Lyra Therapeutics (LYRA) Return on Sales [ROS] (2021 - 2025)
Lyra Therapeutics' Return on Sales [ROS] came in at -101685.71% for Q4 2025, down 96227.34 percentage points from -5458.37% a year earlier and down 76737.71 percentage points from the prior quarter.
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Analysis
Lyra Therapeutics (LYRA) Return on Sales [ROS] (2021 - 2025) Analysis & Trends
For FY2025, Lyra Therapeutics' Return on Sales [ROS] was -7794.47%, down 1513.64 percentage points from FY2024.
- Return on Sales [ROS] has declined in each of the last three years, though with a four-year change of +7509.04 percentage points (FY2021 to FY2025).
- Going back by year, Return on Sales [ROS] was -6280.83% in FY2024 (-1972.75 pp), -4308.09% in FY2023 (-177.05 pp), -4131.03% in FY2022 (+11172.47 pp) and -15303.51% in FY2021.
- The Q4 2025 figure represents the lowest quarterly Return on Sales [ROS] since Q4 2022.
- Year-over-year, Return on Sales [ROS] increased in two of the last eight quarters, with an average year-over-year change of -14260.38 percentage points.
- The fastest year-over-year change in Return on Sales [ROS] over five years came in Q4 2023 (a gain of 126487.11 percentage points), and the weakest in Q4 2022 (a drop of 132740.25 percentage points).
- Business Quant data shows LYRA's Return on Sales [ROS] at -24948.00% (Q3 2025), -4822.95% (Q2 2025) and -4831.15% (Q1 2025) in the three quarters before Q4 2025.
Peer Set
Peer Comparison
| # | Company | Market Cap | Enterprise Value | Gross Profit (Qtr) | ROS (Qtr) |
|---|---|---|---|---|---|
| 1 | Eli Lilly | 1,076.25 Bn | 1,044.84 Bn | 19.71 Bn | 51.16% |
| 2 | Johnson & Johnson | 617.18 Bn | 535.70 Bn | 17.26 Bn | 28.21% |
| 3 | AbbVie | 464.58 Bn | 437.73 Bn | 12.70 Bn | 37.86% |
| 4 | Merck | 356.04 Bn | 310.47 Bn | 12.21 Bn | -3.52% |
| 5 | Novartis Ag | 269.07 Bn | 224.94 Bn | 11.24 Bn | 32.97% |
| 6 | Astrazeneca | 243.21 Bn | 216.77 Bn | 12.86 Bn | 20.57% |
| 7 | Amgen | 217.88 Bn | 173.28 Bn | 7.24 Bn | 34.95% |
| 8 | Gilead Sciences | 179.62 Bn | 153.74 Bn | 6.22 Bn | -133.21% |
| 9 | Pfizer | 158.45 Bn | 105.40 Bn | 10.94 Bn | 28.37% |
| 10 | Lyra Therapeutics | 266,232.31 | 266,232.31 | - | -101,685.71% |
Historic Data
Download Data
Historic Data
| Date | Value |
|---|---|
| Dec 31, 2025 | -101,685.71% |
| Sep 30, 2025 | -24,948.00% |
| Jun 30, 2025 | -4,822.95% |
| Mar 31, 2025 | -4,831.15% |
| Dec 31, 2024 | -5,458.37% |
| Sep 30, 2024 | -6,380.51% |
| Jun 30, 2024 | -8,189.63% |
| Mar 31, 2024 | -4,421.80% |
| Dec 31, 2023 | -11,285.62% |
| Sep 30, 2023 | -3,093.20% |
| Jun 30, 2023 | -3,603.28% |
| Mar 31, 2023 | -4,222.68% |
| Dec 31, 2022 | -137,772.73% |
| Sep 30, 2022 | -4,129.81% |
| Jun 30, 2022 | -2,742.86% |
| Mar 31, 2022 | -2,548.08% |
| Dec 31, 2021 | -5,032.47% |
| Sep 30, 2021 | -79,150.00% |
API Access
Lyra Therapeutics Return on Sales [ROS] API
Pull this series into your own models, spreadsheets and apps with the Business Quant
Historical Metrics API. The request below matches the chart above — change the
frequency, period or values and it follows. Swap YOUR_API_KEY for your own key.
https://data.businessquant.com/historic?slug=return-on-sales-%5Bros%5D&ticker=LYRA&period=max&api_key=YOUR_API_KEYimport requests
url = "https://data.businessquant.com/historic"
params = {"slug": "return-on-sales-[ros]", "ticker": "LYRA", "period": "max", "api_key": "YOUR_API_KEY"}
data = requests.get(url, params=params).json()const res = await fetch("https://data.businessquant.com/historic?slug=return-on-sales-%5Bros%5D&ticker=LYRA&period=max&api_key=YOUR_API_KEY");
const data = await res.json();