Mineralys Therapeutics, Inc. (MLYS) Institutional Ownership

Institutions by Trading Activity

Ownership Statistics

70,594,504Shares Outstanding

82,243,700Shares held by institutions

$2,129,289,393Value of institutional holdings

116.50%Institutional ownership %

14.44%Shares Changed QoQ

218No. of institutional investors

Shares Owned by Institutions

Shares Purchased/Sold by Institutions

Ownership Summary

Mineralys Therapeutics, Inc. (NASDAQ:MLYS) has 218 institutional investors that have filed 13F reports for the period ending December 2025.

These investors held 114.4% of outstanding shares in December 2025, down from 116.4% in September 2025.
Their total shares held in MLYS increased 13.45% quarter over quarter, and separately, investors owning Mineralys Therapeutics increased 96.4% from a year ago.
Of these 218 funds, 133 grew their exposure to Mineralys Therapeutics, 68 cut back, and 17 maintained positions.
The aggregate institutional position in Mineralys Therapeutics amounted to 80.75Mn shares as of December 2025, up by 9.57Mn shares quarter on quarter, and up 33.48Mn shares year over year.
Pictet Asset Management Holding SA leads ownership in MLYS with 1.03Mn shares as of December 31, 2025, equal to 1.47% of outstanding shares.
The most significant purchases of MLYS for the quarter ending December 2025 came from Pictet Asset Management Holding SA (181.56K), Eleva Capital SAS (17.08K), E Fund Management Co., Ltd. (11.86K), FNY Investment Advisers, LLC (500), GF FUND MANAGEMENT CO. LTD. (222).
The largest sales of MLYS for the quarter ending December 2025 came from SG Americas Securities, LLC (4.96K), IFP Advisors, Inc (7).
Business Quant data shows the 10 biggest positions in Mineralys Therapeutics as of December 2025 are held by Pictet Asset Management Holding SA (1.03Mn), SG Americas Securities, LLC (225.83K), Eleva Capital SAS (17.08K), E Fund Management Co., Ltd. (11.86K), GF FUND MANAGEMENT CO. LTD. (1.78K), Versant Capital Management, Inc (513), FNY Investment Advisers, LLC (500), GAMMA Investing LLC (474), MassMutual Private Wealth & Trust, FSB (319), Sterling Capital Management LLC (306).

218 Institutional Holders

82,243,700 Total Shares Held

Rows:

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Owner Name	Date	Shares Held	Change (QoQ)	Change (%)	Value (USD)
RA CAPITAL MANAGEMENT, L.P.	31 Dec, 2025	7,323,750	0	0.00%	$265,778,888.00
Samsara BioCapital, LLC	31 Dec, 2025	5,871,018	-392,133	-6.26%	$213,059,243.00
FMR LLC	31 Dec, 2025	5,057,509	2,986,254	144.18%	$183,537,002.00
BlackRock, Inc.	31 Dec, 2025	4,327,678	656,064	17.87%	$157,051,434.00
Laurion Capital Management LP	31 Dec, 2025	3,426,970	1,706,525	99.19%	$124,364,742.00
VANGUARD GROUP INC	31 Dec, 2025	3,352,880	333,881	11.06%	$121,676,015.00
State Street Corp	31 Dec, 2025	3,184,999	1,881,976	144.43%	$115,583,614.00
Goldman Sachs Group Inc	31 Dec, 2025	2,901,866	2,190,205	307.76%	$105,308,718.00
Caligan Partners LP	31 Dec, 2025	2,772,654	0	0.00%	$100,619,614.00
Franklin Resources Inc	31 Dec, 2025	1,788,747	-21,021	-1.16%	$64,913,629.00
Holocene Advisors, LP	31 Dec, 2025	1,602,035	396,658	32.91%	$58,137,850.00
Andera Partners	31 Dec, 2025	1,591,917	1,591,917	0.00%	$57,770,668.00
SR ONE CAPITAL MANAGEMENT, LP	31 Dec, 2025	1,563,966	-549,967	-26.02%	$56,756,326.00
SUVRETTA CAPITAL MANAGEMENT, LLC	31 Dec, 2025	1,538,662	-593,471	-27.83%	$55,838,044.00
Polar Capital Holdings Plc	31 Dec, 2025	1,401,141	342,365	32.34%	$50,847,407.00
SAMLYN CAPITAL, LLC	31 Dec, 2025	1,304,932	1,304,932	0.00%	$47,355,982.00
JENNISON ASSOCIATES LLC	31 Dec, 2025	1,258,653	882,307	234.44%	$45,676,517.00
GEODE CAPITAL MANAGEMENT, LLC	31 Dec, 2025	1,257,582	134,171	11.94%	$45,644,788.00
Janus Henderson Group Plc	31 Dec, 2025	1,213,265	1,193,417	6,012.78%	$44,005,122.00
Point72 Asset Management, L.P.	31 Dec, 2025	1,207,220	-592,408	-32.92%	$43,810,014.00

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