Stoke Therapeutics, Inc. (STOK) Institutional Ownership

Institutions by Trading Activity

Ownership Statistics

59,657,353Shares Outstanding

11,966,349Shares held by institutions

$372,033,790Value of institutional holdings

111.20%Institutional ownership %

3.34%Shares Changed QoQ

177No. of institutional investors

Shares Owned by Institutions

Shares Purchased/Sold by Institutions

Ownership Summary

Stoke Therapeutics, Inc. (NASDAQ:STOK) currently has 177 active institutional owners and shareholders as of today (December 2025), that have filed 13F forms with the Securities Exchange Commission (SEC).

These investors collectively held 111.2% of the company's total shares outstanding in December 2025, down from 114.5% in September 2025.
The company experienced a 3.34% quarterly change in institutional shares held, alongside an increase of 39.37% in total owners annually.
A review of institutional activity for Stoke Therapeutics shows 94 of 177 filers increasing their positions, while 59 reduced their stake, and 24 remained unchanged.
Collectively, institutional investors increased their stake in Stoke Therapeutics to 66.34Mn shares as of December 2025, a change that is up by 2.15Mn shares quarter on quarter and up 8.48Mn shares year over year.
With 5.60Mn shares, FMR LLC commands the largest institutional position in Stoke Therapeutics as of December 31, 2025, equating to 9.39% of the company.
Among the most significant buyers of Stoke Therapeutics during December 2025 were DEERFIELD MANAGEMENT COMPANY, L.P. (1.82Mn), JANUS HENDERSON GROUP PLC (1.12Mn), STATE STREET CORP (1.07Mn), BVF INC/IL (608.58K), Candriam S.C.A. (446.69K).
Leading sellers of Stoke Therapeutics stock in December 2025 included BAKER BROS. ADVISORS LP (1.30Mn), FMR LLC (1.26Mn), ROYAL BANK OF CANADA (914.16K), BlackRock, Inc. (774.89K), Schonfeld Strategic Advisors LLC (174.91K).
The top 10 institutional holders of Stoke Therapeutics for the quarter ending December 2025 included FMR LLC (5.60Mn), RTW INVESTMENTS, LP (5.55Mn), Lynx1 Capital Management LP (5.40Mn), BlackRock, Inc. (5.21Mn), Redmile Group, LLC (4.03Mn), MORGAN STANLEY (3.55Mn), BAKER BROS. ADVISORS LP (3.34Mn), TORONTO DOMINION BANK (3.17Mn), VANGUARD GROUP INC (3.15Mn), STATE STREET CORP (2.50Mn).

177 Institutional Holders

11,966,349 Total Shares Held

Rows:

Download Data

Owner Name	Date	Shares Held	Change (QoQ)	Change (%)	Value (USD)
FMR LLC	31 Dec, 2025	5,600,920	-1,264,137	-18.41%	$177,773,201.00
RTW INVESTMENTS, LP	31 Dec, 2025	5,546,856	423,331	8.26%	$176,057,209.00
Lynx1 Capital Management LP	31 Dec, 2025	5,404,674	0	0.00%	$171,544,353.00
BlackRock, Inc.	31 Dec, 2025	5,212,554	-774,887	-12.94%	$165,446,463.00
Redmile Group, LLC	31 Dec, 2025	4,034,070	-141,472	-3.39%	$128,041,382.00
MORGAN STANLEY	31 Dec, 2025	3,546,158	9,108	0.26%	$112,555,054.00
BAKER BROS. ADVISORS LP	31 Dec, 2025	3,336,697	-1,297,141	-27.99%	$105,906,763.00
TORONTO DOMINION BANK	31 Dec, 2025	3,173,258	0	0.00%	$100,719,209.00
VANGUARD GROUP INC	31 Dec, 2025	3,149,239	-14,635	-0.46%	$99,956,846.00
STATE STREET CORP	31 Dec, 2025	2,498,049	1,072,176	75.19%	$79,288,075.00
BVF INC/IL	31 Dec, 2025	2,265,674	608,578	36.73%	$71,912,493.00
Siren, L.L.C.	31 Dec, 2025	2,247,347	0	0.00%	$71,330,794.00
DEERFIELD MANAGEMENT COMPANY, L.P.	31 Dec, 2025	1,823,500	1,823,500	0.00%	$57,877,890.00
JANUS HENDERSON GROUP PLC	31 Dec, 2025	1,450,933	1,116,452	333.79%	$46,031,447.00
Polar Capital Holdings Plc	31 Dec, 2025	1,269,131	-54,339	-4.11%	$40,282,218.00
Assenagon Asset Management S.A.	31 Dec, 2025	1,227,723	327,451	36.37%	$38,967,928.00
Point72 Asset Management, L.P.	31 Dec, 2025	1,222,213	-84,485	-6.47%	$38,793,041.00
GEODE CAPITAL MANAGEMENT, LLC	31 Dec, 2025	1,166,145	19,145	1.67%	$37,019,868.00
GOLDMAN SACHS GROUP INC	31 Dec, 2025	1,142,737	-8,192	-0.71%	$36,270,472.00
DIMENSIONAL FUND ADVISORS LP	31 Dec, 2025	827,139	148,832	21.94%	$26,253,770.00

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