NuCana (NCNA) EBITDA (2017 - 2025)

NuCana's (NCNA) quarterly EBITDA came in at -$3.7 million in Q4 2025, down 235.47% year-on-year from $2.7 million in Q4 2024, and down 933.77% quarter-over-quarter from -$360279.7 in Q3 2025.

NuCana (NCNA) EBITDA (2017 - 2025) Analysis & Trends

NuCana has disclosed EBITDA across 9 years of filings, most recently posting -$3.7 million for Q4 2025.

  • EBITDA for Q4 2025 came in at -$3.7 million, down 235.47% year-over-year; the trailing twelve-month figure through Dec 2025 was -$39.5 million (down 60.87% YoY), and the FY2025 annual result was -$26.5 million, up 9.06% from the prior year.
  • EBITDA came in at -$3.7 million for Q4 2025 at NuCana, down from -$360279.7 in the prior quarter.
  • In the past five years, EBITDA ranged from a high of -$360279.7 in Q3 2025 to a low of -$32.2 million in Q2 2025.
  • The 5-year median for EBITDA is -$8.7 million (2024), against an average of -$10.0 million.
  • Peak annual rise in EBITDA reached 93.92% in 2025, while the deepest fall reached 265.09% in 2025.
  • NuCana's EBITDA stood at -$21.2 million in 2021, then increased by 4.63% to -$20.2 million in 2022, then jumped by 44.13% to -$11.3 million in 2023, then surged by 90.18% to -$1.1 million in 2024, then slumped by 235.47% to -$3.7 million in 2025.
  • The last three EBITDA figures came in at -$3.7 million (Q4 2025), -$360279.7 (Q3 2025), and -$32.2 million (Q2 2025), per Business Quant data.

Peer Comparison

# Company Market Cap Enterprise Value Gross Profit (Qtr) EBITDA (Qtr)
1 Alterity Therapeutics 723,416.35 Bn 723,416.32 Bn - -
2 Belite Bio 57,340.00 Bn 57,340.00 Bn - -26.92 Mn
3 Quantum Biopharma 19,125.08 Bn 19,125.08 Bn - -13.63 Mn
4 Legend Biotech 3,262.00 Bn 3,261.71 Bn 242.10 Mn -19.70 Mn
5 Akari Therapeutics 1,789.67 Bn 1,789.67 Bn - -14.44 Mn
6 Evaxion A 1,480.39 Bn 1,480.37 Bn - -3.82 Mn
7 Psyence Biomedical 241.78 Bn 241.78 Bn - -752,618.00
8 Vertex Pharmaceuticals 113.54 Bn 106.29 Bn 2.59 Bn 1.14 Bn
9 Abivax 94.26 Bn 94.26 Bn - -65.83 Mn
10 NuCana 29.13 Bn 29.13 Bn - -3.72 Mn

Historic Data

Download Data
DateValue
Dec 31, 2025 -3.72 Mn
Sep 30, 2025 -360,279.69
Jun 30, 2025 -32.23 Mn
Mar 31, 2025 -3.15 Mn
Dec 31, 2024 -1.11 Mn
Sep 30, 2024 -5.93 Mn
Jun 30, 2024 -8.83 Mn
Mar 31, 2024 -8.67 Mn
Dec 31, 2023 -11.30 Mn
Sep 30, 2023 -8.44 Mn
Jun 30, 2023 -6.80 Mn
Mar 31, 2023 -9.59 Mn
Dec 31, 2022 -20.23 Mn
Sep 30, 2022 -5.28 Mn
Jun 30, 2022 -4.85 Mn
Mar 31, 2022 -11.26 Mn
Dec 31, 2021 -21.21 Mn
Sep 30, 2021 -11.07 Mn
Jun 30, 2021 -12.70 Mn
Mar 31, 2021 -13.46 Mn