Stoke Therapeutics, Inc. (STOK) Institutional Ownership

Institutions by Trading Activity

Ownership Statistics

58,611,677Shares Outstanding

67,891,815Shares held by institutions

$2,143,344,600Value of institutional holdings

115.83%Institutional ownership %

5.60%Shares Changed QoQ

178No. of institutional investors

Shares Owned by Institutions

Shares Purchased/Sold by Institutions

Ownership Summary

Stoke Therapeutics, Inc. (NASDAQ:STOK) showed up in the 13F filings of 178 institutional investors as of December 2025.

Their combined ownership stood at 112.7% of outstanding shares in December 2025, down from 116.0% in September 2025.
Their total shares held in STOK increased 3.04% quarter over quarter, and separately, investors owning Stoke Therapeutics increased 40.16% from a year ago.
Activity in STOK broke down as 96 buyers, 58 sellers, and 24 unchanged among 178 total holders.
Institutional investors collectively held 66.05Mn shares in Stoke Therapeutics as of December 2025, up by 1.95Mn shares quarter on quarter, and up 811.64K shares year over year.
Assenagon Asset Management S.A. leads ownership in STOK with 907.02K shares as of December 31, 2025, equal to 1.55% of outstanding shares.
The largest buyers of Stoke Therapeutics for the quarter ending December 2025 were TEMA ETFS LLC (8.54K), SG Americas Securities, LLC (8.16K), Pictet Asset Management Holding SA (7.58K), E Fund Management Co., Ltd. (7.53K), Generali Investments, Management Co LLC (4.44K).
The biggest sellers of Stoke Therapeutics for the quarter ending December 2025 included Assenagon Asset Management S.A. (320.71K), PSP Research LLC (4.62K).
According to Business Quant data, leading holders of STOK for December 2025 are Assenagon Asset Management S.A. (907.02K), SG Americas Securities, LLC (34.0K), PSP Research LLC (12.0K), TEMA ETFS LLC (8.54K), Pictet Asset Management Holding SA (7.58K), E Fund Management Co., Ltd. (7.53K), STRS OHIO (7.0K), Generali Investments, Management Co LLC (6.91K), Versant Capital Management, Inc (1.59K), GF FUND MANAGEMENT CO. LTD. (1.28K).

178 Institutional Holders

67,891,815 Total Shares Held

Rows:

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Owner Name	Date	Shares Held	Change (QoQ)	Change (%)	Value (USD)
FMR LLC	31 Dec, 2025	5,600,920	-1,264,137	-18.41%	$177,773,201.00
RTW INVESTMENTS, LP	31 Dec, 2025	5,546,856	423,331	8.26%	$176,057,209.00
Lynx1 Capital Management LP	31 Dec, 2025	5,404,674	0	0.00%	$171,544,353.00
BlackRock, Inc.	31 Dec, 2025	5,212,554	-774,887	-12.94%	$165,446,463.00
Redmile Group, LLC	31 Dec, 2025	4,034,070	-141,472	-3.39%	$128,041,382.00
Morgan Stanley	31 Dec, 2025	3,546,158	9,108	0.26%	$112,555,054.00
BAKER BROS. ADVISORS LP	31 Dec, 2025	3,336,697	-1,297,141	-27.99%	$105,906,763.00
Toronto Dominion Bank	31 Dec, 2025	3,173,258	0	0.00%	$100,719,209.00
VANGUARD GROUP INC	31 Dec, 2025	3,149,239	-14,635	-0.46%	$99,956,846.00
State Street Corp	31 Dec, 2025	2,498,049	1,072,176	75.19%	$79,288,075.00
Goldman Sachs Group Inc	31 Dec, 2025	2,285,474	1,134,545	98.58%	$72,540,944.00
BVF INC/IL	31 Dec, 2025	2,265,674	608,578	36.73%	$71,912,493.00
Siren, L.L.C.	31 Dec, 2025	2,247,347	0	0.00%	$71,330,794.00
DEERFIELD MANAGEMENT COMPANY, L.P.	31 Dec, 2025	1,823,500	1,823,500	0.00%	$57,877,890.00
Janus Henderson Group Plc	31 Dec, 2025	1,450,933	1,116,452	333.79%	$46,031,447.00
Opaleye Management Inc.	31 Dec, 2025	1,390,000	707,983	103.81%	$44,118,600.00
Polar Capital Holdings Plc	31 Dec, 2025	1,269,131	-54,339	-4.11%	$40,282,218.00
Assenagon Asset Management S.A.	31 Dec, 2025	1,227,723	327,451	36.37%	$38,967,928.00
Point72 Asset Management, L.P.	31 Dec, 2025	1,222,213	-84,485	-6.47%	$38,793,041.00
GEODE CAPITAL MANAGEMENT, LLC	31 Dec, 2025	1,166,145	19,145	1.67%	$37,019,868.00

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