Stoke Therapeutics, Inc. (STOK) Institutional Ownership

Institutions by Trading Activity

58,611,677Shares Outstanding

67,196,815Shares held by institutions

$2,378,767,251Value of institutional holdings

114.65%Institutional ownership %

4.52%Shares Changed QoQ

178No. of institutional investors

Stoke Therapeutics, Inc. (NASDAQ:STOK) is held by 178 institutional investors per 13F filings through December 2025.

Their combined ownership stood at 112.7% of outstanding shares in December 2025, down from 116.0% in September 2025.
They increased total shares held in STOK by 3.04% quarter over quarter, and investors in Stoke Therapeutics increased 40.16% from a year ago.
Activity in STOK broke down as 96 buyers, 58 sellers, and 24 unchanged among 178 total holders.
Combined, these investors held 66.05Mn shares in STOK for December 2025, up by 1.95Mn shares quarter on quarter, and up 811.64K shares year over year.
FMR LLC leads ownership in STOK with 5.6Mn shares as of December 31, 2025, equal to 9.56% of outstanding shares.
The biggest buyers of Stoke Therapeutics for the quarter ending December 2025 included DEERFIELD MANAGEMENT COMPANY, L.P. (1.82Mn), Goldman Sachs Group Inc (1.13Mn), Janus Henderson Group Plc (1.12Mn), State Street Corp (1.07Mn), BVF INC/IL (608.58K).
The biggest sellers of Stoke Therapeutics for the quarter ending December 2025 included BAKER BROS. ADVISORS LP (1.3Mn), FMR LLC (1.26Mn), Royal Bank Of Canada (914.16K), BlackRock, Inc. (774.89K), Bank Of America Corp /De/ (292.74K).
According to Business Quant data, leading holders of STOK for December 2025 are FMR LLC (5.6Mn), RTW INVESTMENTS, LP (5.55Mn), Lynx1 Capital Management LP (5.4Mn), BlackRock, Inc. (5.21Mn), Redmile Group, LLC (4.03Mn), Morgan Stanley (3.55Mn), BAKER BROS. ADVISORS LP (3.34Mn), Toronto Dominion Bank (3.17Mn), VANGUARD GROUP INC (3.15Mn), State Street Corp (2.5Mn).

67,196,815 Total Shares Held

Rows:

Owner Name	Date	Shares Held	Change (QoQ)	Change (%)	Value (USD)
FMR LLC	31 Dec, 2025	5,600,920	-1,264,137	-18.41%	$177,773,201.00
RTW INVESTMENTS, LP	31 Dec, 2025	5,546,856	423,331	8.26%	$176,057,209.00
Lynx1 Capital Management LP	31 Dec, 2025	5,404,674	0	0.00%	$171,544,353.00
BlackRock, Inc.	31 Dec, 2025	5,212,554	-774,887	-12.94%	$165,446,463.00
Redmile Group, LLC	31 Dec, 2025	4,034,070	-141,472	-3.39%	$128,041,382.00
Morgan Stanley	31 Dec, 2025	3,546,158	9,108	0.26%	$112,555,054.00
BAKER BROS. ADVISORS LP	31 Dec, 2025	3,336,697	-1,297,141	-27.99%	$105,906,763.00
Toronto Dominion Bank	31 Dec, 2025	3,173,258	0	0.00%	$100,719,209.00
VANGUARD GROUP INC	31 Dec, 2025	3,149,239	-14,635	-0.46%	$99,956,846.00
State Street Corp	31 Dec, 2025	2,498,049	1,072,176	75.19%	$79,288,075.00
Goldman Sachs Group Inc	31 Dec, 2025	2,285,474	1,134,545	98.58%	$72,540,944.00
BVF INC/IL	31 Dec, 2025	2,265,674	608,578	36.73%	$71,912,493.00
Siren, L.L.C.	31 Dec, 2025	2,247,347	0	0.00%	$71,330,794.00
DEERFIELD MANAGEMENT COMPANY, L.P.	31 Dec, 2025	1,823,500	1,823,500	0.00%	$57,877,890.00
Janus Henderson Group Plc	31 Dec, 2025	1,450,933	1,116,452	333.79%	$46,031,447.00
Polar Capital Holdings Plc	31 Dec, 2025	1,269,131	-54,339	-4.11%	$40,282,218.00
Assenagon Asset Management S.A.	31 Dec, 2025	1,227,723	327,451	36.37%	$38,967,928.00
Point72 Asset Management, L.P.	31 Dec, 2025	1,222,213	-84,485	-6.47%	$38,793,041.00
GEODE CAPITAL MANAGEMENT, LLC	31 Dec, 2025	1,166,145	19,145	1.67%	$37,019,868.00
DIMENSIONAL FUND ADVISORS LP	31 Dec, 2025	827,139	148,832	21.94%	$26,253,770.00

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