 Dec, 2025	1,564,492	-765,506	-32.85%	$41,130,495.00
5AM Venture Management, LLC	31 Dec, 2025	1,029,298	90,000	9.58%	$27,060,244.00
Caligan Partners LP	31 Dec, 2025	944,257	247,432	35.51%	$24,824,517.00
Point72 Asset Management, L.P.	31 Dec, 2025	874,192	592,160	209.96%	$22,982,508.00
BALYASNY ASSET MANAGEMENT L.P.	31 Dec, 2025	818,326	-28,259	-3.34%	$21,513,791.00
STATE STREET CORP	31 Dec, 2025	749,463	320,991	74.92%	$19,703,382.00
MARSHALL WACE, LLP	31 Dec, 2025	711,891	109,876	18.25%	$18,715,614.00
Trails Edge Capital Partners, LP	31 Dec, 2025	700,000	700,000	0.00%	$18,403,000.00

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