Nautilus Biotechnology, Inc. (NAUT) Institutional Ownership

Ownership Summary

Nautilus Biotechnology, Inc. (NASDAQ:NAUT) showed up in the 13F filings of 68 institutional investors as of December 2025.

• They owned 46.2% of outstanding stock in December 2025, up from 45.8% the prior quarter.
• Their total shares held in NAUT increased 1.98% quarter over quarter, and separately, investors owning Nautilus Biotechnology decreased 24.44% from a year ago.
• Of these 68 funds, 30 grew their exposure to Nautilus Biotechnology, 14 cut back, and 24 maintained positions.
• Altogether, these fund groups held 58.41Mn shares in NAUT by December 2025, up by 1.13Mn shares quarter on quarter, and down 5.96Mn shares year over year.
• As of December 31, 2025, the biggest holder of Nautilus Biotechnology is a16z Capital Management, L.L.C. at 17.65Mn shares, representing 13.98% of shares outstanding.
• The largest buyers of Nautilus Biotechnology for the quarter ending December 2025 were SENTINEL TRUST CO LBA (750.0K), ACADIAN ASSET MANAGEMENT LLC (368.71K), Goldman Sachs Group Inc (179.72K), VANGUARD GROUP INC (166.39K), MARSHALL WACE, LLP (117.06K).
• Top sellers of NAUT stock for the quarter ending December 2025 included RENAISSANCE TECHNOLOGIES LLC (747.76K), GSA CAPITAL PARTNERS LLP (135.15K), Squarepoint Ops LLC (120.51K), Corient Private Wealth LLC (89.56K), DIMENSIONAL FUND ADVISORS LP (79.24K).
• According to Business Quant data, leading holders of NAUT for December 2025 are a16z Capital Management, L.L.C. (17.65Mn), PERCEPTIVE ADVISORS LLC (12.59Mn), Cercano Management LLC (7.17Mn), Madrona Venture Group, LLC (6.02Mn), VANGUARD GROUP INC (2.6Mn), Comprehensive Financial Management LLC (2.21Mn), Amazon Com Inc (1.46Mn), Clarius Group, LLC (1.21Mn), MILLENNIUM MANAGEMENT LLC (1.02Mn), SENTINEL TRUST CO LBA (750.0K).