Aytu Biopharma, Inc (AYTU) Institutional Ownership

Ownership Summary

Aytu Biopharma, Inc (NASDAQ:AYTU) showed up in the 13F filings of 39 institutional investors as of December 2025.

• They owned 37.6% of outstanding stock in December 2025, up from 18.7% the prior quarter.
• They increased total shares held in AYTU by 4.03% quarter over quarter, and investors in Aytu Biopharma increased 34.48% from a year ago.
• Of these 39 holders, 16 added to their stakes in Aytu Biopharma, 8 trimmed positions, and 15 made no changes.
• Combined, these investors held 3.77Mn shares in AYTU for December 2025, up by 146.06K shares quarter on quarter, and up 1.89Mn shares year over year.
• Nantahala Capital Management, LLC leads ownership in AYTU with 1.09Mn shares as of December 31, 2025, equal to 10.83% of outstanding shares.
• Leading buyers of Aytu Biopharma shares for the quarter ending December 2025 were TWO SIGMA INVESTMENTS, LP (38.4K), DIADEMA PARTNERS LP (33.12K), FNY Investment Advisers, LLC (31.47K), DRW Securities, LLC (29.37K), XTX Topco Ltd (25.86K).
• The biggest sellers of Aytu Biopharma for the quarter ending December 2025 included Stonepine Capital Management, LLC (78.15K), Persistent Asset Partners Ltd (45.49K), RENAISSANCE TECHNOLOGIES LLC (5.5K), Tower Research Capital LLC (TRC) (2.61K), Morgan Stanley (161).
• Business Quant data shows the 10 biggest positions in Aytu Biopharma as of December 2025 are held by Nantahala Capital Management, LLC (1.09Mn), Stonepine Capital Management, LLC (813.7K), AWM Investment Company, Inc. (619.57K), DIADEMA PARTNERS LP (305.79K), VANGUARD GROUP INC (278.58K), TWO SIGMA INVESTMENTS, LP (107.13K), RENAISSANCE TECHNOLOGIES LLC (89.62K), Persistent Asset Partners Ltd (79.42K), GEODE CAPITAL MANAGEMENT, LLC (74.1K), TWO SIGMA ADVISERS, LP (42.5K).