Relay Therapeutics, Inc. (RLAY) Institutional Ownership

Institutions by Trading Activity

Ownership Statistics

172,389,209Shares Outstanding

173,805,521Shares held by institutions

$2,249,912,469Value of institutional holdings

100.82%Institutional ownership %

10.03%Shares Changed QoQ

221No. of institutional investors

Shares Owned by Institutions

Shares Purchased/Sold by Institutions

Ownership Summary

Relay Therapeutics, Inc. (NASDAQ:RLAY) appears in 221 institutional 13F filings for the quarter ending December 2025.

These investors collectively held 99.7% of Relay Therapeutics's outstanding shares in December 2025, up from 97.5% in September 2025.
They increased total shares held in RLAY by 9.3% quarter over quarter, and investors in Relay Therapeutics increased 12.76% from a year ago.
Among the 221 funds, 112 bought more Relay Therapeutics shares, 60 sold down, and 49 held their ground.
The aggregate institutional position in Relay Therapeutics amounted to 171.87Mn shares as of December 2025, up by 14.62Mn shares quarter on quarter, and up 6.96Mn shares year over year.
CONGRESS ASSET MANAGEMENT CO holds the largest position in RLAY at 618.94K shares as of December 31, 2025, or 0.36% of shares outstanding.
The largest buyers of Relay Therapeutics for the quarter ending December 2025 were CONGRESS ASSET MANAGEMENT CO (204.77K), OP Asset Management Ltd (58.43K), WEALTH ENHANCEMENT ADVISORY SERVICES, LLC (55.38K), TEMA ETFS LLC (42.54K), E Fund Management Co., Ltd. (18.93K).
The biggest sellers of Relay Therapeutics for the quarter ending December 2025 included Raiffeisen Bank International AG (60.0K), SG Americas Securities, LLC (23.41K), AssuredPartners Investment Advisors, LLC (4.06K), Sterling Capital Management LLC (3.45K), Intellectus Partners, LLC (1.7K).
Relay Therapeutics's 10 largest shareholders as of December 2025 include CONGRESS ASSET MANAGEMENT CO (618.94K), SG Americas Securities, LLC (197.54K), Raiffeisen Bank International AG (190.0K), TEMA ETFS LLC (154.1K), OP Asset Management Ltd (58.43K), WEALTH ENHANCEMENT ADVISORY SERVICES, LLC (55.38K), Intellectus Partners, LLC (42.22K), Pallas Capital Advisors LLC (28.57K), Merit Financial Group, LLC (21.0K), Pictet Asset Management Holding SA (19.59K) per Business Quant data.

221 Institutional Holders

173,805,521 Total Shares Held

Rows:

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Owner Name	Date	Shares Held	Change (QoQ)	Change (%)	Value (USD)
SB INVESTMENT ADVISERS (UK) LTD	31 Dec, 2025	27,904,963	0	0.00%	$236,075,987.00
Commodore Capital LP	31 Dec, 2025	17,000,000	0	0.00%	$143,820,000.00
Point72 Asset Management, L.P.	31 Dec, 2025	13,859,172	-914,504	-6.19%	$117,248,595.00
BlackRock, Inc.	31 Dec, 2025	13,228,502	-530,880	-3.86%	$111,913,127.00
Casdin Capital, LLC	31 Dec, 2025	13,003,574	1,662,193	14.66%	$110,010,236.00
VANGUARD GROUP INC	31 Dec, 2025	9,691,445	295,701	3.15%	$81,989,624.00
Bellevue Group AG	31 Dec, 2025	8,345,364	-246	0.00%	$70,601,779.00
State Street Corp	31 Dec, 2025	6,426,111	1,360,121	26.85%	$54,364,899.00
Nextech Invest, Ltd.	31 Dec, 2025	4,701,506	855,097	22.23%	$39,774,741.00
Goldman Sachs Group Inc	31 Dec, 2025	3,719,268	1,850,397	99.01%	$31,465,006.00
GEODE CAPITAL MANAGEMENT, LLC	31 Dec, 2025	3,409,363	354,777	11.61%	$28,849,082.00
TCG Crossover Management, LLC	31 Dec, 2025	3,220,186	1,409,835	77.88%	$27,242,774.00
Spruce Street Capital LP	31 Dec, 2025	2,984,125	2,984,125	0.00%	$25,245,698.00
DIMENSIONAL FUND ADVISORS LP	31 Dec, 2025	2,480,350	-2,600	-0.10%	$20,983,096.00
MPM BioImpact LLC	31 Dec, 2025	2,232,451	-50,229	-2.20%	$18,886,535.00
BALYASNY ASSET MANAGEMENT L.P.	31 Dec, 2025	2,099,912	924,941	78.72%	$17,765,256.00
Morgan Stanley	31 Dec, 2025	2,018,464	254,368	14.42%	$17,076,206.00
PERCEPTIVE ADVISORS LLC	31 Dec, 2025	1,903,245	1,903,245	0.00%	$16,101,453.00
Alphabet Inc.	31 Dec, 2025	1,568,753	0	0.00%	$13,271,651.00
TWO SIGMA INVESTMENTS, LP	31 Dec, 2025	1,560,265	464,630	42.41%	$13,199,842.00

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