Lexeo Therapeutics, Inc. (LXEO) Institutional Ownership

Institutions by Trading Activity

Ownership Statistics

60,980,867Shares Outstanding

81,912,812Shares held by institutions

$448,063,082Value of institutional holdings

134.33%Institutional ownership %

69.63%Shares Changed QoQ

141No. of institutional investors

Shares Owned by Institutions

Shares Purchased/Sold by Institutions

Ownership Summary

Lexeo Therapeutics, Inc. (NASDAQ:LXEO) showed up in the 13F filings of 141 institutional investors as of December 2025.

These investors collectively held 127.6% of Lexeo Therapeutics's outstanding shares in December 2025, up from 81.0% in September 2025.
They increased total shares held in Lexeo Therapeutics by 61.68% from the prior quarter, while the number of investors in LXEO increased 56.67% year over year.
Of these 141 funds, 105 grew their exposure to Lexeo Therapeutics, 25 cut back, and 11 maintained positions.
Altogether, these fund groups held 77.81Mn shares in LXEO by December 2025, up by 29.68Mn shares quarter on quarter, and up 48.17Mn shares year over year.
WEALTH ENHANCEMENT ADVISORY SERVICES, LLC holds the largest position in LXEO at 15.99K shares as of December 31, 2025, or 0.03% of shares outstanding.
The most significant purchases of LXEO for the quarter ending December 2025 came from WEALTH ENHANCEMENT ADVISORY SERVICES, LLC (15.99K), E Fund Management Co., Ltd. (12.68K), GAMMA Investing LLC (281), Key FInancial Inc (200), GF FUND MANAGEMENT CO. LTD. (194).
Leading sellers of Lexeo Therapeutics shares for the quarter ending December 2025 were Sterling Capital Management LLC (1.44K), SIGNATUREFD, LLC (90).
Per Business Quant, the top 10 investors in LXEO for the quarter ending December 2025 include WEALTH ENHANCEMENT ADVISORY SERVICES, LLC (15.99K), E Fund Management Co., Ltd. (12.68K), Sterling Capital Management LLC (2.19K), GF FUND MANAGEMENT CO. LTD. (1.63K), GAMMA Investing LLC (331), True Wealth Design, LLC (226), Fortitude Family Office, LLC (205), IFP Advisors, Inc (203), SIGNATUREFD, LLC (200), Key FInancial Inc (200).

141 Institutional Holders

81,912,812 Total Shares Held

Rows:

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Owner Name	Date	Shares Held	Change (QoQ)	Change (%)	Value (USD)
Avoro Capital Advisors LLC	31 Dec, 2025	6,600,000	6,600,000	0.00%	$65,538,000.00
Janus Henderson Group Plc	31 Dec, 2025	5,509,635	-595,892	-9.76%	$54,668,943.00
RA CAPITAL MANAGEMENT, L.P.	31 Dec, 2025	5,000,000	5,000,000	0.00%	$49,650,000.00
BlackRock, Inc.	31 Dec, 2025	4,907,563	2,736,471	126.04%	$48,732,100.00
Paradigm Biocapital Advisors LP	31 Dec, 2025	4,763,198	4,763,198	0.00%	$47,298,556.00
Vestal Point Capital, LP	31 Dec, 2025	4,475,000	1,225,000	37.69%	$44,436,750.00
Frazier Life Sciences Management, L.P.	31 Dec, 2025	4,424,725	0	0.00%	$43,937,519.00
VANGUARD GROUP INC	31 Dec, 2025	3,894,310	1,668,020	74.92%	$38,670,499.00
CITADEL ADVISORS LLC	31 Dec, 2025	3,774,317	55,274	1.49%	$37,478,968.00
Affinity Asset Advisors, LLC	31 Dec, 2025	3,200,000	-670,527	-17.32%	$31,776,000.00
Woodline Partners LP	31 Dec, 2025	3,197,760	625,598	24.32%	$31,753,757.00
State Street Corp	31 Dec, 2025	3,187,722	2,642,877	485.07%	$31,654,079.00
ADAR1 Capital Management, LLC	31 Dec, 2025	2,786,322	1,254,369	81.88%	$27,668,178.00
ORBIMED ADVISORS LLC	31 Dec, 2025	2,125,000	2,125,000	0.00%	$21,101,250.00
Point72 Asset Management, L.P.	31 Dec, 2025	1,894,722	-47,127	-2.43%	$18,814,589.00
Octagon Capital Advisors LP	31 Dec, 2025	1,725,000	1,725,000	0.00%	$17,129,250.00
BALYASNY ASSET MANAGEMENT L.P.	31 Dec, 2025	1,635,026	-2,278,762	-58.22%	$16,235,808.00
Goldman Sachs Group Inc	31 Dec, 2025	1,563,710	1,421,308	998.10%	$15,527,640.00
GEODE CAPITAL MANAGEMENT, LLC	31 Dec, 2025	1,445,887	724,006	100.29%	$14,361,075.00
SUVRETTA CAPITAL MANAGEMENT, LLC	31 Dec, 2025	1,250,000	1,250,000	0.00%	$12,412,500.00

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