Lexeo Therapeutics, Inc. (LXEO) Institutional Ownership

Institutions by Trading Activity

Ownership Statistics

0Shares Outstanding

3,759,681Shares held by institutions

$19,794,720Value of institutional holdings

89.09%Institutional ownership %

60.53%Shares Changed QoQ

88No. of institutional investors

Shares Owned by Institutions

Shares Purchased/Sold by Institutions

Ownership Summary

Lexeo Therapeutics, Inc. (NASDAQ:LXEO) is held by 141 institutional investors per 13F filings through December 2025.

Collectively, these holders controlled 127.6% of Lexeo Therapeutics's outstanding shares in December 2025, up from 81.0% in September 2025.
They increased total shares held in Lexeo Therapeutics by 61.68% from last quarter, and the number of investors in LXEO increased 56.67% annually.
Among the 141 funds, 105 bought more Lexeo Therapeutics shares, 25 sold down, and 11 held their ground.
Combined, these investors held 77.81Mn shares in LXEO for December 2025, up by 29.68Mn shares quarter on quarter, and up 48.17Mn shares year over year.
Janus Henderson Group Plc holds the largest position in LXEO at 5.51Mn shares as of December 31, 2025, or 9.04% of shares outstanding.
The largest buyers of Lexeo Therapeutics for the quarter ending December 2025 were RA CAPITAL MANAGEMENT, L.P. (5.0Mn), Paradigm Biocapital Advisors LP (4.76Mn), Avoro Capital Advisors LLC (3.3Mn), BlackRock, Inc. (2.74Mn), State Street Corp (2.64Mn).
The biggest sellers of Lexeo Therapeutics for the quarter ending December 2025 included BALYASNY ASSET MANAGEMENT L.P. (2.28Mn), MILLENNIUM MANAGEMENT LLC (1.41Mn), Affinity Asset Advisors, LLC (670.53K), Janus Henderson Group Plc (595.89K), Blackstone Inc. (219.96K).
According to Business Quant data, leading holders of LXEO for December 2025 are Janus Henderson Group Plc (5.51Mn), RA CAPITAL MANAGEMENT, L.P. (5.0Mn), BlackRock, Inc. (4.91Mn), Paradigm Biocapital Advisors LP (4.76Mn), Vestal Point Capital, LP (4.47Mn), Frazier Life Sciences Management, L.P. (4.42Mn), VANGUARD GROUP INC (3.89Mn), CITADEL ADVISORS LLC (3.77Mn), Avoro Capital Advisors LLC (3.3Mn), Affinity Asset Advisors, LLC (3.2Mn).

141 Institutional Holders

3,759,681 Total Shares Held

Rows:

Download Data

Owner Name	Date	Change (QoQ)	Change (%)	Value (USD)
BlackRock, Inc.	31 Dec, 2025	2,736,471	126.04%	$0.00
Janus Henderson Group Plc	31 Dec, 2025	-595,892	-9.76%	$0.00
Paradigm Biocapital Advisors LP	31 Dec, 2025	4,763,198	0.00%	$0.00
Avoro Capital Advisors LLC	31 Dec, 2025	6,600,000	0.00%	$0.00
RA CAPITAL MANAGEMENT, L.P.	31 Dec, 2025	5,000,000	0.00%	$0.00
Vestal Point Capital, LP	31 Dec, 2025	1,225,000	37.69%	$0.00
Barclays Plc	31 Dec, 2025	26,965	16.67%	$0.00
VANGUARD GROUP INC	31 Dec, 2025	1,668,020	74.92%	$0.00
Frazier Life Sciences Management, L.P.	31 Dec, 2025	0	0.00%	$0.00
Rockefeller Capital Management L.P.	31 Dec, 2025	1,200	600.00%	$0.00
CITADEL ADVISORS LLC	31 Dec, 2025	55,274	1.49%	$0.00
State Street Corp	31 Dec, 2025	2,642,877	485.07%	$0.00
Affinity Asset Advisors, LLC	31 Dec, 2025	-670,527	-17.32%	$0.00
ORBIMED ADVISORS LLC	31 Dec, 2025	2,125,000	0.00%	$0.00
Woodline Partners LP	31 Dec, 2025	625,598	24.32%	$0.00
BALYASNY ASSET MANAGEMENT L.P.	31 Dec, 2025	-2,278,762	-58.22%	$0.00
ADAR1 Capital Management, LLC	31 Dec, 2025	1,254,369	81.88%	$0.00
GEODE CAPITAL MANAGEMENT, LLC	31 Dec, 2025	724,006	100.29%	$0.00
Point72 Asset Management, L.P.	31 Dec, 2025	-47,127	-2.43%	$0.00
SUVRETTA CAPITAL MANAGEMENT, LLC	31 Dec, 2025	1,250,000	0.00%	$0.00

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