| DEERFIELD MANAGEMENT COMPANY, L.P. |
31 Mar, 2026 |
17,248,450 |
0 |
0.00% |
$1,767,103,703.00 |
| FMR LLC |
31 Mar, 2026 |
9,274,959 |
-1,577,925 |
-14.54% |
$950,219,559.00 |
| Paradigm Biocapital Advisors LP |
31 Mar, 2026 |
5,324,433 |
55,000 |
1.04% |
$545,488,161.00 |
| BlackRock, Inc. |
31 Mar, 2026 |
4,824,785 |
19,587 |
0.41% |
$494,299,250.00 |
| Jpmorgan Chase & Co |
31 Mar, 2026 |
3,088,349 |
883,098 |
40.05% |
$298,705,153.00 |
| RA CAPITAL MANAGEMENT, L.P. |
31 Mar, 2026 |
2,534,145 |
654,088 |
34.79% |
$259,623,155.00 |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
31 Mar, 2026 |
2,500,907 |
2,500,907 |
0.00% |
$256,217,922.00 |
| Janus Henderson Group Plc |
31 Mar, 2026 |
2,475,558 |
975,984 |
65.08% |
$253,675,798.00 |
| WELLINGTON MANAGEMENT GROUP LLP |
31 Mar, 2026 |
2,470,491 |
8,668 |
0.35% |
$253,101,802.00 |
| VANGUARD CAPITAL MANAGEMENT LLC |
31 Mar, 2026 |
2,428,488 |
2,428,488 |
0.00% |
$248,798,596.00 |
| PRICE T ROWE ASSOCIATES INC /MD/ |
31 Mar, 2026 |
2,056,133 |
2,056,133 |
0.00% |
$210,652.00 |
| State Street Corp |
31 Mar, 2026 |
2,035,831 |
171,156 |
9.18% |
$208,570,886.00 |
| Polar Capital Holdings Plc |
31 Mar, 2026 |
1,831,253 |
294,394 |
19.16% |
$187,611,870.00 |
| PERCEPTIVE ADVISORS LLC |
31 Mar, 2026 |
1,580,505 |
-84,600 |
-5.08% |
$161,922,737.00 |
| T. Rowe Price Investment Management, Inc. |
31 Mar, 2026 |
1,413,637 |
-275,100 |
-16.29% |
$144,828.00 |
| Deep Track Capital, LP |
31 Mar, 2026 |
1,376,324 |
1,376,324 |
0.00% |
$141,004,394.00 |
| GEODE CAPITAL MANAGEMENT, LLC |
31 Mar, 2026 |
1,298,107 |
59,873 |
4.84% |
$133,017,356.00 |
| Bellevue Group AG |
31 Mar, 2026 |
1,053,268 |
15,800 |
1.52% |
$107,907,307.00 |
| Commodore Capital LP |
31 Mar, 2026 |
833,600 |
283,600 |
51.56% |
$85,402,320.00 |
| ALLIANCEBERNSTEIN L.P. |
31 Mar, 2026 |
784,023 |
-1,422 |
-0.18% |
$78,864,874.00 |