Mineralys Therapeutics, Inc. (MLYS) Institutional Ownership

Institutions by Trading Activity

Ownership Statistics

58,089,153Shares Outstanding

10,808,395Shares held by institutions

$301,986,556Value of institutional holdings

139.86%Institutional ownership %

18.13%Shares Changed QoQ

216No. of institutional investors

Shares Owned by Institutions

Shares Purchased/Sold by Institutions

Ownership Summary

According to SEC filings for the period ending December 2025, Mineralys Therapeutics, Inc. (NASDAQ:MLYS) is held by 216 institutional firms.

The collective stake of institutional investors in Mineralys Therapeutics moved to 139.9% in December 2025, a shift up from the 137.5% reported for September 2025.
Quarterly data indicates a 18.13% shift in institutional share volume, and the annual owner count reflects an increase of 94.59%.
A review of institutional activity for Mineralys Therapeutics shows 130 of 216 filers increasing their positions, while 69 reduced their stake, and 17 remained unchanged.
This class of investors increased its holdings in Mineralys Therapeutics to 81.24Mn shares for the 13F-cycle ending December 2025, up by 12.47Mn shares quarter on quarter, and up 34.74Mn shares year over year.
RA CAPITAL MANAGEMENT, L.P.'s holding of 7.32Mn shares as of December 31, 2025 makes it the primary institutional investor in Mineralys Therapeutics, owning 12.61% of the stock.
Among the most significant buyers of Mineralys Therapeutics during December 2025 were FMR LLC (2.99Mn), Caption Management, LLC (2.12Mn), STATE STREET CORP (1.88Mn), Andera Partners (1.59Mn), SAMLYN CAPITAL, LLC (1.30Mn).
Leading sellers of Mineralys Therapeutics stock in December 2025 included CITADEL ADVISORS LLC (1.67Mn), Capital International Investors (1.23Mn), FARALLON CAPITAL MANAGEMENT LLC (849.76K), Integral Health Asset Management, LLC (750.00K), MORGAN STANLEY (737.49K).
The top 10 institutional holders of Mineralys Therapeutics for the quarter ending December 2025 included RA CAPITAL MANAGEMENT, L.P. (7.32Mn), Samsara BioCapital, LLC (5.87Mn), FMR LLC (5.06Mn), BlackRock, Inc. (4.33Mn), VANGUARD GROUP INC (3.35Mn), STATE STREET CORP (3.18Mn), Caligan Partners LP (2.77Mn), Caption Management, LLC (2.45Mn), FRANKLIN RESOURCES INC (1.79Mn), Laurion Capital Management LP (1.71Mn).

216 Institutional Holders

10,808,395 Total Shares Held

Rows:

Download Data

Owner Name	Date	Shares Held	Change (QoQ)	Change (%)	Value (USD)
RA CAPITAL MANAGEMENT, L.P.	31 Dec, 2025	7,323,750	0	0.00%	$265,778,888.00
Samsara BioCapital, LLC	31 Dec, 2025	5,871,018	-392,133	-6.26%	$213,059,243.00
FMR LLC	31 Dec, 2025	5,057,509	2,986,254	144.18%	$183,537,002.00
BlackRock, Inc.	31 Dec, 2025	4,327,678	656,064	17.87%	$157,051,434.00
VANGUARD GROUP INC	31 Dec, 2025	3,352,880	333,881	11.06%	$121,676,015.00
STATE STREET CORP	31 Dec, 2025	3,184,999	1,881,976	144.43%	$115,583,614.00
Caligan Partners LP	31 Dec, 2025	2,772,654	0	0.00%	$100,619,614.00
Caption Management, LLC	31 Dec, 2025	2,449,200	2,116,200	635.50%	$88,881,468.00
FRANKLIN RESOURCES INC	31 Dec, 2025	1,788,747	-21,021	-1.16%	$64,913,629.00
Laurion Capital Management LP	31 Dec, 2025	1,713,485	-6,960	-0.40%	$62,182,371.00
Holocene Advisors, LP	31 Dec, 2025	1,602,035	396,658	32.91%	$58,137,850.00
Andera Partners	31 Dec, 2025	1,591,917	1,591,917	0.00%	$57,770,668.00
SR ONE CAPITAL MANAGEMENT, LP	31 Dec, 2025	1,563,966	-549,967	-26.02%	$56,756,326.00
SUVRETTA CAPITAL MANAGEMENT, LLC	31 Dec, 2025	1,538,662	-593,471	-27.83%	$55,838,044.00
GOLDMAN SACHS GROUP INC	31 Dec, 2025	1,450,933	739,272	103.88%	$52,654,359.00
Polar Capital Holdings Plc	31 Dec, 2025	1,401,141	342,365	32.34%	$50,847,407.00
SAMLYN CAPITAL, LLC	31 Dec, 2025	1,304,932	1,304,932	0.00%	$47,355,982.00
JENNISON ASSOCIATES LLC	31 Dec, 2025	1,258,653	882,307	234.44%	$45,676,517.00
GEODE CAPITAL MANAGEMENT, LLC	31 Dec, 2025	1,257,582	134,171	11.94%	$45,644,788.00
JANUS HENDERSON GROUP PLC	31 Dec, 2025	1,213,265	1,193,417	6,012.78%	$44,005,122.00

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