ProQR Therapeutics N.V. (PRQR) Institutional Ownership

Institutions by Trading Activity

Ownership Statistics

122,149,211Shares Outstanding

10,854,310Shares held by institutions

$15,738,750Value of institutional holdings

28.77%Institutional ownership %

3.37%Shares Changed QoQ

60No. of institutional investors

Shares Owned by Institutions

Shares Purchased/Sold by Institutions

Ownership Summary

Recent 13F filings as of December 2025 show that 60 institutional investors hold a position in ProQR Therapeutics N.V. (NASDAQ:PRQR).

ProQR Therapeutics saw its institutional ownership percentage fell to 28.8% in December 2025 from 30.6% in September 2025.
Quarterly data indicates a 3.37% shift in institutional share volume, and the annual owner count reflects a decrease of 20.00%.
During the quarter, 30 institutions bought more ProQR Therapeutics shares, 10 sold shares, and 20 of the 60 total investors held their position steady.
The total number of shares held by institutions in ProQR Therapeutics increased to 35.14Mn as of December 2025, a net change of up by 1.15Mn shares quarter on quarter, and down 9.09Mn shares year over year.
As of December 31, 2025, ADAGE CAPITAL PARTNERS GP, L.L.C. held ProQR Therapeutics's largest shareholding position with over 6.25Mn shares, representing 5.12% of total outstanding shares.
Among the most significant buyers of ProQR Therapeutics during December 2025 were UBS Group AG (703.11K), Aberdeen Group plc (651.85K), NOMURA ASSET MANAGEMENT INTERNATIONAL INC. (620.00K), TWO SIGMA INVESTMENTS, LP (422.08K), Privium Fund Management B.V. (359.48K).
Leading sellers of ProQR Therapeutics stock in December 2025 included MORGAN STANLEY (1.53Mn), Affinity Asset Advisors, LLC (1.15Mn), Kynam Capital Management, LP (83.14K), ROYAL BANK OF CANADA (81.90K), ArrowMark Colorado Holdings LLC (81.51K).
The top 10 institutional holders of ProQR Therapeutics for the quarter ending December 2025 included ADAGE CAPITAL PARTNERS GP, L.L.C. (6.25Mn), Privium Fund Management B.V. (5.36Mn), Aberdeen Group plc (2.95Mn), Affinity Asset Advisors, LLC (2.45Mn), Sio Capital Management, LLC (2.16Mn), DAFNA Capital Management LLC (1.57Mn), Kynam Capital Management, LP (1.57Mn), MORGAN STANLEY (1.37Mn), PLATINUM INVESTMENT MANAGEMENT LTD (1.24Mn), ArrowMark Colorado Holdings LLC (1.16Mn).

60 Institutional Holders

10,854,310 Total Shares Held

Rows:

Download Data

Owner Name	Date	Shares Held	Change (QoQ)	Change (%)	Value (USD)
ADAGE CAPITAL PARTNERS GP, L.L.C.	31 Dec, 2025	6,253,467	0	0.00%	$12,632,003.00
Privium Fund Management B.V.	31 Dec, 2025	5,357,762	359,475	7.19%	$10,822,680.00
Aberdeen Group plc	31 Dec, 2025	2,950,676	651,853	28.36%	$5,960,366.00
Affinity Asset Advisors, LLC	31 Dec, 2025	2,454,278	-1,145,722	-31.83%	$4,957,642.00
Sio Capital Management, LLC	31 Dec, 2025	2,164,181	89,042	4.29%	$4,371,646.00
DAFNA Capital Management LLC	31 Dec, 2025	1,567,561	0	0.00%	$3,166,473.00
Kynam Capital Management, LP	31 Dec, 2025	1,566,317	-83,145	-5.04%	$3,163,960.00
MORGAN STANLEY	31 Dec, 2025	1,367,119	-1,534,083	-52.88%	$2,761,581.00
PLATINUM INVESTMENT MANAGEMENT LTD	31 Dec, 2025	1,235,514	0	0.00%	$2,495,738.00
ArrowMark Colorado Holdings LLC	31 Dec, 2025	1,164,722	-81,512	-6.54%	$2,352,738.00
M28 Capital Management LP	31 Dec, 2025	1,019,498	0	0.00%	$2,059,386.00
TWO SIGMA INVESTMENTS, LP	31 Dec, 2025	839,384	422,084	101.15%	$1,695,556.00
Point72 Asset Management, L.P.	31 Dec, 2025	813,650	63,650	8.49%	$1,643,573.00
UBS Group AG	31 Dec, 2025	797,664	703,114	743.64%	$1,611,282.00
NOMURA ASSET MANAGEMENT INTERNATIONAL INC.	31 Dec, 2025	620,000	620,000	0.00%	$1,252,000.00
Walleye Capital LLC	31 Dec, 2025	591,785	59,808	11.24%	$1,195,406.00
CITADEL ADVISORS LLC	31 Dec, 2025	583,222	-73,790	-11.23%	$1,178,108.00
TWO SIGMA ADVISERS, LP	31 Dec, 2025	452,400	223,800	97.90%	$913,848.00
MILLENNIUM MANAGEMENT LLC	31 Dec, 2025	434,991	194,369	80.78%	$878,682.00
Monaco Asset Management SAM	31 Dec, 2025	428,803	-31,197	-6.78%	$866,182.00

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