NuCana (NCNA) Operating Expenses (2017 - 2025)

NuCana's (NCNA) quarterly Operating Expenses came in at -$3.8 million in Q4 2025, down 132.18% year-on-year from $11.8 million in Q4 2024, and up 21.52% quarter-over-quarter from -$4.8 million in Q3 2025.

NuCana (NCNA) Operating Expenses (2017 - 2025) Analysis & Trends

NuCana has disclosed Operating Expenses across 9 years of filings, most recently posting -$3.8 million for Q4 2025.

  • Operating Expenses for Q4 2025 came in at -$3.8 million, down 132.18% year-over-year; the trailing twelve-month figure through Dec 2025 was -$8.7 million (up 29.01% YoY), and the FY2025 annual result was -$27.5 million, up 6.59% from the prior year.
  • Operating Expenses came in at -$3.8 million for Q4 2025 at NuCana, up from -$4.8 million in the prior quarter.
  • In the past five years, Operating Expenses ranged from a high of $9.0 million in Q2 2021 to a low of -$17.3 million in Q4 2022.
  • The 5-year median for Operating Expenses is -$8.4 million (2024), against an average of -$6.3 million.
  • Peak annual rise in Operating Expenses reached 196.88% in 2021, while the deepest fall reached 385.34% in 2021.
  • NuCana's Operating Expenses stood at -$17.1 million in 2021, then dropped by 0.82% to -$17.3 million in 2022, then soared by 41.46% to -$10.1 million in 2023, then soared by 83.89% to -$1.6 million in 2024, then slumped by 132.18% to -$3.8 million in 2025.
  • The last three Operating Expenses figures came in at -$3.8 million (Q4 2025), -$4.8 million (Q3 2025), and $3.4 million (Q2 2025), per Business Quant data.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) Opex (Qtr)
1 Alterity Therapeutics 723,416.35 Bn 723,416.32 Bn - 4.33 Mn
2 Belite Bio 57,340.00 Bn 57,340.00 Bn - 32.68 Mn
3 Quantum Biopharma 19,125.08 Bn 19,125.08 Bn - 2.97 Mn
4 Legend Biotech 3,262.00 Bn 3,261.71 Bn 242.10 Mn -138.30 Mn
5 Akari Therapeutics 1,789.67 Bn 1,789.67 Bn - 15.76 Mn
6 Evaxion A 1,480.39 Bn 1,480.37 Bn - -3.82 Mn
7 Psyence Biomedical 241.78 Bn 241.78 Bn - 574,669.00
8 Vertex Pharmaceuticals 113.54 Bn 106.29 Bn 2.59 Bn 1.85 Bn
9 Abivax 94.26 Bn 94.26 Bn - -67.40 Mn
10 NuCana 29.13 Bn 29.13 Bn - -3.78 Mn

Historic Data

Download Data
DateValue
Dec 31, 2025 -3.78 Mn
Sep 30, 2025 -4.82 Mn
Jun 30, 2025 3.44 Mn
Mar 31, 2025 -3.52 Mn
Dec 31, 2024 -1.63 Mn
Sep 30, 2024 -6.62 Mn
Jun 30, 2024 6.64 Mn
Mar 31, 2024 -10.61 Mn
Dec 31, 2023 -10.11 Mn
Sep 30, 2023 -11.16 Mn
Jun 30, 2023 2.76 Mn
Mar 31, 2023 -10.27 Mn
Dec 31, 2022 -17.27 Mn
Sep 30, 2022 -10.73 Mn
Jun 30, 2022 5.69 Mn
Mar 31, 2022 -15.56 Mn
Dec 31, 2021 -17.13 Mn
Sep 30, 2021 -15.51 Mn
Jun 30, 2021 9.01 Mn
Mar 31, 2021 -14.91 Mn