Sionna Therapeutics, Inc. (SION) Institutional Ownership

Institutions by Trading Activity

Ownership Statistics

0Shares Outstanding

21,638,005Shares held by institutions

$794,331,164Value of institutional holdings

98.21%Institutional ownership %

2.11%Shares Changed QoQ

63No. of institutional investors

Shares Owned by Institutions

Shares Purchased/Sold by Institutions

Ownership Summary

Sionna Therapeutics, Inc. (NASDAQ:SION) showed up in the 13F filings of 97 institutional investors as of December 2025.

Their combined ownership stood at 97.2% of outstanding shares in December 2025, down from 101.3% in September 2025.
Their total shares held in SION decreased -1.68% from the prior quarter, while the number of investors in Sionna Therapeutics stayed flat year over year.
Of these 97 holders, 65 added to their stakes in Sionna Therapeutics, 20 trimmed positions, and 12 made no changes.
Institutional investors collectively held 43.04Mn shares in Sionna Therapeutics as of December 2025, down by 733.28K shares quarter on quarter, and with no net change year over year.
RA CAPITAL MANAGEMENT, L.P. is the top holder of Sionna Therapeutics as of December 31, 2025, with 9.91Mn shares representing 22.38% of outstanding stock.
Top purchasers of SION stock for the quarter ending December 2025 included CITADEL ADVISORS LLC (1.05Mn), EVENTIDE ASSET MANAGEMENT, LLC (639.04K), State Street Corp (453.2K), BlackRock, Inc. (446.99K), Kalehua Capital Management LLC (197.07K).
The largest sales of SION for the quarter ending December 2025 came from Jpmorgan Chase & Co (2.73Mn), Atlas Venture Life Science Advisors, LLC (619.93K), RA CAPITAL MANAGEMENT, L.P. (540.28K), Soleus Capital Management, L.P. (145.0K), ORBIMED ADVISORS LLC (143.3K).
Business Quant data shows the 10 biggest positions in Sionna Therapeutics as of December 2025 are held by RA CAPITAL MANAGEMENT, L.P. (9.91Mn), TPG GP A, LLC (6.74Mn), ORBIMED ADVISORS LLC (3.56Mn), VIKING GLOBAL INVESTORS LP (3.2Mn), Atlas Venture Life Science Advisors, LLC (3.0Mn), Enavate Sciences GP, LLC (2.48Mn), BlackRock, Inc. (1.29Mn), Jpmorgan Chase & Co (1.23Mn), VANGUARD GROUP INC (1.18Mn), PERCEPTIVE ADVISORS LLC (1.18Mn).

97 Institutional Holders

21,638,005 Total Shares Held

Rows:

Download Data

Owner Name	Date	Change (QoQ)	Change (%)	Value (USD)
BlackRock, Inc.	31 Dec, 2025	446,994	52.92%	$0.00
RA CAPITAL MANAGEMENT, L.P.	31 Dec, 2025	-540,277	-5.17%	$0.00
TPG GP A, LLC	31 Dec, 2025	0	0.00%	$0.00
Barclays Plc	31 Dec, 2025	30,529	173.04%	$0.00
ORBIMED ADVISORS LLC	31 Dec, 2025	-143,304	-3.87%	$0.00
Atlas Venture Life Science Advisors, LLC	31 Dec, 2025	-619,925	-17.15%	$0.00
Rockefeller Capital Management L.P.	31 Dec, 2025	96	0.00%	$0.00
VIKING GLOBAL INVESTORS LP	31 Dec, 2025	0	0.00%	$0.00
Enavate Sciences GP, LLC	31 Dec, 2025	0	0.00%	$0.00
Jpmorgan Chase & Co	31 Dec, 2025	-2,725,433	-68.87%	$0.00
Aberdeen Group plc	31 Dec, 2025	-110,587	-11.63%	$0.00
VANGUARD GROUP INC	31 Dec, 2025	41,797	3.66%	$0.00
Siren, L.L.C.	31 Dec, 2025	-25,000	-7.69%	$0.00
PERCEPTIVE ADVISORS LLC	31 Dec, 2025	0	0.00%	$0.00
Soleus Capital Management, L.P.	31 Dec, 2025	-145,000	-35.07%	$0.00
JENNISON ASSOCIATES LLC	31 Dec, 2025	117,903	11.82%	$0.00
Kalehua Capital Management LLC	31 Dec, 2025	197,072	0.00%	$0.00
CITADEL ADVISORS LLC	31 Dec, 2025	1,051,402	2,926.82%	$0.00
SUPERSTRING CAPITAL MANAGEMENT LP	31 Dec, 2025	180,593	0.00%	$0.00
DEERFIELD MANAGEMENT COMPANY, L.P.	31 Dec, 2025	0	0.00%	$0.00

1 - 20 of 97

Research Tools