Opus Genetics, Inc. (IRD) Institutional Ownership

Ownership Summary

Opus Genetics, Inc. (NASDAQ:IRD) showed up in the 13F filings of 59 institutional investors as of December 2025.

• Collectively, these holders controlled 39.5% of Opus Genetics's outstanding shares in December 2025, up from 27.6% in September 2025.
• Their total shares held in IRD increased 43.31% from the prior quarter, while the number of investors in Opus Genetics increased 34.09% year over year.
• Activity in IRD broke down as 37 buyers, 7 sellers, and 15 unchanged among 59 total holders.
• In total, institutional investors held 27.89Mn shares in Opus Genetics as of December 2025, up by 8.43Mn shares quarter on quarter, and up 21.63Mn shares year over year.
• As of December 31, 2025, the biggest holder of Opus Genetics is Caligan Partners LP at 6.08Mn shares, representing 8.6% of shares outstanding.
• The biggest buyers of Opus Genetics for the quarter ending December 2025 included Caligan Partners LP (6.08Mn), ADAGE CAPITAL PARTNERS GP, L.L.C. (4.92Mn), VANGUARD CAPITAL MANAGEMENT LLC (2.45Mn), Boxer Capital Management, LLC (2.25Mn), MARSHALL WACE, LLP (2.16Mn).
• Top sellers of IRD stock for the quarter ending December 2025 included Nantahala Capital Management, LLC (3.1Mn), PERCEPTIVE ADVISORS LLC (2.49Mn), Opaleye Management Inc. (1.12Mn), Mink Brook Asset Management LLC (1.08Mn), Wells Fargo & Company/Mn (238.09K).
• Opus Genetics's 10 largest shareholders as of December 2025 include Caligan Partners LP (6.08Mn), ADAGE CAPITAL PARTNERS GP, L.L.C. (6.03Mn), BIOS Capital Management, LP (3.68Mn), BALYASNY ASSET MANAGEMENT L.P. (2.72Mn), MILLENNIUM MANAGEMENT LLC (2.63Mn), VANGUARD CAPITAL MANAGEMENT LLC (2.45Mn), MARSHALL WACE, LLP (2.31Mn), Boxer Capital Management, LLC (2.25Mn), ADAR1 Capital Management, LLC (1.85Mn), PERCEPTIVE ADVISORS LLC (1.84Mn) per Business Quant data.