Opus Genetics, Inc. (IRD) Institutional Ownership

Ownership Summary

Opus Genetics, Inc. (NASDAQ:IRD) has 59 institutional investors with active 13F positions as of December 2025.

• These investors held 39.5% of outstanding shares in December 2025, up from 27.6% in September 2025.
• Their total shares held in IRD increased 43.31% from the prior quarter, while the number of investors in Opus Genetics increased 34.09% year over year.
• Of these 59 funds, 37 grew their exposure to Opus Genetics, 7 cut back, and 15 maintained positions.
• Combined, these investors held 27.89Mn shares in IRD for December 2025, up by 8.43Mn shares quarter on quarter, and up 21.63Mn shares year over year.
• Caligan Partners LP is the top holder of Opus Genetics as of December 31, 2025, with 6.08Mn shares representing 8.6% of outstanding stock.
• The largest buyers of Opus Genetics for the quarter ending December 2025 were Caligan Partners LP (6.08Mn), ADAGE CAPITAL PARTNERS GP, L.L.C. (4.92Mn), VANGUARD CAPITAL MANAGEMENT LLC (2.45Mn), Boxer Capital Management, LLC (2.25Mn), MARSHALL WACE, LLP (2.16Mn).
• Top sellers of IRD stock for the quarter ending December 2025 included Nantahala Capital Management, LLC (3.1Mn), PERCEPTIVE ADVISORS LLC (2.49Mn), Opaleye Management Inc. (1.12Mn), Mink Brook Asset Management LLC (1.08Mn), Wells Fargo & Company/Mn (238.09K).
• Opus Genetics's 10 largest shareholders as of December 2025 include Caligan Partners LP (6.08Mn), ADAGE CAPITAL PARTNERS GP, L.L.C. (6.03Mn), BIOS Capital Management, LP (3.68Mn), BALYASNY ASSET MANAGEMENT L.P. (2.72Mn), MILLENNIUM MANAGEMENT LLC (2.63Mn), VANGUARD CAPITAL MANAGEMENT LLC (2.45Mn), MARSHALL WACE, LLP (2.31Mn), Boxer Capital Management, LLC (2.25Mn), ADAR1 Capital Management, LLC (1.85Mn), PERCEPTIVE ADVISORS LLC (1.84Mn) per Business Quant data.