Dyne Therapeutics, Inc. (DYN) Institutional Ownership

Ownership Summary

A total of 205 institutions have reported a stake in Dyne Therapeutics, Inc. (NASDAQ:DYN) as of September 2025, according to recent 13F filings with the SEC.

• The percentage of Dyne Therapeutics owned by institutions changed from 112.2% in June 2025 to 109.7% in September 2025, marking a slight down trend.
• On a quarter-over-quarter basis, institutional holdings shifted by 27.40%, with a year-over-year an increase of 2.50% in the count of filers.
• Among the 205 institutional holders of Dyne Therapeutics, 143 added to their stakes while 43 trimmed their positions and 19 held steady.
• The total number of shares held by institutions in Dyne Therapeutics increased to 156.02Mn as of September 2025, a net change of up by 33.55Mn shares quarter on quarter, and up 43.54Mn shares year over year.
• As of September 30, 2025, JANUS HENDERSON GROUP PLC held Dyne Therapeutics's largest shareholding position with over 14.75Mn shares, representing 10.36% of total outstanding shares.
• Among the most significant buyers of Dyne Therapeutics during September 2025 were JANUS HENDERSON GROUP PLC (5.31Mn), MARSHALL WACE, LLP (2.57Mn), VANGUARD GROUP INC (2.11Mn), Vestal Point Capital, LP (2.05Mn), STATE STREET CORP (1.91Mn).
• Leading sellers of Dyne Therapeutics stock in September 2025 included PERCEPTIVE ADVISORS LLC (1.71Mn), PRICE T ROWE ASSOCIATES INC /MD/ (985.87K), BRAIDWELL LP (542.87K), Caption Management, LLC (476.39K), D. E. Shaw & Co., Inc. (467.35K).
• The top 10 institutional holders of Dyne Therapeutics for the quarter ending September 2025 included JANUS HENDERSON GROUP PLC (14.75Mn), VANGUARD GROUP INC (9.76Mn), BlackRock, Inc. (9.63Mn), Atlas Venture Life Science Advisors, LLC (9.13Mn), FCPM III SERVICES B.V. (5.46Mn), FMR LLC (5.40Mn), STATE STREET CORP (5.27Mn), Siren, L.L.C. (4.73Mn), TCG Crossover Management, LLC (4.62Mn), ADAGE CAPITAL PARTNERS GP, L.L.C. (3.55Mn).