Structure Therapeutics Inc. (GPCR) Institutional Ownership

Institutions by Trading Activity

Ownership Statistics

172,793,818Shares Outstanding

4,377,488Shares held by institutions

$293,554,345Value of institutional holdings

33.12%Institutional ownership %

5.81%Shares Changed QoQ

157No. of institutional investors

Shares Owned by Institutions

Shares Purchased/Sold by Institutions

Ownership Summary

The institutional landscape for Structure Therapeutics Inc. (NASDAQ:GPCR) includes 157 filers as of the latest reporting cycle ending September 2025.

These investors collectively held 33.1% of the company's total shares outstanding in September 2025, up from 31.0% in June 2025.
Quarterly data indicates a 5.81% shift in institutional share volume, and the annual owner count reflects a decrease of 3.09%.
Among the 157 institutional holders of Structure Therapeutics, 77 added to their stakes while 52 trimmed their positions and 28 held steady.
Collectively, institutional investors increased their stake in Structure Therapeutics to 57.23Mn shares as of September 2025, a change that is up by 3.14Mn shares quarter on quarter and down 4.63Mn shares year over year.
As of September 30, 2025, WELLINGTON MANAGEMENT GROUP LLP held Structure Therapeutics's largest shareholding position with over 5.69Mn shares, representing 3.29% of total outstanding shares.
Among the most significant buyers of Structure Therapeutics during September 2025 were Avoro Capital Advisors LLC (2.82Mn), BVF INC/IL (1.43Mn), Siren, L.L.C. (1.03Mn), Paradigm Biocapital Advisors LP (372.87K), FMR LLC (335.40K).
Leading sellers of Structure Therapeutics stock in September 2025 included WELLINGTON MANAGEMENT GROUP LLP (1.19Mn), Octagon Capital Advisors LP (1.08Mn), BAKER BROS. ADVISORS LP (952.66K), Deep Track Capital, LP (918.11K), CITADEL ADVISORS LLC (548.54K).
The top 10 institutional holders of Structure Therapeutics for the quarter ending September 2025 included WELLINGTON MANAGEMENT GROUP LLP (5.69Mn), FMR LLC (5.25Mn), Avoro Capital Advisors LLC (5.16Mn), JANUS HENDERSON GROUP PLC (4.45Mn), Deep Track Capital, LP (4.22Mn), BVF INC/IL (3.20Mn), BAKER BROS. ADVISORS LP (1.56Mn), Casdin Capital, LLC (1.55Mn), RA CAPITAL MANAGEMENT, L.P. (1.52Mn), MILLENNIUM MANAGEMENT LLC (1.27Mn).

157 Institutional Holders

4,377,488 Total Shares Held

Rows:

Download Data

Owner Name	Date	Shares Held	Change (QoQ)	Change (%)	Value (USD)
WELLINGTON MANAGEMENT GROUP LLP	30 Sep, 2025	5,689,187	-1,186,582	-17.26%	$159,297,236.00
FMR LLC	30 Sep, 2025	5,250,368	335,403	6.82%	$147,010,304.00
Avoro Capital Advisors LLC	30 Sep, 2025	5,155,555	2,822,222	120.95%	$144,355,540.00
JANUS HENDERSON GROUP PLC	30 Sep, 2025	4,448,826	-124,180	-2.72%	$124,603,170.00
Deep Track Capital, LP	30 Sep, 2025	4,215,811	-918,106	-17.88%	$118,042,708.00
BVF INC/IL	30 Sep, 2025	3,203,917	1,432,500	80.87%	$89,709,676.00
BAKER BROS. ADVISORS LP	30 Sep, 2025	1,556,109	-952,658	-37.97%	$43,571,052.00
Casdin Capital, LLC	30 Sep, 2025	1,555,000	330,000	26.94%	$43,540,000.00
RA CAPITAL MANAGEMENT, L.P.	30 Sep, 2025	1,517,418	0	0.00%	$42,487,704.00
MILLENNIUM MANAGEMENT LLC	30 Sep, 2025	1,274,551	54,496	4.47%	$35,687,428.00
AMERIPRISE FINANCIAL INC	30 Sep, 2025	1,224,144	-364,054	-22.92%	$34,276,032.00
ORBIMED ADVISORS LLC	30 Sep, 2025	1,139,300	-60,000	-5.00%	$31,900,400.00
TCG Crossover Management, LLC	30 Sep, 2025	1,063,000	0	0.00%	$29,764,000.00
Siren, L.L.C.	30 Sep, 2025	1,026,811	1,026,811	0.00%	$28,750,708.00
Rock Springs Capital Management LP	30 Sep, 2025	951,154	-184,725	-16.26%	$26,632,312.00
DRIEHAUS CAPITAL MANAGEMENT LLC	30 Sep, 2025	873,504	200,712	29.83%	$24,458,112.00
Logos Global Management LP	30 Sep, 2025	850,000	0	0.00%	$23,800,000.00
PRINCIPAL FINANCIAL GROUP INC	30 Sep, 2025	787,484	-65,718	-7.70%	$22,049,552.00
FRANKLIN RESOURCES INC	30 Sep, 2025	745,734	3,951	0.53%	$20,880,551.00
PACIFIC HEIGHTS ASSET MANAGEMENT LLC	30 Sep, 2025	700,000	240,000	52.17%	$19,600,000.00

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Structure Therapeutics Inc. (GPCR) Institutional Ownership

Institutions by Trading Activity

Ownership Statistics

Shares Owned by Institutions

Shares Purchased/Sold by Institutions

Ownership Summary

157 Institutional Holders

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