Protalix BioTherapeutics, Inc. (PLX) Institutional Ownership

Institutions by Trading Activity

Ownership Statistics

78,500,000Shares Outstanding

1,245,355Shares held by institutions

$3,711,158Value of institutional holdings

18.66%Institutional ownership %

8.54%Shares Changed QoQ

80No. of institutional investors

Shares Owned by Institutions

Shares Purchased/Sold by Institutions

Ownership Summary

A total of 80 institutions have reported a stake in Protalix BioTherapeutics, Inc. (NYSE:PLX) as of December 2025, according to recent 13F filings with the SEC.

Protalix BioTherapeutics saw its institutional ownership percentage rose to 18.7% in December 2025 from 17.7% in September 2025.
Quarterly data indicates a 8.54% shift in institutional share volume, and the annual owner count reflects an increase of 70.21%.
During the quarter, 41 institutions bought more Protalix BioTherapeutics shares, 21 sold shares, and 18 of the 80 total investors held their position steady.
Collectively, institutional investors increased their stake in Protalix BioTherapeutics to 14.65Mn shares as of December 2025, a change that is up by 1.15Mn shares quarter on quarter and up 10.18Mn shares year over year.
BlackRock, Inc. continues to be the largest institutional holder of Protalix BioTherapeutics as of December 31, 2025, with a position of 3.65Mn shares, representing 4.65% of the company's outstanding stock.
Among the most significant buyers of Protalix BioTherapeutics during December 2025 were CITADEL ADVISORS LLC (280.32K), JANE STREET GROUP, LLC (253.42K), Round Rock Advisors LLC (155.10K), GOLDMAN SACHS GROUP INC (111.98K), BlackRock, Inc. (96.08K).
Leading sellers of Protalix BioTherapeutics stock in December 2025 included Connor, Clark & Lunn Investment Management Ltd. (168.31K), Opaleye Management Inc. (102.38K), DEUTSCHE BANK AG\ (64.77K), RENAISSANCE TECHNOLOGIES LLC (52.10K), Diametric Capital, LP (41.05K).
The top 10 institutional holders of Protalix BioTherapeutics for the quarter ending December 2025 included BlackRock, Inc. (3.65Mn), Opaleye Management Inc. (2.48Mn), RENAISSANCE TECHNOLOGIES LLC (1.26Mn), NORTHERN TRUST CORP (865.71K), GEODE CAPITAL MANAGEMENT, LLC (830.05K), STATE STREET CORP (585.26K), Stratos Wealth Partners, LTD. (500.00K), VANGUARD GROUP INC (488.55K), CITADEL ADVISORS LLC (317.63K), JANE STREET GROUP, LLC (289.92K).

80 Institutional Holders

1,245,355 Total Shares Held

Rows:

Download Data

Owner Name	Date	Shares Held	Change (QoQ)	Change (%)	Value (USD)
BlackRock, Inc.	31 Dec, 2025	3,647,106	96,078	2.71%	$6,564,791.00
Opaleye Management Inc.	31 Dec, 2025	2,478,176	-102,380	-3.97%	$4,460,717.00
RENAISSANCE TECHNOLOGIES LLC	31 Dec, 2025	1,263,300	-52,100	-3.96%	$2,273,940.00
NORTHERN TRUST CORP	31 Dec, 2025	865,708	-36,751	-4.07%	$1,558,274.00
GEODE CAPITAL MANAGEMENT, LLC	31 Dec, 2025	830,054	10,277	1.25%	$1,494,096.00
STATE STREET CORP	31 Dec, 2025	585,261	86,714	17.39%	$1,053,470.00
Stratos Wealth Partners, LTD.	31 Dec, 2025	500,000	0	0.00%	$900,000.00
VANGUARD GROUP INC	31 Dec, 2025	488,552	24,131	5.20%	$879,393.00
CITADEL ADVISORS LLC	31 Dec, 2025	317,628	280,322	751.41%	$571,730.00
JANE STREET GROUP, LLC	31 Dec, 2025	289,917	253,417	694.29%	$521,851.00
GOLDMAN SACHS GROUP INC	31 Dec, 2025	262,809	111,980	74.24%	$473,056.00
UBS Group AG	31 Dec, 2025	262,520	72,244	37.97%	$472,536.00
Connor, Clark & Lunn Investment Management Ltd.	31 Dec, 2025	232,093	-168,305	-42.03%	$417,767.00
Main Street Financial Solutions, LLC	31 Dec, 2025	214,100	85,000	65.84%	$385,380.00
Bank of New York Mellon Corp	31 Dec, 2025	210,867	72,319	52.20%	$379,561.00
BRIDGEWAY CAPITAL MANAGEMENT, LLC	31 Dec, 2025	189,100	0	0.00%	$340,380.00
CHARLES SCHWAB INVESTMENT MANAGEMENT INC	31 Dec, 2025	175,070	0	0.00%	$315,126.00
COMMONWEALTH EQUITY SERVICES, LLC	31 Dec, 2025	171,772	0	0.00%	$309,190.00
Round Rock Advisors LLC	31 Dec, 2025	155,102	155,102	0.00%	$279,184.00
Diametric Capital, LP	31 Dec, 2025	138,929	-41,055	-22.81%	$250,072.00

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