Nautilus Biotechnology, Inc. (NAUT) Institutional Ownership

Ownership Summary

Nautilus Biotechnology, Inc. (NASDAQ:NAUT) is held by 68 institutional investors per 13F filings through December 2025.

• These investors held 46.2% of outstanding shares in December 2025, up from 45.8% in September 2025.
• They increased total shares held in Nautilus Biotechnology by 1.98% from the prior quarter, while the number of investors in NAUT decreased 24.44% year over year.
• Among the 68 funds, 30 bought more Nautilus Biotechnology shares, 14 sold down, and 24 held their ground.
• Combined, these investors held 58.41Mn shares in NAUT for December 2025, up by 1.13Mn shares quarter on quarter, and down 5.96Mn shares year over year.
• a16z Capital Management, L.L.C. holds the largest position in NAUT at 17.65Mn shares as of December 31, 2025, or 13.98% of shares outstanding.
• Top purchasers of NAUT stock for the quarter ending December 2025 included VANGUARD CAPITAL MANAGEMENT LLC (2.55Mn), Clearstead Advisors, LLC (2.33Mn), VANGUARD FIDUCIARY TRUST CO (305.53K), MILLENNIUM MANAGEMENT LLC (253.39K), MARSHALL WACE, LLP (202.82K).
• The largest sellers of Nautilus Biotechnology for the quarter ending December 2025 were Goldman Sachs Group Inc (204.11K), JANE STREET GROUP, LLC (145.04K), Corient Private Wealth LLC (114.79K), OMERS ADMINISTRATION Corp (80.28K), GSA CAPITAL PARTNERS LLP (69.35K).
• Nautilus Biotechnology's 10 largest shareholders as of December 2025 include a16z Capital Management, L.L.C. (17.65Mn), PERCEPTIVE ADVISORS LLC (12.59Mn), Cercano Management LLC (7.17Mn), VANGUARD CAPITAL MANAGEMENT LLC (2.55Mn), Clearstead Advisors, LLC (2.33Mn), Comprehensive Financial Management LLC (2.21Mn), Amazon Com Inc (1.46Mn), MILLENNIUM MANAGEMENT LLC (1.27Mn), SENTINEL TRUST CO LBA (750.0K), ACADIAN ASSET MANAGEMENT LLC (741.25K) per Business Quant data.