As of March 23, 2026, the three largest insider holders of AVXL are Christopher U Missling (President And Ceo, 1.51Mn shares), Athanasios Skarpelos (Director, 1.31Mn shares), Steffen Thomas (Director, 43.65K shares).
| Holder | Position | Shares (Direct) | Shares (Indirect) | Report Date |
|---|---|---|---|---|
| Christopher U Missling | President And Ceo | 1,510,165 | 0 | 12 Sep, 2025 |
| Athanasios Skarpelos | 1,306,458 | 0 | 27 May, 2022 | |
| Steffen Thomas | 43,651 | 0 | 09 Jun, 2025 | |
| Sandra Boenisch | Pfo And Treasurer | 22,963 | 0 | 01 Jul, 2021 |
| Peter D.O. Donhauser | 5,000 | 0 | 17 Jun, 2024 |
* Please note that the shares above only reflect shares from the fund portfolio and the institutional portfolio. Shares from the personal portfolio are excluded from this Institutional Ownership Page. See these insiders' latest transactions here on Insider Page.
| Transaction Date | Insider Name | Security Class | Transaction Type | Shares Traded | Price | Shares Remaining | Ownership | Code |
|---|---|---|---|---|---|---|---|---|
| 06 Jan, 2026 | Christopher U Missling | Stock Option (Right to Buy) | A | 125,000 | $0.00 | 125,000 | D | A |
| 06 Jan, 2026 | Sandra Boenisch | Stock Option (Right to Buy) | A | 12,500 | $0.00 | 12,500 | D | A |
| 02 Oct, 2025 | Christopher U Missling | Stock Option (Right to Buy) | A | 125,000 | $0.00 | 250,000 | D | A |
| 02 Oct, 2025 | Sandra Boenisch | Stock Option (Right to Buy) | A | 12,500 | $0.00 | 25,000 | D | A |
| 11 Sep, 2025 | Christopher U Missling | Common Stock | A | 187,500 | $5.04 | 1,655,213 | D | M |
| 11 Sep, 2025 | Christopher U Missling | Common Stock | D | 145,048 | $9.58 | 1,510,165 | D | F |
| 11 Sep, 2025 | Christopher U Missling | Stock Option (Right to Buy) | D | 187,500 | $0.00 | 0 | D | M |
| 20 Aug, 2025 | Sandra Boenisch | Stock Option (Right to Buy) | A | 12,500 | $0.00 | 12,500 | D | A |
| 20 Aug, 2025 | Christopher U Missling | Stock Option (Right to Buy) | A | 125,000 | $0.00 | 125,000 | D | A |
| 05 Jun, 2025 | Steffen Thomas | Common stock | A | 50,000 | $1.76 | 55,000 | D | M |
| 05 Jun, 2025 | Steffen Thomas | Common stock | D | 11,349 | $7.75 | 43,651 | D | F |
| 05 Jun, 2025 | Steffen Thomas | Stock Option (Right to Buy) | D | 50,000 | $0.00 | 0 | D | M |
| 28 Apr, 2025 | Christopher U Missling | Stock Option (Right to Buy) | A | 125,000 | $0.00 | 125,000 | D | A |
| 28 Apr, 2025 | Sandra Boenisch | Stock Option (Right to Buy) | A | 12,500 | $0.00 | 12,500 | D | A |
| 31 Mar, 2025 | Claus Vander Velden | Stock Option (Right to Buy) | A | 50,000 | $0.00 | 50,000 | D | A |
| 31 Mar, 2025 | Peter D.O. Donhauser | Stock Option (Right to Buy) | A | 50,000 | $0.00 | 50,000 | D | A |
| 31 Mar, 2025 | Jiong Ma | Stock Option (Right to Buy) | A | 50,000 | $0.00 | 50,000 | D | A |
| 31 Mar, 2025 | Athanasios Skarpelos | Stock Option (Right to Buy) | A | 50,000 | $0.00 | 50,000 | D | A |
| 31 Mar, 2025 | Steffen Thomas | Stock Option (Right to Buy) | A | 50,000 | $0.00 | 50,000 | D | A |
| 24 Mar, 2025 | Christopher U Missling | Common Stock | A | 500,000 | $0.92 | 1,750,210 | D | M |