Stoke Therapeutics (STOK) Operating Income (2018 - 2026)

Stoke Therapeutics' (STOK) quarterly Operating Income came in at -$53.4 million in Q1 2026, down 148.02% year-on-year from $111.2 million in Q1 2025, and up 13.06% quarter-over-quarter from -$61.4 million in Q4 2025.

Stoke Therapeutics (STOK) Operating Income (2018 - 2026) Analysis & Trends

Stoke Therapeutics' Operating Income history runs 9 years deep, the most recent figure standing at -$53.4 million for Q1 2026.

  • On a quarterly basis, Operating Income fell 148.02% year-over-year to -$53.4 million in Q1 2026; TTM through Mar 2026 was -$185.2 million, a 584.41% decrease from a year earlier, with the FY2025 full-year figure at -$20.6 million, up 79.69% from the prior year.
  • Operating Income grew to -$53.4 million in Q1 2026 per STOK's latest filing, from -$61.4 million in the prior quarter.
  • Across five years, Operating Income topped out at $111.2 million in Q1 2025 and bottomed at -$61.4 million in Q4 2025.
  • The 5-year median for Operating Income is -$27.3 million (2025), against an average of -$23.2 million.
  • Biggest YoY gain for Operating Income was 492.08% in 2025; the steepest drop was 350.0% in 2025.
  • Year by year, Operating Income stood at -$27.2 million in 2022, then dropped by 8.87% to -$29.6 million in 2023, then jumped by 53.85% to -$13.7 million in 2024, then slumped by 350.0% to -$61.4 million in 2025, then grew by 13.06% to -$53.4 million in 2026.
  • Per Business Quant, the three latest STOK Operating Income figures stand at -$53.4 million (Q1 2026), -$61.4 million (Q4 2025), and -$43.1 million (Q3 2025).

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) Op. Inc (Qtr)
1 Oculis Holding AG 68,785.72 Bn 68,785.72 Bn - -27.75 Mn
2 Nanobiotix 1,895.57 Bn 1,895.51 Bn - -
3 BeOne Medicines 471.35 Bn 466.56 Bn 1.35 Bn 249.90 Mn
4 NuCana 279.75 Bn 279.75 Bn - -3.72 Mn
5 Vertex Pharmaceuticals 120.24 Bn 113.00 Bn 2.59 Bn 1.14 Bn
6 Regeneron Pharmaceuticals 67.80 Bn 59.04 Bn 3.31 Bn 642.90 Mn
7 Belite Bio 62.51 Bn 62.51 Bn - -32.68 Mn
8 Argenx Se 57.38 Bn 57.38 Bn 1.41 Bn 493.00 Mn
9 Revolution Medicines 37.78 Bn 37.78 Bn - -445.22 Mn
10 Stoke Therapeutics 1.87 Bn 1.53 Bn - -53.42 Mn

Historic Data

Download Data
DateValue
Mar 31, 2026 -53.42 Mn
Dec 31, 2025 -61.44 Mn
Sep 30, 2025 -43.09 Mn
Jun 30, 2025 -27.30 Mn
Mar 31, 2025 111.24 Mn
Dec 31, 2024 -13.65 Mn
Sep 30, 2024 -30.00 Mn
Jun 30, 2024 -29.34 Mn
Mar 31, 2024 -28.37 Mn
Dec 31, 2023 -29.59 Mn
Sep 30, 2023 -27.23 Mn
Jun 30, 2023 -33.26 Mn
Mar 31, 2023 -24.69 Mn
Dec 31, 2022 -27.18 Mn
Sep 30, 2022 -27.15 Mn
Jun 30, 2022 -25.24 Mn
Mar 31, 2022 -24.80 Mn
Dec 31, 2021 -24.53 Mn
Sep 30, 2021 -22.68 Mn
Jun 30, 2021 -22.03 Mn