Krystal Biotech, Inc. (KRYS) Institutional Ownership

Institutions by Trading Activity

Ownership Statistics

29,951,000Shares Outstanding

31,141,503Shares held by institutions

$8,175,111,660Value of institutional holdings

103.97%Institutional ownership %

12.27%Shares Changed QoQ

326No. of institutional investors

Shares Owned by Institutions

Shares Purchased/Sold by Institutions

Ownership Summary

Krystal Biotech, Inc. (NASDAQ:KRYS) showed up in the 13F filings of 326 institutional investors as of December 2025.

Their combined ownership stood at 93.3% of outstanding shares in December 2025, down from 94.9% in September 2025.
Their total shares held in KRYS increased 1.26% quarter over quarter, and separately, investors owning Krystal Biotech increased 25.38% from a year ago.
Among the 326 funds, 188 bought more Krystal Biotech shares, 104 sold down, and 34 held their ground.
In total, institutional investors held 27.96Mn shares in Krystal Biotech as of December 2025, up by 348.91K shares quarter on quarter, and down 452.57K shares year over year.
Avoro Capital Advisors LLC leads ownership in KRYS with 5.78Mn shares as of December 31, 2025, equal to 19.29% of outstanding shares.
The most significant purchases of KRYS for the quarter ending December 2025 came from Avoro Capital Advisors LLC (3.0Mn), Bellevue Group AG (409.01K), NORGES BANK (284.57K), Goldman Sachs Group Inc (238.8K), WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC (227.04K).
Top sellers of KRYS stock for the quarter ending December 2025 included BRAIDWELL LP (318.3K), CITADEL ADVISORS LLC (250.48K), Frazier Life Sciences Management, L.P. (200.0K), UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC (168.97K), Jpmorgan Chase & Co (158.08K).
Per Business Quant, the top 10 investors in KRYS for the quarter ending December 2025 include Avoro Capital Advisors LLC (5.78Mn), FMR LLC (4.35Mn), BlackRock, Inc. (3.94Mn), VANGUARD GROUP INC (2.78Mn), State Street Corp (1.34Mn), Soleus Capital Management, L.P. (941.06K), Capital World Investors (809.5K), Redmile Group, LLC (677.7K), Hood River Capital Management LLC (613.3K), GEODE CAPITAL MANAGEMENT, LLC (611.88K).

326 Institutional Holders

31,141,503 Total Shares Held

Rows:

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Owner Name	Date	Shares Held	Change (QoQ)	Change (%)	Value (USD)
Avoro Capital Advisors LLC	31 Dec, 2025	5,777,776	2,999,999	108.00%	$1,424,452,896.00
FMR LLC	31 Dec, 2025	4,349,628	8,181	0.19%	$1,072,357,209.00
BlackRock, Inc.	31 Dec, 2025	3,937,817	103,689	2.70%	$970,829,404.00
VANGUARD GROUP INC	31 Dec, 2025	2,778,845	-13,363	-0.48%	$685,096,446.00
State Street Corp	31 Dec, 2025	1,342,303	-53,664	-3.84%	$330,931,382.00
Soleus Capital Management, L.P.	31 Dec, 2025	941,059	-77,772	-7.63%	$232,008,686.00
Capital World Investors	31 Dec, 2025	809,500	260	0.03%	$199,574,130.00
Redmile Group, LLC	31 Dec, 2025	677,705	16,317	2.47%	$167,081,391.00
Hood River Capital Management LLC	31 Dec, 2025	613,302	6,356	1.05%	$151,203,475.00
GEODE CAPITAL MANAGEMENT, LLC	31 Dec, 2025	611,878	634	0.10%	$150,878,011.00
Goldman Sachs Group Inc	31 Dec, 2025	587,050	238,800	68.57%	$144,731,308.00
DIMENSIONAL FUND ADVISORS LP	31 Dec, 2025	492,968	-40,996	-7.68%	$121,538,226.00
Frazier Life Sciences Management, L.P.	31 Dec, 2025	488,460	-200,000	-29.05%	$120,424,928.00
Bellevue Group AG	31 Dec, 2025	410,323	409,011	31,174.62%	$101,161,033.00
CITADEL ADVISORS LLC	31 Dec, 2025	386,505	-250,483	-39.32%	$95,288,943.00
WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC	31 Dec, 2025	376,340	227,038	152.07%	$92,782,864.00
NORGES BANK	31 Dec, 2025	284,573	284,573	0.00%	$70,158,627.00
Northern Trust Corp	31 Dec, 2025	247,443	-722	-0.29%	$61,004,597.00
FIRST TRUST ADVISORS LP	31 Dec, 2025	245,276	-3,116	-1.25%	$60,470,345.00
CHARLES SCHWAB INVESTMENT MANAGEMENT INC	31 Dec, 2025	242,774	-89	-0.04%	$59,853,502.00

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