Spruce Biosciences SPRB Institutional Ownership

NASDAQ SPRB

$48.58 +1.31 (+2.77%)

At close: Sep 30, 2026 · 4:00 PM EDT

Institutions by Trading Activity

65 Institutions

Increased 54 83.1%

Unchanged 8 12.3%

Reduced 3 4.6%

Ownership Statistics

13F · as of 30 Jun, 2026

Institutional Ownership

82.76%

▲+30.61 pp QoQ

Shares Held by Institutions

2.01Mn

of 2.43Mn outstanding

▲+209.39% QoQ

Shares Outstanding

2.43Mn

419.23K held outside 13F filers

Institutional Investors

filed 13F for Jun 2026

▲+36 vs prior quarter

Net Shares Added (QoQ)

+1.36Mn

accumulated since last quarter

Value of Holdings

$95.10Mn

reported market value

Shares Owned by Institutions

Shares held % of outstanding

Latest —

Average ownership —

Peak ownership —

Shares Purchased/Sold by Institutions

Accumulated Distributed

Latest quarter —

Net over range —

Accumulating quarters —

Ownership Summary

Quarter ending 30 Jun, 2026

Spruce Biosciences, Inc. (NASDAQ:SPRB) has 65 institutional investors that have filed 13F reports for the period ending June 2026.

These investors collectively held 82.8% of Spruce Biosciences's outstanding shares in June 2026, up from 52.1% in March 2026.
Their total shares held in SPRB increased 209.39% from the prior quarter, while the number of investors in Spruce Biosciences increased 2066.67% year over year.
Among the 65 funds, 54 bought more Spruce Biosciences shares, 3 sold down, and 8 held their ground.
Institutional investors collectively held 2.01Mn shares in Spruce Biosciences as of June 2026, up by 1.36Mn shares quarter on quarter, and up 1.98Mn shares year over year.
AIGH Capital Management LLC is the top holder of Spruce Biosciences as of June 30, 2026, with 250.0K shares representing 10.28% of outstanding stock.
The largest buyers of Spruce Biosciences for the quarter ending June 2026 were AIGH Capital Management LLC (250.0K), ORBIMED ADVISORS LLC (200.0K), BlackRock, Inc. (170.9K), VANGUARD CAPITAL MANAGEMENT LLC (119.33K), Cable Car Capital, LP (60.0K).
The biggest sellers of Spruce Biosciences for the quarter ending June 2026 included BALYASNY ASSET MANAGEMENT L.P. (27.86K), CITADEL ADVISORS LLC (18.09K), JONES FINANCIAL COMPANIES LLLP (163).
Spruce Biosciences's 10 largest shareholders as of June 2026 include AIGH Capital Management LLC (250.0K), ORBIMED ADVISORS LLC (200.0K), BlackRock, Inc. (187.84K), MILLENNIUM MANAGEMENT LLC (160.98K), Ikarian Capital, LLC (121.36K), VANGUARD CAPITAL MANAGEMENT LLC (119.33K), Alyeska Investment Group, L.P. (81.67K), GEODE CAPITAL MANAGEMENT, LLC (70.55K), ADAR1 Capital Management, LLC (67.72K), Cable Car Capital, LP (60.0K) per Business Quant data.

Form 13F Holdings

64 Institutional Holders

Report period 30 Jun, 2026

Total shares held 2.01Mn

Of outstanding 82.76%

#	Institution	CIK	Shares Held	% of Outstanding	Change (QoQ)	Change (%)	Value (USD)
1	AIGH Capital Management LLC	0001835943	250,000	10.28%	▲250,000	0.00%	$13.50Mn
2	ORBIMED ADVISORS LLC	0001055951	200,000	8.23%	▲200,000	0.00%	$10.80Mn
3	BlackRock, Inc.	0002012383	187,836	7.73%	▲170,898	+1,008.96%	$10.14Mn
4	MILLENNIUM MANAGEMENT LLC	0001273087	160,981	6.62%	▲49,093	+43.88%	$8.69Mn
5	Ikarian Capital, LLC	0001778253	121,356	4.99%	0	0.00%	$6.55Mn
6	VANGUARD CAPITAL MANAGEMENT LLC	0002100119	119,331	4.91%	▲119,331	0.00%	$6.44Mn
7	Alyeska Investment Group, L.P.	0001453072	81,671	3.36%	▲30,000	+58.06%	$4.41Mn
8	GEODE CAPITAL MANAGEMENT, LLC	0001214717	70,548	2.90%	▲57,659	+447.35%	$3.81Mn
9	ADAR1 Capital Management, LLC	0001940272	67,717	2.79%	▲9,117	+15.56%	$3.66Mn
10	Cable Car Capital, LP	0001699575	60,000	2.47%	▲60,000	0.00%	$3.24Mn
11	CITADEL ADVISORS LLC	0001423053	51,905	2.14%	▼18,094	-25.85%	$2.80Mn
12	State Street Corp	0000093751	50,450	2.08%	▲45,050	+834.26%	$2.72Mn
13	BOOTHBAY FUND MANAGEMENT, LLC	0001549230	42,080	1.73%	0	0.00%	$2.27Mn
14	STEMPOINT CAPITAL LP	0001952142	41,388	1.70%	▲35,028	+550.75%	$2.23Mn
15	Eversept Partners, LP	0001697013	40,000	1.65%	▲40,000	0.00%	$2.16Mn
16	Carlyle Group Inc.	0001527166	38,620	1.59%	0	0.00%	$2.09Mn
17	Goldman Sachs Group Inc	0000886982	32,348	1.33%	▲26,842	+487.50%	$1.75Mn
18	DIADEMA PARTNERS LP	0002026172	30,000	1.23%	▲20,000	+200.00%	$1.62Mn
18	Affinity Asset Advisors, LLC	0001773195	30,000	1.23%	▲30,000	0.00%	$1.62Mn
19	Stonepine Capital Management, LLC	0001440771	28,795	1.18%	▲28,795	0.00%	$1.55Mn

Showing 1 to 20 of 64 holders