Structure Therapeutics Inc. (GPCR) Institutional Ownership

Institutions by Trading Activity

Ownership Statistics

59,200,000Shares Outstanding

1,082,995Shares held by institutions

$77,336,673Value of institutional holdings

108.92%Institutional ownership %

24.56%Shares Changed QoQ

190No. of institutional investors

Shares Owned by Institutions

Shares Purchased/Sold by Institutions

Ownership Summary

Recent 13F filings as of December 2025 show that 190 institutional investors hold a position in Structure Therapeutics Inc. (NASDAQ:GPCR).

The collective stake of institutional investors in Structure Therapeutics moved to 108.9% in December 2025, a shift up from the 96.7% reported for September 2025.
The company experienced a 24.56% quarterly change in institutional shares held, alongside an increase of 15.85% in total owners annually.
A review of institutional activity for Structure Therapeutics shows 120 of 190 filers increasing their positions, while 58 reduced their stake, and 12 remained unchanged.
Collectively, institutional investors increased their stake in Structure Therapeutics to 64.48Mn shares as of December 2025, a change that is up by 12.71Mn shares quarter on quarter and up 3.56Mn shares year over year.
As of December 31, 2025, FMR LLC held Structure Therapeutics's largest shareholding position with over 8.71Mn shares, representing 14.72% of total outstanding shares.
Among the most significant buyers of Structure Therapeutics during December 2025 were FMR LLC (3.46Mn), MORGAN STANLEY (1.51Mn), WELLINGTON MANAGEMENT GROUP LLP (1.43Mn), Avoro Capital Advisors LLC (1.40Mn), Capitolis Liquid Global Markets LLC (878.30K).
Leading sellers of Structure Therapeutics stock in December 2025 included MILLENNIUM MANAGEMENT LLC (1.12Mn), AMERIPRISE FINANCIAL INC (938.63K), Catalio Capital Management, LP (398.91K), Casdin Capital, LLC (380.00K), Aberdeen Group plc (322.00K).
The top 10 institutional holders of Structure Therapeutics for the quarter ending December 2025 included FMR LLC (8.71Mn), WELLINGTON MANAGEMENT GROUP LLP (7.12Mn), Avoro Capital Advisors LLC (6.56Mn), JANUS HENDERSON GROUP PLC (5.09Mn), Deep Track Capital, LP (4.11Mn), BVF INC/IL (3.48Mn), MORGAN STANLEY (2.09Mn), DRIEHAUS CAPITAL MANAGEMENT LLC (1.64Mn), BAKER BROS. ADVISORS LP (1.43Mn), PRINCIPAL FINANCIAL GROUP INC (1.28Mn).

190 Institutional Holders

1,082,995 Total Shares Held

Rows:

Download Data

Owner Name	Date	Shares Held	Change (QoQ)	Change (%)	Value (USD)
FMR LLC	31 Dec, 2025	8,712,251	3,461,883	65.94%	$605,937,057.00
WELLINGTON MANAGEMENT GROUP LLP	31 Dec, 2025	7,121,984	1,432,797	25.18%	$495,333,988.00
Avoro Capital Advisors LLC	31 Dec, 2025	6,555,555	1,400,000	27.16%	$455,938,850.00
JANUS HENDERSON GROUP PLC	31 Dec, 2025	5,090,148	641,322	14.42%	$354,005,522.00
Deep Track Capital, LP	31 Dec, 2025	4,111,782	-104,029	-2.47%	$285,974,438.00
BVF INC/IL	31 Dec, 2025	3,479,022	275,105	8.59%	$241,965,980.00
MORGAN STANLEY	31 Dec, 2025	2,087,834	1,510,093	261.38%	$145,208,903.00
DRIEHAUS CAPITAL MANAGEMENT LLC	31 Dec, 2025	1,642,444	768,940	88.03%	$114,231,980.00
BAKER BROS. ADVISORS LP	31 Dec, 2025	1,432,529	-123,580	-7.94%	$99,632,392.00
PRINCIPAL FINANCIAL GROUP INC	31 Dec, 2025	1,284,210	496,726	63.08%	$89,316,805.00
Casdin Capital, LLC	31 Dec, 2025	1,175,000	-380,000	-24.44%	$81,721,250.00
ORBIMED ADVISORS LLC	31 Dec, 2025	1,161,803	22,503	1.98%	$80,803,399.00
Siren, L.L.C.	31 Dec, 2025	1,078,698	51,887	5.05%	$75,023,446.00
TCG Crossover Management, LLC	31 Dec, 2025	920,857	-142,143	-13.37%	$64,045,604.00
Capitolis Liquid Global Markets LLC	31 Dec, 2025	878,300	878,300	0.00%	$61,085,765.00
FRANKLIN RESOURCES INC	31 Dec, 2025	870,582	124,848	16.74%	$60,548,961.00
ALLIANCEBERNSTEIN L.P.	31 Dec, 2025	848,851	819,292	2,771.72%	$59,037,587.00
DEUTSCHE BANK AG\	31 Dec, 2025	841,162	841,162	0.00%	$58,502,817.00
CITADEL ADVISORS LLC	31 Dec, 2025	772,518	328,718	74.07%	$53,728,627.00
DEERFIELD MANAGEMENT COMPANY, L.P.	31 Dec, 2025	767,993	394,586	105.67%	$53,413,913.00

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