NuCana (NCNA) EBITDA (2017 - 2025)
NuCana's (NCNA) quarterly EBITDA came in at -$3.7 million in Q4 2025, down 235.47% year-on-year from $2.7 million in Q4 2024, and down 933.77% quarter-over-quarter from -$360279.7 in Q3 2025.
NuCana (NCNA) EBITDA (2017 - 2025) Analysis & Trends
NuCana has disclosed EBITDA across 9 years of filings, most recently posting -$3.7 million for Q4 2025.
- EBITDA for Q4 2025 came in at -$3.7 million, down 235.47% year-over-year; the trailing twelve-month figure through Dec 2025 was -$39.5 million (down 60.87% YoY), and the FY2025 annual result was -$26.5 million, up 9.06% from the prior year.
- EBITDA came in at -$3.7 million for Q4 2025 at NuCana, down from -$360279.7 in the prior quarter.
- In the past five years, EBITDA ranged from a high of -$360279.7 in Q3 2025 to a low of -$32.2 million in Q2 2025.
- The 5-year median for EBITDA is -$8.7 million (2024), against an average of -$10.0 million.
- Peak annual rise in EBITDA reached 93.92% in 2025, while the deepest fall reached 265.09% in 2025.
- NuCana's EBITDA stood at -$21.2 million in 2021, then increased by 4.63% to -$20.2 million in 2022, then jumped by 44.13% to -$11.3 million in 2023, then surged by 90.18% to -$1.1 million in 2024, then slumped by 235.47% to -$3.7 million in 2025.
- The last three EBITDA figures came in at -$3.7 million (Q4 2025), -$360279.7 (Q3 2025), and -$32.2 million (Q2 2025), per Business Quant data.
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | EBITDA (Qtr) |
|---|---|---|---|---|---|
| 1 | Alterity Therapeutics | 723,416.35 Bn | 723,416.32 Bn | - | - |
| 2 | Belite Bio | 57,340.00 Bn | 57,340.00 Bn | - | -26.92 Mn |
| 3 | Quantum Biopharma | 19,125.08 Bn | 19,125.08 Bn | - | -13.63 Mn |
| 4 | Legend Biotech | 3,262.00 Bn | 3,261.71 Bn | 242.10 Mn | -19.70 Mn |
| 5 | Akari Therapeutics | 1,789.67 Bn | 1,789.67 Bn | - | -14.44 Mn |
| 6 | Evaxion A | 1,480.39 Bn | 1,480.37 Bn | - | -3.82 Mn |
| 7 | Psyence Biomedical | 241.78 Bn | 241.78 Bn | - | -752,618.00 |
| 8 | Vertex Pharmaceuticals | 113.54 Bn | 106.29 Bn | 2.59 Bn | 1.14 Bn |
| 9 | Abivax | 94.26 Bn | 94.26 Bn | - | -65.83 Mn |
| 10 | NuCana | 29.13 Bn | 29.13 Bn | - | -3.72 Mn |
Historic Data
Download Data| Date | Value |
|---|---|
| Dec 31, 2025 | -3.72 Mn |
| Sep 30, 2025 | -360,279.69 |
| Jun 30, 2025 | -32.23 Mn |
| Mar 31, 2025 | -3.15 Mn |
| Dec 31, 2024 | -1.11 Mn |
| Sep 30, 2024 | -5.93 Mn |
| Jun 30, 2024 | -8.83 Mn |
| Mar 31, 2024 | -8.67 Mn |
| Dec 31, 2023 | -11.30 Mn |
| Sep 30, 2023 | -8.44 Mn |
| Jun 30, 2023 | -6.80 Mn |
| Mar 31, 2023 | -9.59 Mn |
| Dec 31, 2022 | -20.23 Mn |
| Sep 30, 2022 | -5.28 Mn |
| Jun 30, 2022 | -4.85 Mn |
| Mar 31, 2022 | -11.26 Mn |
| Dec 31, 2021 | -21.21 Mn |
| Sep 30, 2021 | -11.07 Mn |
| Jun 30, 2021 | -12.70 Mn |
| Mar 31, 2021 | -13.46 Mn |