Aytu Biopharma, Inc (AYTU) Institutional Ownership

Institutions by Trading Activity

10,036,359Shares Outstanding

3,771,522Shares held by institutions

$8,550,040Value of institutional holdings

37.58%Institutional ownership %

4.03%Shares Changed QoQ

39No. of institutional investors

Aytu Biopharma, Inc (NASDAQ:AYTU) showed up in the 13F filings of 39 institutional investors as of December 2025.

These investors held 37.6% of outstanding shares in December 2025, up from 18.7% in September 2025.
Their total shares held in AYTU increased 4.03% from the prior quarter, while the number of investors in Aytu Biopharma increased 34.48% year over year.
Activity in AYTU broke down as 16 buyers, 8 sellers, and 15 unchanged among 39 total holders.
Institutional investors collectively held 3.77Mn shares in Aytu Biopharma as of December 2025, up by 146.06K shares quarter on quarter, and up 1.89Mn shares year over year.
BELLEVUE ASSET MANAGEMENT, LLC leads ownership in AYTU with 25.01K shares as of December 31, 2025, equal to 0.25% of outstanding shares.
Top sellers of AYTU stock for the quarter ending December 2025 included FNY Investment Advisers, LLC (31.51K).
Per Business Quant, the top 4 investors in AYTU for the quarter ending December 2025 include BELLEVUE ASSET MANAGEMENT, LLC (25.01K), Daytona Street Capital LLC (10.0K), FNY Investment Advisers, LLC (90), VISION FINANCIAL MARKETS LLC (2).

3,771,522 Total Shares Held

Rows:

Owner Name	Date	Shares Held	Change (QoQ)	Change (%)	Value (USD)
Nantahala Capital Management, LLC	31 Dec, 2025	1,086,812	0	0.00%	$2,825,711.00
Stonepine Capital Management, LLC	31 Dec, 2025	813,704	-78,151	-8.76%	$2,115,630.00
AWM Investment Company, Inc.	31 Dec, 2025	619,574	0	0.00%	$1,610,892.00
DIADEMA PARTNERS LP	31 Dec, 2025	305,788	33,118	12.15%	$795,049.00
VANGUARD GROUP INC	31 Dec, 2025	278,583	0	0.00%	$724,316.00
TWO SIGMA INVESTMENTS, LP	31 Dec, 2025	107,133	38,397	55.86%	$278,546.00
RENAISSANCE TECHNOLOGIES LLC	31 Dec, 2025	89,623	-5,500	-5.78%	$233,020.00
Persistent Asset Partners Ltd	31 Dec, 2025	79,415	-45,489	-36.42%	$206,479.00
GEODE CAPITAL MANAGEMENT, LLC	31 Dec, 2025	74,097	3,091	4.35%	$192,685.00
TWO SIGMA ADVISERS, LP	31 Dec, 2025	42,500	2,700	6.78%	$110,500.00
DIMENSIONAL FUND ADVISORS LP	31 Dec, 2025	35,363	4,399	14.21%	$91,944.00
FNY Investment Advisers, LLC	31 Dec, 2025	31,600	31,470	24,207.69%	$82.00
DRW Securities, LLC	31 Dec, 2025	29,368	29,368	0.00%	$76,356.00
XTX Topco Ltd	31 Dec, 2025	25,860	25,860	0.00%	$67,236.00
BELLEVUE ASSET MANAGEMENT, LLC	31 Dec, 2025	25,013	25,013	0.00%	$65,033.00
BlackRock, Inc.	31 Dec, 2025	22,793	0	0.00%	$59,262.00
PERRITT CAPITAL MANAGEMENT INC	31 Dec, 2025	20,000	20,000	0.00%	$52,000.00
Rothschild Wealth LLC	31 Dec, 2025	20,000	20,000	0.00%	$52,000.00
Northern Trust Corp	31 Dec, 2025	19,169	19,169	0.00%	$49,839.00
CITADEL ADVISORS LLC	31 Dec, 2025	15,551	15,551	0.00%	$40,433.00

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