Monopar Therapeutics (MNPR) Institutional Ownership

Institutions by Trading Activity

Ownership Statistics

4,909,522Shares Outstanding

101,208Shares held by institutions

$5,487,498Value of institutional holdings

111.71%Institutional ownership %

31.09%Shares Changed QoQ

69No. of institutional investors

Shares Owned by Institutions

Shares Purchased/Sold by Institutions

Ownership Summary

According to SEC filings for the period ending December 2025, Monopar Therapeutics (NASDAQ:MNPR) is held by 69 institutional firms.

The collective stake of institutional investors in Monopar Therapeutics moved to 111.7% in December 2025, a shift up from the 88.3% reported for September 2025.
Quarterly data indicates a 31.09% shift in institutional share volume, and the annual owner count reflects an increase of 283.33%.
The latest 13F cycle for Monopar Therapeutics reveals that of 69 total investors, 52 funds grew their exposure, whereas 9 reduced theirs and 8 made no changes.
The total number of shares held by institutions in Monopar Therapeutics increased to 5.48Mn as of December 2025, a net change of up by 1.30Mn shares quarter on quarter, and up 2.91Mn shares year over year.
The top institutional stake in Monopar Therapeutics as of December 31, 2025 belongs to JANUS HENDERSON GROUP PLC, which owns 1.32Mn shares, or 26.83% of the company.
Among the most significant buyers of Monopar Therapeutics during December 2025 were Siren, L.L.C. (212.30K), Saturn V Capital Management LP (170.33K), RA CAPITAL MANAGEMENT, L.P. (156.00K), Polar Capital Holdings Plc (105.75K), ADAR1 Capital Management, LLC (103.91K).
Leading sellers of Monopar Therapeutics stock in December 2025 included DRIEHAUS CAPITAL MANAGEMENT LLC (30.92K), ADAGE CAPITAL PARTNERS GP, L.L.C. (19.73K), TCG Crossover Management, LLC (11.09K), WELLINGTON MANAGEMENT GROUP LLP (5.39K), UBS Group AG (3.72K).
The top 10 institutional holders of Monopar Therapeutics for the quarter ending December 2025 included JANUS HENDERSON GROUP PLC (1.32Mn), RA CAPITAL MANAGEMENT, L.P. (667.21K), ADAGE CAPITAL PARTNERS GP, L.L.C. (639.47K), Saturn V Capital Management LP (325.70K), VANGUARD GROUP INC (293.82K), BlackRock, Inc. (254.86K), ADAR1 Capital Management, LLC (233.91K), WELLINGTON MANAGEMENT GROUP LLP (226.07K), Siren, L.L.C. (212.30K), DEERFIELD MANAGEMENT COMPANY, L.P. (170.56K).

69 Institutional Holders

101,208 Total Shares Held

Rows:

Download Data

Owner Name	Date	Shares Held	Change (QoQ)	Change (%)	Value (USD)
JANUS HENDERSON GROUP PLC	31 Dec, 2025	1,317,410	30,042	2.33%	$85,908,306.00
RA CAPITAL MANAGEMENT, L.P.	31 Dec, 2025	667,207	156,000	30.52%	$43,568,617.00
ADAGE CAPITAL PARTNERS GP, L.L.C.	31 Dec, 2025	639,467	-19,728	-2.99%	$41,757,195.00
Saturn V Capital Management LP	31 Dec, 2025	325,701	170,331	109.63%	$21,268,275.00
VANGUARD GROUP INC	31 Dec, 2025	293,816	85,598	41.11%	$19,186,185.00
BlackRock, Inc.	31 Dec, 2025	254,857	51,106	25.08%	$16,642,161.00
ADAR1 Capital Management, LLC	31 Dec, 2025	233,908	103,909	79.93%	$15,274,192.00
WELLINGTON MANAGEMENT GROUP LLP	31 Dec, 2025	226,068	-5,395	-2.33%	$14,762,241.00
Siren, L.L.C.	31 Dec, 2025	212,298	212,298	0.00%	$13,863,059.00
DEERFIELD MANAGEMENT COMPANY, L.P.	31 Dec, 2025	170,558	10,793	6.76%	$11,137,437.00
TCG Crossover Management, LLC	31 Dec, 2025	141,915	-11,085	-7.25%	$9,267,050.00
Polar Capital Holdings Plc	31 Dec, 2025	105,750	105,750	0.00%	$6,905,475.00
GEODE CAPITAL MANAGEMENT, LLC	31 Dec, 2025	99,007	14,046	16.53%	$6,466,445.00
Deep Track Capital, LP	31 Dec, 2025	95,408	95,408	0.00%	$6,230,142.00
Vivo Capital, LLC	31 Dec, 2025	90,500	0	0.00%	$5,909,650.00
STATE STREET CORP	31 Dec, 2025	83,989	11,751	16.27%	$5,484,482.00
MILLENNIUM MANAGEMENT LLC	31 Dec, 2025	76,674	69,340	945.46%	$5,006,812.00
Bank of New York Mellon Corp	31 Dec, 2025	64,857	47,687	277.73%	$4,235,177.00
Alyeska Investment Group, L.P.	31 Dec, 2025	40,000	27,785	227.47%	$2,612,000.00
DRIEHAUS CAPITAL MANAGEMENT LLC	31 Dec, 2025	33,715	-30,921	-47.84%	$2,201,590.00

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