Dyne Therapeutics, Inc. (DYN) Institutional Ownership

Institutions by Trading Activity

Ownership Statistics

115,792,623Shares Outstanding

24,397,973Shares held by institutions

$372,801,027Value of institutional holdings

138.04%Institutional ownership %

10.54%Shares Changed QoQ

222No. of institutional investors

Shares Owned by Institutions

Shares Purchased/Sold by Institutions

Ownership Summary

A total of 222 institutions have reported a stake in Dyne Therapeutics, Inc. (NASDAQ:DYN) as of December 2025, according to recent 13F filings with the SEC.

The collective stake of institutional investors in Dyne Therapeutics moved to 138.0% in December 2025, a shift up from the 134.7% reported for September 2025.
In percentage terms, this reflects as a holdings change of 10.54% quarter on quarter, and an increase of 12.69% year over year.
Of these 222 institutional investors, 142 increased their holdings in Dyne Therapeutics, while 60 of them reduced positions, and 20 investors maintained their exposure.
Collectively, institutional investors increased their stake in Dyne Therapeutics to 159.84Mn shares as of December 2025, a change that is up by 15.24Mn shares quarter on quarter and up 48.24Mn shares year over year.
The top institutional stake in Dyne Therapeutics as of December 31, 2025 belongs to JANUS HENDERSON GROUP PLC, which owns 13.89Mn shares, or 11.99% of the company.
Among the most significant buyers of Dyne Therapeutics during December 2025 were Orbis Allan Gray Ltd (4.80Mn), PERCEPTIVE ADVISORS LLC (2.94Mn), ADAGE CAPITAL PARTNERS GP, L.L.C. (1.62Mn), BlackRock, Inc. (1.56Mn), SAMLYN CAPITAL, LLC (1.49Mn).
Leading sellers of Dyne Therapeutics stock in December 2025 included Vestal Point Capital, LP (2.65Mn), MARSHALL WACE, LLP (2.34Mn), CITADEL ADVISORS LLC (2.24Mn), Point72 Asset Management, L.P. (1.39Mn), BRAIDWELL LP (1.25Mn).
The top 10 institutional holders of Dyne Therapeutics for the quarter ending December 2025 included JANUS HENDERSON GROUP PLC (13.89Mn), VANGUARD GROUP INC (11.22Mn), BlackRock, Inc. (11.19Mn), Atlas Venture Life Science Advisors, LLC (9.13Mn), STATE STREET CORP (6.69Mn), FMR LLC (6.57Mn), FCPM III SERVICES B.V. (5.46Mn), ADAGE CAPITAL PARTNERS GP, L.L.C. (5.17Mn), Orbis Allan Gray Ltd (4.80Mn), TCG Crossover Management, LLC (4.62Mn).

222 Institutional Holders

24,397,973 Total Shares Held

Rows:

Download Data

Owner Name	Date	Shares Held	Change (QoQ)	Change (%)	Value (USD)
JANUS HENDERSON GROUP PLC	31 Dec, 2025	13,887,722	-857,783	-5.82%	$271,603,659.00
VANGUARD GROUP INC	31 Dec, 2025	11,215,565	1,455,151	14.91%	$219,376,451.00
BlackRock, Inc.	31 Dec, 2025	11,190,838	1,555,929	16.15%	$218,892,793.00
Atlas Venture Life Science Advisors, LLC	31 Dec, 2025	9,130,465	0	0.00%	$178,591,895.00
STATE STREET CORP	31 Dec, 2025	6,692,745	1,423,828	27.02%	$130,910,092.00
FMR LLC	31 Dec, 2025	6,569,921	1,168,005	21.62%	$128,507,653.00
FCPM III SERVICES B.V.	31 Dec, 2025	5,462,846	0	0.00%	$106,853,268.00
ADAGE CAPITAL PARTNERS GP, L.L.C.	31 Dec, 2025	5,172,000	1,618,000	45.53%	$101,164,320.00
Orbis Allan Gray Ltd	31 Dec, 2025	4,801,928	4,801,928	0.00%	$93,925,712.00
TCG Crossover Management, LLC	31 Dec, 2025	4,615,144	0	0.00%	$90,272,217.00
JPMORGAN CHASE & CO	31 Dec, 2025	3,549,909	184,664	5.49%	$69,436,220.00
Siren, L.L.C.	31 Dec, 2025	3,502,941	-1,226,233	-25.93%	$68,517,526.00
PERCEPTIVE ADVISORS LLC	31 Dec, 2025	3,478,944	2,938,500	543.72%	$68,048,145.00
GEODE CAPITAL MANAGEMENT, LLC	31 Dec, 2025	3,263,429	395,824	13.80%	$63,844,380.00
ARMISTICE CAPITAL, LLC	31 Dec, 2025	3,249,708	185,708	6.06%	$63,564,288.00
Frazier Life Sciences Management, L.P.	31 Dec, 2025	3,153,082	434,977	16.00%	$61,674,284.00
T. Rowe Price Investment Management, Inc.	31 Dec, 2025	2,870,568	58,146	2.07%	$56,149.00
Deep Track Capital, LP	31 Dec, 2025	2,650,000	650,000	32.50%	$51,834,000.00
Vivo Capital, LLC	31 Dec, 2025	2,614,960	0	0.00%	$51,148,618.00
GOLDMAN SACHS GROUP INC	31 Dec, 2025	2,283,191	382,976	20.15%	$44,659,216.00

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