Krystal Biotech, Inc. (KRYS) Institutional Ownership

Institutions by Trading Activity

Ownership Statistics

30,235,294Shares Outstanding

310,791Shares held by institutions

$89,458,081Value of institutional holdings

92.16%Institutional ownership %

2.15%Shares Changed QoQ

317No. of institutional investors

Shares Owned by Institutions

Shares Purchased/Sold by Institutions

Ownership Summary

According to SEC filings for the period ending December 2025, Krystal Biotech, Inc. (NASDAQ:KRYS) is held by 317 institutional firms.

The collective stake of institutional investors in Krystal Biotech moved to 92.2% in December 2025, a shift down from the 94.6% reported for September 2025.
Institutional share ownership changed by 2.15% QoQ, while the number of institutional owners saw an increase of 21.92% YoY.
A review of institutional activity for Krystal Biotech shows 184 of 317 filers increasing their positions, while 99 reduced their stake, and 34 remained unchanged.
Collectively, institutional investors increased their stake in Krystal Biotech to 27.86Mn shares as of December 2025, a change that is up by 587.18K shares quarter on quarter and down 40.34K shares year over year.
As of December 31, 2025, FMR LLC held Krystal Biotech's largest shareholding position with over 4.35Mn shares, representing 14.39% of total outstanding shares.
Among the most significant buyers of Krystal Biotech during December 2025 were Bellevue Group AG (409.01K), NORGES BANK (284.57K), WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC (227.04K), JANUS HENDERSON GROUP PLC (209.37K), Avoro Capital Advisors LLC (111.11K).
Leading sellers of Krystal Biotech stock in December 2025 included BRAIDWELL LP (318.30K), CITADEL ADVISORS LLC (250.48K), Frazier Life Sciences Management, L.P. (200.00K), UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC (168.97K), MILLENNIUM MANAGEMENT LLC (134.06K).
The top 10 institutional holders of Krystal Biotech for the quarter ending December 2025 included FMR LLC (4.35Mn), BlackRock, Inc. (3.94Mn), Avoro Capital Advisors LLC (2.89Mn), VANGUARD GROUP INC (2.78Mn), STATE STREET CORP (1.34Mn), Soleus Capital Management, L.P. (941.06K), Capital World Investors (809.50K), Redmile Group, LLC (677.71K), Hood River Capital Management LLC (613.30K), GEODE CAPITAL MANAGEMENT, LLC (611.88K).

317 Institutional Holders

310,791 Total Shares Held

Rows:

Download Data

Owner Name	Date	Shares Held	Change (QoQ)	Change (%)	Value (USD)
FMR LLC	31 Dec, 2025	4,349,628	8,181	0.19%	$1,072,357,209.00
BlackRock, Inc.	31 Dec, 2025	3,937,817	103,689	2.70%	$970,829,404.00
Avoro Capital Advisors LLC	31 Dec, 2025	2,888,888	111,111	4.00%	$712,226,448.00
VANGUARD GROUP INC	31 Dec, 2025	2,778,845	-13,363	-0.48%	$685,096,446.00
STATE STREET CORP	31 Dec, 2025	1,342,303	-53,664	-3.84%	$330,931,382.00
Soleus Capital Management, L.P.	31 Dec, 2025	941,059	-77,772	-7.63%	$232,008,686.00
Capital World Investors	31 Dec, 2025	809,500	260	0.03%	$199,574,130.00
Redmile Group, LLC	31 Dec, 2025	677,705	16,317	2.47%	$167,081,391.00
Hood River Capital Management LLC	31 Dec, 2025	613,302	6,356	1.05%	$151,203,475.00
GEODE CAPITAL MANAGEMENT, LLC	31 Dec, 2025	611,878	634	0.10%	$150,878,011.00
DIMENSIONAL FUND ADVISORS LP	31 Dec, 2025	492,968	-40,996	-7.68%	$121,538,226.00
Frazier Life Sciences Management, L.P.	31 Dec, 2025	488,460	-200,000	-29.05%	$120,424,928.00
Bellevue Group AG	31 Dec, 2025	410,323	409,011	31,174.62%	$101,161,033.00
CITADEL ADVISORS LLC	31 Dec, 2025	386,505	-250,483	-39.32%	$95,288,943.00
WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC	31 Dec, 2025	376,340	227,038	152.07%	$92,782,864.00
GOLDMAN SACHS GROUP INC	31 Dec, 2025	293,525	-54,725	-15.71%	$72,365,654.00
NORGES BANK	31 Dec, 2025	284,573	284,573	0.00%	$70,158,627.00
NORTHERN TRUST CORP	31 Dec, 2025	247,443	-722	-0.29%	$61,004,597.00
FIRST TRUST ADVISORS LP	31 Dec, 2025	245,276	-3,116	-1.25%	$60,470,345.00
CHARLES SCHWAB INVESTMENT MANAGEMENT INC	31 Dec, 2025	242,774	-89	-0.04%	$59,853,502.00

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