Annexon, Inc. (ANNX) Institutional Ownership

Institutions by Trading Activity

Ownership Statistics

148,437,838Shares Outstanding

14,797,871Shares held by institutions

$74,581,270Value of institutional holdings

91.12%Institutional ownership %

41.28%Shares Changed QoQ

153No. of institutional investors

Shares Owned by Institutions

Shares Purchased/Sold by Institutions

Ownership Summary

Annexon, Inc. (NASDAQ:ANNX) currently has 153 active institutional owners and shareholders as of today (December 2025), that have filed 13F forms with the Securities Exchange Commission (SEC).

Annexon saw its institutional ownership percentage rose to 91.1% in December 2025 from 68.2% in September 2025.
On a quarter-over-quarter basis, institutional holdings shifted by 41.28%, with a year-over-year an increase of 2.00% in the count of filers.
Among the 153 institutional holders of Annexon, 102 added to their stakes while 28 trimmed their positions and 23 held steady.
This class of investors increased its holdings in Annexon to 135.26Mn shares for the 13F-cycle ending December 2025, up by 39.52Mn shares quarter on quarter, and up 23.37Mn shares year over year.
As of December 31, 2025, FMR LLC held Annexon's largest shareholding position with over 10.22Mn shares, representing 6.89% of total outstanding shares.
Among the most significant buyers of Annexon during December 2025 were ADAGE CAPITAL PARTNERS GP, L.L.C. (4.00Mn), Redmile Group, LLC (3.75Mn), Longaeva Partners L.P. (3.10Mn), MAK CAPITAL ONE LLC (2.96Mn), STATE STREET CORP (2.60Mn).
Leading sellers of Annexon stock in December 2025 included DEUTSCHE BANK AG\ (943.61K), FMR LLC (858.69K), GOLDMAN SACHS GROUP INC (637.69K), SPHERA FUNDS MANAGEMENT LTD. (478.18K), MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC (424.89K).
The top 10 institutional holders of Annexon for the quarter ending December 2025 included FMR LLC (10.22Mn), Redmile Group, LLC (10.05Mn), BVF INC/IL (9.13Mn), BlackRock, Inc. (8.96Mn), VANGUARD GROUP INC (7.75Mn), ADAGE CAPITAL PARTNERS GP, L.L.C. (5.50Mn), Bain Capital Life Sciences Investors, LLC (5.25Mn), Bellevue Group AG (5.16Mn), STATE STREET CORP (4.65Mn), AMERIPRISE FINANCIAL INC (4.35Mn).

153 Institutional Holders

14,797,871 Total Shares Held

Rows:

Download Data

Owner Name	Date	Shares Held	Change (QoQ)	Change (%)	Value (USD)
FMR LLC	31 Dec, 2025	10,222,470	-858,693	-7.75%	$51,316,800.00
Redmile Group, LLC	31 Dec, 2025	10,050,644	3,750,000	59.52%	$50,454,233.00
BVF INC/IL	31 Dec, 2025	9,128,080	2,128,080	30.40%	$45,822,962.00
BlackRock, Inc.	31 Dec, 2025	8,960,434	1,061,426	13.44%	$44,981,380.00
VANGUARD GROUP INC	31 Dec, 2025	7,753,387	1,918,275	32.87%	$38,922,003.00
ADAGE CAPITAL PARTNERS GP, L.L.C.	31 Dec, 2025	5,500,000	4,000,000	266.67%	$27,610,000.00
Bain Capital Life Sciences Investors, LLC	31 Dec, 2025	5,249,069	0	0.00%	$26,350,326.00
Bellevue Group AG	31 Dec, 2025	5,157,290	0	0.00%	$25,889,596.00
STATE STREET CORP	31 Dec, 2025	4,652,185	2,601,877	126.90%	$23,353,969.00
AMERIPRISE FINANCIAL INC	31 Dec, 2025	4,348,782	2,156,428	98.36%	$21,830,887.00
Woodline Partners LP	31 Dec, 2025	4,000,074	1,361,799	51.62%	$20,080,371.00
BALYASNY ASSET MANAGEMENT L.P.	31 Dec, 2025	3,299,256	2,001,996	154.32%	$16,562,265.00
Longaeva Partners L.P.	31 Dec, 2025	3,100,000	3,100,000	0.00%	$15,562,000.00
MAK CAPITAL ONE LLC	31 Dec, 2025	2,958,527	2,958,527	0.00%	$14,851,806.00
Nuveen, LLC	31 Dec, 2025	2,915,324	2,232,766	327.12%	$14,634,927.00
GEODE CAPITAL MANAGEMENT, LLC	31 Dec, 2025	2,902,896	465,952	19.12%	$14,576,148.00
MORGAN STANLEY	31 Dec, 2025	2,856,143	-173,705	-5.73%	$14,337,838.00
MILLENNIUM MANAGEMENT LLC	31 Dec, 2025	2,836,857	14,034	0.50%	$14,241,022.00
Opaleye Management Inc.	31 Dec, 2025	2,600,000	0	0.00%	$13,052,000.00
Palo Alto Investors LP	31 Dec, 2025	2,384,192	2,384,192	0.00%	$11,968,644.00

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