Structure Therapeutics Inc. (GPCR) Institutional Ownership

Ownership Summary

Structure Therapeutics Inc. (NASDAQ:GPCR) showed up in the 13F filings of 192 institutional investors as of December 2025.

• These investors held 36.0% of outstanding shares in December 2025, up from 32.3% in September 2025.
• Their total shares held in GPCR increased 20.82% from the prior quarter, while the number of investors in Structure Therapeutics increased 17.79% year over year.
• Of these 192 holders, 119 added to their stakes in Structure Therapeutics, 61 trimmed positions, and 12 made no changes.
• Altogether, these fund groups held 63.16Mn shares in GPCR by December 2025, up by 10.88Mn shares quarter on quarter, and up 2.3Mn shares year over year.
• FMR LLC leads ownership in GPCR with 8.4Mn shares as of December 31, 2025, equal to 4.79% of outstanding shares.
• The largest buyers of Structure Therapeutics for the quarter ending December 2025 were PRICE T ROWE ASSOCIATES INC /MD/ (2.0Mn), CAPITOLIS LIQUID GLOBAL MARKETS LLC (1.15Mn), AMERICAN CENTURY COMPANIES INC (931.07K), Paradigm Biocapital Advisors LP (545.29K), Principal Financial Group Inc (469.55K).
• The biggest sellers of Structure Therapeutics for the quarter ending December 2025 included Avoro Capital Advisors LLC (6.56Mn), TCG Crossover Management, LLC (780.45K), DEUTSCHE BANK AG\ (509.3K), Franklin Resources Inc (338.99K), FMR LLC (308.8K).
• Business Quant data shows the 10 biggest positions in Structure Therapeutics as of December 2025 are held by FMR LLC (8.4Mn), WELLINGTON MANAGEMENT GROUP LLP (7.26Mn), Avoro Capital Advisors LLC (6.56Mn), Janus Henderson Group Plc (5.51Mn), Deep Track Capital, LP (4.28Mn), BVF INC/IL (3.46Mn), Morgan Stanley (2.31Mn), PRICE T ROWE ASSOCIATES INC /MD/ (2.0Mn), Principal Financial Group Inc (1.75Mn), DRIEHAUS CAPITAL MANAGEMENT LLC (1.58Mn).