OnKure Therapeutics's three largest insider shareholders as of September 09, 2026 are Bioventures, L.P. Acorn (TenPercentOwner, 2.84Mn shares), Asset Management, Lp Cormorant (TenPercentOwner, 1.81Mn shares), Asset Management, Lp Cormorant (TenPercentOwner, 1.81Mn shares).
| # | Insider | Position | Direct | Indirect | Total | Share of Insiders | Last Filed |
|---|---|---|---|---|---|---|---|
| 1 | Bioventures, L.P. Acorn | TenPercentOwner | 1,709,944 | 1,129,730 | 2,839,674 | 53.2% | 19 May, 2025 |
| 2 | Asset Management, Lp Cormorant | TenPercentOwner | 0 | 1,813,439 | 1,813,439 | 34.0% | 14 May, 2025 |
| 3 | Holdings A/S Novo | TenPercentOwner | 333,034 | 0 | 333,034 | 6.2% | 23 Jun, 2023 |
| 4 | Niall O'Donnell | Director | 0 | 218,871 | 218,871 | 4.1% | 10 May, 2023 |
| 5 | Braden Michael Leonard | Other | 10,208 | 34,574 | 44,782 | 0.8% | 09 Oct, 2024 |
| 6 | Isaac Manke | Director | 20,583 | 0 | 20,583 | 0.4% | 02 Jan, 2026 |
| 7 | Jason A. Leverone | Chief Financial Officer | 18,802 | 0 | 18,802 | 0.4% | 24 Jun, 2026 |
| 8 | Edward T Mathers | Director | 15,310 | 0 | 15,310 | 0.3% | 02 Jan, 2026 |
| 9 | Nicholas A Saccomano | President And Ceo | 11,247 | 0 | 11,247 | 0.2% | 24 Jun, 2026 |
| 10 | Gregory J. Flesher | President And Ceo | 10,960 | 0 | 10,960 | 0.2% | 13 Dec, 2021 |
| 11 | Ashley Hall | Chief Development Officer | 3,960 | 0 | 3,960 | 0.1% | 29 Aug, 2023 |
| 12 | Vineet R. Jindal | Chief Financial Officer | 3,660 | 0 | 3,660 | 0.1% | 13 Dec, 2021 |
| 13 | Alejandro Dorenbaum | Chief Medical Officer | 3,000 | 0 | 3,000 | 0.1% | 13 Dec, 2022 |
| 14 | Michael Cruse | Chief Operating Officer | 0 | 1,370 | 1,370 | 0.0% | 02 Sep, 2022 |
| 15 | R Michael Carruthers | Director | 494 | 0 | 494 | 0.0% | 08 Oct, 2024 |
Each row is that insider’s most recently reported position, from Form 4 filings over the last 60 months — which is why this total does not tie to the quarterly series above, where a quarter counts only the insiders who filed in it. Shares held through a fund or institutional portfolio are counted on the institutional ownership page instead.
| Date | Insider | Position | Transaction | Shares | Price | Value | Shares Held After | Ownership |
|---|---|---|---|---|---|---|---|---|
| 07 Aug, 2026 | Isaac Manke | Director | Acquired A | 300,000 | $0.00 | $0 | 300,000 | Direct |
| 07 Aug, 2026 | R Michael Carruthers | Director | Acquired A | 22,350 | $0.00 | $0 | 22,350 | Direct |
| 07 Aug, 2026 | Valerie Malyvanh Jansen | Director | Acquired A | 22,350 | $0.00 | $0 | 22,350 | Direct |
| 07 Aug, 2026 | Dylan Hartley | Chief Scientific Officer | Acquired A | 50,000 | $0.00 | $0 | 50,000 | Direct |
| 07 Aug, 2026 | Samuel Agresta | Chief Medical Officer | Acquired A | 50,000 | $0.00 | $0 | 50,000 | Direct |
| 07 Aug, 2026 | Andrew John Phillips | Director | Acquired A | 22,350 | $0.00 | $0 | 22,350 | Direct |
| 07 Aug, 2026 | Michael G Grey | Director | Acquired A | 22,350 | $0.00 | $0 | 22,350 | Direct |
| 07 Aug, 2026 | Edward T Mathers | Director | Acquired A | 22,350 | $0.00 | $0 | 22,350 | Direct |
| 07 Aug, 2026 | Jason A. Leverone | Chief Financial Officer | Acquired A | 50,000 | $0.00 | $0 | 50,000 | Direct |
| 07 Aug, 2026 | Nicholas A Saccomano | President And Ceo | Acquired A | 150,000 | $0.00 | $0 | 150,000 | Direct |
| 07 Aug, 2026 | Samuel Agresta | Chief Medical Officer | Disposed D | 18,588 | — | — | 0 | Direct |
| 07 Aug, 2026 | Dylan Hartley | Chief Scientific Officer | Disposed D | 137,603 | — | — | 0 | Direct |
| 07 Aug, 2026 | Nicholas A Saccomano | President And Ceo | Disposed D | 2,359 | — | — | 0 | Direct |
| 07 Aug, 2026 | Jason A. Leverone | Chief Financial Officer | Disposed D | 5,781 | — | — | 0 | Direct |
| 07 Aug, 2026 | Isaac Manke | Director | Disposed D | 15,300 | — | — | 0 | Direct |
| 07 Aug, 2026 | Samuel Agresta | Chief Medical Officer | Acquired A | 18,588 | — | — | 18,588 | Direct |
| 07 Aug, 2026 | Jason A. Leverone | Chief Financial Officer | Acquired A | 5,781 | — | — | 5,781 | Direct |
| 07 Aug, 2026 | Dylan Hartley | Chief Scientific Officer | Acquired A | 137,603 | — | — | 137,603 | Direct |
| 07 Aug, 2026 | Nicholas A Saccomano | President And Ceo | Acquired A | 2,359 | — | — | 2,359 | Direct |
| 07 Aug, 2026 | Isaac Manke | Director | Acquired A | 15,300 | — | — | 15,300 | Direct |