Annexon, Inc. (ANNX) Institutional Ownership

Institutions by Trading Activity

149,123,701Shares Outstanding

140,323,057Shares held by institutions

$842,639,957Value of institutional holdings

94.10%Institutional ownership %

43.65%Shares Changed QoQ

161No. of institutional investors

Annexon, Inc. (NASDAQ:ANNX) has 161 institutional investors that have filed 13F reports for the period ending December 2025.

Their combined ownership stood at 91.2% of outstanding shares in December 2025, up from 68.8% in September 2025.
They increased total shares held in Annexon by 39.62% from the prior quarter, while the number of investors in ANNX increased 7.33% year over year.
Of these 161 funds, 105 grew their exposure to Annexon, 32 cut back, and 24 maintained positions.
Institutional investors collectively held 135.93Mn shares in Annexon as of December 2025, up by 38.57Mn shares quarter on quarter, and up 21.1Mn shares year over year.
STRS OHIO holds the largest position in ANNX at 55.5K shares as of December 31, 2025, or 0.04% of shares outstanding.
Leading buyers of Annexon shares for the quarter ending December 2025 were STRS OHIO (55.5K), E Fund Management Co., Ltd. (25.55K), WEALTH ENHANCEMENT ADVISORY SERVICES, LLC (21.93K), Pictet Asset Management Holding SA (16.7K), Merit Financial Group, LLC (10.74K).
The largest sales of ANNX for the quarter ending December 2025 came from Sterling Capital Management LLC (1.6K).
Per Business Quant, the top 10 investors in ANNX for the quarter ending December 2025 include STRS OHIO (55.5K), Allegheny Financial Group (42.9K), E Fund Management Co., Ltd. (25.55K), WEALTH ENHANCEMENT ADVISORY SERVICES, LLC (21.93K), Pictet Asset Management Holding SA (16.7K), Merit Financial Group, LLC (10.74K), Sterling Capital Management LLC (4.37K), GF FUND MANAGEMENT CO. LTD. (3.23K), Farther Finance Advisors, LLC (1.36K), IFP Advisors, Inc (645).

140,323,057 Total Shares Held

Rows:

Owner Name	Date	Shares Held	Change (QoQ)	Change (%)	Value (USD)
FMR LLC	31 Dec, 2025	10,222,470	-858,693	-7.75%	$51,316,800.00
Redmile Group, LLC	31 Dec, 2025	10,050,644	3,750,000	59.52%	$50,454,233.00
BVF INC/IL	31 Dec, 2025	9,128,080	2,128,080	30.40%	$45,822,962.00
BlackRock, Inc.	31 Dec, 2025	8,960,434	1,061,426	13.44%	$44,981,380.00
VANGUARD GROUP INC	31 Dec, 2025	7,753,387	1,918,275	32.87%	$38,922,003.00
ADAGE CAPITAL PARTNERS GP, L.L.C.	31 Dec, 2025	5,500,000	4,000,000	266.67%	$27,610,000.00
Bain Capital Life Sciences Investors, LLC	31 Dec, 2025	5,249,069	0	0.00%	$26,350,326.00
Opaleye Management Inc.	31 Dec, 2025	5,200,000	2,600,000	100.00%	$26,104,000.00
Bellevue Group AG	31 Dec, 2025	5,157,290	0	0.00%	$25,889,596.00
State Street Corp	31 Dec, 2025	4,652,185	2,601,877	126.90%	$23,353,969.00
Ameriprise Financial Inc	31 Dec, 2025	4,348,782	2,156,428	98.36%	$21,830,887.00
Woodline Partners LP	31 Dec, 2025	4,000,074	1,361,799	51.62%	$20,080,371.00
Goldman Sachs Group Inc	31 Dec, 2025	3,537,490	1,131,058	47.00%	$17,758,200.00
BALYASNY ASSET MANAGEMENT L.P.	31 Dec, 2025	3,299,256	2,001,996	154.32%	$16,562,265.00
Longaeva Partners L.P.	31 Dec, 2025	3,100,000	3,100,000	0.00%	$15,562,000.00
MAK CAPITAL ONE LLC	31 Dec, 2025	2,958,527	2,958,527	0.00%	$14,851,806.00
Nuveen, LLC	31 Dec, 2025	2,915,324	2,232,766	327.12%	$14,634,927.00
GEODE CAPITAL MANAGEMENT, LLC	31 Dec, 2025	2,902,896	465,952	19.12%	$14,576,148.00
Morgan Stanley	31 Dec, 2025	2,856,143	-173,705	-5.73%	$14,337,838.00
MILLENNIUM MANAGEMENT LLC	31 Dec, 2025	2,836,857	14,034	0.50%	$14,241,022.00

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