Edgewise Therapeutics, Inc. (EWTX) Institutional Ownership

Institutions by Trading Activity

Ownership Statistics

105,492,779Shares Outstanding

122,648,774Shares held by institutions

$3,802,111,994Value of institutional holdings

116.26%Institutional ownership %

11.45%Shares Changed QoQ

194No. of institutional investors

Shares Owned by Institutions

Shares Purchased/Sold by Institutions

Ownership Summary

Edgewise Therapeutics, Inc. (NASDAQ:EWTX) has 194 institutional investors with active 13F positions as of December 2025.

Their combined ownership stood at 115.1% of outstanding shares in December 2025, up from 106.5% in September 2025.
Their total shares held in EWTX increased 10.7% quarter over quarter, and separately, investors owning Edgewise Therapeutics decreased 2.51% from a year ago.
Among the 194 funds, 114 bought more Edgewise Therapeutics shares, 53 sold down, and 27 held their ground.
Altogether, these fund groups held 121.43Mn shares in EWTX by December 2025, up by 11.74Mn shares quarter on quarter, and up 21.25Mn shares year over year.
As of December 31, 2025, PEREGRINE CAPITAL MANAGEMENT LLC held the largest stake in Edgewise Therapeutics with 208.67K shares, accounting for 0.2% of total shares outstanding.
The biggest buyers of Edgewise Therapeutics for the quarter ending December 2025 included PEREGRINE CAPITAL MANAGEMENT LLC (208.67K), MOODY ALDRICH PARTNERS LLC (71.01K), Eleva Capital SAS (17.46K), Pictet Asset Management Holding SA (7.62K), STRS OHIO (6.9K).
Leading sellers of Edgewise Therapeutics shares for the quarter ending December 2025 were SG Americas Securities, LLC (84.92K), Farther Finance Advisors, LLC (14), Sterling Capital Management LLC (10).
Edgewise Therapeutics's 10 largest shareholders as of December 2025 include PEREGRINE CAPITAL MANAGEMENT LLC (208.67K), MOODY ALDRICH PARTNERS LLC (114.14K), Eleva Capital SAS (17.46K), Connecticut Capital Management Group, LLC (9.84K), Pictet Asset Management Holding SA (7.62K), STRS OHIO (6.9K), PSP Research LLC (6.5K), SG Americas Securities, LLC (3.8K), GF FUND MANAGEMENT CO. LTD. (2.38K), GAMMA Investing LLC (2.29K) per Business Quant data.

194 Institutional Holders

122,648,774 Total Shares Held

Rows:

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Owner Name	Date	Shares Held	Change (QoQ)	Change (%)	Value (USD)
ORBIMED ADVISORS LLC	31 Dec, 2025	15,518,492	0	0.00%	$385,091,379.00
RA CAPITAL MANAGEMENT, L.P.	31 Dec, 2025	10,428,437	0	0.00%	$258,781,664.00
BlackRock, Inc.	31 Dec, 2025	6,630,576	279,089	4.39%	$164,537,741.00
BAKER BROS. ADVISORS LP	31 Dec, 2025	6,575,940	-730,000	-9.99%	$163,181,951.00
Paradigm Biocapital Advisors LP	31 Dec, 2025	6,541,210	371,079	6.01%	$162,320,126.00
Novo Holdings A/S	31 Dec, 2025	5,350,000	0	0.00%	$132,760,250.00
BRAIDWELL LP	31 Dec, 2025	5,210,831	0	0.00%	$129,306,771.00
VANGUARD GROUP INC	31 Dec, 2025	4,871,624	67,683	1.41%	$120,889,349.00
Janus Henderson Group Plc	31 Dec, 2025	4,566,850	-412,481	-8.28%	$113,326,384.00
Siren, L.L.C.	31 Dec, 2025	4,529,990	632,891	16.24%	$112,411,702.00
PERCEPTIVE ADVISORS LLC	31 Dec, 2025	4,457,974	662,080	17.44%	$110,624,625.00
DRIEHAUS CAPITAL MANAGEMENT LLC	31 Dec, 2025	4,191,193	1,962,908	88.09%	$104,004,458.00
Cormorant Asset Management, LP	31 Dec, 2025	3,285,000	-725,000	-18.08%	$81,517,275.00
Morgan Stanley	31 Dec, 2025	2,910,881	2,041,203	234.71%	$72,233,511.00
UBS Group AG	31 Dec, 2025	2,117,073	2,002,945	1,755.00%	$52,535,166.00
GEODE CAPITAL MANAGEMENT, LLC	31 Dec, 2025	1,746,222	28,581	1.66%	$43,340,399.00
State Street Corp	31 Dec, 2025	1,717,343	17,434	1.03%	$42,615,867.00
MPM BioImpact LLC	31 Dec, 2025	1,655,256	-65,485	-3.81%	$41,075,178.00
First Light Asset Management, LLC	31 Dec, 2025	1,573,701	158,707	11.22%	$39,051,392.00
Bellevue Group AG	31 Dec, 2025	1,528,518	-1,247,479	-44.94%	$37,930,174.00

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