NuCana (NCNA) EBITDA (2017 - 2025)
NuCana (NCNA) reported EBITDA of -$3.7 million for Q4 2025, down 235.47% on a YoY basis from $2.7 million in Q4 2024, and down 254.32% sequentially from -$1.1 million in Q3 2025.
NuCana (NCNA) EBITDA (2017 - 2025) Analysis & Trends
NuCana (NCNA) has 9 years of EBITDA data on file, last reported at -$3.7 million in Q4 2025.
- For the quarter ending Q4 2025, EBITDA fell 235.47% year-over-year to -$3.7 million; the trailing twelve-month figure through Dec 2025 stood at -$24.1 million (up 16.9% YoY), and the FY2025 full-year result was -$26.5 million, up 9.06% from the prior year.
- EBITDA retreated to -$3.7 million in Q4 2025, from -$1.1 million in the prior quarter.
- In the past five years, EBITDA ranged from a high of -$1.1 million in Q3 2025 to a low of -$21.2 million in Q4 2021.
- A 5-year average of -$10.4 million and a median of -$10.5 million in 2024 frame the typical range for EBITDA.
- Across the five-year window, EBITDA jumped 90.18% in 2024 and slumped 235.47% in 2025, its largest moves.
- Tracing NCNA's EBITDA over 5 years: stood at -$21.2 million in 2021, then grew by 4.63% to -$20.2 million in 2022, then soared by 44.13% to -$11.3 million in 2023, then jumped by 90.18% to -$1.1 million in 2024, then tumbled by 235.47% to -$3.7 million in 2025.
- Business Quant data shows NCNA's EBITDA at -$3.7 million in Q4 2025, -$1.1 million in Q3 2025, and -$15.8 million in Q2 2025.
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | EBITDA (Qtr) |
|---|---|---|---|---|---|
| 1 | Oculis Holding AG | 67,072.09 Bn | 67,072.09 Bn | - | -27.75 Mn |
| 2 | Nanobiotix | 1,894.61 Bn | 1,894.55 Bn | - | - |
| 3 | Akari Therapeutics | 1,014.18 Bn | 1,014.18 Bn | - | -15.76 Mn |
| 4 | BeOne Medicines | 471.64 Bn | 466.85 Bn | 1.35 Bn | 249.90 Mn |
| 5 | Vertex Pharmaceuticals | 121.72 Bn | 114.47 Bn | 2.59 Bn | 1.14 Bn |
| 6 | Regeneron Pharmaceuticals | 68.28 Bn | 59.52 Bn | 3.31 Bn | 642.90 Mn |
| 7 | Belite Bio | 61.40 Bn | 61.40 Bn | - | -32.68 Mn |
| 8 | Argenx Se | 56.94 Bn | 56.94 Bn | 1.18 Bn | 394.00 Mn |
| 9 | Revolution Medicines | 37.37 Bn | 37.37 Bn | - | -445.22 Mn |
| 10 | NuCana | 14.60 Bn | 14.60 Bn | - | -3.72 Mn |
Historic Data
Download Data| Date | Value |
|---|---|
| Dec 31, 2025 | -3.72 Mn |
| Sep 30, 2025 | -1.05 Mn |
| Jun 30, 2025 | -15.78 Mn |
| Mar 31, 2025 | -3.59 Mn |
| Dec 31, 2024 | -1.11 Mn |
| Sep 30, 2024 | -6.92 Mn |
| Jun 30, 2024 | -10.54 Mn |
| Mar 31, 2024 | -10.49 Mn |
| Dec 31, 2023 | -11.30 Mn |
| Sep 30, 2023 | -10.45 Mn |
| Jun 30, 2023 | -7.85 Mn |
| Mar 31, 2023 | -11.12 Mn |
| Dec 31, 2022 | -20.23 Mn |
| Sep 30, 2022 | -7.29 Mn |
| Jun 30, 2022 | -6.57 Mn |
| Mar 31, 2022 | -14.04 Mn |
| Dec 31, 2021 | -21.21 Mn |
| Sep 30, 2021 | -13.75 Mn |
| Jun 30, 2021 | -14.97 Mn |
| Mar 31, 2021 | -15.84 Mn |