Mineralys Therapeutics, Inc. (MLYS) Institutional Ownership

Institutions by Trading Activity

Ownership Statistics

0Shares Outstanding

15,321,178Shares held by institutions

$360,047,683Value of institutional holdings

99.92%Institutional ownership %

-1.02%Shares Changed QoQ

165No. of institutional investors

Shares Owned by Institutions

Shares Purchased/Sold by Institutions

Ownership Summary

Mineralys Therapeutics, Inc. (NASDAQ:MLYS) has 218 institutional investors with active 13F positions as of December 2025.

These investors held 114.4% of outstanding shares in December 2025, down from 116.4% in September 2025.
Their total shares held in MLYS increased 13.45% quarter over quarter, and separately, investors owning Mineralys Therapeutics increased 96.4% from a year ago.
Activity in MLYS broke down as 133 buyers, 68 sellers, and 17 unchanged among 218 total holders.
Combined, these investors held 80.75Mn shares in MLYS for December 2025, up by 9.57Mn shares quarter on quarter, and up 33.48Mn shares year over year.
RA CAPITAL MANAGEMENT, L.P. holds the largest position in MLYS at 7.32Mn shares as of December 31, 2025, or 10.37% of shares outstanding.
Top purchasers of MLYS stock for the quarter ending December 2025 included FMR LLC (2.99Mn), State Street Corp (1.88Mn), Laurion Capital Management LP (1.71Mn), Andera Partners (1.59Mn), SAMLYN CAPITAL, LLC (1.3Mn).
The largest sellers of Mineralys Therapeutics for the quarter ending December 2025 were FARALLON CAPITAL MANAGEMENT LLC (2.52Mn), CITADEL ADVISORS LLC (1.67Mn), Capital International Investors (1.23Mn), Integral Health Asset Management, LLC (750.0K), Morgan Stanley (737.49K).
Per Business Quant, the top 10 investors in MLYS for the quarter ending December 2025 include RA CAPITAL MANAGEMENT, L.P. (7.32Mn), Samsara BioCapital, LLC (5.87Mn), FMR LLC (5.06Mn), BlackRock, Inc. (4.33Mn), Laurion Capital Management LP (3.43Mn), VANGUARD GROUP INC (3.35Mn), State Street Corp (3.18Mn), Caligan Partners LP (2.77Mn), Franklin Resources Inc (1.79Mn), Holocene Advisors, LP (1.6Mn).

218 Institutional Holders

15,321,178 Total Shares Held

Rows:

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Owner Name	Date	Change (QoQ)	Change (%)	Value (USD)
BlackRock, Inc.	31 Dec, 2025	656,064	17.87%	$0.00
RA CAPITAL MANAGEMENT, L.P.	31 Dec, 2025	0	0.00%	$0.00
Samsara BioCapital, LLC	31 Dec, 2025	-392,133	-6.26%	$0.00
Barclays Plc	31 Dec, 2025	-468,765	-67.74%	$0.00
FMR LLC	31 Dec, 2025	2,986,254	144.18%	$0.00
Caligan Partners LP	31 Dec, 2025	0	0.00%	$0.00
Rockefeller Capital Management L.P.	31 Dec, 2025	237	764.52%	$0.00
Laurion Capital Management LP	31 Dec, 2025	1,706,525	99.19%	$0.00
Holocene Advisors, LP	31 Dec, 2025	396,658	32.91%	$0.00
VANGUARD GROUP INC	31 Dec, 2025	333,881	11.06%	$0.00
Andera Partners	31 Dec, 2025	1,591,917	0.00%	$0.00
State Street Corp	31 Dec, 2025	1,881,976	144.43%	$0.00
SR ONE CAPITAL MANAGEMENT, LP	31 Dec, 2025	-549,967	-26.02%	$0.00
Franklin Resources Inc	31 Dec, 2025	-21,021	-1.16%	$0.00
Polar Capital Holdings Plc	31 Dec, 2025	342,365	32.34%	$0.00
SUVRETTA CAPITAL MANAGEMENT, LLC	31 Dec, 2025	-593,471	-27.83%	$0.00
Point72 Asset Management, L.P.	31 Dec, 2025	-592,408	-32.92%	$0.00
Goldman Sachs Group Inc	31 Dec, 2025	739,272	103.88%	$0.00
Pictet Asset Management Holding SA	31 Dec, 2025	-76,286	-8.21%	$0.00
SAMLYN CAPITAL, LLC	31 Dec, 2025	1,304,932	0.00%	$0.00

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