Structure Therapeutics Inc. (GPCR) Institutional Ownership

Institutions by Trading Activity

Ownership Statistics

0Shares Outstanding

5,908,523Shares held by institutions

$259,738,671Value of institutional holdings

30.42%Institutional ownership %

3.06%Shares Changed QoQ

170No. of institutional investors

Shares Owned by Institutions

Shares Purchased/Sold by Institutions

Ownership Summary

Structure Therapeutics Inc. (NASDAQ:GPCR) is held by 192 institutional investors per 13F filings through December 2025.

They owned 36.0% of outstanding stock in December 2025, up from 32.3% the prior quarter.
They increased total shares held in Structure Therapeutics by 20.82% from last quarter, and the number of investors in GPCR increased 17.79% annually.
Of these 192 funds, 119 grew their exposure to Structure Therapeutics, 61 cut back, and 12 maintained positions.
The aggregate institutional position in Structure Therapeutics amounted to 63.16Mn shares as of December 2025, up by 10.88Mn shares quarter on quarter, and up 2.3Mn shares year over year.
FMR LLC is the top holder of Structure Therapeutics as of December 31, 2025, with 8.71Mn shares representing 4.97% of outstanding stock.
The biggest buyers of Structure Therapeutics for the quarter ending December 2025 included FMR LLC (3.46Mn), Morgan Stanley (1.51Mn), WELLINGTON MANAGEMENT GROUP LLP (1.43Mn), Avoro Capital Advisors LLC (1.4Mn), DEUTSCHE BANK AG\ (841.16K).
The largest sellers of Structure Therapeutics for the quarter ending December 2025 were MILLENNIUM MANAGEMENT LLC (1.12Mn), Ameriprise Financial Inc (938.63K), Invesco Ltd. (440.54K), Catalio Capital Management, LP (398.91K), Casdin Capital, LLC (380.0K).
Per Business Quant data, the top 10 holders of Structure Therapeutics for the quarter ending December 2025 are FMR LLC (8.71Mn), WELLINGTON MANAGEMENT GROUP LLP (7.12Mn), Avoro Capital Advisors LLC (6.56Mn), Janus Henderson Group Plc (5.09Mn), Deep Track Capital, LP (4.11Mn), BVF INC/IL (3.48Mn), Morgan Stanley (2.09Mn), DRIEHAUS CAPITAL MANAGEMENT LLC (1.64Mn), BAKER BROS. ADVISORS LP (1.43Mn), Principal Financial Group Inc (1.28Mn).

192 Institutional Holders

5,908,523 Total Shares Held

Rows:

Download Data

Owner Name	Date	Change (QoQ)	Change (%)	Value (USD)
BlackRock, Inc.	31 Dec, 2025	166,144	62.95%	$0.00
FMR LLC	31 Dec, 2025	3,461,883	65.94%	$0.00
Avoro Capital Advisors LLC	31 Dec, 2025	7,955,555	154.31%	$0.00
WELLINGTON MANAGEMENT GROUP LLP	31 Dec, 2025	1,432,797	25.18%	$0.00
Deep Track Capital, LP	31 Dec, 2025	-104,029	-2.47%	$0.00
PEAK6 LLC	31 Dec, 2025	4,910	44.64%	$0.00
Janus Henderson Group Plc	31 Dec, 2025	641,322	14.42%	$0.00
Siren, L.L.C.	31 Dec, 2025	51,887	5.05%	$0.00
Barclays Plc	31 Dec, 2025	-77,078	-90.78%	$0.00
BVF INC/IL	31 Dec, 2025	275,105	8.59%	$0.00
TCG Crossover Management, LLC	31 Dec, 2025	-142,143	-13.37%	$0.00
Rockefeller Capital Management L.P.	31 Dec, 2025	720	97.04%	$0.00
Morgan Stanley	31 Dec, 2025	1,510,093	261.38%	$0.00
Logos Global Management LP	31 Dec, 2025	-250,000	-29.41%	$0.00
DRIEHAUS CAPITAL MANAGEMENT LLC	31 Dec, 2025	768,940	88.03%	$0.00
STEMPOINT CAPITAL LP	31 Dec, 2025	221,738	171.44%	$0.00
BAKER BROS. ADVISORS LP	31 Dec, 2025	-123,580	-7.94%	$0.00
Aberdeen Group plc	31 Dec, 2025	-322,000	-54.87%	$0.00
Principal Financial Group Inc	31 Dec, 2025	496,726	63.08%	$0.00
Catalio Capital Management, LP	31 Dec, 2025	-398,909	-61.20%	$0.00

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