Sionna Therapeutics, Inc. (SION) Institutional Ownership

Institutions by Trading Activity

44,255,053Shares Outstanding

43,073,576Shares held by institutions

$1,702,052,356Value of institutional holdings

97.33%Institutional ownership %

-1.63%Shares Changed QoQ

97No. of institutional investors

Sionna Therapeutics, Inc. (NASDAQ:SION) showed up in the 13F filings of 97 institutional investors as of December 2025.

These investors collectively held 97.2% of Sionna Therapeutics's outstanding shares in December 2025, down from 101.3% in September 2025.
Their total shares held in SION decreased -1.68% from the prior quarter, while the number of investors in Sionna Therapeutics stayed flat year over year.
Among the 97 funds, 65 bought more Sionna Therapeutics shares, 20 sold down, and 12 held their ground.
In total, institutional investors held 43.04Mn shares in Sionna Therapeutics as of December 2025, down by 733.28K shares quarter on quarter, and with no net change year over year.
STRS OHIO holds the largest position in SION at 2.9K shares as of December 31, 2025, or 0.01% of shares outstanding.
Top purchasers of SION stock for the quarter ending December 2025 included STRS OHIO (2.9K), GF FUND MANAGEMENT CO. LTD. (127), GAMMA Investing LLC (61), SIGNATUREFD, LLC (24), Fortitude Family Office, LLC (15).
According to Business Quant data, leading holders of SION for December 2025 are STRS OHIO (2.9K), GF FUND MANAGEMENT CO. LTD. (1.0K), GAMMA Investing LLC (238), Farther Finance Advisors, LLC (196), Sterling Capital Management LLC (105), SIGNATUREFD, LLC (24), Fortitude Family Office, LLC (15), Root Financial Partners, LLC (10).

43,073,576 Total Shares Held

Rows:

Owner Name	Date	Shares Held	Change (QoQ)	Change (%)	Value (USD)
RA CAPITAL MANAGEMENT, L.P.	31 Dec, 2025	9,905,045	-540,277	-5.17%	$407,493,551.00
TPG GP A, LLC	31 Dec, 2025	6,744,962	0	0.00%	$277,487,737.00
ORBIMED ADVISORS LLC	31 Dec, 2025	3,561,655	-143,304	-3.87%	$146,526,487.00
VIKING GLOBAL INVESTORS LP	31 Dec, 2025	3,195,181	0	0.00%	$131,449,746.00
Atlas Venture Life Science Advisors, LLC	31 Dec, 2025	2,995,602	-619,925	-17.15%	$123,239,066.00
Enavate Sciences GP, LLC	31 Dec, 2025	2,478,030	0	0.00%	$101,946,154.00
BlackRock, Inc.	31 Dec, 2025	1,291,599	446,994	52.92%	$53,136,382.00
Jpmorgan Chase & Co	31 Dec, 2025	1,231,819	-2,725,433	-68.87%	$50,677,035.00
VANGUARD GROUP INC	31 Dec, 2025	1,184,951	41,797	3.66%	$48,748,883.00
PERCEPTIVE ADVISORS LLC	31 Dec, 2025	1,179,098	0	0.00%	$48,508,092.00
JENNISON ASSOCIATES LLC	31 Dec, 2025	1,115,278	117,903	11.82%	$45,882,536.00
CITADEL ADVISORS LLC	31 Dec, 2025	1,087,325	1,051,402	2,926.82%	$44,732,551.00
DEERFIELD MANAGEMENT COMPANY, L.P.	31 Dec, 2025	970,590	0	0.00%	$39,930,073.00
Aberdeen Group plc	31 Dec, 2025	839,960	-110,587	-11.63%	$34,555,954.00
State Street Corp	31 Dec, 2025	693,395	453,196	188.68%	$28,526,270.00
EVENTIDE ASSET MANAGEMENT, LLC	31 Dec, 2025	639,045	639,045	0.00%	$26,290,311.00
BAKER BROS. ADVISORS LP	31 Dec, 2025	400,000	0	0.00%	$16,456,000.00
GEODE CAPITAL MANAGEMENT, LLC	31 Dec, 2025	380,042	63,478	20.05%	$15,638,406.00
Siren, L.L.C.	31 Dec, 2025	300,000	-25,000	-7.69%	$12,342,000.00
Soleus Capital Management, L.P.	31 Dec, 2025	268,500	-145,000	-35.07%	$11,046,090.00

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