Maze Therapeutics, Inc. (MAZE) Institutional Ownership

Institutions by Trading Activity

Ownership Statistics

45,586,364Shares Outstanding

16,116,923Shares held by institutions

$757,011,873Value of institutional holdings

103.07%Institutional ownership %

13.55%Shares Changed QoQ

133No. of institutional investors

Shares Owned by Institutions

Shares Purchased/Sold by Institutions

Ownership Summary

The institutional landscape for Maze Therapeutics, Inc. (NASDAQ:MAZE) includes 133 filers as of the latest reporting cycle ending December 2025.

Institutional ownership in Maze Therapeutics edged up to 103.1% in December 2025, compared to 94.3% in September 2025.
In percentage terms, this reflects as a holdings change of 13.55% quarter on quarter, and an unavailable change year over year.
Of these 133 institutional investors, 97 increased their holdings in Maze Therapeutics, while 19 of them reduced positions, and 17 investors maintained their exposure.
The total number of shares held by institutions in Maze Therapeutics increased to 46.98Mn as of December 2025, a net change of up by 5.61Mn shares quarter on quarter, and down N/A shares year over year.
The top institutional stake in Maze Therapeutics as of December 31, 2025 belongs to Frazier Life Sciences Management, L.P., which owns 4.57Mn shares, or 10.02% of the company.
Among the most significant buyers of Maze Therapeutics during December 2025 were JANUS HENDERSON GROUP PLC (2.39Mn), BlackRock, Inc. (971.14K), Bellevue Group AG (887.71K), Caligan Partners LP (550.19K), Squadron Capital Management LLC (490.00K).
Leading sellers of Maze Therapeutics stock in December 2025 included TRV GP IV, LLC (1.60Mn), Matrix Capital Management Company, LP (1.17Mn), Alphabet Inc. (1.02Mn), Logos Global Management LP (277.30K), BALYASNY ASSET MANAGEMENT L.P. (234.51K).
The top 10 institutional holders of Maze Therapeutics for the quarter ending December 2025 included Frazier Life Sciences Management, L.P. (4.57Mn), TRV GP IV, LLC (4.47Mn), Deep Track Capital, LP (4.25Mn), ARCH Venture Management, LLC (4.12Mn), JANUS HENDERSON GROUP PLC (3.14Mn), BlackRock, Inc. (2.29Mn), a16z Capital Management, L.L.C. (1.70Mn), VANGUARD GROUP INC (1.70Mn), VR Adviser, LLC (1.55Mn), Alphabet Inc. (1.39Mn).

133 Institutional Holders

16,116,923 Total Shares Held

Rows:

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Owner Name	Date	Shares Held	Change (QoQ)	Change (%)	Value (USD)
Frazier Life Sciences Management, L.P.	31 Dec, 2025	4,567,274	0	0.00%	$189,222,162.00
TRV GP IV, LLC	31 Dec, 2025	4,473,958	-1,600,000	-26.34%	$185,356,080.00
Deep Track Capital, LP	31 Dec, 2025	4,246,440	297,530	7.53%	$175,930,009.00
ARCH Venture Management, LLC	31 Dec, 2025	4,120,053	0	0.00%	$170,693,796.00
JANUS HENDERSON GROUP PLC	31 Dec, 2025	3,142,587	2,390,713	317.97%	$130,197,379.00
BlackRock, Inc.	31 Dec, 2025	2,287,155	971,139	73.79%	$94,756,831.00
a16z Capital Management, L.L.C.	31 Dec, 2025	1,702,225	0	0.00%	$70,523,182.00
VANGUARD GROUP INC	31 Dec, 2025	1,697,015	362,060	27.12%	$70,307,332.00
VR Adviser, LLC	31 Dec, 2025	1,548,569	317,800	25.82%	$64,157,214.00
Alphabet Inc.	31 Dec, 2025	1,388,583	-1,023,888	-42.44%	$57,528,994.00
General Catalyst Group Management, LLC	31 Dec, 2025	1,035,910	0	0.00%	$42,917,751.00
Woodline Partners LP	31 Dec, 2025	1,035,229	0	0.00%	$42,889,537.00
TRV GP V, LLC	31 Dec, 2025	950,800	0	0.00%	$39,391,644.00
Logos Global Management LP	31 Dec, 2025	950,000	-277,300	-22.59%	$39,358,500.00
Bellevue Group AG	31 Dec, 2025	887,708	887,708	0.00%	$36,777,742.00
MARSHALL WACE, LLP	31 Dec, 2025	847,472	69,771	8.97%	$35,110,765.00
ArrowMark Colorado Holdings LLC	31 Dec, 2025	767,383	222,251	40.77%	$31,792,678.00
Casdin Capital, LLC	31 Dec, 2025	758,857	0	0.00%	$31,439,446.00
FMR LLC	31 Dec, 2025	728,605	72,991	11.13%	$30,186,105.00
Caligan Partners LP	31 Dec, 2025	550,191	550,191	0.00%	$22,794,413.00

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