C4 Therapeutics, Inc. (CCCC) Institutional Ownership

Institutions by Trading Activity

Ownership Statistics

73,104,545Shares Outstanding

7,902,356Shares held by institutions

$14,461,311Value of institutional holdings

108.76%Institutional ownership %

59.12%Shares Changed QoQ

96No. of institutional investors

Shares Owned by Institutions

Shares Purchased/Sold by Institutions

Ownership Summary

According to SEC filings for the period ending December 2025, C4 Therapeutics, Inc. (NASDAQ:CCCC) is held by 96 institutional firms.

The percentage of C4 Therapeutics owned by institutions changed from 72.0% in September 2025 to 108.8% in December 2025, marking a slight up trend.
The company experienced a 59.12% quarterly change in institutional shares held, alongside a decrease of 15.79% in total owners annually.
The latest 13F cycle for C4 Therapeutics reveals that of 96 total investors, 65 funds grew their exposure, whereas 19 reduced theirs and 12 made no changes.
The aggregate institutional position in C4 Therapeutics now stands at 79.51Mn shares as of December 2025, after investors increased their holdings (up by 29.54Mn shares quarter on quarter which is up 15.03Mn shares year over year).
The top institutional stake in C4 Therapeutics as of December 31, 2025 belongs to Point72 Asset Management, L.P., which owns 9.44Mn shares, or 12.91% of the company.
Among the most significant buyers of C4 Therapeutics during December 2025 were Point72 Asset Management, L.P. (9.44Mn), RA CAPITAL MANAGEMENT, L.P. (8.00Mn), Bain Capital Life Sciences Investors, LLC (6.06Mn), MORGAN STANLEY (4.01Mn), SUSQUEHANNA INTERNATIONAL GROUP, LLP (1.26Mn).
Leading sellers of C4 Therapeutics stock in December 2025 included ORBIMED ADVISORS LLC (3.83Mn), Soleus Capital Management, L.P. (3.25Mn), MILLENNIUM MANAGEMENT LLC (835.26K), WASATCH ADVISORS LP (507.82K), ROYAL BANK OF CANADA (181.97K).
The top 10 institutional holders of C4 Therapeutics for the quarter ending December 2025 included Point72 Asset Management, L.P. (9.44Mn), MORGAN STANLEY (8.98Mn), RA CAPITAL MANAGEMENT, L.P. (8.00Mn), Bain Capital Life Sciences Investors, LLC (7.17Mn), Lynx1 Capital Management LP (7.10Mn), VANGUARD GROUP INC (4.38Mn), WASATCH ADVISORS LP (4.34Mn), Soleus Capital Management, L.P. (3.80Mn), BANK OF AMERICA CORP /DE/ (2.39Mn), SILVERARC CAPITAL MANAGEMENT, LLC (1.99Mn).

96 Institutional Holders

7,902,356 Total Shares Held

Rows:

Download Data

Owner Name	Date	Shares Held	Change (QoQ)	Change (%)	Value (USD)
Point72 Asset Management, L.P.	31 Dec, 2025	9,439,328	9,439,328	0.00%	$18,029,116.00
MORGAN STANLEY	31 Dec, 2025	8,981,662	4,009,630	80.64%	$17,154,974.00
RA CAPITAL MANAGEMENT, L.P.	31 Dec, 2025	8,000,000	8,000,000	0.00%	$15,280,000.00
Bain Capital Life Sciences Investors, LLC	31 Dec, 2025	7,171,910	6,060,000	545.01%	$13,698,348.00
Lynx1 Capital Management LP	31 Dec, 2025	7,098,133	0	0.00%	$13,557,434.00
VANGUARD GROUP INC	31 Dec, 2025	4,379,815	1,188,258	37.23%	$8,365,446.00
WASATCH ADVISORS LP	31 Dec, 2025	4,344,918	-507,823	-10.46%	$8,298,793.00
Soleus Capital Management, L.P.	31 Dec, 2025	3,803,942	-3,250,000	-46.07%	$7,265,529.00
BANK OF AMERICA CORP /DE/	31 Dec, 2025	2,387,586	334,424	16.29%	$4,560,290.00
SILVERARC CAPITAL MANAGEMENT, LLC	31 Dec, 2025	1,994,224	96,841	5.10%	$3,808,968.00
BlackRock, Inc.	31 Dec, 2025	1,969,814	374,175	23.45%	$3,762,346.00
SUSQUEHANNA INTERNATIONAL GROUP, LLP	31 Dec, 2025	1,775,783	1,260,346	244.52%	$3,391,746.00
RENAISSANCE TECHNOLOGIES LLC	31 Dec, 2025	1,602,580	665,630	71.04%	$3,060,928.00
TWO SIGMA INVESTMENTS, LP	31 Dec, 2025	1,509,603	674,877	80.85%	$2,883,342.00
ORBIMED ADVISORS LLC	31 Dec, 2025	1,404,902	-3,830,244	-73.16%	$2,683,363.00
MILLENNIUM MANAGEMENT LLC	31 Dec, 2025	1,188,969	-835,256	-41.26%	$2,270,931.00
GOLDMAN SACHS GROUP INC	31 Dec, 2025	1,089,020	629,127	136.80%	$2,080,028.00
TWO SIGMA ADVISERS, LP	31 Dec, 2025	1,068,200	305,100	39.98%	$2,040,262.00
GEODE CAPITAL MANAGEMENT, LLC	31 Dec, 2025	988,878	263,574	36.34%	$1,889,264.00
JANE STREET GROUP, LLC	31 Dec, 2025	874,794	671,226	329.73%	$1,670,856.00

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