Edgewise Therapeutics, Inc. (EWTX) Institutional Ownership

Institutions by Trading Activity

Ownership Statistics

99,519,620Shares Outstanding

40,034,243Shares held by institutions

$1,204,230,029Value of institutional holdings

122.07%Institutional ownership %

11.16%Shares Changed QoQ

191No. of institutional investors

Shares Owned by Institutions

Shares Purchased/Sold by Institutions

Ownership Summary

Edgewise Therapeutics, Inc. (NASDAQ:EWTX) currently has 191 active institutional owners and shareholders as of today (December 2025), that have filed 13F forms with the Securities Exchange Commission (SEC).

The collective stake of institutional investors in Edgewise Therapeutics moved to 122.1% in December 2025, a shift up from the 112.6% reported for September 2025.
On a quarter-over-quarter basis, institutional holdings shifted by 11.16%, with a year-over-year a decrease of 5.45% in the count of filers.
The latest 13F cycle for Edgewise Therapeutics reveals that of 191 total investors, 110 funds grew their exposure, whereas 54 reduced theirs and 27 made no changes.
This class of investors increased its holdings in Edgewise Therapeutics to 121.49Mn shares for the 13F-cycle ending December 2025, up by 12.19Mn shares quarter on quarter, and up 22.09Mn shares year over year.
As of December 31, 2025, ORBIMED ADVISORS LLC held Edgewise Therapeutics's largest shareholding position with over 15.52Mn shares, representing 15.59% of total outstanding shares.
Among the most significant buyers of Edgewise Therapeutics during December 2025 were MORGAN STANLEY (2.04Mn), UBS Group AG (2.00Mn), DRIEHAUS CAPITAL MANAGEMENT LLC (1.96Mn), BANK OF AMERICA CORP /DE/ (1.15Mn), ALLIANCEBERNSTEIN L.P. (958.91K).
Leading sellers of Edgewise Therapeutics stock in December 2025 included Bellevue Group AG (1.25Mn), BAKER BROS. ADVISORS LP (730.00K), Cormorant Asset Management, LP (725.00K), MILLENNIUM MANAGEMENT LLC (568.99K), JANUS HENDERSON GROUP PLC (412.48K).
The top 10 institutional holders of Edgewise Therapeutics for the quarter ending December 2025 included ORBIMED ADVISORS LLC (15.52Mn), RA CAPITAL MANAGEMENT, L.P. (10.43Mn), BlackRock, Inc. (6.63Mn), BAKER BROS. ADVISORS LP (6.58Mn), Paradigm Biocapital Advisors LP (6.54Mn), Novo Holdings A/S (5.35Mn), BRAIDWELL LP (5.21Mn), VANGUARD GROUP INC (4.87Mn), JANUS HENDERSON GROUP PLC (4.57Mn), Siren, L.L.C. (4.53Mn).

191 Institutional Holders

40,034,243 Total Shares Held

Rows:

Download Data

Owner Name	Date	Shares Held	Change (QoQ)	Change (%)	Value (USD)
ORBIMED ADVISORS LLC	31 Dec, 2025	15,518,492	0	0.00%	$385,091,379.00
RA CAPITAL MANAGEMENT, L.P.	31 Dec, 2025	10,428,437	0	0.00%	$258,781,664.00
BlackRock, Inc.	31 Dec, 2025	6,630,576	279,089	4.39%	$164,537,741.00
BAKER BROS. ADVISORS LP	31 Dec, 2025	6,575,940	-730,000	-9.99%	$163,181,951.00
Paradigm Biocapital Advisors LP	31 Dec, 2025	6,541,210	371,079	6.01%	$162,320,126.00
Novo Holdings A/S	31 Dec, 2025	5,350,000	0	0.00%	$132,760,250.00
BRAIDWELL LP	31 Dec, 2025	5,210,831	0	0.00%	$129,306,771.00
VANGUARD GROUP INC	31 Dec, 2025	4,871,624	67,683	1.41%	$120,889,349.00
JANUS HENDERSON GROUP PLC	31 Dec, 2025	4,566,850	-412,481	-8.28%	$113,326,384.00
Siren, L.L.C.	31 Dec, 2025	4,529,990	632,891	16.24%	$112,411,702.00
PERCEPTIVE ADVISORS LLC	31 Dec, 2025	4,457,974	662,080	17.44%	$110,624,625.00
DRIEHAUS CAPITAL MANAGEMENT LLC	31 Dec, 2025	4,191,193	1,962,908	88.09%	$104,004,458.00
Cormorant Asset Management, LP	31 Dec, 2025	3,285,000	-725,000	-18.08%	$81,517,275.00
MORGAN STANLEY	31 Dec, 2025	2,910,881	2,041,203	234.71%	$72,233,511.00
UBS Group AG	31 Dec, 2025	2,117,073	2,002,945	1,755.00%	$52,535,166.00
GEODE CAPITAL MANAGEMENT, LLC	31 Dec, 2025	1,746,222	28,581	1.66%	$43,340,399.00
STATE STREET CORP	31 Dec, 2025	1,717,343	17,434	1.03%	$42,615,867.00
MPM BioImpact LLC	31 Dec, 2025	1,655,256	-65,485	-3.81%	$41,075,178.00
First Light Asset Management, LLC	31 Dec, 2025	1,573,701	158,707	11.22%	$39,051,392.00
Bellevue Group AG	31 Dec, 2025	1,528,518	-1,247,479	-44.94%	$37,930,174.00

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