Structure Therapeutics Inc. (GPCR) Institutional Ownership

Ownership Summary

Structure Therapeutics Inc. (NASDAQ:GPCR) has 192 institutional investors with active 13F positions as of December 2025.

• These investors collectively held 36.0% of Structure Therapeutics's outstanding shares in December 2025, up from 32.3% in September 2025.
• Their total shares held in GPCR increased 20.82% quarter over quarter, and separately, investors owning Structure Therapeutics increased 17.79% from a year ago.
• During the quarter, 119 of these 192 funds increased positions in GPCR, 61 reduced exposure, and 12 held steady.
• In total, institutional investors held 63.16Mn shares in Structure Therapeutics as of December 2025, up by 10.88Mn shares quarter on quarter, and up 2.3Mn shares year over year.
• FMR LLC holds the largest position in GPCR at 8.4Mn shares as of December 31, 2025, or 4.79% of shares outstanding.
• Top purchasers of GPCR stock for the quarter ending December 2025 included PRICE T ROWE ASSOCIATES INC /MD/ (2.0Mn), CAPITOLIS LIQUID GLOBAL MARKETS LLC (1.15Mn), AMERICAN CENTURY COMPANIES INC (931.07K), Paradigm Biocapital Advisors LP (545.29K), Principal Financial Group Inc (469.55K).
• Leading sellers of Structure Therapeutics shares for the quarter ending December 2025 were Avoro Capital Advisors LLC (6.56Mn), TCG Crossover Management, LLC (780.45K), DEUTSCHE BANK AG\ (509.3K), Franklin Resources Inc (338.99K), FMR LLC (308.8K).
• Business Quant data shows the 10 biggest positions in Structure Therapeutics as of December 2025 are held by FMR LLC (8.4Mn), WELLINGTON MANAGEMENT GROUP LLP (7.26Mn), Avoro Capital Advisors LLC (6.56Mn), Janus Henderson Group Plc (5.51Mn), Deep Track Capital, LP (4.28Mn), BVF INC/IL (3.46Mn), Morgan Stanley (2.31Mn), PRICE T ROWE ASSOCIATES INC /MD/ (2.0Mn), Principal Financial Group Inc (1.75Mn), DRIEHAUS CAPITAL MANAGEMENT LLC (1.58Mn).