Nautilus Biotechnology, Inc. (NAUT) Institutional Ownership

Ownership Summary

A total of 65 institutions have reported a stake in Nautilus Biotechnology, Inc. (NASDAQ:NAUT) as of September 2025, according to recent 13F filings with the SEC.

• Nautilus Biotechnology saw its institutional ownership percentage fell to 45.8% in September 2025 from 46.7% in June 2025.
• The company experienced a -0.45% quarterly change in institutional shares held, alongside a decrease of 21.69% in total owners annually.
• The latest 13F cycle for Nautilus Biotechnology reveals that of 65 total investors, 17 funds grew their exposure, whereas 28 reduced theirs and 20 made no changes.
• This class of investors decreased its holdings in Nautilus Biotechnology to 57.84Mn shares for the 13F-cycle ending September 2025, down by 259.20K shares quarter on quarter, and down 6.35Mn shares year over year.
• The top institutional stake in Nautilus Biotechnology as of September 30, 2025 belongs to a16z Capital Management, L.L.C., which owns 17.65Mn shares, or 13.98% of the company.
• Among the most significant buyers of Nautilus Biotechnology during September 2025 were RENAISSANCE TECHNOLOGIES LLC (387.76K), ACADIAN ASSET MANAGEMENT LLC (174.06K), CITADEL ADVISORS LLC (151.23K), Clarius Group, LLC (149.19K), Crewe Advisors LLC (136.05K).
• Leading sellers of Nautilus Biotechnology stock in September 2025 included BlackRock, Inc. (427.46K), GOLDMAN SACHS GROUP INC (197.22K), DIMENSIONAL FUND ADVISORS LP (186.06K), JANE STREET GROUP, LLC (142.18K), Corient Private Wealth LLC (116.21K).
• The top 10 institutional holders of Nautilus Biotechnology for the quarter ending September 2025 included a16z Capital Management, L.L.C. (17.65Mn), PERCEPTIVE ADVISORS LLC (12.59Mn), Cercano Management LLC (7.17Mn), Madrona Venture Group, LLC (6.02Mn), VANGUARD GROUP INC (2.43Mn), Comprehensive Financial Management LLC (2.21Mn), AMAZON COM INC (1.46Mn), Clarius Group, LLC (1.21Mn), RENAISSANCE TECHNOLOGIES LLC (1.01Mn), MILLENNIUM MANAGEMENT LLC (967.55K).