Edgewise Therapeutics, Inc. (EWTX) Institutional Ownership

Institutions by Trading Activity

Ownership Statistics

0Shares Outstanding

7,822,727Shares held by institutions

$236,833,060Value of institutional holdings

113.52%Institutional ownership %

8.36%Shares Changed QoQ

177No. of institutional investors

Shares Owned by Institutions

Shares Purchased/Sold by Institutions

Ownership Summary

Edgewise Therapeutics, Inc. (NASDAQ:EWTX) showed up in the 13F filings of 194 institutional investors as of December 2025.

They owned 115.1% of outstanding stock in December 2025, up from 106.5% the prior quarter.
Their total shares held in EWTX increased 10.7% from the prior quarter, while the number of investors in Edgewise Therapeutics decreased 2.51% year over year.
During the quarter, 114 of these 194 funds increased positions in EWTX, 53 reduced exposure, and 27 held steady.
Altogether, these fund groups held 121.43Mn shares in EWTX by December 2025, up by 11.74Mn shares quarter on quarter, and up 21.25Mn shares year over year.
ORBIMED ADVISORS LLC is the top holder of Edgewise Therapeutics as of December 31, 2025, with 15.52Mn shares representing 14.71% of outstanding stock.
Top purchasers of EWTX stock for the quarter ending December 2025 included Morgan Stanley (2.04Mn), UBS Group AG (2.0Mn), DRIEHAUS CAPITAL MANAGEMENT LLC (1.96Mn), ALLIANCEBERNSTEIN L.P. (958.91K), Soleus Capital Management, L.P. (910.0K).
The biggest sellers of Edgewise Therapeutics for the quarter ending December 2025 included Bellevue Group AG (1.25Mn), BAKER BROS. ADVISORS LP (730.0K), Cormorant Asset Management, LP (725.0K), MILLENNIUM MANAGEMENT LLC (598.99K), Janus Henderson Group Plc (412.48K).
Per Business Quant data, the top 10 holders of Edgewise Therapeutics for the quarter ending December 2025 are ORBIMED ADVISORS LLC (15.52Mn), RA CAPITAL MANAGEMENT, L.P. (10.43Mn), BlackRock, Inc. (6.63Mn), BAKER BROS. ADVISORS LP (6.58Mn), Paradigm Biocapital Advisors LP (6.54Mn), Novo Holdings A/S (5.35Mn), BRAIDWELL LP (5.21Mn), VANGUARD GROUP INC (4.87Mn), Janus Henderson Group Plc (4.57Mn), Siren, L.L.C. (4.53Mn).

194 Institutional Holders

7,822,727 Total Shares Held

Rows:

Download Data

Owner Name	Date	Change (QoQ)	Change (%)	Value (USD)
BlackRock, Inc.	31 Dec, 2025	279,089	4.39%	$0.00
ORBIMED ADVISORS LLC	31 Dec, 2025	0	0.00%	$0.00
Paradigm Biocapital Advisors LP	31 Dec, 2025	371,079	6.01%	$0.00
Barclays Plc	31 Dec, 2025	18,738	5.29%	$0.00
RA CAPITAL MANAGEMENT, L.P.	31 Dec, 2025	0	0.00%	$0.00
BRAIDWELL LP	31 Dec, 2025	0	0.00%	$0.00
Rockefeller Capital Management L.P.	31 Dec, 2025	364	0.00%	$0.00
BAKER BROS. ADVISORS LP	31 Dec, 2025	-730,000	-9.99%	$0.00
Siren, L.L.C.	31 Dec, 2025	632,891	16.24%	$0.00
Novo Holdings A/S	31 Dec, 2025	0	0.00%	$0.00
UBS Group AG	31 Dec, 2025	2,002,945	1,755.00%	$0.00
VANGUARD GROUP INC	31 Dec, 2025	67,683	1.41%	$0.00
MPM BioImpact LLC	31 Dec, 2025	-65,485	-3.81%	$0.00
Janus Henderson Group Plc	31 Dec, 2025	-412,481	-8.28%	$0.00
Bellevue Group AG	31 Dec, 2025	-1,247,479	-44.94%	$0.00
PERCEPTIVE ADVISORS LLC	31 Dec, 2025	662,080	17.44%	$0.00
Integral Health Asset Management, LLC	31 Dec, 2025	0	0.00%	$0.00
DRIEHAUS CAPITAL MANAGEMENT LLC	31 Dec, 2025	1,962,908	88.09%	$0.00
Soleus Capital Management, L.P.	31 Dec, 2025	910,000	0.00%	$0.00
Cormorant Asset Management, LP	31 Dec, 2025	-725,000	-18.08%	$0.00

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