Compass Therapeutics, Inc. (CMPX) Institutional Ownership

Institutions by Trading Activity

Ownership Statistics

146,235,556Shares Outstanding

35,913,997Shares held by institutions

$229,490,441Value of institutional holdings

111.13%Institutional ownership %

12.45%Shares Changed QoQ

162No. of institutional investors

Shares Owned by Institutions

Shares Purchased/Sold by Institutions

Ownership Summary

According to SEC filings for the period ending December 2025, Compass Therapeutics, Inc. (NASDAQ:CMPX) is held by 162 institutional firms.

Compass Therapeutics saw its institutional ownership percentage rose to 111.1% in December 2025 from 104.0% in September 2025.
Quarterly data indicates a 12.45% shift in institutional share volume, and the annual owner count reflects an increase of 76.09%.
The latest 13F cycle for Compass Therapeutics reveals that of 162 total investors, 111 funds grew their exposure, whereas 33 reduced theirs and 18 made no changes.
This class of investors increased its holdings in Compass Therapeutics to 162.51Mn shares for the 13F-cycle ending December 2025, up by 17.99Mn shares quarter on quarter, and up 61.15Mn shares year over year.
As of December 31, 2025, TANG CAPITAL MANAGEMENT LLC held Compass Therapeutics's largest shareholding position with over 16.79Mn shares, representing 11.48% of total outstanding shares.
Among the most significant buyers of Compass Therapeutics during December 2025 were DEERFIELD MANAGEMENT COMPANY, L.P. (3.61Mn), BVF INC/IL (3.01Mn), BRAIDWELL LP (2.79Mn), Palo Alto Investors LP (2.53Mn), BlackRock, Inc. (2.02Mn).
Leading sellers of Compass Therapeutics stock in December 2025 included Blackstone Inc. (3.71Mn), SILVERARC CAPITAL MANAGEMENT, LLC (1.78Mn), ROYAL BANK OF CANADA (1.70Mn), FMR LLC (1.56Mn), BALYASNY ASSET MANAGEMENT L.P. (1.23Mn).
The top 10 institutional holders of Compass Therapeutics for the quarter ending December 2025 included TANG CAPITAL MANAGEMENT LLC (16.79Mn), ORBIMED ADVISORS LLC (15.22Mn), SUVRETTA CAPITAL MANAGEMENT, LLC (14.18Mn), Vivo Capital, LLC (9.55Mn), BlackRock, Inc. (9.39Mn), VANGUARD GROUP INC (8.05Mn), Enavate Sciences GP, LLC (7.79Mn), BVF INC/IL (7.76Mn), Blackstone Inc. (6.13Mn), STATE STREET CORP (4.89Mn).

162 Institutional Holders

35,913,997 Total Shares Held

Rows:

Download Data

Owner Name	Date	Shares Held	Change (QoQ)	Change (%)	Value (USD)
TANG CAPITAL MANAGEMENT LLC	31 Dec, 2025	16,790,809	-21,154	-0.13%	$90,166,644.00
ORBIMED ADVISORS LLC	31 Dec, 2025	15,219,994	0	0.00%	$81,731,368.00
SUVRETTA CAPITAL MANAGEMENT, LLC	31 Dec, 2025	14,182,379	81,220	0.58%	$76,159,375.00
Vivo Capital, LLC	31 Dec, 2025	9,545,466	0	0.00%	$51,259,152.00
BlackRock, Inc.	31 Dec, 2025	9,388,624	2,017,877	27.38%	$50,416,912.00
VANGUARD GROUP INC	31 Dec, 2025	8,048,374	985,575	13.95%	$43,219,768.00
Enavate Sciences GP, LLC	31 Dec, 2025	7,788,150	0	0.00%	$41,822,366.00
BVF INC/IL	31 Dec, 2025	7,764,842	3,014,842	63.47%	$41,697,202.00
Blackstone Inc.	31 Dec, 2025	6,126,182	-3,713,926	-37.74%	$32,897,597.00
STATE STREET CORP	31 Dec, 2025	4,890,525	1,784,012	57.43%	$26,262,119.00
ADAGE CAPITAL PARTNERS GP, L.L.C.	31 Dec, 2025	4,436,500	-750,000	-14.46%	$23,824,005.00
Rock Springs Capital Management LP	31 Dec, 2025	3,927,202	-547,500	-12.24%	$21,089,075.00
DEERFIELD MANAGEMENT COMPANY, L.P.	31 Dec, 2025	3,606,000	3,606,000	0.00%	$19,364,220.00
GEODE CAPITAL MANAGEMENT, LLC	31 Dec, 2025	3,502,526	558,057	18.95%	$18,813,341.00
Blue Owl Capital Holdings LP	31 Dec, 2025	3,466,525	875,000	33.76%	$18,615,239.00
Sofinnova Investments, Inc.	31 Dec, 2025	3,365,446	1,336,560	65.88%	$18,072,445.00
MILLENNIUM MANAGEMENT LLC	31 Dec, 2025	3,109,286	-128,286	-3.96%	$16,696,866.00
BRAIDWELL LP	31 Dec, 2025	2,786,778	2,786,778	0.00%	$14,964,998.00
FMR LLC	31 Dec, 2025	2,579,711	-1,557,851	-37.65%	$13,853,048.00
Palo Alto Investors LP	31 Dec, 2025	2,532,419	2,532,419	0.00%	$13,599,090.00

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